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Volume 36 (1986)
- Issue 6 Pages 415-
- Issue 5 Pages 359-
- Issue 4 Pages 319-
- Issue 3 Pages 221-
- Issue 2 Pages 115-
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Volume 36, Issue 2
Displaying 1-11 of 11 articles from this issue
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[in Japanese]1986 Volume 36 Issue 2 Pages 115-125
Published: May 10, 1986
Released on J-STAGE: October 15, 2009
JOURNAL FREE ACCESSDownload PDF (1323K) -
HIROSHI KIMURA1986 Volume 36 Issue 2 Pages 127-141
Published: May 10, 1986
Released on J-STAGE: October 15, 2009
JOURNAL FREE ACCESSThe purpose of this study was to examine human colonic and rectal adenomas and carcinomas histopathologically with reference to the adenoma-cancer sequence. In addition, experimental studies were perfored with reference to the same point. In these experiments, animals were killed at various times, ranging from five to 35 weeks after the final instillation of MNNG via the anus.
1. The distribution of human adenomas and carcinomas throughout the large bowel is similar.
2. Larger adenomas in human cases indicated a greater rate of severe dysplasia and malignancy. The malignancy rate was 17.5%.
3. In the histopathological study of early colonic and rectal cancer (as carcinoma confined to the mucosa and submucosa), it could be considered that 42 (76.4%) of the lesion arised from adenomas.
4, In the experimental study, the a/c ratio (the ratio of the total number of adenomas and cancers at various sacrifice times) decreased with the passage of time.
5. In the experiment, the ratio of mild dysplasia decreased with time (p<0.05), whereas severe dysplasia increased (p<0.02).
6. In the experiment, microscopical minute atypical lesions were frequently observed in the mucosa, but cancer could not be seen in these lesions.
From the results of these clinical and experimental studies on the adenoma-cancer sequence, it was concluded that a greater part of colorectal cancers could arise in adenomas.View full abstractDownload PDF (6884K) -
MASAKO FURUYA1986 Volume 36 Issue 2 Pages 143-149
Published: May 10, 1986
Released on J-STAGE: October 15, 2009
JOURNAL FREE ACCESSSerial observations on the electrocardiograms in 278 cases of definite acute myocardial infarction revealed the disappearance of diagnostic Q waves in 34 (12.2%) of them during a mean follow-up of 12.1 months. A vectorcardiographic diagnosis of old myocardial infarction was possible in 14 of these 34 cases without Q waves on the basis of abnormal distortion and/or indentation of the QRS loop. The cases with old myocardial infarction were divided into three groups, namely those without abnormal Q waves and without any obvious evidence of myocardial infarction in vectorcardiography (group I), those without abnormal Q waves but with diagnostic vectorcardiographic abnormalities (group II) and those with persistent abnormal Q waves (group III). The severity of coronary atherosclerosis did not differ among the three groups. On the other hand, the involvement of myocardial contraction was the least extensive in group I, more extensive in group II and the most extensive in group III. Thus, vectorcardiography was more sensitive in the diagnosis of old myocardial infarction than routine 12-lead electrocardiogram. The present results also indicate that serial observations on electrocardiograms are of considerable value in myocardial infarction for assessment of the extent of myocardial lesions.View full abstractDownload PDF (1210K) -
AKIRA OGAWA1986 Volume 36 Issue 2 Pages 151-163
Published: May 10, 1986
Released on J-STAGE: October 15, 2009
JOURNAL FREE ACCESSNormal adult rat and human tissues and a total of 107 human brain tumors were evaluated immunohistochemically for the expression of intermediate filament-related proteins by the use of antibodies against vimentin, keratin, desmin and GFA protein.
