All issues
Successor
Volume 43 (1993)
- Issue 6 Pages 609-
- Issue 5 Pages 473-
- Issue 4 Pages 311-
- Issue 3 Pages 215-
- Issue 2 Pages 109-
- Issue 1 Pages 1-
Volume 43, Issue 3
Displaying 1-9 of 9 articles from this issue
- |<
- <
- 1
- >
- >|
-
MAYUMI FUKUDA1993 Volume 43 Issue 3 Pages 215-224
Published: May 01, 1993
Released on J-STAGE: October 21, 2009
JOURNAL FREE ACCESSFirst phase of insulin secretion in response to glucose challenge is markedly impaired in non insulin dependent diabetes mellitus. The aim of this study is to clarify the significant effect of first-phase of insulin secretion on peripheral and hepatic glucose kinetics in conscious dogs. Catheters inserted into the portal and hepatic veins, femoral artery and superior mesenteric vein were kept patent on the dogs' backs. Fourteen days after surgery, two different experiments were performed as follows ; 1) Oral glucose administration test (OGTT), 2) Intraportal glucose infusion to mimic the profiles of plasma glucose in the portal vein after oral glucose load, concomitantly infusing (a) basal insulin or (b) basal and first-phase insulin, in the presence of glucagon and somatostatin. Hepatic glucose uptake could not be observed and plasma glucose levels were significantly increased after intraportal glucose infusion only when the basal insulin was infused. Additional first phase insulin promoted hepatic glucose uptake only for a short time and did not improve the glucose tolerance curve. These results indicate that both the first and second phases of insulin release are relevant to full counterregulation of glucose metabolism. The basal level of insulin is not sufficient to promote hepatic glucose uptake after glucose load.View full abstractDownload PDF (1559K) -
WITH SPECIAL REFERENCE TO THE RENIN-ANGIOTENSIN SYSTEMATSUKO YAGI1993 Volume 43 Issue 3 Pages 225-235
Published: May 01, 1993
Released on J-STAGE: October 21, 2009
JOURNAL FREE ACCESSThe present studies were conducted in patients with primary aldosteronism (PA) before and during more than 3 months of spironolactone (SPL) treatment and essential hypertension (EHT) to evaluate the effects of SPL on aldosterone secretion. All patients were hospitalized and received a furosemide test and angiotensin II infusion test (Ang II test) under the sodium restricted diet.
Furosemide significantly increased both plasma renin activity (PRA) and plasma aldosterone concentration (PAC) in EHT, while neither PRA nor PAC responded to the furosemide in untreated PA. In contrast, furosemide significantly increased both PRA and PAC in PA given SPL (PAC : 345.6±55.8 to 492.7±76.8 pg/ml, p<0.05, mean±SE ; PRA : 2.60±0.80 to 7.00±2.00 ng/ml/hr, p<0.05).
On the other hand, angiotensin II (Ang II) infusion induced a dose-dependent increase in PAC and a decrease in PRA in EHT. Although PAC and PRA did not respond to Ang II in untreated PA, dose-dependent increase was observed when Ang II was administered to SPL treated PA. Thus, aldosterone secretion is dependent mainly on ACTH in untreated PA, while it is more strongly regulated by the renin-angiotensin-system than ACTH after SPL.View full abstractDownload PDF (1685K) -
KAZUMA OKAMOTO1993 Volume 43 Issue 3 Pages 237-244
Published: May 01, 1993
Released on J-STAGE: October 21, 2009
JOURNAL FREE ACCESSAuditory event related potentials were recorded in 80 normal subjects (37 males and 43 females) aged from 10 to 81 years on an oddball task. The stimulus was a pure tone delivered binaurally at 75 dB SPL with a frequency of 1 kHz (frequent 80%) or 2 kHz (rare, target 20%). The subjects responded to target stimuli either by counting or by pressing a button. EEG was recorded from Cz and Pz referred to linked mastoids. The period from the tone delivery to the button-pressing was recorded and it was defined as the reaction time. The mean (RT) and the standard deviation (SD) of the reaction time were calculated.
The SD was interpreted to indicate the concentration of the subjects on the task. Results were as follows. The count condition may reflect aging more than the button-pressing condition. The N200 is related with the cognition of the stimulus more directly than the P300. The latency of P300 increased with age at a rate of 1.04 msec/year for count condition and 0.989 msec/year for button condition. The amplitude of P300 is more influenced by the concentration of subjects on the task than by aging.View full abstractDownload PDF (1148K) -
IWAO HASHIDA1993 Volume 43 Issue 3 Pages 245-259
Published: May 01, 1993
Released on J-STAGE: October 21, 2009
JOURNAL FREE ACCESSIt is well known that hyperthermia potentiates the effect of ionizing radiation on tumors. Maximal thermal enhancement ratio in tumors has been recognized when hyperthermia is combined with radiotherapy simultaneously. However hyperthermia simultaneously combined with external irradiation is hard to perform due to the machines and machine time. And the disadvantage of this procedure is that not only the effect on tumors, but also the damage to normal tissues may be enhanced. On these view points, we have attempted to combine the regional hyperthermia with interstitial or intracavital low dose rate irradiation simultaneously. Based on phantom experiments, the temperature around of the edge of needles increased earlier than other sites when needles were placed in a vertical situation, but increased similarly in a parallel situation. And the temperature around the ovoids, especially measured at the center between two ovoids was higher than that of other sites. From this experimental study, it is suggested that hyperthermia simultaneously combined with low dose rate irradiation seems to be potential, if the temperature of these hot points is under 43°C. Thereafter a pilot clinical trial was conducted for four patients with malignancy involving intrapelvic organs.View full abstractDownload PDF (6159K) -
KAZUHIKO OKABE1993 Volume 43 Issue 3 Pages 261-269
Published: May 01, 1993
Released on J-STAGE: October 21, 2009
JOURNAL FREE ACCESSRelatively low molecular weight poly (DL-lactic acids, DL-LA'S) (Mn= 1400, 2000 and 4400) were synthesized by direct polycondensation without catalysts. A poly (DL-LA, Mn=1400) characterized by a typical parabolic-type degradation pattern, and perfectly degraded in vitro and in vivo at the first and 2nd weeks, respectively, from the start of the observation. In contrast, several additional weeks were required for the poly (DL-LA, Mn=2000 and 4400) which was characterized by an S-type degradation pattern.
