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Volume 43 (1993)
- Issue 6 Pages 609-
- Issue 5 Pages 473-
- Issue 4 Pages 311-
- Issue 3 Pages 215-
- Issue 2 Pages 109-
- Issue 1 Pages 1-
Volume 43, Issue 2
Displaying 1-13 of 13 articles from this issue
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DURING CARDIAC MUSCLE DEVELOPMENT AND UNDER THYROID HORMONE STRESSMASASHI ARAI1993 Volume 43 Issue 2 Pages 109-121
Published: March 01, 1993
Released on J-STAGE: October 21, 2009
JOURNAL FREE ACCESSThe purpose of this study was to determine the expression of genes encoding sarcoplasmic reticulum proteins responsible for calcium release, uptake and storage during cardiac muscle development with age and cardiac hypertrophy/atrophy induced by the manipulation of thyroid function. New Zealand white rabbits were used as experimental animals. Cardiac muscle exclusively expressed cardiac isoform of ryanodine receptor, Ca2+-ATPase and calsequestrin, and their expression levels were gradually increased from fetal to adult stages examined. In hyperthyroid hearts, the steady-state level of cardiac ryanodine receptor mRNA and cardiac Ca2+-ATPase mRNA were coordinately increased, but decreased in hypothyroidism. In accord with the changes in Ca2+-ATPase mRNA levels, the Ca2+-ATPase protein was also increased in hyperthyroid ventricles and decreased in hypothyroid ventricles. On the other hand, calsequestrin mRNA levels did not change significantly in hyperthyroid and hypothyroid hearts. These results suggest that the rate of calcium release and uptake increased in hyperthyroid hearts and decreased in hypothyroid hearts, even though the amount of Ca2+ cycled is unaltered between different thyroid hormone levels. This study further indicates that the mRNA levels of various sarcoplasmic reticulum proteins responsible for calcium transport are coordinately regulated in response to diverse functional requirements during development and pathophysiological stress.View full abstractDownload PDF (4268K) -
KUNIO SATO1993 Volume 43 Issue 2 Pages 123-131
Published: March 01, 1993
Released on J-STAGE: October 21, 2009
JOURNAL FREE ACCESSFourteen patients with uremia (10 men, 4 women), undergoing hemodialysis (HD) three times a week, were studied. Endothelin (ET) concentrations were measured by radioimmunoassay. The plasma immunoreactive-endothelin (ir-ET) concentrations were found to be markedly higher in the uremic patients before HD than in normal controls or in essential hypertensive patients with normal renal function. After HD, the plasma levels of ir-ET significantly decreased, though not in association with a reduction in blood pressure.
The blood samples and aliquots of dialysate were obtained at the beginning and the end of HD from 6 patients. Since the antisera (Amersham, U.K.) used had cross reactivity with ET1, ET-2 and big ET-1, both the plasma and dialysate samples were analyzed by HPLC. Both ET1 and big ET-1 levels in plasma were significantly decreased by one course of HD, but the ratio of ET-1 to big ET-1 was unchanged. In dialysate, ET-1 was detectable at the beginning and the end of HD, but big ET-1 was beneath the detection limit, which suggested that ET-1 was converted from big ET-1 in the systemic circulation.
Moreover, the changes in uremic plasma levels of ir-ET or ET-1 did not correlate with changes in the mean blood pressure on a single chronic HD, indicating that circulating ET-1 in blood is not involved directly in the maintenance of blood pressure in uremic patients undergoing HD.View full abstractDownload PDF (1118K) -
AFTER SUBARACHNOID HEMORRHAGEHIROCHIYO WADA1993 Volume 43 Issue 2 Pages 133-145
Published: March 01, 1993
Released on J-STAGE: October 21, 2009
JOURNAL FREE ACCESSFor the treatment of vasospasm after aneurysmal subarachnoid hemorrhage, ticlopidine, 200mg/day, was administered orally to 10 patients (group T), and sodium ozagrel, 80 mg/day, wasadministered intravenously to 25 patients (group S) during the period of anticipated vasospasmafter clipping. In group T, the initial CT showed that two of the patients were in group 2 and eight in group 3, according to the Fisher scale. In group S, two of the patients were in group1, six in group 2 and seventeen in group 3. Plasma levels of the specific platelet protein, beta-thromboglobulin (β-TG) and platelet factor 4 (PF4) were measured successively as amonitor of platelet activity. Using the Glasgow outcome scale, the results were estimated asfollows in group T ; eight patients showed good recovery (GR), none showed moderatedisability (MD), severe disability (SD) or a persistent vegetative state (PVS), and there weretwo deaths (D) : in group S, twenty patients showed GR, two MD, one SD, none PVS and two D.
