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冨永 和喜, 品川 茂, 酒井 清孝, 東仲 宣, 稲垣 利恵子, 青木 利三郎, 小崎 正已, 木村 幸三郎, 鈴木 満, 高橋 雅俊
1978 年 7 巻 6 号 p.
1083-1086
発行日: 1978/12/15
公開日: 2011/10/07
ジャーナル
フリー
We performed an experiment on canine dogs and an experiment using fresh human blood in vitro.
In direct haemoperfasion with Resin (XAD-4), a decrease of thrombocytes and leukocytes did not occur.
We were able not to decrease the direct haemoperfusion by using fresh frozen human plasma in the closed circulation method for thirty minutes.
This process sufficiently coated the “XAD-4”. After each closed circulation process was finished, we soon performed direct haemoperfusi on on each patient
We used this method on a total of five patients.
In these haemoperfusions, fresh frozen human plasma, not on whole blood transfusion, was used. We were able to obtain satisfactory results in all five cases.
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近藤 正道, 越野 勇, 川俣 孝, 松下 通明, 川村 明夫, 今忠 正, 葛西 洋一
1978 年 7 巻 6 号 p.
1087-1090
発行日: 1978/12/15
公開日: 2011/10/07
ジャーナル
フリー
The effect of repeated hemoperfusion by tincoated XAD-4 resin on blood cells was first assessed. This necessitated improvement of the resin in terms of its blood compatibility without compromising with its effectiveness.
The resin was coated with various concentrations of Cellulose Acetate and Collodion and investigated for their adsorbability for ICG and Pentobarbital. The result indicated that their adsorbability, corrpared with those of uncoated XAD-4 resin, were all maintained and was not affected by the concentration under 0.5%. Therefore, concentration of 0.5% was selected for both the materials for further in vivo studies on blood compatibility. Platelet depletion was fairly well controlled, being better than that of WBC, but not to complete satisfaction. Hemperfusion procedure per se with the coated resins ware well tolerated and carried out without additional heparin nor urokinase during the run up to 3 hours.
Further investigation on the coated resins for animal models with hepatic insufficiency as well as thickening the coating over 0.5% is warranted before proceeding for their clinical investigation.
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大坪 修, 高橋 郁夫, 土肥 健純, 杉本 久之, 草場 亮輔, 葛原 敬八郎, 山田 豊, 稲生 綱政
1978 年 7 巻 6 号 p.
1091-1094
発行日: 1978/12/15
公開日: 2011/10/07
ジャーナル
フリー
Even nowadays, there i s no artificial liver which compl ately performs the function of the liver. So, we tried making aplasma cross circulating artificial liver which acts not only as detoxi c but also metabolic, in our animal experiments and we attained success.
The machine we used is composed of two parts. One is the plasma separating apparatus and the other is a separator plasma exchanging part which performs coti nous plasma exchange between hepatic failure dog and donor.
As plasma separator, we tried many kinds of membrene such as nucleopore membrane filter, juragade and polycarbonate hollow fiber.
By this plasma separator, 5-20ml/min plasma is obtained when the blood flow is 100-200ml/min. The hepatic failure canine was made by portacaval shunting, ligati on of the hepatic artery and sometimes hepatectomy. Usually, palsma doss circulating time is 3 hours and in some cases 12 hours.
The results were quite satisfactory. S-ammonia, S-transaminase and bilirubin titer were lowered and no side effects were noticed in both canine. The donor canine can be used many times.
This method can perform all functions of the liver and may be available for clinical use except in HBs antigenemic patients.
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井上 昇, 山崎 善弥, 藤森 義蔵, 三条 健昌, 杉浦 光雄, 和田 達雄, 堺隆 弘, 藤原 研司, 織田 敏次, 阿部 力臨, 古田 ...
1978 年 7 巻 6 号 p.
1095-1098
発行日: 1978/12/15
公開日: 2011/10/07
ジャーナル
フリー
The simple, inexpensive and effective method for plasmapheresis has been developed and applied to patients with extrahepatic cholestasis as well as fulminant hepatic failure. The plasma to be discarded is obtained by ultrafiltration of whole blood through a cellulose acetate hollow fiber with a pore size of less than 0, 3μ and effective surface area of 0.65m
2 during extracorporeal circulation. Access to the plasmapheresis circuit is obtained via a V-V shunt between inferior vena cava and cubital vein.
(30-40)ml/min, of plasma is obtained from 100 ml/min. of whole blood. The removal and infusion of plasma are designed to be carried out with the same rate by the same pump.