In normal adult tissues vimentin was characteristic of cell types of mesenchymal origin such as vascular endothelial cells, fibroblasts, chondrocytes and arachnoidal cells. A strong staining reaction to keratin was observed in all stratified squamous epithelia, including those from epidermis, dermal appendage, epithelia of bile duct, pancreatic duct, urinary epithelia, tracheal and bronchial epithelia, and myoepithelial cells of various glands. Desmin was present in striated and smooth muscle cells.
Of various histological types of brain tumors examined prositive immunostaining was demonstrated in cells of gliomas, meningiomas (including hemangiopericytic type), schwannomas, a malignant melanoma and in stromal cells of hemangioblastomas. All medulloblastomas were negative for vimentin. Gliomas were found to contain two types of intermediate filament proteins, vimentin and GFA protein, simultaneously. A positive reaction for keratin was seen in craniopharyngiomas, basal layer of epidermoid cysts, epithelial part of a teratoma and in some metastatic carcinomas of the brain. There was no tumor which has cells to contain desmin.View full abstractDownload PDF (12201K) -
HYOICHI KAWASHIMA1986 Volume 36 Issue 2 Pages 165-180
Published: May 10, 1986
Released on J-STAGE: October 15, 2009
JOURNAL FREE ACCESSVarious non-conjugative cryptic plasmids were detected from drug-sensitive clinical isolates of Shigella. The size of cryptic plasmids isolated from S. flexneri was 2.55 Md. These plasmids belonged to the same incompatibility group as that of pMS76 isolated from S. flexneri variant X. When the S. flexneri strains carrying a cryptic plasmid and R9-5 were transformed of pBR322, mobilization of pBR322 occurred at a high frequency from these strains. Mobilization of pBR322 also occurred between E. coli strains when the donor carried a set of these three plasmids.
The mobilization gene, mob on pMS76 was cloned onto plasmid pUC8 and found to be located on the SmaI-Cla-I Kpn I-MluI-Pvu I DNA fragment (1.9 Kb).
The product of the mob gene was 19KD protein.View full abstractDownload PDF (2534K) -
MASAKO HATORI, KIRA HASEGAWA, HIDEO FUJINUMA, HIDEKI SHINOHARA, SACHIH ...1986 Volume 36 Issue 2 Pages 181-187
Published: May 10, 1986
Released on J-STAGE: October 15, 2009
JOURNAL FREE ACCESSMultistage treadmill exercise testing was performed in 61 patients with myocardial infarction proved significant coronary artery stenosis within six months after the acute episode.
Significant ST depression developed in 35 cases (57%) and the ST depression was more frequent in inferior infarction (75%) and in those with multivessel disease (40.5%).
The maximum heart rate, the maximum blood pressure and the maximum pressure-rate product were significantly low in the patients with a positive exercise test as compared to those with a negative test. The incidence of multivessel disease was 68% when the maximum pressure-rate product was less than 20, 000, while 93% when the value was less than 17, 000. On the other hand, one vessel disease could be expected when the maximum pressure-rate product exceeded 25, 000. The ventricular premature beats were frequently observed in anterior infarction and/or multivessel disease.
The above findings indicate the usefulness of multistage treadmill exercise testing after myocardial infarction for the assessment of the severity of coronary artery disease.View full abstractDownload PDF (957K) -
YUICHI IINO, HIROSHI ISHIKAWA, MASAO YOSHIDA, MASARU IZUO, HIROO TAKIK ...1986 Volume 36 Issue 2 Pages 189-192
Published: May 10, 1986
Released on J-STAGE: October 15, 2009
JOURNAL FREE ACCESSThe effects of various hormones and immunopotentiators on 7, 12-dimethylbenz (a) anthracene (DMBA)-induced carcinogenesis in the SD rat mammary glands were studied. Female SD rats aged six weeks were given 20 mg of DMBA by gastric intubation.
