Infectious mononucleosis (IM) is a syndrome caused by primary infection with Epstein-Barr Virus (EBV).
We studies 36 cases of IM on clinical manifestatioin, all satisfied criteria for diagnosis of IM presented by Evans AS in 1972. 33 cases were examined with seorological studies for antibodies to EBV-specific antigens (viral capsid antigen, early antigen, and EB nuclear antigen).
EBV specific antibodies required to diagnosis IM serologicaly were positive in 22 cases. Frequency in each symptom were found as follows: fever in 97%, lymphadenopathy in 86%, tonsilitis in 70%, hepatomegaly in 63%, and exanthema in 38%. More than 10 percent of atypical lymphocytes were found in the peripheral blood. Non-specific tests for antibody (Paul-Bunnell test) were negative in 95.8%.
Intimate contact, such as exchange of saliva by means of kiss, for example, is said to be required for transmission of EBV. With advent of culture being more free in mind among pepole towards 21 century, IM may be seen more prevail in Japan, so that more confirmative diagnosis of IM should be requisite for otolaryngologist with confident evaluation of symptoms and serological examination in IM.
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