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Volume 53, Issue Supplement2
Displaying 1-13 of 13 articles from this issue
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Kensei Naito2010 Volume 53 Issue Supplement2 Pages s35-s39
Published: 2010
Released on J-STAGE: August 15, 2011
JOURNAL FREE ACCESSIt is considered that aerosol inhalation for upper airway diseases began in B.C. 500. Today, aerosol inhalation therapy for upper airway allergies and inflammation has been the major treatment in the daily otorhinolaryngology clinic in Japan. However, this therapy still has several problems to resolve, for example, mean average of aerosol particle diameter, distribution of particle diameter, volume of vaporized aerosol, air pressure during local exposure to aerosol particle, kinds of dissolved medicine in the aerosol particles, anaphylaxis to the dissolved antibiotics, evidence based efficacy of aerosol therapy to upper airway diseases, and bacterial contamination of equipment during and after use in patients' infected airway. Our department has partly resolved these problems in recent years. As well we demonstrated that only exposure of the upper airway to hyperthermal aerosol without any medicine was effective in nasal allergy patients. Furthermore, we are attempting to develop the application of aerosol therapy for immunization against infectious diseases, miss-swallowing, and treatment of upper airway malignant tumors.View full abstractDownload PDF (490K) -
Kei Masuda2010 Volume 53 Issue Supplement2 Pages s40-s45
Published: 2010
Released on J-STAGE: August 15, 2011
JOURNAL FREE ACCESSPediatric inhalation therapy is a form of treatment with regard to various pathologies existing throughout the respiratory tract, aiming to protect the airway, supply oxygen, and administer medication. When introducing inhalation therapy it is important to know the anatomical and physiological characteristics of patients in their childhood. The conditions and procedures for improving inhalation efficiency must be studied and the optimum method chosen. The patient can also not inhale effectively without training. Coughing is a common symptom in child visits to the department of otorhinolaryngology. Inhalation therapy has frequently been conducted for chronic coughing, however many difficulties are associated with making definite diagnoses, which makes sufficient auscultation and follow-up observations necessary. In pediatrics, there is sufficient evidence to apply inhalation therapy for bronchial asthma as the number one therapy. Through an understanding of the pathology, treatment methods have been established and guidelines prepared. It is also recommended to promote the treatment of child patients with inhaled corticosteroids, but many problems exist. Issues remain that need to be investigated in order to develop child inhalation therapy, and the accumulation of further evidence is required.View full abstractDownload PDF (800K) -
[in Japanese], [in Japanese]2010 Volume 53 Issue Supplement2 Pages s46-s48
Published: 2010
Released on J-STAGE: August 15, 2011
JOURNAL FREE ACCESSDownload PDF (310K) -
Takuji Koike, Tatsunari Harashima, Kosumi Oshiro2010 Volume 53 Issue Supplement2 Pages s49-s54
Published: 2010
Released on J-STAGE: August 15, 2011
JOURNAL FREE ACCESSLocal therapy has been performed using a nasal spray or nebulizer. However, the drug distribution area in the nasal cavity has been unclear. In this study, a simple method for clarifying the area of drug distribution in the nasal cavity by image analysis was proposed, and the drug distribution areas in a silicon model of the nasal cavity were investigated following distribution of the drug with nasal sprays and an ultrasonic nebulizer. The areas of drug distribution were found to change according to the angle of the nozzle of the spray. When the angle of the spray was inserted to the nostril at the angle of 30 degrees to the horizontal plane, the drug was mainly sprayed around the inferior nasal concha. In contrast, when the angle was more than 45 degrees, the drug was distributed to the middle nasal concha or the upper area of the nasal cavity. In case of the ultrasonic nebulizer, the drug was widely spread in the nasal cavity. The viscosity of the drug had no influence on the drug distribution. There was a tendency for the drug to be distributed to the upper area of the nasal cavity by sniffing, however, the effect changed according to the angle of the nozzle.View full abstractDownload PDF (645K) -
Shoji Matsune2010 Volume 53 Issue Supplement2 Pages s55-s58
Published: 2010
Released on J-STAGE: August 15, 2011
JOURNAL FREE ACCESSRecently, corticosteroid nasal sprays have been evaluated as being quite effective for treatment of patients with allergic rhinitis and, therefore, are recommended as the first choice of medical treatment in ARIA (Allergic Rhinitis and its Impact on Asthma). On the other hand, we have studied and reported on the importance of vascular endothelial growth factor (VEGF) in the pathophysiology of allergic rhinitis. Two major physiological or pathological functions of VEGF have been well-recognized as angiogenesis and increasing vascular permeability in tumor growth and inflammation. In this study, the effects of a corticosteroid nasal spray, mometasone, on both the clinical symptoms of perennial allergic rhinitis and VEGF production in the nasal mucosa were assessed. After two weeks of mometasone use, sneeze, watery rhinorrhea and nasal obstruction apparently improved and VEGF in nasal lavage after antigen provocation tended to be reduced. According to a cell-culture study using fibroblasts in the inferior turbinate mucosa obtained from the operation for perennial allergic rhinitis cases, the existence of messenger RNA (mRNA) for VEGF receptors was confirmed and mRNA for VEGF which increased after stimulation by VEGF was significantly suppressed by mometasone in a dose dependent manner. An inhibitory effect on VEGF production from fibroblasts was suggested to be one of the important steps of the clinical effect of mometasone on allergic rhinitis.View full abstractDownload PDF (499K) -
