JIBI INKOKA TEMBO
Online ISSN : 1883-6429
Print ISSN : 0386-9687
ISSN-L : 0386-9687
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Volume 42, Issue 3
Displaying 1-15 of 15 articles from this issue
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  • [title in Japanese]
    [in Japanese]
    1999 Volume 42 Issue 3 Pages 230-231
    Published: June 15, 1999
    Released on J-STAGE: March 18, 2011
    DOIhttps://doi.org/10.11453/orltokyo1958.42.230
    JOURNAL FREE ACCESS
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  • CAROTID ARTERY RESECTION FOR ADVANCED HEAD AND NECK CARCINOMA
    Yoshitaka Okamoto
    1999 Volume 42 Issue 3 Pages 232-239
    Published: June 15, 1999
    Released on J-STAGE: March 18, 2011
    DOIhttps://doi.org/10.11453/orltokyo1958.42.232
    JOURNAL FREE ACCESS
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    Carotid artery resection has been shown to yield a chance of cure in patients with advanced head and neck carcinoma involving the carotid artery. The criteria for the identification of those who are vulnerable to neurologic injury after resection have not been established. Interposition grafting covered with muscle flap minimized the risk of neurologic morbidity, although it is technically difficult when there is involvement of the internal carotid artery close to the skull base. Positron emission tomography during balloon test occlusion of the internal carotid artery is a rapid quantitative means of determining the cerebral blood flow, paticularly when resection is performed without reconstruction. However, if an extensive resection of skull base including carotid canal and sigmoid sinus is planned, the extracranial-intracranial bypass should be considered to minimize the risks of neurologic morbidity. In these cases, the temporary occulusion of the carotid artery is not an accurate prediction of the morbidity after permanent occlusion
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  • APOPTOSIS OF THE MOUSE OLFACTORY EPITHELIUM
    Takeo Donjo
    1999 Volume 42 Issue 3 Pages 240-251
    Published: June 15, 1999
    Released on J-STAGE: March 18, 2011
    DOIhttps://doi.org/10.11453/orltokyo1958.42.240
    JOURNAL FREE ACCESS
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    In the death of nervous system cells, synapses forming period, acute damage, neurodegenerative dysfunctions and aging occur. This is known as apoptosis. In this study olfactory bulbectomized mice were used as models of acute damage, and using the TUNEL method, scanning electron microscopy (SEM) and transmission electron microscopy (TEM), the possibility was investigated that the resulting olfactory cell death was apoptosis. The day after bulbectomy, many TUNEL positive olfactory cells were observed. One week later minimum values were measured, and they displayed a higher value than normal olfactory epithelium. The day after bulbectomy, an extreme loss of olfactory cilium mat and small, spherical, apoptopic cells in the olfactory epithelium cortical layer were found by SEM. Cells with a concentration of chromatin and fragmentation of the nucleus, apoptotic cells, were found by TEM. Furthermore, macrophages that had phagocytosed these apoptopic corpuscles were observed. It was also observed that apoptotic cells were expelled directly from the nasal cavity without being phagocytosed by the macrophages. From the above findings, it was confirmed that olfactory cell death occurred the day after bulbectomy, was apoptosis. Additionally, anti-NGF (nerve growth factor) antibodies were administered to the olfactory bulb and mice were prepared with olfactory bulbs desensitized to NGF and the TUNEL method was used to verify the changes. The results were the same as after bulbectomy. Then it was confirmed that the olfactory cell death in mice was apoptosis due to desensitivity to NGF. The above findings suggest that NGF is an important factor. If NGF can avoid olfactory cell apoptosis, this may be useful for treatment of olfactory disorders.
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  • EFFECT OF THE ENVIRONMENT OF SWIMMING ON THE DEVELOPMENT OF ALLERGIC RHINITIS
    ANALYSIS OF THE FACTORS INFLUENCE PREVALENCE RATES AND INCIDENCE RATE OF ALLERGIC RHINITIS
    Tomohiko Endo
    1999 Volume 42 Issue 3 Pages 252-275
    Published: June 15, 1999
    Released on J-STAGE: March 18, 2011
    DOIhttps://doi.org/10.11453/orltokyo1958.42.252
    JOURNAL FREE ACCESS
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    The effects on allergic rhinitis of the environmental factors associated with swimming were analyzed through the literature, clinical observations, epidemiological studies and animal experiments. Consequently, the symptoms of allergic rhinitis seem worsen through exposure to several environmental factors including quality control of the swimming pool water.
