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Volume 40, Issue 2
Displaying 1-15 of 15 articles from this issue
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[in Japanese]1997 Volume 40 Issue 2 Pages 144-145
Published: April 15, 1997
Released on J-STAGE: March 18, 2011
JOURNAL FREE ACCESSDownload PDF (4350K) -
Iwao Ohtani, Hiroshi Ogawa, Tohru Tadaki, Yohko Baba, Tetsuya Akaike, ...1997 Volume 40 Issue 2 Pages 146-155
Published: April 15, 1997
Released on J-STAGE: March 18, 2011
JOURNAL FREE ACCESSThe congenital cholesteatoma in the tympanic cavity has two types ; one is the closed type composed of a keratotic cyst and the other is the open type, wherein wide flat surface of epidermis forms part of the middle ear mucosa. The purpose of this paper is to compare clinical characteristics between two types of congenital cholesteatoma.
At an early stage, the closed type which is usually asymptomatic, is identified accidentally as a globular whitish mass through a normal tympanic membrane. It is found in the anterior-superior quadrant in the majority of these cases. The small anterior-superior cholesteatoma which has usually intact ossicles mainly originated from the tendon of the tensor tympani muscle or the medial surface of the malleus. The advanced cholesteatoma which is presented aural symptoms is found in the posterior-superior quadrant, and has ossicular damage.
On the other hand, the open type cholesteatoma has normal appearing tympanic membrane, so that it is found accidentally by an exploratory tympanotomy under a diagnosis of conductive hearing loss preoperatively. This is the reason why the open type cholesteatoma is usually associated with anomalies of the ossicles. The open type cholesteatoma seems not to grow and to remain silent due to evacuation of desquamated keratotic debris via the Eustachian tube until it is affected by infection or surgical stimulus. When the open type cholesteatoma is found during tympanotomy it is necessary to remove it completely.View full abstractDownload PDF (3564K) -
Yasuhiro Arai, Mamoru Tsukuda, Izumi Motimatsu, Seiitirou Yuyama, Yasu ...1997 Volume 40 Issue 2 Pages 156-164
Published: April 15, 1997
Released on J-STAGE: March 18, 2011
JOURNAL FREE ACCESSUsing cultured cells of head and neck squamous cell carcinomas, effect of exogeneous recombinant human epidermal growth factor (EGF), expression of EGF receptor (EGFR), effect of anti-EGFR monoclonal antibody on cell growth or chemotherapy were examined.
The detectable levels of EGF in culture supernatants were not observed in all tumors. EGFR expression were observed in all tumors, and this expression of EGFRwas enhanced by the addition of interferon-α, β or tumor necrosis factor-a into the culture. Increase of cell growth was observed in two tumors by the addition of EGF and this effect of EGF was inhibited by anti-EGFR monoclonal antibody, furthermore cell cycle of these tumors were changed (high accumulation on S+G2 M phase). Inhibition rate on tumor growth by cisplatin get higher by addition of EGF, and anti-tumor effect of cisplatin is enhanced by addition of anti-EGFR monoclonal antibady.body.
This results indicate that anti-EGFR antibody may be useful in clinical chemotherapy of head and neck squamous cell carcinomas.View full abstractDownload PDF (1457K) -
Hidehiro Maruoka1997 Volume 40 Issue 2 Pages 165-171
Published: April 15, 1997
Released on J-STAGE: March 18, 2011
JOURNAL FREE ACCESSThe purpose of this study was to examine the relationship between cell proliferation and infiltration in laryngeal squamous-cell carcinoma and the increase and/or decrease of p 53, p 21, Rb, and PCNA, using immunohistochemical staining.
Among patients with laryngeal squamous-cell carcinoma, visited Tokyo Medical College from 1986 to 1993, 29 patients were selected because of having evaluable biopsy samples obtained before treatment.
Patient biopsy samples were used to prepare 4 μmparafin- embedded sections. Immunohistochemical staining with labeled streptavidin biotin (LSAB) technique was performed using anti-human mouse monoclonal antibodies of p 53, p 21, Rb, and PCNA as primary antibodies, and biotin labeled anti-mouse immunoglobulin antibodies as secondary antibodies. The samples with p 53, p 21, and Rb expression must be positive in this procedure. As for PCNA, the PCNA positive rate was calculated among 1, 000 cells morphologically determined to be cancer.
Among 29 samples p 53 was positive in 18 (62.0%), p 21 was positive in 18 (62.0%), and Rb was positive in 21 (72.4%). A PCNA positive rate of 40% or higher was observed in 18 samples (62.0%).