Terumichi Fujikura2010 Volume 53 Issue Supplement2 Pages s59-s63
Published: 2010
Released on J-STAGE: August 15, 2011
JOURNAL FREE ACCESSNebulizer therapy for allergic rhinitis has been considered in approximately 90% of medical otorhinolaryngology institutions. However the meaning of nebulizer therapy for patients with allergic rhinitis in that situation is unclear. We did a survey of patients with perennial allergic rhinitis concerning nebulizer treatment. Many patients seemed to be treating themselves according to the doctor's instruction without realizing the effects of this therapy. In the case of the adhesion of the nasal topical steroid to the nasal cavity, half the number of patients sprayed the region, such as the nasal vestibule or the bottom part of cavity, with inefficient absorption. We consider that many patients use their nasal spray inadequately. Therefore we designed a home treatment study using a portable nebulizer unit during the Japanese cedar pollinosis season. The total nasal symptom score during the season was generally less than 3 and patient's satisfaction was very high. This nebulizer therapy was useful for the treatment of pollinosis. Nebulizer therapy should be revaluated as an effective drug delivery system. Considering the use of topical nasal corticosteroids that are administrated once a day, the meaning of nebulizer therapy will be a controller rather than a reliever.View full abstractDownload PDF (756K) -
Haruka Okubo, Motofumi Ohki, Sota Yamaguchi, Yoshiko Ishii, Shuichiro ...2010 Volume 53 Issue Supplement2 Pages s64-s69
Published: 2010
Released on J-STAGE: August 15, 2011
JOURNAL FREE ACCESSCurrently, nasal allergies are an important disease group that affects the entire nation of Japan. Nasal allergies are treated primarily using the drugs specified in the Practical Guidelines for the Management of Allergic Rhinitis in Japan. Of the various drug therapies currently available, local treatments are considered highly effective. In recent years, portable nebulizers have been developed, and their usefulness for upper respiratory diseases has been recognized. In the present study, the usefulness of portable nebulizers for the treatment of hay fever was compared to that of nasal instillation. The results showed good effects, and no clear differences between the two treatments. The deposition of the drug solution inside the nasal cavity was compared between nebulizer treatment and nasal instillation in healthy human volunteers. With nebulizer treatment, the drug solution was widely deposited inside the nasal cavity. In contrast, with nasal instillation, the drug solution was deposited over a limited area, depending on how the head was tilted at the time of instillation. These results suggest that portable nebulizers are effective for the treatment of nasal allergies.View full abstractDownload PDF (639K) -
Sota Yamaguchi, Motofumi Ohki, Haruka Ookubo, Yoshiko Ishii, Shuichiro ...2010 Volume 53 Issue Supplement2 Pages s70-s74
Published: 2010
Released on J-STAGE: August 15, 2011
JOURNAL FREE ACCESSWe investigated the usefulness of mesh-type nebulizers in nasal diseases. This experiment was conducted in two adults with no nasal diseases. We used two mesh type nebulizers (OMRON Micro Air NE-U22®, and PARI eMotion®) with attached nasal nozzles in this nuclear medicine study. Aerosols nebulized by the OMRON Micro Air NE-U22® were widely distributed in the nasal cavity, whereas aerosols nebulized by the PARI eMotion® were distributed in the throat and trachea in addition to the nasal cavity. Based on this experiment, it appeared that differences in the distribution of aerosols were due to the total output rate. As this experiment used a nasal nozzle, the deposition rate of the aerosols may have differed. When a nasal nozzle is used on a mesh-type nebulizer, the shape of the nozzle needs to be considered.View full abstractDownload PDF (697K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...2010 Volume 53 Issue Supplement2 Pages s75-s78
Published: 2010
Released on J-STAGE: August 15, 2011
JOURNAL FREE ACCESS -
Osamu Shibasaki, Yasuhiro Kase2010 Volume 53 Issue Supplement2 Pages s79-s84
Published: 2010
Released on J-STAGE: August 15, 2011
JOURNAL FREE ACCESSThe method of administering any drug solution to the external auditory canal in Japan is limited to using a dropper for liquids or topically applying ointment. In the present study, the possibility of an external ear spray was examined as a method of conveniently administering adequate drug solution to the external auditory canal. We used a trial product as an external ear spray, and used a cylinder made of paper as an external ear model. Regarding actual use, a questionnaire was used to compare the external ear spray to a liquid dropper. The results showed that the external ear spray could deliver the drug to a wider area of the external auditory canal compared with the dropper. Many respondents stated that the external ear spray was moreover more convenient to use than the dropper.
