Since 34 of Showa (1959), we have carried out the hyposensitization treatment on 95patients of allergic rhinitis with the allergens which induced positive reaction in the intradermal testings in each individuals. Some of patients were treated concomitantly with other drugs, autoserum and Asthremedin.
(1) The hyposensitization treatment has been carried out on 95 patients of allergic rhinitis for a period of more than 3 years by intradermal injections on the flexor surface of the upper arm of 0.02ml. of allergen extract once a week, then, intervals being gradually prolonged according to the size of wheal and erythema.
Some of patients were treated with two or more kinds of allergens.
(2) The allergen extracts used were house dust extract of 1: 10, 1: 100, and 1: 1000 dilution, Alternaria extract, Botrytis cinerea extract, cat hair extract and others, and, of these, house dust extract of 1: 10 dilution was used most frequently, i.e. on 60 patients (63.1%).
(3) Concomitant treatments performed consisted of the oral administration of Metron and Neo-Restamin, the intradermal injection of Asthremedin (for patients who were suffering from asthma and urticaria coincidentally), and the autoserum treatment (for patients whose symptoms tended to worsen in the premenstrual period) (58 patients, 61.1%).
(4) Thirty-seven of 95 patients (38.9%) were treated by the hyposensitization alone.
(5) Results of the hyposensitization treatment of allergic rhinitis, obtained by analysis of 41 answers (those of residents in Tokyo) to the questionnaire, are as follows:
a) Cure and improvement were obtained in 27 of 41 patients (65.8%).
b) Eight (19.5%) of patients classified as cured or improved were those who were treated by the hyposensitization alone, and others were subjected to the concomitant treatments.
c) Of 27 patients classified as cured or improved, 14 (51.9%) patients were those on whom the treatment was started within a period of 2 years after the onset of the disease, and, in general, the higher percentage of improvement were obtained in a group of patients on whom the treatment was started within the shorter period after the onset of the disease.
d) Ten or less injections were sufficient for cure or improvement in 18 of 27 patients (66.6%), but more than 51 injections were required in 3 patients.
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