A week after the DMBA administration, these rats were divided into six groups : tamoxifen (TAM) (0.4mg/kg/day, PS), medroxyprogesterone acetate (MPA) (10mg/kg/day, IM), oophorectomy (Ovex) (a week after DMBA administration), OK-432 (0.1K· E/kg/week, IP), PSK (60mg/kg/day, PS) and the control group. Each group had been administered the respective drug between first and 12th weeks, and the presence of mammary tumors had been investigated every week up to the 15th week. Mammary tumors in the control group appeared only between the sixth and 12th weeks.
The period of administration in the therapeutic groups agreed with that of the appearance of mammary tumors in the control.
The occurrence of mammary tumors at the 12th and 15th weeks in each group was 94.5% in control, 60.9% and 82.6% in PSK, 69.6% and 73.9% in OK-432, 18.2% and 36, 4% in TAM, 0% in Ovex and 0% in MPA.
The first appearance periods of DMBA tumors were 7.9±1.7 weeks in control, 8.5±1.7 weeks in OK-432, 9.6±2.7 weeks in PSK and 12.1±2.9 weeks in TAM.
Compared with the control group, those receiving hormones and immunopotentiators showed a significantly lower rate in the appearance of DMBA tumors and a delay in the first appearance period of DMBA tumors.View full abstractDownload PDF (402K) -
YOH-ICHI KON, TUGIO HIGUCHI, KEN IGARASHI, TOHRU KIMURA, NORIYUKI NAGA ...1986 Volume 36 Issue 2 Pages 193-201
Published: May 10, 1986
Released on J-STAGE: October 15, 2009
JOURNAL FREE ACCESSEndoscopic biliary drainage (EBD) was undertaken in 91 cases of bile duct obstruction from June 1982 to December 1985, 13 cases of benign diseases (11 of choledocholithiasis, one of chronic pancreatitis and one of postoperative choledochal stricture) and 78 cases of malignant diseases (eight of papillary cancer, 27 of bile duct cancer, 14 of gallbladder cancer, 28 of pancreatic cancer and one of gastric cancer).
We changed the method of EBD from that without a tapered catheter (Methode I), to one with a tapered catheter (Methed II) in June of 1984. The success rate was subsequently improved from 60.5% to 83.3%. The effectiveness rate was also improved from 73.1% to 98.5%.
For evaluation of the effect on reducing jaundice, the correlation analysis, regression analysis and analysis of covariance were used to estimate the value of total bilirubin at each one week following EBD or PTCD. EBD was better than PTCD for reducing the level of bilirubin.
In conclusion, EBD is preferred method of biliary drainage for patients of bile duct obstruction. Duodenobiliary drainage, in particular is of great benefit to inoperable patients as permanent palliative drainage.View full abstractDownload PDF (2524K) -
MASAYASU KOJIMAHARA1986 Volume 36 Issue 2 Pages 203-206
Published: May 10, 1986
Released on J-STAGE: October 15, 2009
JOURNAL FREE ACCESSA case of renal angiomyolipoma found at autopsy is reported. The tumor was composed of mature adipose tissue, tortuous blood vessels and smooth muscle cells. Malignant changes were not observed in this tumor.View full abstractDownload PDF (2699K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese]1986 Volume 36 Issue 2 Pages 207-210
Published: May 10, 1986
Released on J-STAGE: October 15, 2009
JOURNAL FREE ACCESSDownload PDF (2867K) -
HISAO KUMAKURA, SHOICHI TANGE, ATSUKO HESHIKI1986 Volume 36 Issue 2 Pages 211-220
Published: May 10, 1986
Released on J-STAGE: October 15, 2009
JOURNAL FREE ACCESSDSA is a method of computer subtraction of one and part of contrast filled images via digitalized signal. By way of contrast injection, intravenous digital subtraction angiography (IVDSA) and intraarterial digital subtraction angiography (IADSA) were disignated. DSA has superior contrast resolution, which enables us to demonstrate early venous drainage & tumor stain with small amount of contrast material to compare to conventional angiography. It's clinical application, merit and demerit were discussed.View full abstractDownload PDF (7906K)
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