The efficacies of ticlopidine and sodium ozagrel for the treatment of vasospasm werecompared and found to be nearly equal. An abnormally high level of β-TG and PF4 andoccurrences of symptomatic vasospasm were related. Determination of β-TG and PF4 levelsmight be useful as indices of vasospasm treatment.View full abstractDownload PDF (1654K) -
TOMIO SAWADA, SUSUMU OHWADA, IZUMI TAKEYOSHI, SEIJI NAKAMURA, YUKIO MI ...1993 Volume 43 Issue 2 Pages 147-152
Published: March 01, 1993
Released on J-STAGE: October 21, 2009
JOURNAL FREE ACCESSWe clarified clinicopathological features of poorly differentiated adenocarcinoma (20 patients, 8 %) and mucinous carcinoma (11 patients, 4%) as compared with well and moderately differentiated adenocarcinoma (221 patients, 86%) of the colon.
Poorly differentiated adenocarcinoma was likely to be located in the rectum. In poorly differentiated adenocarcinoma, the average age of patients was younger, male patients were predominant, lymph node metastasis and invasion through vessels were more frequent, and invasion through the bowel wall was deeper as compared with well and moderately differentiated adenocarcinoma. Mucinous carcinoma was more frequent in female patients. Most mucinous carcinomas were located in the rectum, followed by the right colon. Mucinous carcinomas formed larger tumors than well and moderately differentiated adenocarcinomas (68 mm versus 51 mm, p< 0.05). Mucinous carcinoma was characterized by peritoneal carcinosis (45.5% versus 7.4%, p<0.01) as compared with well and moderately differentiated adenocarcinoma. The cumulative 5-year survival rates in patients with poorly differentiated adenocarcinoma and mucinous carcinoma were 33% and 30%, respectively, both of which were worse than well and moderately differentiated adenocarcinoma.View full abstractDownload PDF (688K) -
A RETROSPECTIVE STUDY OF CLINICAL FEATURES AND TREATMENT RESULTSETSUO KAWADA, HIROKAZU MURAKAMI, MASAMITSU KARASAWA, TAKUJI NARUSE, JU ...1993 Volume 43 Issue 2 Pages 153-158
Published: March 01, 1993
Released on J-STAGE: October 21, 2009
JOURNAL FREE ACCESSOne hundred and fifty-five consecutive patients with acute myeloid leukemia (AML) seen between 1980 and 1989 were studied. Patients aged 60 years or more was retrospectively compared with those aged 59 years or less, regarding clinical features and treatment results. Clinical features at presentation did not differ significantly between the elderly and the rest of patients. Attenuated chemotherapy with dose reduction was given to the elderly patients. Remission (CR) rate, first CR duration for the elderly were 58%, eight months and three months respectively, whereas in the younger patients these were 81%, fifteen months and fourteen months respectively. The difference was significant for the CR rate and survival duration, but not for CR duration.View full abstractDownload PDF (830K) -
FUMIO WATANUKI, SUSUMU OHWADA, SEIJI NAKAMURA, YOSIFUMI TANAHASHI, YUK ...1993 Volume 43 Issue 2 Pages 159-163
Published: March 01, 1993
Released on J-STAGE: October 21, 2009
JOURNAL FREE ACCESSBetween 1983 and 1992, surgical intervention was attempted in 14 patients with hilar carcinoma of the bile duct. Local excision of the lesion alone was performed in four patients and hepatic resection in 10, in nine of whom resection of the caudate lobe was also undertaken. The histological free margin was observed in only five of 10 patients with hepatic resection (microscopic curative resection rate, 35.7%). The positive rate of surgical margins was 21% on the duodenal side, 36% on the resected side, 50% on the hepatic side and 21% on the paraaortic lymph-nodes. The modified Bismuth-Corlette classification was useful for selection of the type of surgical intervention in hilar carcinoma of the bile duct. It is suggested that rational resection of the bile duct including hepatectomy and extensive lymphadenectomy is necessary for widening the radical resection and to improve the surgical outcome of hilar carcinoma of the bile duct.View full abstractDownload PDF (638K) -
TOSHIJI SHITARA, SHIN-ICHIROU YUGAMI, MANABU SOTOMATSU, HIROAKI KANEKO ...1993 Volume 43 Issue 2 Pages 165-167
Published: March 01, 1993
