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Volume 44 (2001)
- Issue 6 Pages 446-
- Issue 5 Pages 320-
- Issue 4 Pages 250-
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Volume 34 (1991)
- Issue 6 Pages 595-
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- Issue 3 Pages 261-
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- Issue 1 Pages 5-
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Volume 31 (1988)
- Issue 6 Pages 757-
- Issue 5 Pages 613-
- Issue 4 Pages 425-
- Issue 3 Pages 273-
- Issue 2 Pages 127-
- Issue 1 Pages 9-
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Volume 44, Issue Supplement1
Displaying 1-8 of 8 articles from this issue
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A RANDOMIZED, DOUBLE-BLIND TESTYoshio Nishizawa, Yasuko Nishizawa, Fumi Yoshioka, Fumiyo Nagano, [in ...2001 Volume 44 Issue Supplement1 Pages 5-13
Published: August 15, 2001
Released on J-STAGE: March 18, 2011
JOURNAL FREE ACCESSSince the cyclooxygenase (COX) and 5-lipoxygenase (5-LO) pathway share arachidonic acid cascade (CAAC) as a common substrate, blockade of the prostanoid pathway by NSAIDs was proposed to shunt arachidonate down the 5-LO pathway, leading to elevated formation of cys-LTs and hence to an adverse respiratory reaction.
We investigated whether inhaled Saiboku-to (Japanese herbal medicine, Cai-pu-tang : CPT) attenuates the response to bronchial challenge with L-lysine aspirin (LLA) and the associated increase in LTC4 and LTD4 in bronchoalveolar lavage fluid (BALF) in 74 bronchial asthmatic patients with aspirin-induced asthma (AIA). Each subject was challanged twice with a single threshold dose of LLA, which caused a FEV1.0 of 20% or more decrease in a preliminary test, immediately after inhation of various concentrations of mainly 1, 000 μg/ml CPT in 5 ml physiological saline or the same dose of physiological saline as placebo in a randomized double-blind controlled protocol. FEV1.0 was recorded at 30 min intervals for 4h. LTC4 and LTD4 in BALF and LTE4 in urine were measured by combined high-performance liquid chromatography and radioimmunoassay. After placebo, LASA caused an obstructive reaction in all patients, both LTC4 and LTD4 in BALF and LTE4 in urine increased after challenge. Preinhaled CPT provided almost completed protection against bronchoconstriction by challange in all patients. Increased LTC4 and LTD4 in BALF by challenge with LLA was also suppressed. This data confirms that preinhalation of CPT is highly effective in preventing AIA and sugggests that this effect is mediated by inhibition of LT production. Inhalation of placebo or CPT for 6 months as 100 μg/ ml×5ml/3 times/day in a randomized double-blind test was done in 74 patients with AIA. Inhalation of CPT significantly improved quality of life (QOL), e. g., total-diseases-related symptoms (DRS), its components, the QWB, sore, face scale (vs before p < 0.01, vs placebo p<0.01), and symptoms induced by AIA (vs before : p<0.01, vs placebo p<0.01). These improvements of AIA and QOL are discussed.View full abstractDownload PDF (1382K) -
Yuji Yoshiyama, Maki Nishino, Tomoko Yazaki, Motoko Kanke2001 Volume 44 Issue Supplement1 Pages 14-19
Published: August 15, 2001
Released on J-STAGE: March 18, 2011
JOURNAL FREE ACCESSUltrasonic nebulization is widely used in inhalant therapy, but problems remain in drug stability in inhalant solutions and a special preparations are required for nebulizaton.
We studied the effect of an ultrasonic nebulizer developed by Omron on the stability of a newly marketed inhalent solution, cefmenoxime hydrochloride. Drug ratios remained at 93% or more in stability tests using the new nebulizer, which generates. This smaller aerosol particles than a compressor nebulizer and leaves a small dead volume in the container.
We concluded that this new ultrasonic nebulization is suited for inhalant therapy using cefmenoxime hydrochloride.View full abstractDownload PDF (814K) -
Eri Suzumura, Kazuhiko Takeuchi, Yuichi Majima2001 Volume 44 Issue Supplement1 Pages 20-23
Published: August 15, 2001
Released on J-STAGE: March 18, 2011
JOURNAL FREE ACCESSNasal mucociliary transport is an upper airway defense mechanism. To determine the effects of spa bathing on human nasal mucociliary function, we measured the saccharin nasal transit time as an index of nasal mucociliary clearance.
