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Volume 35, Issue 2
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[in Japanese]1985 Volume 35 Issue 2 Pages 123-130
Published: April 10, 1985
Released on J-STAGE: October 15, 2009
JOURNAL FREE ACCESSDownload PDF (902K) -
EVALUATIONS IN PATIENTS WITH ISCHEMIC HEART DISEASE AND IDIOPATHIC CARDIOMYOPATHYSETSUKO YAMAMOTO1985 Volume 35 Issue 2 Pages 131-141
Published: April 10, 1985
Released on J-STAGE: October 15, 2009
JOURNAL FREE ACCESSCirculatory responses to 60° head-up tilt were studied in 12 normal subjects and 53 cardiac patients with ischemic heart disease or idiopathic cardiomyopathy.
In normal subjects, 60° head-up tilt caused obvious increase in heart rate and diastolic pressure, a slight decrease in systolic pressure and marked decrease in cardiac output.
The circulatory changes occurring during application of the tilt were less pronounced in cardiac patients than in the normal subjects. Moreover, in contrast to the situation in normal subjects, cardiac output was increased in cardiac patients who had a cardiac index of less than 2.2l/min/m2 and in whom left ventricular end-diastolic pressure at rest was greater than 16mm Hg. The increase in cardiac output during the period of tilt was negatively correlated with cardiac output at rest and was positively correlated with left ventricular end-diastolic pressure at rest.
Although there are various contributory factors in explaining the altered circulatory responses observed during head-up tilting in cardiac patients with low cardiac output, we suppose that reduction of preload may be playing an important role.View full abstractDownload PDF (1117K) -
YUTAKA KABURAGI1985 Volume 35 Issue 2 Pages 143-152
Published: April 10, 1985
Released on J-STAGE: October 15, 2009
JOURNAL FREE ACCESSIn order to investigate the metabolism and mechanism of action of testosterone in the central nervous system, the following experiments were performed :
1. The pathway of testosterone metabolism in the anterior pituitary and the hypothalamus of male Wistar rats was analyzed using GC-MS. Main metabolites were identified as androst-4-ene-3, 17-dione, 5α-androstan-17β-ol-3-one, 5α-androstane-3α, 17β-diol, 5α-androstane-3β, 17β-diol, androst-4-ene-3α, 17β-diol and androst-4-ene-3β, 17β-diol.
2. The metabolism of androst-4-ene-diol into 5α-androstanediol in the CNS was then analyzed using androst-4-ene-3α, 17β-diol-3-D1 (D = deuterium) and androst-4-ene-3β, 17β-diol-3-D1 as the incubation substrate. Twenty to thirty percent of androst-4-ene-3α, 17β-diol was converted directly into 5α-androstane-3α, 17β-diol, but androst-4-ene-3β, 17β-diol was not converted into 5α-androstane-3β, 17β-diol.
3. Change in 5α-reductase activity in the CNS after castration was analyzed by measuring the amount of 5α-reduced metabolites (5α-DHT & 5α-androstanediol) formed by the incubation of testosterone-14C with a homogenate of the CNS tissues.
It was evident that the 5α-reductase activity of the pituitary increased 5-fold at 5 weeks after castration, but in the hypothalamus no significant change was recognized.View full abstractDownload PDF (1391K) -
ATSUSHI SASAKI1985 Volume 35 Issue 2 Pages 153-167
Published: April 10, 1985
Released on J-STAGE: October 15, 2009
JOURNAL FREE ACCESSBy using the PAP method (Sternberger) the cellular distribution of neurofilament protein (NFP. -200K, 160K, 68K-) and neuron-specific enolase (NSE) was studied in normal human brain and in human neuronal and nonneuronal neoplasms.
In normal adult brain nerve cells and their fibers were generally immunoreactive with antisera against the three NF component proteins. The dendrites of pyramidal cells in the cerebral cortex, however, were not stained by 200K antibody. Some fibers in the brains of stillborn infants were similarly unstained by 200K antibody. NSE was present in neurons and their processes in both adult and prenatal brains.
Ganglion cells and maturing neuroblastic cells constituting intracranial and extracranial neuronal tumors stained positively for NFP and NSE. 68K and 160K components were often detected in immature neuroblasts. Among 10 medulloblastomas examined, 3 were focally stained positively for 68K and 160K NFP while 5 showed immunoreactivity for NSE.
