巻号一覧
82 巻 (1970)
- 11-12 号 p. 435-
- 9-10 号 p. 373-
- 7-8 号 p. 355-
- 5-6 号 p. 231-
- 3-4 号 p. 41-
- 1-2supplement 号 p. 1-
- 1-2 号 p. 1-
71 巻 (1959)
- 12-2 号 p. 8243-
- 12-1 号 p. 7861-
- 11supplement 号 p. 1-
- 11-2 号 p. 7531-
- 11-1 号 p. 7095-
- 10-2 号 p. 6691-
- 10-1 号 p. 6223-
- 9-2 号 p. 5773-
- 9-1 号 p. 5405-
- 8-2 号 p. 4993-
- 8-1 号 p. 4515-
- 7-2 号 p. 4069-
- 7-1 号 p. 3623-
- 6-2 号 p. 3149-
- 6-1 号 p. 2783-
- 5-2 号 p. 2423-
- 5-1 号 p. 1989-
- 4-2 号 p. 1655-
- 4-1 号 p. 1145-
- 3supplement-2 号 p. 1-
- 3supplement-1 号 p. 1-
- 3-2 号 p. 1145-
- 3-1 号 p. 691-
- 2-2 号 p. 691-
- 2-1 号 p. 323-
- 1 号 p. 1-
前身誌
82 巻, 11-12 号
選択された号の論文の15件中1～15を表示しています
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日域 大陸1970 年 82 巻 11-12 号 p. 435-445
発行日: 1970/12/30
公開日: 2009/03/30
ジャーナル フリーThe ribosomal protein of the Ehrlich Ascites tumor was purified.
The maximum absorbancy of the ribosome was 260 mμ and the minimum was 237 mμ. The sedimentation coefficient of the ribosome was 75 S20W, and the chemical composition of P:N:Ribose was 1:1.46:1.09.
The purified ribosomal protein was electrophoretically single, and the maximum absorbancy was 268 mμ and the minimum was 232 mμ. The sedimentation coefficient of the ribosomal protein was 1.59 S20W. The molecular weight presumed about 6000. The chemical composition of the ribosomal protein of P:N:Ribose was 1:1.7:0.005.
These results indicated that the ribosomal protein was nucleoprotein or phosphoprotein. The components of the ribosomal protein were rich in basic amino acids, especially lysin, and poor tyrosine and phenylalanine.抄録全体を表示PDF形式でダウンロード (2618K) -
後藤 信行1970 年 82 巻 11-12 号 p. 447-458
発行日: 1970/12/30
公開日: 2009/03/30
ジャーナル フリー腹水肝癌細胞AH-130の脂質過酸化反応欠損の機構について研究し,その原因の一部を明らかにすることができた.
1) AH-130腹水肝癌細胞の脂質過酸化反応欠損の要因の一つは,基質と考えられるリン脂質のアラキドン酸含量の絶対量の減少にある.
2) 他の一つの原因は, AH-130肝癌細胞のアセトン可溶性分画に存在する脂質過酸化反応を阻害する物質にある.
3) アセトン可溶性分画をリン脂質分画から分離すれば,リン脂質分画は過酸化反応を誘起させることができる.
4) アセトン可溶性分画中の脂質過酸化反応阻害作用は,癌細胞のみならず正常肝細胞にも弱いながら認められるが,正常肝組織中には阻害物の含有量が低いと考えられる.
5) アセトン可溶性阻害物質は化学的には既知の抗酸化剤とは異る物質で,現在なお物質の決定をみるにいたつていない.
最後に細胞増殖や加令と,脂質過酸化反応との密接な関係について考察し,それに対する反応阻害物質の役割について考案した.抄録全体を表示PDF形式でダウンロード (1388K) -
津田 博文1970 年 82 巻 11-12 号 p. 459-468
発行日: 1970/12/30
公開日: 2009/03/30
ジャーナル フリーPDF形式でダウンロード (2650K) -
津田 博文1970 年 82 巻 11-12 号 p. 469-482
発行日: 1970/12/30
公開日: 2009/03/30
ジャーナル フリーPDF形式でダウンロード (5163K) -
津田 博文1970 年 82 巻 11-12 号 p. 483-492
発行日: 1970/12/30
公開日: 2009/03/30
ジャーナル フリーA histochemical and electron microscopic studies of 48 cases of human stomach cancers were made and the following results were obtained.