All samples of T 1 a or T 1 b showed positive p 21. However, many samples of T 2 or later stage showed negative results. All of the p 21-positive samples also demonstrated positive for Rb. This indicates that the disorder in the cell cycle regulating mechanism may promote cancer progress in laryngeal cancers of T 2 or of later stage. The sample with strong cancer infiltration tended to be positive for p 53, and have a PCNA positive rate of 40% or higher. These results indicate that measurements of p 53, p 21, Rb, and PCNA is useful in evaluating the grade and the infiltration of laryngeal cancer.View full abstractDownload PDF (5159K) -
Nobu Usui, Toshiaki Hara, Michihiro Watanabe, Motofumi Ohki, Tomoaki K ...1997 Volume 40 Issue 2 Pages 172-179
Published: April 15, 1997
Released on J-STAGE: March 18, 2011
JOURNAL FREE ACCESSThe purpose of this study is to evaluate nasal hyperresposiveness in patients with nasal polyps and to assess the effect of nasal inhalation of methacholine on the nasal patency. A methacholine nasal aerosol provocation test by Astograph was carried out in 41 cases of nasal polyps. The nasal airway resistance and the thread test for nasal secretion were examined before and after the methacholine nasal aerosol provocation test.
Three parameters were extracted from the doseresponse curve by the methacholine nasal aerosolprovocation test. Rrs. N cont represents the nasal respiratory resistance immediately before provocation. Dmin. N indicates the minimum dose of mechacholine required to cause an increase of the nasal respiratory resistance. Sd. N reflects a slope signifying an increase of the nasal respiratory resistance.
Results : 1) A significant correlation was found between Rrs. N cont and Sd. N. 2) Whether this reaction was a response in the nasal cavity was examined. As a result, it was considered of a reaction in the nasal cavity. Furthermore, 3) It was examined whether a response in the nasal cavity was due to an influence of the enlargement of nasal mucosa or nasal discharge. As a result, no correlation was found between the two. Therefore, it is probable that the methacholine hyperresponsiveness of nasal polyp cases was due to the influence of the enlargement of nasal mucosa.
Conclusions : The nasal cavity of nasal polyps increased Sd. N with narrowing by methacholine nasal aerosol. But it was not related to Dmin. N. No significant correlation was found between the thread test for nasal secretion on the one hand and Dmin. N and Sd. N on the other.View full abstractDownload PDF (960K) -
Terumichi Fujikura, Rika Akimoto, Syunkichi Baba1997 Volume 40 Issue 2 Pages 180-185
Published: April 15, 1997
Released on J-STAGE: March 18, 2011
JOURNAL FREE ACCESSFrom November 1995 to July 1996, we treated five patients with deep neck infection, containing two cases of gas gangrene. We also discussed recent 36 cases of deep neck infection including our 5 cases. Recent case reports of deep neck infection, especially cases of non-Clostridial gas gangrene, are increasing. For the treatment administration of antibiotics protecting against both aerobic and anaerobic bacterial infection is necessary. For example, administration of PIPC and CLDM is useful as the first choice. We treated 5 cases by administration of PIPC and CLDM, with surgical drainage for 3 cases. The appropriate therapy should be carried out quickly before the infection leads to a severe state and the planing of surgical drainage is also necessary at the same time. For the planing of surgical treatment CT scan is useful. Therefore if abscess formation is suspected CT scan should be done early without hesitations. Because the patients with deep neck infections often visit clinicians whose specialty is not otorhinolaryngology, the pathogenesis and severity should be discussed sufficiently with them. We have to care the cases which possibly lead to severe deep neck infections, such as the cases with diffuse neck swelling and redness, peri-tonsillitis, odontogenous infection, to prevent an increase in such cases.View full abstractDownload PDF (1675K) -
Tadataka Ishikawa, Makoto Hamamoto, Shinji Ohguro, Akikatsu Kataura1997 Volume 40 Issue 2 Pages 186-191
Published: April 15, 1997
Released on J-STAGE: March 18, 2011
JOURNAL FREE ACCESSWe selected 157 cases (male cases were 39 and female cases were 118) of pustulosis palmoris et plantaris (PPP) where smokers or non-smokers were clear, treated with bilateral tonsillectomy at our department between January 1985 and December 1995. They were followed-up for more than 6 months after operation. The efficacy of tonsillectomy for improving the skin lesion was scored as 10 points before operation, mainly based upon individual evaluation by each patient. 118 cases (75.2 %) of those 157 tonsillectomy cases have had smoking habits (84.6% of male cases, 72.0% of female cases). These smoking rate in cases with PPP are higher than the general smoking rate in Japan. In female cases, nonsmoker group (0.81 score after operation) improved the skin lesion after operation in higher rate than in smokers group (2.00) (P < 0.01) and also post tonsillectomy improvement of skin lesion in non-smokers group after operation (0.96) was higher than in smokers group with habits of more than 10 pieces of tobacco per day (2.14) (P <0.05), but not in male.These results suggest that smoking may be affecting the efficacy of tonsillectomized cases in female with PPP.View full abstractDownload PDF (825K) -
Kazuhiro Yamamoto, Kazuo Yao, Yasuhiro Momiyama, Akihiro Mathuoka1997 Volume 40 Issue 2 Pages 192-199
Published: April 15, 1997
Released on J-STAGE: March 18, 2011
JOURNAL FREE ACCESSA kidney transplant recipient with mucormycosis in the nose and paranasal sinuses which had occurred during a treatment by immunosuppressive agents is reported. Mucormycosis in this case was the type of nose-brain-eye and invaded the intra-cranial region rapidly. However, it was difficult to diagnose because of normal findings in X-ray study of the nose and skull before surgery, but MRI was one of suitable methods for diagnosis of the case. Usefulness of MRI for an early diagnosis of this disease should be confirmed in future. When some symptoms in the nose and/or eye appear in a patient with immunodeficiency we should pay attentions to this disease.View full abstractDownload PDF (5198K) -
Naohiro Wakisaka, Ikuo Nagayama, Mitsuru Furukawa, Tatsuhiro Sato, Hid ...1997 Volume 40 Issue 2 Pages 200-204
Published: April 15, 1997
Released on J-STAGE: March 18, 2011
JOURNAL FREE ACCESSA case of extramedullary plasmacytoma originating from the nasopharynx is reported. A 32-year-old female complained of a left ear fullness. A smooth, elastic soft mass was found in the left Rosenmullar fossa. Biopsy of the lesion showed the mass consisted of well-matured plasma cells. The cells were found to be neoplastic as they were positive for monoclonal lg G-λ.
