In 42 patients with acute cerebral thrombosis (within one month after stroke), 64 patients with chronic cerebral thrombosis (over one month after stroke), and 20 healthy age-matched control persons, ADP-and collagen-induced platelet aggregation (Born's method), platelet retention rate in glass bead columns (Salzman's method), serum total cholesterol and triglyceride levels, and platelet life span (Stuart's method) were determined.
In chronic cerebral thrombosis, ADP-induced platelet aggregation was significantly enhanced, while in acute cerebral thrombosis, platelet aggregability was not significantly different from that of the healthy control. A transient but significant decrease in platelet aggregability and retention rate was observed during the 3rd to 6th day after the stroke.
Serum triglyceride level was significantly higher in chronic cerebral thrombosis than in the healthy control, although both triglyceride and cholesterol levels were not correlated to either platelet aggregability or retention rate.
In patients with chronic cerebral thrombosis, the life span of platelet was slightly shorter than in the healthy control.

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Mouse peritoneal exudate macrophages induced by peptone (macrophages) were activated with a lymphokine, macrophage activating factor (MAF), and became cytotoxic against various tumor cells. Peritoneal resident adherent-cells from normal mice were not activated with MAF.
When macrophages were incubated with aggregated human immunoglobulin G (agg-HGG) for 30 min, they showed no response to MAF. The preventing effect of agg-HGG depended on the doses of HGG added. Agg-BGG also prevented the macrophage activation with MAF. On the contrary, pretreatment of macrophages with heated BSA or monomeric HGG exibited no effect on macrophage activation with MAF. Pretreatment with the Fc rich fraction eliminated the responsiveness of macrophages to MAF, while pretreatment with F (ab')₂ rich fraction did not. These facts suggest that the inhibition is caused by the interaction of Fc receptor with Fc portion of immunoglobulin G.
Post-treatment of activated macrophages with HGG did not influence on the cytotoxic activity. MAF was adsorbed onto the macrophages, which had been pretreated with agg-HGG, as well as to the untreated macrophages. This fact indicate that the binding of HGG to Fc receptor does not interfere the interaction of MAF receptors and MAF molucules.
Then, the author speculate possible inhibiting mechanism of IgG on the macrophage activation with MAF as follow : the binding of Fc portion may trigger a central off signal to macrophage activation with MAF.

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The first survey for the object of promotion and practice of breast feeding is now followed by the second survey concerning grade of infant growth, mothers' attitude on breast feeding and their reflections on their past ways of infant care and feeding. The subjects were infants, aged 2 years to 2 years and 5 months on May 1, 1977, and their mothers, totalling 466. The chief findings were as follows :
1) The mean birth weight was highest in breast feeding group, followed by the mixed and bottle feeding groups in the descending order. When the body weight was assessed at 2 years to 2 years and 5 months by the percentile method, the bottle-fed group tended to be somewhat inferior than the others both in males and females, but there were no marked differences. As for the morbidity rate as a whole or as classified by illness, there was no difference among the three groups of feeding.
2) Early cessation of breast feeding was observed for 97.4% of the mixed feeding group and 84. 6% of the bottle feeding group. The primary reason was poor mammary secretion. Also the mother's prejudiced view that breast-feeding had not contributed to body weight gain was also the reason why breast feeding was supplemented by bottle feeding. It was considered necessary from these facts to give mothers correct informations about the determination of mammary secretion, the evaluation of growth and development.
3) Those who had known the breast feeding promotion campaign, accounted for 85.0% of the total subjects of the present survey 86.5% for the bottle feeding group, 85.6% for the breast feeding group, and 83.1% for the mixed feeing group. There was thus no marked difference between different feeding groups. Those who practiced the breast feeding numbered 208 (44.6%) inclusive of 30 subjects who had not known the campaign. Thus the knowledge of the campaign did not result in the practice of breast feeding.
4) There was difference in the intensity of decision for breast feeding between those who had known the campaign in the health center and mothers' class and those who had learned it through mass communications such as newspaper and television and other routes. The former constituted only 29.2% of the total subjects.
It is evident from the above findings that puplic health nurcing of communities and health centers, and guidance by physicians of medical instituted and of midwives play important roles in the promotion of breast feeding. Moreover are indispensable for this purpose, the understadings and cooperations common to all those who are in some way or other, concerned with maternal and child health. Furthermore, the health policy for mother and infant must be establish by taking into consideration also social aspects such as women's working.