Alteration of the molecular weight of the poly (DL-LA) made it possible to control the degree of in vitro-in vivo degradation and the degradation pattern.
A calcitonin agonist was incorporated into a small cylinder of the polymer by the melt-pressing technique. The initial burst of drug in vitro-in vivo released from the cylindrical formulation could be retarded by adjusting the molecular weight of the poly (DL-LA), and the resulting constant release of drug was maintained over a maximum period of 5 weeks.View full abstractDownload PDF (2783K) -
TATSUO HASHIZUME1993 Volume 43 Issue 3 Pages 271-280
Published: May 01, 1993
Released on J-STAGE: October 21, 2009
JOURNAL FREE ACCESSTo investigate the differences of malignant behavior between the esophageal cancer and the gastric cancer, the nuclear DNA content was cytophotometrically analysed using biopsy specimens of 88 cases of esophageal cancer and 100 cases of gastric cancer.
The DNA ploidy patterns were classified into type A1 and type A2 according to the degree of scatter of the cells. Nodal metastases occured more frequently in type A2 compared to type A1. The nuclear DNA content was closely related to the lymph node metastasis. The incidence of lymph node metastasis in type A2 submucosal esophageal cancer was remarkably similar to that in type A2 gastric cancer confined to the proper muscle layer (83.3% vs 75.0%). Considering that the esophageal cancer had distant metastases even in type A1 ploidy pattern, surgical indication of the esophageal cancer was quite limited compared to the gastric cancer. In both the esophageal cancer and the gastric cancer, it was concluded that surgical treatment should be based on the own biological properties of each cancer.View full abstractDownload PDF (1676K) -
KAYOKO MURAYAMA, MORIO SAWAMURA, HIROKAZU MURAKAMI, SADAO SATO, HISAMI ...1993 Volume 43 Issue 3 Pages 281-287
Published: May 01, 1993
Released on J-STAGE: October 21, 2009
JOURNAL FREE ACCESSWe have experienced 170 cases of malignant lymphoma over the past decade. Seventy-nine cases (41%) had extranodal lymphoma. The most frequent site of extranodal lymphoma was the stomach (24 cases), followed by Waldeyers ring (10), skin and subcutaneous tissue (10), small intestine and colon (9), and the spleen (4).
One hundred thirty cases had non-Hodgkin lymphoma, of which 65 cases (50%) had primary extranodal lymphoma (P-EN). Localized cases were more often observed in P-EN than nodal lymphoma (LN). No significant difference was seen in clinical signs, laboratory data, and CR rate between P-EN and LN. In P-EN, the CR rate of those treated with both surgery and chemotherapy was higher than that of those treated only with chemotherapy. Survival for pateints with LN and P-EN were almost the same.View full abstractDownload PDF (947K) -
HISASHI KURIBARA1993 Volume 43 Issue 3 Pages 289-293
Published: May 01, 1993
Released on J-STAGE: October 21, 2009
JOURNAL FREE ACCESSTo evaluate whether the 5-HT1A agonist buspirone has an anti-conflict action, a behavioral study on the effects of buspirone was carried out, and the effects were compared with those of the benzodiazepine anxiolytic diazepam. Buspirone (1-10 mg/kg i.p.) did not attenuate the mouse's conflict behaviors in the three different situations ; electric shock presentation to lever-pressing for food reinforcement (Geller-type), shock presentation to water consumption (Vogel-type), and presentation of hypertonic NaCl solution (3 %), but rather suppressed consumption of food, water and the NaCl solution. On the other hand, diazepam (0.5-2 mg/kg s.c.) significantly and dose-dependently attenuated the conflict behaviors in all situations. The present results suggest that the 5-HT1A agonist buspirone does not show anxiolytic action as similar to that of benzodiazepine anxiolytics.View full abstractDownload PDF (770K) -
MOTOYOSHI MOTEKI, TAKASHI SATOU, TERUTAKA NISHIMATSU1993 Volume 43 Issue 3 Pages 295-300
Published: May 01, 1993
Released on J-STAGE: October 21, 2009
JOURNAL FREE ACCESSSeven cases of incomplete spinal cord injury with spinal canal stenosis underwent laminoplasty after administration of large doses of methylprednisolone during the acute stage. Among them, five cases who received proposed operation after the conservative therapy improved even though the symptoms were relatively slight (two cases went up one grade on Frankel' s classification). Two severe cases underwent emergency operation in their early stage of injury, and the in results were indistinguishable from the natural course. Within the functional limits of the present MRI for the evaluating spinal cord injury, emergency operation should be performed in order to facilitate early rehabilitation rather than to restore nerve function. Administration of large doses of methylprednisolone for a short period was effective as the conservative therapy for incomplete cord injury. In addition no significant side effects were observed.View full abstractDownload PDF (1585K)
- |<
- <
- 1
- >
- >|