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Volume 34 (1991)
- Issue 6 Pages 595-
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Volume 31 (1988)
- Issue 6 Pages 757-
- Issue 5 Pages 613-
- Issue 4 Pages 425-
- Issue 3 Pages 273-
- Issue 2 Pages 127-
- Issue 1 Pages 9-
- Issue Supplement9 Pag･･･
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Volume 31, Issue Supplement8
Displaying 1-6 of 6 articles from this issue
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Akira Hara, [in Japanese], [in Japanese]1988 Volume 31 Issue Supplement8 Pages 1053-1059
Published: October 15, 1988
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThe concentrations of furosemide (FU) in sequential samples from scala tympani (ST) and scala vestibuli (SV) perilymph after intravenous injection of 100 mg/kg FU were measured by high-performance liquid chromatography (HPLC) with or without blocking the cochlear aqueduct (CA). An analysis of amino acid content in perilymph was also perfomred by HPLC using phenyl isothiocyanate derivatization as the sample volume withdrawn through the round window (RW) or the hole in the third turn of the cochlea was varied from 100 nl to 5 μl.
We found pronounced gradient and difference of FU concentrations between ST and SV perilymph. The elimination curve of FU in ST, however, became very similar to that in CSF as the CA was not blocked.
Up to 200 nl of sample volume, the glycine and alanine contents of ST perilymph was similar to that of SV perilymph. With larger volumes, the glycine and alanine contents rapidly declined toward that of CSF.
Our data suggest that perilymph samples taken through the RW without blocking the CA are contaminated with CSF if more than 200 nl is withdrawn. If ST perilymph is sampled from the third turn even without blocking CA, larger volumes (up to 1.7 μl) can be withdrawn without significant CSF contamination.View full abstractDownload PDF (690K) -
[in Japanese], [in Japanese], [in Japanese]1988 Volume 31 Issue Supplement8 Pages 1061-1064
Published: October 15, 1988
Released on J-STAGE: August 10, 2011
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[in Japanese], [in Japanese], [in Japanese]1988 Volume 31 Issue Supplement8 Pages 1065-1068
Published: October 15, 1988
Released on J-STAGE: August 10, 2011
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[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...1988 Volume 31 Issue Supplement8 Pages 1069-1077
Published: October 15, 1988
Released on J-STAGE: August 10, 2011
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[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...1988 Volume 31 Issue Supplement8 Pages 1079-1087
Published: October 15, 1988
Released on J-STAGE: August 10, 2011
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[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...1988 Volume 31 Issue Supplement8 Pages 1089-1103
Published: October 15, 1988
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSDownload PDF (1384K)
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