The Nagoya 1-60 strain of Sendai virus was noculated intranasally into the SPF mice. The pathology of the olfactory and respiratory regions were studied using histopathological observation and immunofluorescent antibody staining technique. The following results and conclusions were obtained.
1. Histopathologically, in five days after the inoculation of Sendai virus, severe damages with destruction of the ciliated epithelium was observed in the respiratory region. After ten days however only slight inflammatory changes remained. On the other hand, the olfactory region disclosed no remarkable inflammatory changes.
2. The appearance of immunofluorescence was most striking in the surface of the olfactory epithelium and the ciliated epithelium on days 2 and 3 after intranasal inoculation, and then it gradually subsided.
3. Considering these findings, there seems to exist the receptors against Sendai virus not only in the respiratory region but also in the olfactory region, therefore, Sendai virus can adhere and increase in the both regions. However, the olfactory region appeared more resistive to the pneumotropic virus, Sendai virus than the respiratory region.
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