1. Induction of asthmatic paroxysm was successfully performed on an inpatient with asthma due to Mabushi (straw on which silk worms are raised) usiug Mabushi or its extract solution.
2. Artifical induction was attempted on this patient by inhalation of various food powders, but without any success.
3. The patient was positive in skin, ocular, rhinic, pharyngeal test and Prausnitz-Küstner reaction with protein fraction of Mabvshi. Further, the inductiou succeeded on this patient with this protein fraction.
4. Inhalation test and analysis of the antigen by skin and other allergic reactions disclosed that the antigen was present in the protein fraction of Mabushi.
5. The serum of this patient was negative in precipitation against this protein fraction.
6. Desensitization with this fraction was confirmed by inhalation, and skin and other allergic reactions.

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The author sought antigen of konjac asthma-allergic and inhalating asthma-which is rare in Japan.
1. Inhalation, skin and precipitation test, performed on coniac asthma patients, revealed that the responsible antigen was present also in ammonium sulfate fraction of the flying conjac powder.
2.This ammonium sulfate fraction could further be separated into two fractions by Tiselius method, filter paper and zone electrophoresis.
3.According to the analysis by the latter two, it is highly probable that protein fraction of the antigen may be bound to a polysaccharide fraction.
4.Induction experiments were carried out on two conjac asthma patients using the two fractions separated by zone electrephoresis, and the antigenicity was demonstrated in an fraction which was found further away from the origin.

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The ghosts obtained from long stored erythrocytes appear to be small spherical bodies, and their shape transformation to normal discoidal form took place after the addition of adenosine triphosphate or adenosine diphosphate. Detailed conditions of the transformation were studied and at the same time volume change of the ghosts was observed by the same procedure as in the estimation of hematocrit value. In addition to this, adenosine triphosphatase activity of ghosts was also studied.
The possibility that the Shape thansformation of the ghosts might be due to the existence of a sort of protein differs from actomyosine in muscle and also reacts wlth adenosine triphosphate, was discussed.

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When a burn, covering 20 per cent of the body surface, was produced in male rats of Wistar strain after the ligation of the pylorus, ulcer developed in the glandular part of the stomach at the rate of 90 per cent, gastric juice secretion diminished below that in controls the amount of the juice and hydrochloric acid and total amount of pepsin decreased, and adrenal weight increased.
When a burn was produced after giving electric damage to the hypothalamus, different effects were elicited according to the site of the damage. In the case of the lesion in the posterior hypothalamus, the development of ulcer rather increased. and the amount of the juice and hydrochloric acid and the total amount of pepsin remarkably diminished with significant decrease of adrenal weight. When, however, the lesion was in the medial or anterior hypothalamus, it was observed that the juice secretion, the total amount of pepsin and adrenal weight were significantly higher than in the cases of posterior lesion, showing no remarkable changes in the ulcer development.
There was intimate correlation between changes in adrenal weight and the total amount of pepsin, which are both considered to be attributed to the action of ACTH released by the stress of the burn. And the part most closely connected with this release was found to be the posterior hypothalamus. The release of ACTH seemed to have no direct bearing on the development of gastric ulcer after the formation of burn in the rat.

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Effects of anticholinergic drugs on gastric secretin induced by cinchophen were investigated on dogs with total gastric pouch, and it was found out that Antrenyl, Pro-banthine and Tropin all strongly inhibited such secretion, but that a little larger doses than that of insulin were necessary ; effect of Banthine was rather inferior to the above. These anticholinergic drugs were not considered to exert any inhibitory action on the hypothalamic-pituitary-adrenocortical system, which is related to the gastric secretion by cinchophen, but to inhibit the release of the secretory substance into the stomach by acting on its glandular cells. Regitin and chlorpromazine did not show any inhibitory acticn on gastric secretion by cinchophen.
Combined administrarion of cinchophen and Tropin for 3 weeks produced ulcer as in controls.

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Investigations for α-haemolysin, necrotoxin and leucocidin were carried out with 287 strains of coagulase-positive staphylococci, isolated from purulent foci and rhino-pharynx in this clinic in the period from April 1957 to May 1959. As the result, a relationship was found between the potency of the three kinds of toxins and phage types. Namely, many of group I strains especially type 80/847B, and almost all group II strains had toxins with high potency, while many of group III ones had toxins of low potencncy. Further, in nontypable strains, there were far more of low potency than in typable strains. A great many of strains from hospital infectioms belonged to type 80/847B and a small number bolonged to group III. However, a considerable number of type 80/847B and group III strains were isolated from the nose and pharynx of hospital inhabitants. This suggests that type 80/847B strains have strong infecting power, and group III weak one. Since the former in major cases possess high potent toxins and the latter low potent ones, some relation is considered to be present between these toxins and infecting power.

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Fifty four newborns, 659 female and 774 male sucklings with mormal hip joints, and 220 female and 40 male sucklings with congenital hip dislocation were investigated for the skincrease on the medial side of the thigh, with the following results :
1) This crease is produced in the foetus by adducting force, exerted on the flexion of the hip and knee joint, and disappears in about 2 years after birth. This is dfferent from other skin-creases in this respect, and therefore can adequately be named “forced skincrease”.
2) The skin-crease which is found under inguinal groove nearly in parallel with it disappears relatively early.
3) Symmetry or asymmetry of these creases respectively found on the two thighs can not have any diagnostic significance.
4) When the skin-creases respsctively found on the both thighs are asymmetry under the inguinal grooves, or when they are asymmetry, being respectively found a little higher and lower than the middle parts of the thighs, or when they are asymmetry, two being found slightly above and below the middle part of one thigh, and one on the middle part of the other thigh, there is strong suspicion of dislocation.

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1. In order to investigate effects of steroids on the activity of chorionic gonadotropin in rabbits, its minimum doses to induce ovulation were compared in rabbits administered estradiol benzoate, progesterone, norethisterone, testosterone propionate, progesterone with estradiol benzoate, and tosterone propionate with estradiol benzoate, and in adrenalectomized rabbits. And it was found that estrogens increased sensibility of the ovary to chorionic gonadotropin, while gestagens and androgens decreased it. The sensibility was also decreased after adrenalectomy in more than 5 days.
2. For the object of investgating effects of steroids on the action of pregnant mares' serum gonadotropin (PMS), estradiol benzoate, methylestrenolone and norethisterone were administered in combination with PMS to normal immature and hypophysectomized immature rats, and their ovaries were compared both macroscopically and histologically with those of animals given PMS alone. From the results it was inferred that the inhibition of PMS action by estrogen would be effected through the hypophysis. Nearly the same was inferred concerning the action of norethisterone. Methylestrenolone, however, it was discussed, would exert direct action on the ovary as well as indirect action through the intermediation of the hypophysis. In the hypophysectomized animals, increase in medium-sized follicles without antrum and decrease in degenerative changes of ova and granulosa were observed as direct effects of estrogen on the ovary, and fibrotic changes of interstitial tissue, inhibition of corpus lnteum formation and degenerative changes of corpus luteum as those of methylestrenolone.

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