    Experimental studies suggest that the symptoms of rhinitis are exacerbated through the mechanism of the increased permiability of the nasal mucosa and enhanced antibody production against foreign bodies.
    It is recommended that quality control of swimming pool water and an appropriate amount of exercise are essential for safer and more healthy swimming.
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  • DETECTION OF CYCLIN D1/CDK 4 mRNA AND PROTEINS OF THE HEAD AND NECK CANCER
    Hiroyuki Ito
    1999 Volume 42 Issue 3 Pages 276-282
    Published: June 15, 1999
    Released on J-STAGE: March 18, 2011
    DOIhttps://doi.org/10.11453/orltokyo1958.42.276
    JOURNAL FREE ACCESS
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    Cyclin D1 is a cell cycle regulator essential for GlS phase progression. It also complexes with many other cell cycle related proteins such as cdk 4 and PCNA. We investigated cyclin D1 mRNA and cdk 4 amplification in 40 cases of head and neck squamous cell carcinomas. A sensitive in situ RT-PCR technique was used to monitor gene amplification in paraffin embedded samples. Overexpression ofcyclin D1 and PCNA proteins was also examined using monoclonal antibodies. Cyclin D1 mRNA amplification was observed in 16 (40%) of the 40 cases. Cdk 4 mRNA amplification was detected in 10 (25%) cases, cyclin D1 protein overexpression in 20 (50%), and PCNA protein overexpression in 19 (48%). No correlations between the results and age, pathological differentiation, clinical staging or lymph node metastasis were found, however, a strong correlation was observed between cyclin D1 and cdk 4 mRNA amplification, suggesting that these genes are amplified in the same phase in the tumor cell cycles. We also observed that the expression of cyclin D1 and cdk 4 mRNA amplification were correlated with the overexpression of PCNA protein. The findings are consistent with the notion that the expressions of cyclin D1 and cdk 4 play important roles in cell regulation in head and neck carcinomas.
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  • IMAGE-GUIDED ENDOSCOPIC ENDONASAL SURGERY FOR PARANASAL CYSTS
    Nobuyoshi Otori, Shinichi Haruna, Mamoru Yoshikawa, Hiroshi Moriyama
    1999 Volume 42 Issue 3 Pages 283-288
    Published: June 15, 1999
    Released on J-STAGE: March 18, 2011
    DOIhttps://doi.org/10.11453/orltokyo1958.42.283
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    We evaluated the advantages and disadvantages of image-guided surgery for paranasal cysts. Twelve patients, including two postoperative frontal cysts, eight postoperative maxillary cysts, one ethmoidal cyst and one sphenoidal cyst, were endonasally operated on from September 1998 to February 1999, with a electro magnetic navigation system, The Insta TrakTM (Visualization Technology Inc. USA). The system is composed of a computer, a metal probe with a non-metallic suction tube attachment, and a headset with an electro magnetic sensor. Location of the probe is displayed as an intersection point onthe patient's reconstructed axial, coronal and sagital CT images. In all cases, Insta TrakTM showed the surgeon the appropriate location and direction of each cyst wall and where the wall should be opened to the nasal cavity. The Insta TrakTM also indicated the location of the orbit, naso-lacrimal duct and/or skull base, thus, preventing intraoperative complications. We, therefore, concluded that the imageguided system successfully integrated the most up-todate technology with a surgeon's anatomical knowledge for improved treatment of endscopic endonasal opening of paranasal cysts. Moreover, when the cyst is apart from nasal cavity and/or when there are multiple cysts, the usefulness of image-guided surgery may be maximized. However, the surgeon must consider possible errors of the navigated point that may be caused by from the headset during surgery as well as errors the machine may originally possess.
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  • EXTERNAL AUDITORY MEATAL FRACTURE CAUSED BY A BLOW TO THE MANDIBLE: A CASE REPORT
    Hideki Muraoka, Akiko Ishihara
    1999 Volume 42 Issue 3 Pages 289-291
    Published: June 15, 1999
    Released on J-STAGE: March 18, 2011
    DOIhttps://doi.org/10.11453/orltokyo1958.42.289
    JOURNAL FREE ACCESS
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    The case of a 67-year-old male with a fracture of the external auditory meatus is reported. A blow to the mandible incurred in a fall produced the fracture. Otoscopic examination revealed marked protrusion of the anterior bony portion of the meatus. The fragment was displaced posteriorly so that the meatus was narrowed immediately lateral to the tympanic membrane. There was no evidence of any other fractures in the mandible or temporal bone. The patient's course has been favorable during the 40 months since the reduction.