1) According to their cytological features, the stomach cancers were classified into following types, 1) Papillary adenocarcinoma, and adenocarcinoma with large tubules, 2) Adenocarcinomawith small tubules, 3) Carcinoma simplex (subdivided mucocellular type, microvilli type, funiculus type, surface convex type, surface projection type and embryonal type.) The differences of differentiation of plasma membrane was very marked in these groupes, but those of cell organellas are less marked.
2) Production of the mucous is most prominent in adenocarcinoma with small tubules.
3) The some relationship between the aminopeptidase or alkalin phosphatase positive type cancer and their ultrastructural features aro observed.抄録全体を表示PDF形式でダウンロード (2998K) -
特にいわゆる家族性精薄を中心として薄井 省吾, 庄盛 敦子, 細川 清1970 年 82 巻 11-12 号 p. 493-502
発行日: 1970/12/30
公開日: 2009/03/30
ジャーナル フリー100 cases of institutionalized adult mental retardation are divided into three groups according to the presumed etiology.
1. Familial group (so called familial mental retardation); that is, some pathological or organic change in the brain are excluded from the clinical symptom and past history, and same kind of mental retardation is found in some of their family members.
2. Idiopathic group; clinical symptom, past and family history suggest no precise etiology. 3. Pathological group;
19 cases of so called familial mental retardation are presented and compaired with the other two groups.
Social and mental age are very low and abnormal findings on EEG or PEG are found in most of these cases.
From these results, complicated relation between intelligence and pathology of brain are suggested.抄録全体を表示PDF形式でダウンロード (630K) -
田辺 正忠, 杉田 勝彦, 森野 靖雄, 渡辺 節生, 羽井佐 芳雄, 久万田 泰昌1970 年 82 巻 11-12 号 p. 503-509
発行日: 1970/12/30
公開日: 2009/03/30
ジャーナル フリーPossiblity of differential diagnosis by means of the scintigram of thyroid gland was investigated with 15 cases with chronic inflammation, 54 with benign tumor, 22 with malignant tumor as the subjects of the study. The results are briefly summarized as follows.
1) In chronic inflammatory diseases most cases show an irregularity of the color band, and the lesion site is mostly located in the upper pole followed by the lower pole.
2) In cases of benign tumor warm nodules are decidedly predominant as compared with other diseases, and the margin is mostly either sharp or diffuse, especially sharp one in benign tumor than in malignant one. The peripheral contour is mostly concave. Enlargement of the lesion area is more often observed than in other diseases, and this tendency is especially marked in warm nodule. There can be often observed oppressive deformation. There is no difference of the color level between the right and the left sides. Lesion site does not differ from the right to the left side and it is mostly on the right exterior side and the left lower pole.
3) In malignant tumor, most cases show a large lesion. Ones with irregular margin are more numerous than in other diseases, but here it requires differentiation from inflammation. There is no swelling on the sideof lesion. The oppressive deformity is not so frequent as in benign cases. The affected side in most cases shows a lower color level as compared with healthy side. The lesion site in this case is mostly located in the upper pole.抄録全体を表示PDF形式でダウンロード (1902K) -
角南 重夫, 緒方 正名1970 年 82 巻 11-12 号 p. 511-515
発行日: 1970/12/30
公開日: 2009/03/30
ジャーナル フリーConcerning cause of the SMON, there are many opinions from epidemiological, clinical and pathological points of view, and yet no distinct cause has been found. In order to clarify the cause by epidemiological procedure, we tried to investigate the relation between chinoform administration and the SMON from the data of the clinical cards in a hospital.
1) The average amount of chinoform administered during the whole course of treatment to the SMON patients in Y district was about 281 g. and that in all Jaqan was about 147 g, while the average amount calculated from the data of Berggren and others was 863 g.
2) The average amount of chinoform administered to SMON patients until nervous symptom appeared was 69 g in Y district, and that was 52 g in all Japan.
3) The SMON patients of multiple occurrences in a family were all administered chinoform.
The eight of nine SMON patients of multiple occurrences in a hospital were administered chinoform.
4) The tendency was recognized that SMON patients who received appendectomy had stayed for rather longer duration in a hospital and the SMON patients who did not receive appendectomy had relatively benign progress.
