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Volume 36 (1986)
- Issue 6 Pages 415-
- Issue 5 Pages 359-
- Issue 4 Pages 319-
- Issue 3 Pages 221-
- Issue 2 Pages 115-
- Issue 1 Pages 1-
Volume 36, Issue 4
Displaying 1-4 of 4 articles from this issue
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TOSHIMASA ARAI1986 Volume 36 Issue 4 Pages 319-332
Published: September 01, 1986
Released on J-STAGE: October 15, 2009
JOURNAL FREE ACCESSWith the aim of elucidating the metabolic basis of platelet abnormalities in chronic myeloproliferative disorders (MPD), the contents of 4 major ribonucleotides (ATP, ADP, GTP & GDP) in platelets and the release of these nucleotides on stimulation with thrombin were studied in 16 patients and 15 healthy subjects. Thrombin-induced platelet aggregation was decreased in six MPD patients, while arachidonate-induced aggregation was unimpaired in all patients. The ADP content in unstimulated platelets from patients with MPD was significantly depressed as compared with healthy subjects. The release of major ribonucleotides into the suspending media was also markedly reduced in MPD patients after maximal stimulation of platelets with thrombin. In 6 patients showing reduced aggregation, platelet cycloxygenase activity was found to be normal, whereas platelet lipoxygenase activity was significantly reduced. However, the sum of the major arachidonate metabolites generated by thrombin stimulation did not differ significantly between MPD patients and healthy subjects. These findings support the contention that the platelet abnormality in chronic MPD is mainly due to acquired metabolic defects in the storage pool of platelets.View full abstractDownload PDF (2225K) -
SPATIAL RELATIONSHIP BETWEEN QRS LOOP AND T LOOP, AND ITS CHANGE WITH AGETAKASHI SUZUKI, KATSUHIKO SONE, SANAYASU ONO1986 Volume 36 Issue 4 Pages 333-340
Published: September 01, 1986
Released on J-STAGE: October 15, 2009
JOURNAL FREE ACCESSVectorcardiograms from 205 normal children aged 1 month to 15 years were studied, and the following results were obtained.
(1) Orientation and magnitude of the maximal QRS and T vector : The maximal QRS vectors of infants and small children pointed toward the left and front, and those of older children also pointed toward the left but to the rear. By contrast, the maximal T vectors of infants and small children were directed toward the left and rear, and those of older children leftward and anteriorly.The magnitudes of QRS vectors were greatest between the ages of 6 and 15 years, being up to 2.0 mV.
(2) Frequency of open QRS loop and the magnitude of its ST vector : Open QRS loop was found in 116 of the 205 cases (56.6%), and its mean ST vector was 0.068 mV. Of these open QRS loop case ST vector over 0.1 mV were shown in 11 cases, but all of these were less than 0.17 mV, and pointed toward the front, left and low.
(3) Maximal length-to-width ratio of the spatial T loop (L/W) : The mean L/W of T loop in these children was 9.4, which is larger than that of adults. That of infants was smaller than that of older children.
(4) Spatial QRS-T angle : The spatial QRS-T angle was large in infants and gradually became smaller with age.
(5) Magnitude of QRS-vector-to-T-vector ratio (QRS/T) : QRS/T ratio was large in infants, but approached that found in adults one with increasing age.
Both the 5th percentile lower limits of L/W of the T loop and the 95th percentile upper limits of the QRS-T angle thus seem to be indicators of abnormality in each age group.View full abstractDownload PDF (1012K) -
HIROO TAKIKAWA, YUICHI IINO, HIROO HACHIYA, HIROSHI ISHIKAWA, MASAO YO ...1986 Volume 36 Issue 4 Pages 341-344
Published: September 01, 1986
Released on J-STAGE: October 15, 2009
JOURNAL FREE ACCESSEstrogen receptors (ER) were determined in 50 human mammary tumor tissues by the dextran-coated charcoal method using 16α-125I-estradiol-17β (125I-E2 Kit) and the sucrose density gradient method using 3H-estradiol-17β (3H-E2). In this study, if a tumor tissue contained more than 5 fmol of ER per mg cytosol protein, it was judged to be ER-positive and if 0 to 5 fmol was present, as ER-negative. The coincident rate of positivity and negativity of ER between the two methods was 90 % (45/50) and the correlation coefficient for the binding sites of ER was r=0.863 in 19 ER-positive cases.
These results showed that in ER assay, the 125I-E2 Kit was as useful as 3H-E2, and that the former was rapid, simple and practical.View full abstractDownload PDF (387K) -
TANJI SUZUKI, GEN-ICHI NAKANO, KEIICHI MUKAWA, KOSAKU SAKAMOTO, TERUHI ...1986 Volume 36 Issue 4 Pages 345-350
Published: September 01, 1986
Released on J-STAGE: October 15, 2009
JOURNAL FREE ACCESSFrom 1970 to 1984, 691 cases of primary gastric cancer were treated in our department. According to the General Rules for Gastric Cancer Study, 342 cases were macroscopically referred as Stage IV. Of the 342 cases, 276 patients, whose prognostic factors were all clear and free from remote metastasis, were examined. From the results of this study, it was revealed that prognosis for cases of disseminating metastasis to the adjacent peritoneum (P1), metastasis to lymph nodes of Group 3 (N3 (+)), invasion to contiguous structures (S3), S3N3 (+), and P1 N3 (+) was relatively good, if resection was performed. Such patients should be treated surgically even if noncurable.View full abstractDownload PDF (689K)
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