JIBI INKOKA TEMBO

INHALED PARTICLE DEPOSITION DURING STEADY-STATE INSPIRATION FLOW IN A HUMAN LARYNX MODEL

Hiroshi Takano, Naohiro Nishida, Masayuki Itoh, Noboru Hyo, Yuichi Maj ...

2007 Volume 50 Issue Supplement3 Pages 103-108
Published: August 15, 2007
Released on J-STAGE: March 18, 2011

DOIhttps://doi.org/10.11453/orltokyo1958.50.Supplement3_103

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To evaluate the clinical effectiveness of aerosol therapy for the upper airways, particle deposition at the human laryngeal region has been analyzed with various steady-state inspiration flow-patterns. The flow profiles and trajectory of aerosol particles were calculated by 3-D thermo-fluid analysis with the finite volume method (FVM) using an 8 parallel CPU computational system. A reconstructed physical model of the real laryngeal airways was modified from the 3-D CAM modeling function of Rhinoceros based on the magnetic resonance imaging (MRI) images. By using 104 MRI images taken vertically and horizontally at intervals of 2 mm on the oral cavity and the pharynx-larynx respectively, a 3-D physical model of the laryngeal airways was obtained.
The numerical results of the flow profile analyzed by the steady-state inspiration model showed that vortex flow occurred with time near the larynx, showing a uniform flow profile in both the oral cavity and upper side of pharynx. A vortex appeared at the anterior part of the epiglottis and below the vocal cords. However, it was confirmed that few particles were deposited on the vocal cords. In these cases, the particle deposition took place mostly at the oral cavity and the otopharynx, in agreement with the data of a previous paper (Takano, et al., 2006) for unsteady-state respiratory flow. On the other hand, the frequency of the particle deposition was affected by the flow volume of inspiration efficiency and the impaction in the laryngeal region was well in agreement with the data sets of the ICRP task group (1993) for larynx deposition.

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CMX NEBULIZER EFFICACY IN PREVENTING INFECTION AFTER SINUS SURGERY

Risa Hamasaki, Toshiyuki Fujisawa, Mayuki Nakashima, Kenji Suzuki

2007 Volume 50 Issue Supplement3 Pages 109-112
Published: August 15, 2007
Released on J-STAGE: March 18, 2011

DOIhttps://doi.org/10.11453/orltokyo1958.50.Supplement3_109

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The lack of drugs approved for preventing postoperative infection means that the antibiotic regimen differs among physicians. A 7-days course of antibiotics is usually prescribed by otolaryngologists in such a case. We evaluated the role of CMX nebulizer in preventing infection after rhinosinusitis surgery. We compared CMX nebulizer and oral antibiotics use based on SIRS symptoms and standaed diagnostic criteria. We also compared insurance claim points for the 2 groups. We found that the nebulizer user group was treated more effectively and at lower cost.

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EVALUATION OF OUTPATIENT INHALATION GUIDANCE FOR INFANT CHILDHOOD ASTHMA

Tomoko Okawa, Seigo Shirakawa, Tomoko Yazaki, Yuji Yoshiyama, Motoko K ...

2007 Volume 50 Issue Supplement3 Pages 113-128
Published: August 15, 2007
Released on J-STAGE: March 18, 2011

DOIhttps://doi.org/10.11453/orltokyo1958.50.Supplement3_113

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A tendency towards increase in the incidence of asthma is noted around the world and the age at onset has also shown a tendency to decrease. Although inhalation therapy is useful, noncompliance is a problem in childhood asthma. It was thought that rational drug therapy might be encouraged if the pharmacist provided outpatient inhalation treatment guidance, not limited to provision of an accurate inhalation technigue, but also including establishment of a rapport to obtain an insight into the mental condition and daily life of the children/guardians. Improvement was noted with the provision of such guidance to the infants children and guardianins in terms of almost all of the investigatied items, including the level of understanding of the inhalation technique by the child/guardian, daily asthma treatment, QOL, peak flow rate, and the treatment point. Especially, paying greater attention by providing repeated guidance for children with autism, and promoting a sense of intimacy and reliability towards the medical treatment staff, more and more patients understood asthma better and could be convinced to provide consent for inhalational treatment, allowing appropriate management of asthma.

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HYPERTHERMIC AEROSOL THERAPY

Shoji Matsune

2007 Volume 50 Issue Supplement3 Pages 129-132
Published: August 15, 2007
Released on J-STAGE: March 18, 2011

DOIhttps://doi.org/10.11453/orltokyo1958.50.Supplement3_129

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Hyperthermic aerosol therapy is a steam inhalation therapy using aerosol particles of distilled water at 43°C. In the 1980's and 1990's, Japanese otolaryngologists began to use in this therapy as a sort of physiological therapy for rhinosinusitis. Since then much clinical evidence has been collected to show the beneficial effects of this therapy in rhinosinusitis, especially in cases of allergic rhinitis. Recently, it has been suggested that the immunological defense ability is supported and promoted by this therapy via stabilization of the autonomic nervous system. Hyperthermia aerosol therapy is expected to join the ranks of hot-spring and sauna therapy or aroma therapy in the field of health promotion and disease prevention.

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DESCRIPTION OF OUR DREAMS FOR THE FUTURE ABOUT AEROSOL INHALATION THERAPY FOR DISEASES OF THE PHARYNX AND LARYNX

Kensei Naito

2007 Volume 50 Issue Supplement3 Pages 133-137
Published: August 15, 2007
Released on J-STAGE: March 18, 2011

DOIhttps://doi.org/10.11453/orltokyo1958.50.Supplement3_133

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In Japan, local aerosol inhalation therapy for inflammatory conditions of the pharynx and larynx is well established, however, the use of aerosol therapy has been restricted to a few conditions for several reasons. To expand the indications of pharyngeal and laryngeal aerosol therapy in our field, we recently introduced steroid inhalation therapy for laryngeal granuloma or laryngeal allergy. Furthermore, we describe the development of portable, effective and sterilized equipment for aerosol therapy inhalation, pharyngeal and laryngeal inhalation therapy with Chinese blended medicines, local vaccination against infectious diseases by aerosol administration, immunotherapy against laryngeal allergy, photodynamic therapy against early pharyngeal and laryngeal malignancies and improvement of swallowing in dysphagia patients by capsaicin inhalation as our future dreams for the use of aerosol therapy for pharyngeal and laryngeal diseases in this paper.

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[title in Japanese]

[in Japanese]

2007 Volume 50 Issue Supplement3 Pages 138-141
Published: August 15, 2007
Released on J-STAGE: March 18, 2011

DOIhttps://doi.org/10.11453/orltokyo1958.50.Supplement3_138

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[in Japanese]

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