Subjects were 20 healthy men aged 22 to 37 years (mean : 26.5 years). Saccharin transit time during spa bathing was significantly higher than without (573.0±42.6 vs 1383.1±281.4, p<0.0058). Saccharin transit time after spa bathing did not differ from that without. We concluded that spa bathing at a comfortable temperature activates nasal mucociliary transport.View full abstractDownload PDF (485K) -
Arata Yonekura, Kenji Suzuki, [in Japanese], Makoto Murayama, Toshiyuk ...2001 Volume 44 Issue Supplement1 Pages 24-27
Published: August 15, 2001
Released on J-STAGE: March 18, 2011
JOURNAL FREE ACCESSAntimicrobial agents for nebulization were selected based on safety, tastelessness and odorlessness, a low possibility of allergic reactions, and high antimicrobial activily against target bacteria. In answer to a questionnnaire, almost all practitioners independently stated that nasal neblulization was useful. Even though most recognized this usefulness, they conducted it by selecting devices and drugs arbitrarily because of the absence of a clear standard for therapy. Nebulization is an important otolaryn-gological therapy, making it is necessary to use it in association with evidencebased medicine (EBM) in the clinical setting.View full abstractDownload PDF (598K) -
Kenji Suzuki, Arata Yonekura, Jun Mori, Tadao Nishimura2001 Volume 44 Issue Supplement1 Pages 28-32
Published: August 15, 2001
Released on J-STAGE: March 18, 2011
JOURNAL FREE ACCESSActivity against target causative bacteria, good solubility, low stimulation of nasal mucosa, near odorlessness and tastelessness, low antigenicity, and stable activity in a solution are criteria for antimicrobial agents in nebulization therapy. Since aminoglycosides fulfill almost all of the above criteria, they are commonly used as nebulization therapy agents, but do not show sufficient minimal inhibitory concentration (MICs) against Streptococcus pneumoniae, Hemophilus influenzae, Moraxella catarrhalis, and Staphylococcus aureus. Cefmenoxime (CMX) has sufficient MIC against these organisms and is highly recommended as a nebulization agent for paranasal sinusitis.View full abstractDownload PDF (701K) -
[in Japanese]2001 Volume 44 Issue Supplement1 Pages 33-37
Published: August 15, 2001
Released on J-STAGE: March 18, 2011
JOURNAL FREE ACCESSDownload PDF (791K) -
Ryuichiro Saijo, Yuichi Majima, Noboru Hyo, Tomohiro Kunisada, [in Jap ...2001 Volume 44 Issue Supplement1 Pages 38-43
Published: August 15, 2001
Released on J-STAGE: March 18, 2011
JOURNAL FREE ACCESSWe restored a human nasosinus model whose sinuses underwent functional endoscopic sinus surgery. The nasal cavity was constructed from a cast made at autopsy, and the maxillary and ethmoid sinuses were reconstructed from computed tomogarphy (CT) images. Anterior and posterior ethmoid cells were dissected and the diameter of the maxillary ostium enlarged to 10 mm.
We evaluated the depositional patterns of carbon particles, administered by jet nebulizer, whose aerodynamic diameter was 6.99 μm or 14.61 μm. Both sizes were well deposited on the ostiomeatal complex, the maxillary sinus, and the ethmoid sinuses. We also evaluated the effects of the nebulizer nozzle angle on particle deposition in the nasal cavity. We found that a 45° angle was more effective than a 30°.
Our results indicate that both particle size and nozzle angle are important factors in aerosol deposition.View full abstractDownload PDF (3828K) -
Toshiko Mamiya, Kensei Naito2001 Volume 44 Issue Supplement1 Pages 44-50
Published: August 15, 2001
Released on J-STAGE: March 18, 2011
JOURNAL FREE ACCESSAerosol therapy is widely used to treat chronic sinusitis at ear, nose, and throat (ENT) clinics. Sending aerosolized particles efficiently to inflamed paranasal sinus mucosa is an important issue in this area. We compared the extent of aerosolized particle inflow into an adult artificial maxillary sinus (Koken Co., Ltd) using of 3 types of nebulizer-Nissho compressor A (jet nebulizer), Azwell Nescojet AZ-11 (jet nebulizer), and Azwell UN-701 (ultrasonic nebulizer). The greater the ostium size, the greater the aerosolized particle transfer to the maxillary sinus. The greatest inflow of aerosolized particles was by Nissho compressor-A. No significant difference in clinical efficacy for chronic sinusitis patients was seen in the 3 types of nebulizer.View full abstractDownload PDF (1532K)
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