JIBI INKOKA TEMBO

PHYSIOLOGICAL SALINE NASAL SPRAY TRANSIENTLY IMPROVES MUCOCILIARY CLEARANCE

Kazuhiko Takeuchi, Eri Suzumura

2013 Volume 56 Issue Supplement3 Pages s181-s184
Published: August 15, 2013
Released on J-STAGE: August 15, 2014

DOIhttps://doi.org/10.11453/orltokyo.56.s181

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Conclusion: Nasal spraying of physiological saline significantly improves the nasal mucociliary transport within a short time.
Objectives: To examine the effect of a nasal spray of physiological saline on the nasal mucociliary transport.
Method: The subjects were 13 people (4 men and 9 women) without any nasal diseases or nasal symptoms at the time of the test. The subjects ranged in age from 23 to 53 years, with a mean age of 29.3 years. The saccharin test was performed on three different days in each subject. On the first day, the saccharin time was measured without any pretreatment. On the second day, the saccharin time was measured 5 minutes in the subjects after nasal spray of saline twice into each nostril. On the third day, the saccharin time was measured 15 minutes after the nasal spray had been used in the subjects.
Results: The saccharin time measured 5 minutes after the nasal spray was significantly shorter than that measured without the nasal spray by the Wilcoxon's signed-rank test (p<0.05 with Bonferroni's correction). The saccharin time measured 15 minutes after the nasal spray was not significantly different from that measured on the second day. There was no significant difference between the saccharin time on the first day and that on the third day.

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THE EFFECT OF NEBULIZATION WITH A VIBRATING PULSE IN PATIENTS WITH RESISTIVE SINUSITIS

Motofumi Ohki, Mamoru Yoshikawa, Sota Yamaguchi, Haruka Okubo, Yoshiko ...

2013 Volume 56 Issue Supplement3 Pages s185-s189
Published: August 15, 2013
Released on J-STAGE: August 15, 2014

DOIhttps://doi.org/10.11453/orltokyo.56.s185

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Maxillary sinus puncture and irrigation has been recommended for patients with acute and chronic sinusitis. Nasal irrigation therapy is also becoming popular in some countries. On the other hand, nasal nebulization is considered as a useful therapy in Japan, although there is lack of sufficient evidence. The aim of our study was to determine/discuss the usefulness of nebulization with a vibrating pulse in patients with sinusitis.
Five patients with unilateral sinusitis were treated with a pulsating nebulizer system (PARI Sinus^®, PARI, Germany). The patients were requested to inhale nebulized topical steroid twice a day for 3 or 4 weeks and the effect of this treatment was studied. The results showed that the symptoms and findings on the plain sinus at X-ray improved with the treatment. It is expected that the ratio of deposition of nebulized particles into the sinuses will be increased with this system. Our results suggest that the pulsating nebulizer system is a useful tool for the treatment of patients with mild unilateral sinusitis.

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DATABASE OF PROHIBITED OTC DRUGS FOR ANTI-DOPING

Shoko Hanyu, Tomoko Miyazaki, Yuji Yoshiyama

2013 Volume 56 Issue Supplement3 Pages s190-s195
Published: August 15, 2013
Released on J-STAGE: August 15, 2014

DOIhttps://doi.org/10.11453/orltokyo.56.s190

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Doping, which is a big social problem, especially among the younger generation in many countries, is not only an issue involving sportspersons, but also has harmful effects on health. However, there is little information about doping, and the knowledge of the general public about the problem is limited. Therefore, it is necessary for pharmacists, who have the largest opportunity to administer drugs to the general public, to participate in anti-doping activities. Drug information has a very important role in clinical pharmacy. More information on prohibited OTC drugs is needed for anti-doping personnel to solve doping problems. The purpose of this study was to prepare a database for proper use of prohibited OTC drugs to facilitate anti-doping, and to provide quick and accurate information from the database. All beta-2 agonists (including both optical isomers where relevant) are prohibited, except for salbutamol (maximum 1600 micrograms over 24 hours), formoterol (maximum 36 micrograms over 24 hours) and salmeterol when taken by inhalation in accordance with the manufacturers' recommended therapeutic regime. There are 104 class 1 OTC drugs in Japan. Of these, 18 OTC drugs are prohibited at all times and 3 are prohibited in-competition. The database of prohibited OTC drugs to ensure the success of anti-doping was made into a booklet. Based on this database, we can choose OTC drugs to suit the patients' needs while taking anti-doping into consideration. Therefore, the database of prohibited OTC drugs to encourage anti-doping is a useful resource in clinical practice.

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COMPUTATIONAL FLUID DYNAMICS ANALYSIS FOR AEROSOL TRANSFER CHARACTERISTICS TO THE MAXILLARY SINUS

Takahisa Yamamoto, Naoko Fujii, Toshiyuki Fujisawa, Seiichi Nakata, No ...

2013 Volume 56 Issue Supplement3 Pages s196-s201
Published: August 15, 2013
Released on J-STAGE: August 15, 2014

DOIhttps://doi.org/10.11453/orltokyo.56.s196

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There are individual differences in the shapes of the nasal cavity, ostium and maxillary sinus that might affect the intranasal transport phenomena of aerosol therapy. In recent years, there have been developments and advances in medical imaging techniques, especially in computerized tomography (CT), that provide detailed information on the human body. In this paper, we report on the computational fluid dynamics (CFD) simulation to define the intranasal aerosol transport characteristics and transfer characteristics to the maxillary sinus based on CT data and numerical simulation models. The analysis was conducted on two subjects: one was a female in her forties whose nasal cavity had enough space to allow air ventilation (Case 1) and the other was a male with nasal obstruction caused by a deviated nasal septum and sub-ostium (Case 2). From the results of CFD, aerosol particles were widely transported in the nasal cavity of Case 1, but were hardly transferred to the maxillary sinus via the ostium. On the other hand, in Case 2, transportation of the aerosol particles was inhibited due to the deviated nasal septum and nasal obstruction. Aerosol transfer to the maxillary sinus was, however, relatively high as compared with that in Case 1. It is for these reasons that high-velocity flow is found near the ostium and Case 2 had not only a main ostium, but also a sub-ostium. These results here show that the deviated nasal septum did not necessarily inhibit aerosol transfer between the nasal cavity and the maxillary sinus.

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