I. Clinical observation of the “rebound phenomenon” of human ovarian function The so-called “rebound phenomenon” by Matsumoto anp Igarashi was.
clinically reexamined, and especially the indication and application of this phenomenon were studied with the following results.
1) Debouts pill of estrogen or estradiol benzoate was given to 162 sterile women in the for mer half of the menstrual cycle, and as the result ovulation was inhibited in 79.5% the high phase of BBT was prolonged in the succeeding cycles of its 51.9%, and 17.8% became pregnant
2) Improvement was produced by this treatment in cases with remrkable luteal dysfunction and the high phase of BBT lasting 79 days, but pregnancy was induced in few of them.
Pregnancy, however, occurrd in many with the 1012 dayhigh phase, which was slightly shortened by this treatment.
3) In 2 out of 4 cases with anovulatory cycle, ovulation was induced by the treatment, but the rebound effect was not certain.
4) Out of the used estrogen preparations, estradol valevianate had highest efficacy.
5) To produce the rebound effect, it is necessary to inhibit ovulation. And for this purposeit is desirable that estrogen may begiven within 7 days of the menstrual cycle.Also cervical mucus gives the indication of the adequate time of the administration.
6) The rebound effect was not observed in the administration of 19-norsteroids, especially norethysterone.
7) In addition, a few rebounb phenomena of other special types were observed and discussed.
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