The lymphocytes are divided into subpopulations according to their origin and function. B cells are precursor cells of antibody producing cells. T cells are the lymphocytes which are originally derived from haematopoietic organ as B cells but have differentiated and acquired their own properties in the thymus.
Most of the antigens alone do not stimulate B cells to differentiate into antibody producing cells. They require the factor produced by T cells (helper T cell) at the some time. The proliferation and differentiation of B cells are controlled by another kind of T cells (suppressor T cell)
Thus adequate antibody production is controlled and facilitated by these two types of T cells.
Dysfunction of suppressor T cells may allow excess production of reagin or autoantibody, and this may lead to the appearance of allergic or autoimmune diseases.
Transplanted allogenic cells, tumor cells, and virus infected cells are eliminated mainly by T cells (effector or killer T cell) and sometimes by antibodies in collaboration with complement or the cells having receptor f or Fc portion of IgG antibody (K cell). Target cell killing by K cells is called “antibody dependent cell mediated cytotoxicity (ADCC) ”.
Most so called cellular immunities are mediated by the lymphokines: effector molecules produced by activated lymphocytes. Macrophage chematactic factor (MCF), migration inhibitory factor (MIF) and other lymphokines cause accumwnlation of macrophages and inflammation in the area where lymphocytes react with antigen and establish a “delayed type hypersensitivity reaction”. Macrophage activating factor (MAF) increases the activity of macrophages and leads to the killing of phagotized bacteria such as salmonella, tuberculosis, listeria, and leplosis.
Immune response is characterized as a specific reaction with antigens. The lymphocytes are only the cells which have antigen specificity. Therefore they play the central role in immune responses.
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