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Volume 11, Issue 1
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[in Japanese]1961 Volume 11 Issue 1 Pages 1-12
Published: January 01, 1961
Released on J-STAGE: November 11, 2009
JOURNAL FREE ACCESSDownload PDF (2140K) -
Kenji Matsuyama, Yasuo Ooyama, Yujiro Oosawa, Eiichi Shimokozuru, Kiyo ...1961 Volume 11 Issue 1 Pages 13-17
Published: January 01, 1961
Released on J-STAGE: November 11, 2009
JOURNAL FREE ACCESSAn autopsy case of cholangitis lenta in a man of thirty four years old was reported. Chronic suppurative cholangitis as the focus of sepsis lenta was observed. With respect to the pathogenesis, it was considered that intracanalicular ascending infection caused by paracolon bacilli, which were demonstrated in circulating blood and pus in the bile duct, was responsible for cholangitis lenta. While, bacterial endocarditis was not noticed.View full abstractDownload PDF (1769K) -
Manabu Honma, Shoji Hoshi, Takashi Okonogi1961 Volume 11 Issue 1 Pages 18-24
Published: January 01, 1961
Released on J-STAGE: February 22, 2010
JOURNAL FREE ACCESSWe have observed the peculiar vacuolar degeneration in the heart muscles of Guinea pigs injected some toxics substances : venom from Habu-snake (Trimeresurus flavoviridis, ) Mamushi-snake (Agkistrodon halys) and diphtheria-toxin.
Of our many experimental cases, in which the quantity of the venom was variously tried, diffuse myocardial hydropic vacuolar degenerations were gained only at the rate of Habu-snake venom…… 2/12 (50γ and 100γ dry weight : injected intramuscularly; the animals were killed in 5 and 72 hours respectively).Mamushi-snake venom ……1/8 (40mg dry weight;injected intramus-cularly, the animals died in 6 hours). Diphtheria-toxin ……5/7 (after 7 days' continuous administration of 5mg hydrocortisone. the animals received 3mid diphtheriatoxin intramuscularly, and died in 48-96hours).
Pathological changes in these three groups were almost similar. The first damaged area was in the subendocardium; when the pathological changes was rather extensive, the damaged area occupied as wide as 1/3 of the total myocardium on the cut surface. The heart-muscle enlarged, myoplasm almost disappeared except on the fringe, and the greater part of the myofibrils were degenerated and lost.
Not all of our experimental cases showed such changes : and even when the dosis was sublethal, we observed the changes similar to those of the death cases. It is supposed that these changes result from hypoxydosis due to functional failure of the vascular vessels and metabolic imbalances in the whole body caused by primary or secondary effect of these toxic substances.View full abstractDownload PDF (2390K) -
Shoji Hoshi, Manabu Honma, Hisayoshi Iizuka, Takashi Okonogi1961 Volume 11 Issue 1 Pages 25-29
Published: January 01, 1961
Released on J-STAGE: November 11, 2009
JOURNAL FREE ACCESS1) Pathological studies were made in mice by intraperitoneal and intramuscular administrations of Habu-venom at various intervals and in varing dosis.
2) Animals treated with intraperitoneal injection died at shorter period and in smaller dosis than those with intramuscular administration. Microscopically, a significant difference, however, was not noted in the various internal organs such as ; heart, liver, kidneys and brain in the animals which died in early stage within 10 hours.
3) It is considered that the survival time of the animals treated with intraperijoneal injection was shortened chiefly by rapid absorbtion of injected venom and by associated appearance of intraperitoneal hemorrhage.View full abstractDownload PDF (1438K)
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