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Volume 31 (1988)
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Volume 50, Issue 3
Displaying 1-11 of 11 articles from this issue
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[in Japanese]2007 Volume 50 Issue 3 Pages 134-135
Published: June 15, 2007
Released on J-STAGE: March 18, 2011
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Yuichi Kurono, Tatsuya Fukuiwa2007 Volume 50 Issue 3 Pages 136-141
Published: June 15, 2007
Released on J-STAGE: March 18, 2011
JOURNAL FREE ACCESSUpper respiratory tract is equipped with several host-defense mechanisms in order to protect the host against continuous invasion by microorganisms and allergens.Secretory IgA is the chief agent of mucosal immune system and excludes microorganisms by agglutination without destroying them. Nasal associated lymphoid tissue (NALT) acts as an inductive site to induce secretory IgA in upper respiratory tract and has different organogenesis from the other inductive sites. Recent studies demonstrated that CD3-CD4+CD45+cells, Id2 gene, and CXCL13, are essential to construct NALT. Not only the mechanisms in inducing mucosal immune responses in upper respiratory tract, but also the usefulness of intra-nasal vaccination has been attracted. Intra-nasal immunization of mice with pneumococcal surface protein A (PspA) ofStreptococcus pneumoniaeand outer membrane protein P6 ofHaemophilus influenzaeenhanced the clearance of those bacteria from nasal and middle ear cavities. Moreover, intra-nasal immunization with phosphorylcholine (PC) elicited protective mucosal immunity against most different strains of S.pneumoniaeandH. influenzae, indicating that PC might be a promising wide spectrum vaccine. Since mucosal immune responses are associated with type I allergy mediated by IgE, mucosal vaccine might be effective to prevent nasal allergy. In facts, intra-nasal immunization with ovalbumin induced mucosal immune tolerance. Further, clinical trials have demonstrated that sublingual immunization with pollen extracts improved nasal symptoms and medication scores. Those finding suggest that mucosal vaccination can be applied for preventing upper respiratory infections and for the treatment of nasal allergy.View full abstractDownload PDF (1246K) -
Shintaro Chiba2007 Volume 50 Issue 3 Pages 142-156
Published: June 15, 2007
Released on J-STAGE: August 16, 2011
JOURNAL FREE ACCESSI report the retrospective study of 100 children who suspected of having obstructive sleep apnea (OSA) and undergoing polysomnography from April 1, 2002, to March 30, 2006. Of the 100 children, 99 were diagnosed with OSA using diagnostic criteria of the International Classification of Sleep Disorders II. Children with OSA did not show much apnea but showed hypopnea as a respiratory event and their sleep architecture was almost normal. Esophageal measurement was useful in the evaluation of respiratory effort and PAP scoring was useful in the evaluation of sleep instability. In this study, many OSA children had hypertrophy of the tonsils, nasal obstruction, and a small jaw strong predictors of childhood OSA. Two years after treatment (tonsillectomy), SD scores of body weight and height showed significant growth. The degree of the facial axis of the small jaw showed significant growth.
In conclusion, new, accurate methods for the evaluation of respiratory effort and sleep stability associated with neurocognitive functions are needed. Early treatment is important for children with OSA to ensure normal physical and mental growth. The evaluation of the craniofacial structure is very important because many adult Japanese patients with OSA without obesity show small jaws. Childhood craniofacial structure may influence adult OSA and early treatment for children with OSA should prove useful in preventing adult OSA.View full abstractDownload PDF (5122K) -
STUDY IN PATIENTS WITH CEDAR POLLEN ALLERGEN SPECIFIC HYPOSENSITIZATIONTsuyoshi Yoshimura, Osamu Nohara, Takechika Omori, Naoya Ui, [in Japan ...2007 Volume 50 Issue 3 Pages 157-163
Published: June 15, 2007
Released on J-STAGE: March 18, 2011
JOURNAL FREE ACCESSObjective : We studied change in specific IgE antibody levels in patients with Japanese cedar pollinosis treated by immunotherapy.
Methods : Specific IgE levels (IgE levels) forCryptomeria japonica (Cry j) andChamaecyparis obtusa (Cha o) in patients with Japanese cedar pollinosis treated by immunotherapy from 1999 to 2004 were measured and the change in these was studied by age.
Results : From 2000 to 2003, we observed a large amount of cedar pollen, and IgE levels significantly elevated postseasonally for years from 2000 to 2002 and IgE levels preseasonally dominantly elevated than those postseasonally. At 2004, we observed a small amount of cedar pollen, IgE levels showed the same at 1999 before a large amount of cedar pollen exposure.
Conclusions : IgE levels were strongly affected by the amount of cedar pollen exposure, and IgE levels were elevated after a large amount of cedar pollen exposure and followed through to the next season, and IgE levels returned to basal levels after a small amount.Even if patients were treated with cedar pollen allergen specific hyposensitization, IgE levels were affected after a large amount of cedar pollen exposure.