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  • TENDENCIES OF JAPANESE CEDAR POLLINOSIS PATIENTS WHO VISIT OUR OUTPATIENT CLINIC
    Terumichi Fujikura, Norio Sahashi, Rika Akimoto, Fusako Saji, [in Japa ...
    1999 Volume 42 Issue 3 Pages 292-297
    Published: June 15, 1999
    Released on J-STAGE: March 18, 2011
    DOIhttps://doi.org/10.11453/orltokyo1958.42.292
    JOURNAL FREE ACCESS
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    Patients who have been suffering from Japanese cedar pollinosis for more than five years tend to visit our outpatient clinic before beginning of the cedar pollen season. The mean of the day of first visit in season was 2 to 16 days before being exposed to pollen. The patients, however, do not always visit our hospital for the purpose of preseasonal medication. The ratio of those who do is 36% of patients who have been suffering from Japanese cedar pollinosis for more than five years. The ratio of patients who visit the clinic immediately after onset of symptoms or before the symptoms get severe is 28%.
    On the other hand, patients who have been suffering from Japanese cedar pollinosis for only three years tend to visit the clinic after they have been exposed to a large amount of pollen with resultant severe nasal symptoms. The ratio of those patients is 48% of patients who have been suffering from Japanese cedar pollinosis for only three years.
    Although about 40% of all patients are treated with preseasonal medication, many patients visit our hospital after the onset of nasal symptoms. Because the number of patients with Japanese cedar pollinosis is thought to be increasing, their treatment requirements are various. Although preseasonal medication is useful, it is difficult to recommend all patients to visit the hospital before the beginning of the season. The treatment requirements for each patient must be assessed individually. The planning of treatment for patients who visit our hospital after the onset of nasal symptoms is also necessary.
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  • PAIN RELIEF WITH LIDOCAINE JELLY AFTER PARANASAL SINUS SURGERY
    Minoru Iida, Tomihiko Tsuji, Yukio Hamada, Masanori Ishii
    1999 Volume 42 Issue 3 Pages 298-300
    Published: June 15, 1999
    Released on J-STAGE: March 18, 2011
    DOIhttps://doi.org/10.11453/orltokyo1958.42.298
    JOURNAL FREE ACCESS
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    A method was devised for achieving relief of pain after paranasal sinus surgery by applying lidocaine jelly to Beschitin®F (gauze) and packing it in the nasal cavity for an extended period of time. The changes in lidocaine concentration in the blood were also monitored. The results showed that 87.5% of the patients treated experienced effective pain relief, while the data on the blood concentrations of lidocaine confirmed that this treatment is extremely safe. Accordingly, it can be concluded that this method using lidocaine-jelly-coated gauze packing is both an effective and safe technique for relieving pain after paranasal sinus surgery.
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1999 Volume 42 Issue 3 Pages 301-305
    Published: June 15, 1999
    Released on J-STAGE: March 18, 2011
    DOIhttps://doi.org/10.11453/orltokyo1958.42.301
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    [in Japanese]
    1999 Volume 42 Issue 3 Pages 306-312
    Published: June 15, 1999
    Released on J-STAGE: March 18, 2011
    DOIhttps://doi.org/10.11453/orltokyo1958.42.306
    JOURNAL FREE ACCESS
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    [in Japanese]
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1999 Volume 42 Issue 3 Pages 313-325
    Published: June 15, 1999
    Released on J-STAGE: March 18, 2011
    DOIhttps://doi.org/10.11453/orltokyo1958.42.313
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese]
    1999 Volume 42 Issue 3 Pages 327-328
    Published: June 15, 1999
    Released on J-STAGE: March 18, 2011
    DOIhttps://doi.org/10.11453/orltokyo1958.42.327
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    [in Japanese], [in Japanese]
    1999 Volume 42 Issue 3 Pages 329-332
    Published: June 15, 1999
    Released on J-STAGE: March 18, 2011
    DOIhttps://doi.org/10.11453/orltokyo1958.42.329
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1999 Volume 42 Issue 3 Pages 333-342
    Published: June 15, 1999
    Released on J-STAGE: March 18, 2011
    DOIhttps://doi.org/10.11453/orltokyo1958.42.333
    JOURNAL FREE ACCESS
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    [in Japanese]
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