The tendency was also recognized that the amount of chinoform administered to the SMON patients who received appendectomy was a little larger than that administered to the SMON patients who did not receive appendectomy抄録全体を表示PDF形式でダウンロード (316K) -
第1編 クロロキンと所謂制癌剤の併用療法に関する基礎的研究森 俊雄1970 年 82 巻 11-12 号 p. 517-528
発行日: 1970/12/30
公開日: 2009/03/30
ジャーナル フリーA fibroblast-inhibiting agent, chloroquine, was administered against Basford cancer in combination with several anti-tumor drugs.
1) In combination with mitomycin C, cyclosphamide and hematoporphyllin-Hg, chloroquine showed more inhibitory effect on the growth of the tumor in comparison with single administration of these drugs.
2) The combination of chloroquine and prednisolone showed almost the same inhibitory effect on the growth of the tumor as single administration of either drug.
3) The combination of chloroquine and chromomycin A3 was less effective than administration of chromomycin A3 alone.
4) Histologically, the combination of chloroquine and mitomycin C induced an increase of necrotic areas, degeneration of cancer cells and inhibition of stromal connective tissue fromation in comparison with single administration of either drug.
5) From these results it is considered that a fibroblast-inhibiting agent, chloroquine, when used in combination with anti-tumor agents which inhibit DNA synthesis is more effective against malignant tumors.抄録全体を表示PDF形式でダウンロード (1554K) -
第2編 クロロキンと所謂制癌剤併用の担腫瘍動物鉄代謝に及ぼす影響について森 俊雄1970 年 82 巻 11-12 号 p. 529-538
発行日: 1970/12/30
公開日: 2009/03/30
ジャーナル フリーStudies on iron metabolism, especially on organ iron were performed in mice with Bashford cancer treated by combined administration of chloroquine and several anti-tumor agents.
1) Chloroquine alone tended to inhibit the storage of non-hemin iron in the tumor tissues or organs.
2) No definite tendency was shown in the storage of non-hemin iron following administration of anti-tumor agents alone.
3) Generally, it was difficult to find a definite tendency in organs such as the liver and spleen after combined administration, but in the tumors the storage of non-hemin iron (γ/g) tended to be more inhibited by combined administration than in controls and in mice treated by anti-tumor drugs alone.
4) These data suggest that the combined chemotherapy with choroquine and several antitumor drugs exhibits more effective anti-tumor activity with respect to iron metabolism of animals bearing Bashford cancer than single administration of anti tumor drugs.抄録全体を表示PDF形式でダウンロード (532K) -
第3編 クロロキンとマイトマイシンC併用による各種癌患者の治療に関する研究森 俊雄1970 年 82 巻 11-12 号 p. 539-547
発行日: 1970/12/30
公開日: 2009/03/30
ジャーナル フリーOn the basis of our unique idea that damage of the stromal tissue might result secondarily in damage of the cancer cells, an attempt was made to administer a fibroblast-inhibiting agent, chloroquine, in combination with mitomycin C in 20 patients with malignant tumors.
1) Of the 20 cases treated, the combined chemotherapy was effective in 6, induced no significant change in 6, caused aggravation in 3, and its evaluation was impossible in 5.
2) Of various malignant tumors treated, excellent therapeutic effects were obtained in patients with pleuritis carcinomatosa.. Among subjective complaints this regimen was most efficacious in alleviating pain.
3) Side effects of chloroquine were slight and its prolonged administration was possibl. Leucopenia often associated with administration of antitumor agents was relatively rare.
4) Accordingly, the combined chemotherapy with chloroquine and mitomycin C appears to be recommendable in the treatment of human tumors from the unique chemotherapeutic point of view.抄録全体を表示PDF形式でダウンロード (516K) -
藤井 義信1970 年 82 巻 11-12 号 p. 549-560
発行日: 1970/12/30
公開日: 2009/03/30
ジャーナル フリーThe sterilizing effect and hemolytic effect of cornin, extracted from skeletal muscle of rabbit were studied in vivo and in vitro. The results are summarized as follows:
