Bone marrow cells (B-cells) and thymus cells (T-cells) collected from normal mice were separately incubated in vitro with immune (i) RNA. They were adoptively transferred to X-irradiated mice and their abilities to induce the increase in the number of specific antibody-carrying cells-and to induce the immunologic memory were investigated.
The number of antibody-carrying cells increased in the spleens of recipient mice, which had been transferred with one of the following cell mixtures ; 1) the mixture of iRNA-treated T-cells (i-T) and iRNA-treated B-cells (i-B), 2) non-treated T-cells (n-T) and i-B, 3) i-B only, or 4) iRNA-treated spleen cells obtained from nude mice. By the contrast, it did not increase in the spleens of mice which had been transferred with the mixture of i-T and n-B, or n-T and n-B. By the antigenic stimulation at 4weeks after the cell transfer, the anamnestic (secondary) antibody-production response was observed in the recipient mice which had been transferred with the mixture of i-T and i-B, or of i-T and n-B, but was not in the recipients with the mixture of n-T and i-B, or of n-T and n-B.

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For the purpose of studying the health care for the females at marriageable age, who are considered to have administratively been neglected, a survey was performed on the consciousness of young females about the health care and on their attitudes to mass health examination. The subjects were randomly selected 500 unmarried females in the service area of S health center of Gunma. The responses were obtained from 348 subjects. The main results were as follws :
1) Those receiving mass health examination in some form or other during 1977, accounted for 74.7% (260) of the subjects who responded. Of these 260, the examinees at the work places or of population examination, performed by the tuberculosis prevention law, together numbered 215, constituting 82.7% of the total.
2) The percentage of examinees differed according to the occupation, commercial workers, teachers, nurses and those working in medical institutions showing low per cents. As for the reason of the absence from the examination, “having no time” and “not informed” together constituted 65%. There are thus problems concerning the method of notification on the side of the examination undertaker and indifference on the side of subjects to be examined.
3) As for the health care to young females, 81.3% of the responses mentioned the necessity of care not only of the present health but also of their prospective maternity. On the other hand, those who considered the examination in 1977 to be useful for their health accounted for only 52.8% of the examinees and 36.4% of the non-examinees.
4) In the age-group of the present subjects many subjectively conjectured their body types. Of those whose weight index (Minowa) fell in the normal range and in the thin group, 51.8% and 2.9%, respectively, evaluated themselves to be obese. It is necessary to add that only 6.5% of the examinees received physical measurements, suggesting the need of strong guidance in this respect.

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In an immunization program against rubella, it is considered useful for this purpose to promote the education on maternity. From this viewpoint, a survey was performed for the presence of antibody against and the knowledge about rubella.
The subjects were 328 girls of 3rd grade of 3 junior high schools of Gunma, urban, suburban-rural and mountainous. The main results were as follows :
1) Those harbouring antibody (the HI antibody at titer of 8 folds and over) accounted for 74.1% in total, and the percentage was lower in the suburban rural and mountainous regions than in the urban. The percent of titers of 256 folds and higher was conversely higher in the former two than in the latter.
2) Those who were said to have previously suffered rubella showed higher percent in the mountainous than in the urban region. As for the age of the onset, 10 years and less were more frequent in the urban, and over 10 years were frequent in the suburban-rural and mountainous regions.
3) As for the relation between the statement of past history of rubella and the HI antibody titer, 16 of 181 cases (8.8%) who previously suffered rubella showed titers of less than 8 folds. As for the relation between the age of the onset and antibody titers, 5 of 138 cases (3.6%) of the onset at 10years and over showed antibody titers less than 8 folds.
On the other hand, 61 out of 120 (50.8%), who were said to have suffered no rubella, and 17 out of 27 (63.0%) who were not certain, showed the titers of 8 folds and higher.
4) As for the knowledge about rubella, those giving correct answers concerning the general symptoms of this disease accounted for 82.8%, and those who knew the syndrome of congenital rubella 71.5%.
It was estimated that these who said that they have suffered rebella despite lower antibody titers (the HI antibody titer less than 8 folds) may have been clustered in the group who gave erroneous responses or no responses.

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Adult mongrel dogs were subjected to hemorrhagic shock and small portions of the pancreas were repeatedly excised to determine the intracellular redistribution of lysosomal hydrolases. The tissue was homogenized and centrifused for the separation of cytoplasmic (S-2) and lysosomal (S-3) fractions. Acid hydrolases in cytoplasmic fraction were cited as free type and ones in lysosomal pellets as bound type. In the late stage of oligemic shock and terminal stage of re-transfusion, free type enzymes such as β-glucuronidase and cathepsin-D increased significantly, being associated with the elevation of plasma hydrolase activity. The ratio of free type to bound one were markedly elevated in the late course of the experiment. These results suggests that lysosomes in pancreas become fragile after certain period of ischemia.

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A case of the simple nonspecific giant ulcer at the middle part of the esophagus was reported. A 66 year-old woman was hospitalized with complaint of dysphagia and retrosternal pain. X-ray pictures showed slight irregularity like filling defect in the right-posterior wall of the middle part of the esophagus. Endoscopically, giant ulcer with marginal elevation measuring about 15cm in dianeter was observed. Biopsied specimen of the esophageal mucosa showed no malignancy histologically. Morphologic findings were different from those of the ulcer disease combined with reflux esophagitis near the esophago-gastric junction.

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Three cases of child murder by parent were reported.
Case 1 : aged 26, female, killed her son by strangulation. Before this tragedy, she was depressive with an overvalued idea about her childen's anorexia and a feeling of inability to raise the children and of inadequacy as a mother. After killing her son, she attempted suicide but failed. The psychiatric diagnosis was reactive depression.
Case 2 : aged 32, male, with a history of three admissions to mental hospital with the diagnosis of hallucinatory-paranoid schizophrenia, killed his son by suffocation and attempted suicide by burning himself. Prior to the fatal event, he had suffered from anxiety and insomnia due to a great deal of vacillation between remarrige and reconciliation with his divorced wife. His recollection of the crime was incomplete with a spotty amnesia and the motives of his murder were not clear and understandable. The diagnosis was a recurrence of schizophrenia.
Case 3 : aged 39, female, tried to kill herself and her three children with car exhaust gas, but only the youngest son died. Her husband's unfaithfullness and violence had led to disturbed marital relationship resulting in her suicidal attempt and waste of money to spite her husband. The diagnosis was hysterical personality.
The personal factors, psychiatric states and motives of the infanticide were presented and discussed referring to the relevant literature.

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