Abbreviations :
Cry j : Cryptomeria japonica
Cha o : Chamaecyparis obtusa
IgE : immunoglobrin E
HD : house dustView full abstractDownload PDF (958K) -
Akemi Matsushima, Toshiyuki Kokatsu, Takashi Hirao, Mamoru Tsukuda2007 Volume 50 Issue 3 Pages 164-169
Published: June 15, 2007
Released on J-STAGE: March 18, 2011
JOURNAL FREE ACCESSA 50-year-old woman with a history of adult-onset asthma and sinusitis was referred to our hospital because the otitis media had proved very difficult to control. She was found to have bilateral aural fullness and discharge. Progression of otitis media could be controlled to some extent by steroid therapy.
After the steroid therapy had been discontinued, the patient presented with pulmonary infiltrates and polyneuropathy. The clustering of asthma, eosinophilia, polyneuropathy, pulmonary infiltrates and extravascular eosinophilic infiltration confirmed a diagnosis of Churg Strauss syndrome (CSS). After steroid treatment with hydrocortisone injections, the patient's symptoms resolved. This case highlights the importance of recognizing the association between CSS and eosinophilic ottis media.View full abstractDownload PDF (2770K) -
Kozue Kodama, Yasushi Ohta, Takeharu Kanazawa, Keijyu Tsubaki, Yukiko ...2007 Volume 50 Issue 3 Pages 170-177
Published: June 15, 2007
Released on J-STAGE: March 18, 2011
JOURNAL FREE ACCESSWe report two patients of acute sinusitis with intracranial complications, and discuss the clinical features of an additional 36 patients with rhinogenic intracranial complications reported since 1990. A 29-year-old male was diagnosed as having acute frontal sinusitis associated with a frontal brain abscess and epidural abscess, and underwent endoscopic endonasal sinus surgery (ESS) followed by debridement of the epidural abscess via craniotomy and external decompression. Another patient, a 16-year-old female, was diagnosed as having acute frontal sinusitis associated with an epidural abscess, and underwent ESS for the sinusitis and burr hole debridement of the epidural abscess. Both patients were successfully cured by systemic administration of antibiotics and the local treatments. The results of analysis of the 36 reported patients and the present two patients with rhinogenic intracranial complications, revealed that intracranial abscess, such as brain abscess, was a more frequent complication than meningitis, and that the frontal sinus was the most frequent site of the primary infection. Most of the patients had undergone ESS, and more than half of the patients had undergone drainage operations conducted by a neurosurgeon, in addition to systemic administration of antibiotics. Precise diagnosis by contrast enhanced CT and MRI, and prompt and adequate treatment are essential for patients with rhinogenic intracranial complications.View full abstractDownload PDF (3615K) -
Tomihiko Tsuji, Nobuo Kiuchi, Kousuke Hattori, Izumi Koizuka2007 Volume 50 Issue 3 Pages 178-181
Published: June 15, 2007
Released on J-STAGE: March 18, 2011
JOURNAL FREE ACCESSWe report two cases of tympanic perforation thought to have been caused by otomycosis of the external ear canal. One patient visited the author's clinic with the complaint of feeling like her right ear was plugged up, while the second patient presented with earache. Neither patient had a compromised immune system, and neither had a history of ear surgery. In both patients, white clusters were observed on the tympanum, and microbiological studies revealed Aspergillus sp. The ear canal was cleansed and irrigated with povidone iodine. Clotrimazole ointment and solution were applied externally, however, tympanic perforation occurred during the course of the treatment. The perforation was treated conservatively and spontaneous closure occurred within about two months. It is concluded that, if white clusters that appear like fungal growths are observed on the tympanum, they should be removed as thoroughly as possible and antifungal therapy should be initiated immediately. These steps are important for preventing tympanic perforation.View full abstractDownload PDF (2032K) -
[in Japanese], [in Japanese], [in Japanese]2007 Volume 50 Issue 3 Pages 182-185
Published: June 15, 2007
Released on J-STAGE: March 18, 2011
JOURNAL FREE ACCESS -
[in Japanese]2007 Volume 50 Issue 3 Pages 186-191
Published: June 15, 2007
Released on J-STAGE: March 18, 2011
JOURNAL FREE ACCESS -
[in Japanese]2007 Volume 50 Issue 3 Pages 192-194
Published: June 15, 2007
Released on J-STAGE: March 18, 2011
JOURNAL FREE ACCESSDownload PDF (2745K) -
[in Japanese]2007 Volume 50 Issue 3 Pages 195-198
Published: June 15, 2007
Released on J-STAGE: March 18, 2011
JOURNAL FREE ACCESSDownload PDF (612K)
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