Both NFP and NSE were detected in some of the non-neuronal neoplasms. These tumors included small cell carcinoma of the lung and rhabdomyosarcomas. Astrocytic tumors were also shown to be positive for NSE. Immunohistochemical demonstration of NFP and NSE in undifferentiated tumors, therefore, seems to be of limited value as evidence of neuronal differentiation.View full abstractDownload PDF (14549K) -
TOSHIHIDE IIJIMA, TAKAHIRO KOJIMA, MASAO OSUMI, SEIICHI TAKENOSHITA, Y ...1985 Volume 35 Issue 2 Pages 169-173
Published: April 10, 1985
Released on J-STAGE: October 15, 2009
JOURNAL FREE ACCESSA 44 year old female patient with Banti syndrome was treated twice by partial splenic embolization using Gelfoam particles and antibiotics. The size of the spleen became markedly decreased and the blood findings were improved during one and a half year follow-up.View full abstractDownload PDF (2405K) -
MASAYASU KOJIMAHARA1985 Volume 35 Issue 2 Pages 175-177
Published: April 10, 1985
Released on J-STAGE: October 15, 2009
JOURNAL FREE ACCESSTwo cases of adrenal myelolipoma are reported. The tumors were found during autopsy of two patients who had died of diabetes mellitus with cardiovascular disease. Histologically, myelolipoma consisted of myeloid elements and fatty cells in the adrenal cortex.View full abstractDownload PDF (910K) -
MASAKO FURUYA, MASAKO HATORI, SHOICHI TOMONO1985 Volume 35 Issue 2 Pages 179-183
Published: April 10, 1985
Released on J-STAGE: October 15, 2009
JOURNAL FREE ACCESSA quantitative analysis of T loop in appearing Frank lead vectorcardiograms was made in patients with hypertrophic cardiomyopathy and anterior myocardial infarction with negative T wave of over 0.5mV in the precordial lead of electrocardiograms.
The maximum QRS vector of hypertrophic cardiomyopathy cases was significantly greater than that of anterior myocardial infarction. It was usually directed to the left, inferiorly in hypertrophic cardiomyopathy, and left posteriorly in anterior myocardial infarction.
The Maximum T vector in hypertrophic cardiomyopathy was greater than in anterior myocardial infarction, but the difference was small. Maximum T vector of the hypertrophic cardiomyopathy was usually directed anteriorly more than-140°, while that in the majority of the myocardial infarction was directed posteriorly by than-140°.
In the forms of T loop, the occurrence of wide T loop was greater in myocardial infarction than in cases of hypertrophic cardiomyopathy without apical hypertrophy. Howerer, no significant difference was demonstrated between anterior myocardial infarction and apical hypertrophy.
When hypertrophic cardiomyopathy was divided into apical hypertrophy and others, as to QRS loop and T loop, no apparent differences were demonstrated.View full abstractDownload PDF (805K) -
TAKASHI SUZUKI, KATSUHIKO SONE, SANAYASU ONO1985 Volume 35 Issue 2 Pages 185-189
Published: April 10, 1985
Released on J-STAGE: October 15, 2009
JOURNAL FREE ACCESSVectorcardiograms were recorded from 159 patients with MCLS and 75 normal children. The ages of MCLS cases ranged from 6 months to 15 years, while those of the normal children ranged from 7 months to 13 years.
The maximal length to width ratios of spacial T loop (L/W), open QRS-loop and its ST vector were studied.
The criteria of wide T-loop was defined as less than 3.4, which is the 5 th percentile lower limit for normal children. Among the MCLS patients, there were 26 cases (26/159, 16.4%) with wide T-loop ; 8 of these were in a coronary dilatation group (8/30, 26.7%), while the remaining 18 cases were in a coronary normal group (18/107, 16.8%). By contrast, there were no wide T-loop cases in a coronary aneurysm group.
With regard to the ratio of open QRS and the value of ST vector, there was no significant difference between normal children and those with MCLS, but in the coronary aneurysm group many open QRS-loop and large ST vector cases were seen.
Because wide T-loop is one of the signs of myocardial damage, the results show that some myocardial damage persists in MCLS patients. This myocardial damage seems to be post myocardial changes due to myocarditis in MCLS.View full abstractDownload PDF (732K)
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