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Basic problems relating to the clinical application of acetyl salicylic acid (aspirin) as as antithrombotic agent were studied. In patients with cerebral thrombosis, myocardial infarction, diabetes mellitus and so on, collagen-induced platelet aggregation and malondialdehyde (MDA) production in their platelets were determined after single ingestion of various amounts of aspirin. Ingestion of 300 mg of aspirin resulted in equal inhibition of MDA production and of collagen-induced aggregation to that of 750 mg of aspirin.
In most patients who ingested aspirin every three days, stable inhibition of collagen-induced platelet aggregation was obtained during whole period of observation. But because some individual variations were present in aggregation-inhibiting effect of aspirin, platelet aggregation should be measured at appropriate intervals on using aspirin as an antithrombotic agent.
In four patients with cerebral thrombosis, one patient with transient ischemic attack, and one patient with myocardial infarction, the life span of platelets, measured by the method of Stuart MJ et al., was shorter than in healthy persons. From these findings, it is suggested that platelets are consumed more rapidly in these patients than in healthy persons, and that aspirin might be one of useful antithrombotic agents.

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A 25-year-old female and a 30-year-old male were diagnosed as corrected transposition of great vessels. No associated cardiac anomalies were demonstrated in the former case, although the right ventricular systolic pressure was slightly elevated. On the other hand, the latter case was associated with incompetence of arterial A-V valve of mild degree.

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A 33-year-old man who suffered from continuous painful muscular rigidity in the extremities and trunk was reported. Other clinical symptoms were finger tremor, involuntary movement in the extremities, gait disturbance and insomnia.
He had abused methamphetamin and suffered from the transient hallucination and paranoid state.
First he remarked paresthesia and muscular pain in his neck, shoulder and left upper arm. Afterward he suffered from continuous painful muscular rigidity in the extremities and trunk and was admitted to the hospital.
There was no abnormal laboratory findings in particular.
Chlorpromazine, levomepromazine, diazepam, active vitamin B₁, B₁₂ and trihexyphenidyl had no effect on his sickness. When we gave him carbamazepine 600mg per day, it was very effective. His complains disappeared within two weeks.
Regarding about the diagnosis, the stiff-man syndrome and Isaacs syndrome were discussed.

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The recent development of radioimmunoassay methods for the measurement of human prolactin has increased the chance of diagnosing the amenorrhea with hyperprolactinemia or prolactin-secreting pituitary microadenoma. In this paper two infertile women showing anovulatory amenorrhea associated with prolactin-secreting pituitary microadenomas were described.
Case 1. Y.K. was 27 years old. she had menarche at 13 years of age and irregular periods until she was 27 years old. Her basal body temperature curve showed mono-phasic, and plasma FSH and LH levels were within normal range. Although she was treated with clomiphene 100mg daily for 5 days or 150mg daily for 5 days, no ovulation was induced. A subsequent investigation showed slight galactorrhea and significant elevation of the plasma prolactin levels (340-500ng/ml). Roentgen examination of the sella turcica showed an asymmetrical floor suggesting a existence of pituitary microadenoma. A simultaneous intravenous injection of synthetic LH-RH 100μg and TRH 500μg indicated that the LH and FSH response were within normal range but prolactin response was very large. Following treatment with bromocriptine 5mg daily for 14 days, she had anovulatory menstruation. With the treatment of bromocriptine 7.5mg daily plasma prolactin was suppressed within normal range (20-30ng/ml). And then she showed ovulation and conceived. From the 9th week of gestation until midtrimester she had moderate headache. Examination of visual fields in 25th week of gestation was almost normal. Otherwise the course of her pregnancy was uneventful. At term she spontaneously delivered a normal boy weighed 3380g. Her weight gain during pregnancy was small (4.50). Lactation was sufficient for the child's nutrition. After parturition 13 months have passed until today, she still showed a persistent slight galactorrhea.
Case 2. Y.O., age 28 had menarche at 14 years of age, and then irregular periods. Since 1975 she was treated with sexovid or clomiphene without result. She had no galactorrhea. Her plasma FSH and LH levels were within normal limit, but prolactin levels showed significant elevation (110-240ng/ml). Roentgen examination _of the sella turcica with plain and polytomography revealed slight bony erosion with asymmetrcal floor suggesting the existence of microadenoma. Neurologic evaluation and EEG were normal. A simultaneous intravenous injection of synthetic LH-RH 100μg and TRH 500μg indicated that the LH and FSH response were deficient, but prolactin response was moderate. Following treatment with bromocriptine 5mg daily for 7 days and then 7.5mg daily, plasma prolactin levels were suppressed to the range of 20-36ng/ml. Following 4 week administration bromocriptine, ovulation occured following a single injection of progesterone 50mg. At this ovulation time she conceived. From the early part of pregnancy until 18th week of gestation she sometimes had slight headache. In 25th week of gestation examination of visual fields was normal. Otherwise the pregnancy passed uneventfully. At term she spontaneously delivered a normal boy weighed 3230g. Her weight gain during pregnancy was small (6kg). Lactation was not sufficient for the child's nutrition. After parturition she has no menstruation until today for 1 year.

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