Released on J-STAGE: October 21, 2009
JOURNAL FREE ACCESSAutologous red cells were collected from five normal bone marrow donors aged 7-14 years (median, 10 years). Recombinant human erythropoietin was administered to four of the five donors to enhance hematopoiesis. The median volume of blood removed from the donors was 18.2ml/kg. Preoperative blood donation and retransfusion led to no significant complications. No donors required homologous blood transfusion. This technique is useful for marrow donors even in the pediatric age group.View full abstractDownload PDF (353K) -
TSUNEHIRO ISHIDA, NORITAKA SUGAMATA, YUICHI IINO, TAKAO YOKOE, HIDETAD ...1993 Volume 43 Issue 2 Pages 169-178
Published: March 01, 1993
Released on J-STAGE: October 21, 2009
JOURNAL FREE ACCESSA comparative study of physical examination and imaging systems for preoperative diagnosis of breast cancer was performed on 207 cases treated at our hospital from January 1990 through December 1992. All cases were confirmed by histologic examination. The rate of accurate diagnosis was 90% for physical examination (PE), 86% for mammography (MMG), 84% for ultrasonography (US) and 90% for aspiration cytology. US showed the highest rate of definite malignancy. MMG was useful for the accurate diagnosis of nonpalpable breast cancer and tumors less than 1.0 cm in size. In younger patients, the diagnostic rate of PE was higher and that of MMG was worse. It was also low in noninvasive carcinoma and special types of invasive cancer. All of PE, MMG and US were positive in 80% and negative in 6%. We conclude that MMG is more effective than US, on combination with PE, for detection and screening of breast cancer. Two patients with a nonpalpable cancer of the contralateral breast detected by mammographic microcalcification are presented.View full abstractDownload PDF (4646K) -
TETSUO ANZAI, TETSUO KOYANO, MOTOI KANOU, SHIGEKI MURATA, SEIICHIRO KI ...1993 Volume 43 Issue 2 Pages 179-183
Published: March 01, 1993
Released on J-STAGE: October 21, 2009
JOURNAL FREE ACCESSA 66 year-old man was diagnosed as having a mycotic abdominal aortic aneurysm (MAAA) by CT and USG during examination for fever, abdominal pain and pulsatile mass. Antibiotics and antihypertensive drugs reduced inflammation and the size of aneurysm. Blood culture was negative. An anatomical reconstruction was done 13 days after the admission.
Pathological findings indicated inflammatory pseudoaneurysm. The patient's course has been uneventful for the sixteen months since his operation.
MAAA is rare and often requires emergency surgery, but in some cases cautious observation until disappearance of inflammation is useful for achieving a safer operation.View full abstractDownload PDF (1599K) -
SATORU KAKIZAKI, SEIJI SAKURAI, TAKEHIKO ABE, HITOSHI TAKAGI, AKIRA KO ...1993 Volume 43 Issue 2 Pages 185-192
Published: March 01, 1993
Released on J-STAGE: October 21, 2009
JOURNAL FREE ACCESSA case of primary carcinoid tumor of the liver associated with hepatocellular carcinoma is reported. A 75-year-old male was treated for hepatic cirrhosis and hepatocellular carcinoma. He died of hepatic failure. The autopsy revealed a carcinoid tumor of the liver and hepatocellular carcinoma (Edmondson type II). The carcinoid tumor was positive for immunostaining with chromogranin and NSE, and neuroendocrine secretory granules were seen at the ultrastructural level. Neither tumor showed any mixed areas nor was primary carcinoid tumor found elsewhere. Primary carcinoid of the liver is very rare, and this case is the first report, to our knowledge, of primary carcinoid tumor of the liver associated with hepatocellular carcinoma.View full abstractDownload PDF (5571K) -
1993 Volume 43 Issue 2 Pages 193-198
Published: March 01, 1993
Released on J-STAGE: October 21, 2009
JOURNAL FREE ACCESSDownload PDF (1215K) -
1993 Volume 43 Issue 2 Pages 199-205
Published: March 01, 1993
Released on J-STAGE: October 21, 2009
JOURNAL FREE ACCESSDownload PDF (1096K) -
1993 Volume 43 Issue 2 Pages 207-214
Published: March 01, 1993
Released on J-STAGE: October 21, 2009
JOURNAL FREE ACCESSDownload PDF (1307K)
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