This method has been applied to patients with extrahepatic obstructive janudice before operation and a patient with fulminanant hepatic failure.
The results were satisfactory.
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藤森 義蔵, 山崎 善弥, 杉浦 光雄, 和田 達雄, 井上 昇, 織田 敏次, 片岡 金吉, 藤崎 誼達, 阿部 力, 古田 忠昭, 稲垣 ...
1978 年 7 巻 6 号 p.
1099-1102
発行日: 1978/12/15
公開日: 2011/10/07
ジャーナル
フリー
Autoascit
R has been developed to treat the intractble ascites for these several years. By this device, cells and bacteria from the ascitic fluid are removed, and the sterilized, cell-free and concentrated ascitic fluid is reinfused into the blood stream. The device has been applied to more than 200 cases of the intractble ascities with satisfactory results. Some of these cases were accompanied by remarked jaundice. In such cases, a newly developed synthetic resin i. e. the sorbent to adsorbe the toxic substance joined to protein in hepatic support system, was succesfully utilized to remove, excess bilirubin from the ascitic fluid.
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水戸 廸郎
1978 年 7 巻 6 号 p.
1103
発行日: 1978/12/15
公開日: 2011/10/07
ジャーナル
フリー
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末永 松彦, 一瀬 邦弘, 松井 則明, 秋葉 隆, 佐々木 成, 中川 成之輔, 武 内重五郎, 笹岡 拓雄, 東海林 隆男, 金山 正明
1978 年 7 巻 6 号 p.
1104-1107
発行日: 1978/12/15
公開日: 2011/10/07
ジャーナル
フリー
To obtain a quantitative method for evaluation of direct hemoperfusion(DHP) for hepatic coma, changes of EEG before and after treatment were studied.
EEG was analyzed from background and paroxymal activity(triphasic waves). Only two cases survived. Levels of consciousness and EEG findings, however, were more or less improved with DHP even in the fatal cases. Signiticant correlation was observed between level classification by Ohta and background activity, according to Spearman's rank correlation(r=0.64, p<0.01). In cases whose clinical symptoms were improved with DHP, initial background activities were in the range of θ to δ band i n the improved cases and i n the range of θ to flat waves. There was no difference in triphasic waves between the two.
Conclusion: (1) Effect of DHP appear in EEG as disappearance of triphasic waves in the early stage of recovery and as normalization of background activity in the later stage. (2) Degree of consciousness disturbance well correlates with background activity. (3) Improvement of EEG can be predicted when i t remains from θ to δ at the initial phase.
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山崎 善弥, T. TAKAHAMA, 藤森 義蔵, 三條 健昌, 杉浦 光雄, 和田 達雄, 松本 博志, 井上 昇, 堺 隆弘, 藤原 ...
1978 年 7 巻 6 号 p.
1108-1111
発行日: 1978/12/15
公開日: 2011/10/07
ジャーナル
フリー
We have studied on monitoring system for the patients, suffering from F. H. F. and being treated by hepatic support under intensive care, In this paper, the computative analysis of teviation from EEG, using Medical Signal Analyzer (MSA), is reported.
MSA has been developed in order to evaluate the medical electrical signals by analyzing them mathematically. Probability Density Function (PDF), Peak Point Histgram (PPD) value, Integrated Histogram (IH) value, and Frequency Distribution Histogram (FDH) value composed from EEG pattern, and these standard Deviations and mean values are calculated automatically. Thus the status of the patient has been easilly grasped by reading the graph made by plotting the standard deviation from the components of EEG.
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山下 賀正, 阿岸 鉄三, 金子 岩和, 小作 保雄, 太田 和夫
1978 年 7 巻 6 号 p.
1112-1115
発行日: 1978/12/15
公開日: 2011/10/07
ジャーナル
フリー
Clinical eveluation of charcoal hemoperfusion which was performed in 7cases of drug intoxication, 12 cases of acute hepatic failure, 21 cases of chronic hepatic failure and 5 cases of chronic renal failure was presented. In drug intoxication, charcoal hemoperfusion was effective in most cases. In hepatic coma due to acute and chronic hepatic failure, charcoal hemoperfusion improved consciousness in a half of the cases, but an actual survival rate was unsatisfactory. In chronic renal failure, charcoal hemoperfusion was effective in the cases with peripheral neuropathy.