1. Muscle cornin has no effect whatever on sterility when administrated into new born mice and adult mice.
2. There is no difference on the period of pregnancy and on the new born numbers as compared with no treated control.
3. When the erythrocytes are incubated with muscle cornin and then transfered into the hypotonic salt solution, the hemolytic effect occurs below 0.7 per cent salt solution.抄録全体を表示PDF形式でダウンロード (797K) -
位相差顕微鏡映画撮影法による観察山田 俊典1970 年 82 巻 11-12 号 p. 561-574
発行日: 1970/12/30
公開日: 2009/03/30
ジャーナル フリーThe cornin extracted from normal rat liver marked antimitotic effect on the cell which had been long term cultured cell line originated from normal rat liver. The phase-contrast cinemicrography and autoradiography were used in this study. Obtained results are as follows:
The cell in mitotic stage was divided in the medium containing 0.1% rat liver cornin. However, the cell of resting stage did not proceed for mitotic stage. 6 hours after application of this concentration of cornin, some of resting cells produced to damage. 10 hours after the cell was transformed to slight contraction.
In the case of application of 0.5% cornin, the mitotic processes were complately stopped, and formation of blister from cell surface was observed. A large number of cells were rised from glass surface after 8 hours of application.
After the cells were immersed to 0.1% of cornin for 24 hours, the picnosis of the nucleus was observed.
By autoradiographic experiments, 3H-thymidine and 3H-uridine were incorporated into the nuclei and nucleolei for 24 hours and 12 hours incubation respectively.
On the basis of the above mentioned it seems to be that liver cornin had inhibited the processes at G2 or early prophase stages in the cell cycle than the nucleic acid synthesis.抄録全体を表示PDF形式でダウンロード (2808K) -
その評価と副作用防止対策木村 郁郎, 木畑 正義, 半沢 敦正, 守谷 欣明, 大熨 泰亮, 高田 宏美, 西崎 良知, 国政 郁哉, 西下 明, 谷崎 勝朗, 高 ...1970 年 82 巻 11-12 号 p. 575-584
発行日: 1970/12/30
公開日: 2009/03/30
ジャーナル フリーBleomycin was administered to 35 patients with lung cancer (primary lung cancer in 28 cases, metastatic lung cancer in 7 cases), and produced following results. Fibroblast-inhibiting agents were simultaneously administered as multiple combination therapy, “CPBP”, with chloroquine, phytonadione, Bleomycin and prednisolone. In consequence, beneficial effect was seen in a fairly large number of cases including small sized lung cancer and terminal cancer cases. In comparison with other antineoplastic agents, Bleomycin had the advantage of not causing hematopoietic disturbances in host.
It is considered, however, that the therapeutic efficacy of Bleomycin above mentioned can not be evaluated without prevention of its side effects. Of 67 cases given Bleomycin treatment 10 cases showed fever and 8 cases lung disturbances. Among these side effects lung disturbances rather than hematopoietic disturbances should be kept in mind. In 44 cases of cancer patients who were treated with combination of Blcomycin and a fibroblast-inhibiting agent, chloroquine, lung disturbances were seen in only 4 of them. On the other hand, in 12 cases of malignant lymphoma which were treated without the combined therapy, 4 of them showed lung disturbances-a high rate pulmonary complications than in cancer. In an experimental study of combination of Bleomycin and dextran sulfate inhibition of lung disturbances was observed histologically. And an increase of α and β globulin, triglyceride, seromucoid and fibrinogen was depressed by this combination therapy. This combination therapy also inhibited metastasis by intravenous inoculation of Ehrlich ascites tumor cell in lungs impaired by administration of Bleomycin. It is important that an effective method of preventing side effects of Bleomycin is established so that enough dose of the drug can be admistered.抄録全体を表示PDF形式でダウンロード (2629K) -
小倉 義郎, 滝口 峻, 荒川 清, 谷 亙, 笠井 英夫, 寺島 直之, 森田 稔1970 年 82 巻 11-12 号 p. 585-589
発行日: 1970/12/30
公開日: 2009/03/30
ジャーナル フリーKartagener's syndrome has been noticed since Max Kartagener had reported eleven cases with chronic sinusitis, bronchiectasis, and situs inversus viscerum. The following case report demonstrated Kartageners syndrome at the Okayama University Hospital. A 20 year old woman visited the clinic with the chief complaint of coughing and sputum. On examination she was proved to have bronchiectasis and situs inversus viscerum. She also had nasal sinusitis for which she was operated at her fifteen years of age.抄録全体を表示PDF形式でダウンロード (1052K)
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