We reviewed 123 cases of extramedullary plasmacytomas reported in Japanese literatures including our case. Primary therapy is important for the management of the extramedullary plasmacytomas. Although we were obliged to treat by surgical resection alone in our case, it should be recommended that they are intially treated by combined therapy including surgical resection, radiation therapy, and/or chemotherapy.View full abstractDownload PDF (1448K) -
Ryuta Ninomiya, Masanori Ishii, Hiroshi Moriyama, Shinichiro Ushigome1997 Volume 40 Issue 2 Pages 205-210
Published: April 15, 1997
Released on J-STAGE: March 18, 2011
JOURNAL FREE ACCESSA case of osteopetrosis (marble bone disease) was encountered, in which (a) osteosclerosis centering in the craniofacial bone, (b) chronic sinusitis due to osteosclerosis and stenosis of ostium maxillare, and (c) mixed deafness caused by narrowing of the internal auditory canal and middle ear osteosclerosis were noted. Hearing impairment due to disorder of conductive components was found to be ascribable to not only exudative otitis media caused by narrowing of the auditory canal (CT finding) but also osteosclerosis of the auditory ossicle (surgical finding). Tympanoplasty was performed by modified Type III approach, where the posterior wall was conserved, while myringoplasty was performed by underlaying temporal fascia. Because the tubal function had been decreased due to marked tubal stenosis, a ventilation tube was indwelt. After operation, left hearing was improved from the preoperative value of 67.5 dB to the postoperative value of 31.3 dB. Within our literature survey, there were no reports of cases operated on or cases with osteosclerosis of auditory ossicles in association with osteopetrosis. In treatment of patients with hearing impairment associated with osteopetrosis, we think that the middle ear cavity should be actively opened to observe the pathological state, followed by surgical approach if deemed necessary.View full abstractDownload PDF (2057K) -
[in Japanese], [in Japanese]1997 Volume 40 Issue 2 Pages 211-216
Published: April 15, 1997
Released on J-STAGE: March 18, 2011
JOURNAL FREE ACCESSDownload PDF (1306K) -
[in Japanese]1997 Volume 40 Issue 2 Pages 217-219
Published: April 15, 1997
Released on J-STAGE: March 18, 2011
JOURNAL FREE ACCESSDownload PDF (1796K) -
Yuichi Nakano1997 Volume 40 Issue 2 Pages 220-226
Published: April 15, 1997
Released on J-STAGE: March 18, 2011
JOURNAL FREE ACCESSIn reviewing a history of surgery for middle ear inflammation from the primitive simple mastoidectomy to the latest tympanoplasty, opening and eradication of the mastoid air cell systems are essentially performed. In radical mastoidectomy, the mastoidectomy cavity was widely opened to the external auditory meatus, and this procedure results in destroying the air cell systems and forming abnormal anatomical structure. Several surgical techniques were proposed to manage the mastoidectomy cavity. Mastoidectomy preserving posterior wall of external auditory meatus, so called “closed method” oftympamoplasty, was one of the technique to dissolve the problem. In this method, the mastoidectomy cavity opened to the tympanic cavity instead of external auditory meatus. Increased aeration volume of the middle ear cavity was supplied only through the Eustachian tude, and its dysfunction induced tympanic membrane retraction and cholesteatoma formation.
Importance and necessity of the air cell systems were observed by clinical examinations and experiments using piglet, whose middle ear has air cell systems resembling to human middle ear, and our results showed that the mucosa of air cell systems performed active gas-exchange and maintained middle ear pressure.
According to these results, an importance of preserving gas-exchange capacity of the air cell systems in the mastoid surgery was described.View full abstractDownload PDF (3425K) -
[in Japanese], [in Japanese]1997 Volume 40 Issue 2 Pages 227-230
Published: April 15, 1997
Released on J-STAGE: March 18, 2011
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[in Japanese]1997 Volume 40 Issue 2 Pages 231-245
Published: April 15, 1997
Released on J-STAGE: March 18, 2011
JOURNAL FREE ACCESS
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