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大内 清昭, 小山 研二, 山内 英生, 高木 靖, 大和田 康夫, 伊藤 賢司, 渡部 秀一, 松原 修二, 三井 照夫, 佐藤 寿雄, ...
1978 年 7 巻 6 号 p.
1116-1119
発行日: 1978/12/15
公開日: 2011/10/07
ジャーナル
フリー
A practical hepatic detoxification device should contain multiple sorbents to remove the varied and chemically different compounds that accumulate in the blood of hepatic failure patients. Three effective and specific sorbents for the removal of bilirubin, ammonia and free fatty acids were selected
To use the sorbent effectively and to overcome the associated problems of blood cell removal and sorbent particle carry-over, a membrane plasma filtration system has been studied. The cellulose acetate hollow fiber has the advantage of a high plasma filtration coefficient and low level losses of blood cells.
In ex vivo experiments using jaund iced dogs, selected sorbents, combined with the hollow fiber filter, removed bilirubin, ammon is and free fatty acids effectively.
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高橋 郁夫, 山田 豊, 杉本 久之, 大坪 修, 草場 亮輔, 葛原 敬八郎, 稲生 綱政
1978 年 7 巻 6 号 p.
1120-1123
発行日: 1978/12/15
公開日: 2011/10/07
ジャーナル
フリー
We treated nine hepatic failure and two drags intoxication patients with Direct Hemoperfusion (DHP) which activated charcoal was coated with cellurose and hydrone. Cellurosecoating activated charcoal weight was 300g, hydrone-coating was 160g.
Three patients was treated only with DHP, two was connected coil type dialyser, three was connected Hollow fiber dialyser and case 9 was connected Polyacrylonitrile membrane (PAN) diafiltration.
Three patients was alived but one of them died after the one month due to acute renal failure
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西村 昭男
1978 年 7 巻 6 号 p.
1124
発行日: 1978/12/15
公開日: 2011/10/07
ジャーナル
フリー
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申 曽洙, 新光 聡子, 松尾 政子, 藤田 嘉一, 井上 聖士, 坂井 瑠美
1978 年 7 巻 6 号 p.
1125-1128
発行日: 1978/12/15
公開日: 2011/10/07
ジャーナル
フリー
The effect on dialysis performance by various kinds of dialysate supply system was evaluated from the clearance studies of urea, creatinine and uric acid.
1) In single pass system, slight decrease of clearance during dialysis was observed.
2) In recirculating single pass system, rapid decrease of clearance for initial 30-60min. was observed, after then no decrease.
3) In recirculating system (Rhodial 75), linear regression of clearance during dialysis was observed.
4) In recirculating adsorbent system (TM 101), marked decrease of urea clearance was observeved, while ctreat. and uric acid clearance were maintained on high level.
5) In recirculating adsorbent system (REDY), no decrease of clearance was observed, however, clearance was low in general.
Thus, dialysate supply system have had much effect for dialysis performance.
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岡 文俊, 谷口 昌弘, 阿部 富弥, 佐野 嘉彦, 前野 義博
1978 年 7 巻 6 号 p.
1129-1132
発行日: 1978/12/15
公開日: 2011/10/07
ジャーナル
フリー
This study was performed due to the improvement and development of the machine being able to supply bicarbonate dialysate instead of acetate dialyeate. In adjustment of dialyeate we used hot water, bicarbonate solution and the solution except bicarbonate and in their dilution we used time variation method. We carried out about 3000 hemodialyses with this machine. As the result, the acid-base balance, the concentration, and the temperature of dialyeate was stable and disequilibrium syndrome during hemodialysis was much decreased.
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阿岸 鉄三, 鈴木 利昭, 太田 和夫
1978 年 7 巻 6 号 p.
1133-1136
発行日: 1978/12/15
公開日: 2011/10/07
ジャーナル
フリー
Peritoneo-caval shunt pumps which unidirectionally transferred ascites from the abdominal cavity into the superior caval vein were implanted in 20 intractable ascites patients. Clinical effects evidenced with reduction in body weight and abdominal girth in association with increased urinary production were obtained in all patients. The longest survivor with a pump implanted has been doing well over 10 months. Functional failure due to obstruction of pumps occurred in 3 patients.
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天野 泉, 稲垣 豊, 橋本 敏博, 小林 千太郎, 大野 秀作
1978 年 7 巻 6 号 p.