The results of our study suggest that the external ear spray is a potentially useful method for delivering drugs to the ear and merits further study.View full abstractDownload PDF (1288K) -
Akane Kakuyama, Takenori Tamaki, Toshimi Iizuka, Hideto Ariumi, Tomoko ...2010 Volume 53 Issue Supplement2 Pages s85-s89
Published: 2010
Released on J-STAGE: August 15, 2011
JOURNAL FREE ACCESSTo reduce the medical expense, the Japanese government is promoting generic drug use. Recently many “value added” generic drugs have been developed in Japan. These generic drugs are usually developed using innovative pharmaceutical technologies and such products achieve the goal of being more patient friendly by improving delivery system, flavor or ease of use. We have created a “Value added” Generic Drugs database to ensure accurate and appropriate use of these drugs. The purpose of this study was to show the utility of the database in clinical practice. In the present study, patients who had been treating their allergic rhinitis with Fluticasone Propionate Nasal Spray switched from the brand name to the “value added” generic drugs. We assessed changes in the patient's compliance and the therapeutic efficacy of the “value added” generic drugs. The therapeutic efficacy was maintained after switching to the “value added” drug. We suggested that the “value added” generic drug have an equivalent effect to the brand name, moreover, patient compliance was improved with the use of the “value added” drug. We can choose the generic drugs that more suit patients' needs by considering the “value added” generic drugs, so the “Value added” Generic Drugs database should become a useful source in clinical practice.View full abstractDownload PDF (441K) -
Susumu Araki, Mamoru Suzuki2010 Volume 53 Issue Supplement2 Pages s90-s96
Published: 2010
Released on J-STAGE: August 15, 2011
JOURNAL FREE ACCESSTreatment with a nasal nebulizer is usually carried out for seasonal allergic rhinitis. On the other hand, there is no effective local treatment for seasonal allergic conjunctivitis and contact dermatitis in the outpatient clinic. We devised a fomentation system using the facial nebulizer with steam mist and eye drops for seasonal allergic conjunctivitis and contact dermatitis. Thirty-eight patients with Japanese cedar pollen allergy were treated using the nebulizer in 2008. The ratio of the improvement was higher in eye symptoms (eye itching and tearing eyes) than in nasal symptoms. Three patients with grass pollen allergy were treated using the nebulizer in 2009. The improvement rates were 100% for eye itching and tearing eyes, and 75% for the facial dryness. In the outpatient clinic, the effects of humidity and thermotherapy in fomentation using the facial nebulizer were able to be successfully used in the treatment of seasonal allergic conjunctivitis and contact dermatitis.View full abstractDownload PDF (1150K) -
Keiko Kashiba, Masahiro Komori, Yoshinori Omotehara, Naoaki Yanagihara ...2010 Volume 53 Issue Supplement2 Pages s97-s100
Published: 2010
Released on J-STAGE: August 15, 2011
JOURNAL FREE ACCESSPurpose: The nasal medication spray is routinely used in the ENT office for the treatment of rhinitis and sinusitis. However, patients may sometimes feel discomfort with its use, or have a phobia against this device. To reduce the discomfort, a new spray has been developed, in which the drops sprayed are half the size of the previous systems, and the volume per second has been reduced by two-thirds. The present study was designed to compare the discomfort between the use of the new sprayer and the old one.
Materials and methods: Twenty healthy volunteers were examined. Three otolaryngologists randomly sprayed the subject's nose cavity with saline six times, at one second intervals at random. On the every spray, their feeling was assessed; a score of 1 indicated comfortable; a score of 2, no particular feeling; a score of 3, a little uncomfortable; a score of 4, uncomfortable; and a score of 5, very uncomfortable.
Results: The mean of the degree of discomfort was 2.6±0.9 or 3.1±1.0 with the new or the old sprayer, respectively. There were significant differences between the two.
Conclusion: The study demonstrated that the new sprayer can effectively reduce patients' discomfort during treatment.View full abstractDownload PDF (748K)
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