1137-1139
発行日: 1978/12/15
公開日: 2011/10/07
ジャーナル
フリー
Shaldon's femoral vein catheter made of Teflon material is very useful as blood access for urgent hemodialysis. But, The hard Teflon material is dangerous against the soft human vessels. We have developed a elastic PVC femoral vein catheter in which has Teflon stylet. We have clinical experiences with the PVC femoral vein catheter.
The features of the PVC femoral vein catheter are:
1) The catheter is a wearable type
2 The catheter was suitable for walking
3) The catheterization was very easy
4) No complication was found during the setting of the catheter
5) The blood flow through the catheter was very well
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阿岸 鉄三, 山形 桂仁, 清野 勇, 太田 和夫
1978 年 7 巻 6 号 p.
1140-1143
発行日: 1978/12/15
公開日: 2011/10/07
ジャーナル
フリー
Thermographic observation was made on the blood access for hemodialysis in order to evaluate the function and to detect the circulatory complications. Thermograms are superior to angiograms in regard to presentation of dynamic situation of the peripheral circulation of the blood access, but inferior in realization of localized lesions such as stenosis.
Conclusion was made that thermography and angiography are to be collaboratively indicated for such purpose of examination.
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越川 昭三
1978 年 7 巻 6 号 p.
1144
発行日: 1978/12/15
公開日: 2011/10/07
ジャーナル
フリー
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山下 達博, 番匠 谷孝広, 大倉 美知男, 土谷 太郎, 中光 晴彦
1978 年 7 巻 6 号 p.
1145-1147
発行日: 1978/12/15
公開日: 2011/10/07
ジャーナル
フリー
Hemofiltration and direct hemoperfusion with activated charcoal and the like have been reported as the methods of non-dialysate dialysis. However, with these two methods, high T. M. P. and special devices are usually required to remove enough fluid.
On discovering that the combination of water absorbent (TTY-300) and dialysis membrane can remove about 3 times the amount of fluid removed by conventional dialysis at the same T. M. P., we are convinced that the possibility of non-dialysate dialysis with TTY-300 combined with other resins has been opened up. This method features that fluid removal can be controlled by the quantity of the absorbent and that dialysis can be performed at any place without any special device.
We shall make a report of the study for a new possible dialyzer in terms of the effects on electrolyte concentration and mass transfer and correlation of T. M. P. and fluid removal.
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三田地 広和, 早川 政史, 広瀬 正美, 宇津宮 寿彦, 小川 広秋, 高橋 源作, 稲垣 豊, 天野 泉
1978 年 7 巻 6 号 p.
1148-1151
発行日: 1978/12/15
公開日: 2011/10/07
ジャーナル
フリー
We have developed the bicarbonate contained dialysate supply system which was set up in dialysate single pass method.
We controled pH of the dialysate by means of the bubbling of CO
2 gas.
We had clinical experiences with the system for a half year.
Electrolytes and pH of the patients were maintained within normal level and so their conditions were very well.
For example, the increase of their hematcrits was observed and non-symptomatic dialysis was obtained. In conclusion, suibable for the prevention of dialysis disequibrum syndrome. In future, we confirm the bicarbonate contained dialysate will be effective in the therapy of the itching or the asthma in dialysis patients.
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早川 政史, 三田地 広和, 小川 秋広, 高橋 源作, 橋本 敏博, 稲垣 豊, 小林 千太郎, 大野 秀作, 天野 泉
1978 年 7 巻 6 号 p.
1152-1154
発行日: 1978/12/15
公開日: 2011/10/07
ジャーナル
フリー
We have developed the continuous dialysate prescription system in dialysate central supply method for the purpose of application of adequate dialysis to all the dialysis patient.
It is a good point for us to control quite feely the electrolytes (Na
+, K
+, Ca
++or HCO
3-) concentration of dialysate.
The system was excellent in the prevention of dialysis disequibrium syndrome and the therapy of complications such as livea disease, cardiovascular disease or osteodistrophy.
Non symptomatic dialysis by the system resulted in the increase of hematcrit of the patient we think the system must be set up in all the dialysis enter.
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番匠 谷孝広, 金尾 元生, 大倉 美知男, 山下 違博, 坂本 太郎, 土谷 太郎, 中光 晴彦
1978 年 7 巻 6 号 p.
1155-1158
発行日: 1978/12/15
公開日: 2011/10/07
ジャーナル
フリー
The dialysate with acetate as a buffer system has been used in hemodialysis, as the dialysate with bicarbonate has many unsolved problems, such as precipitation of Ca(HCO
3)
2, Mg (HCO
3)
2, etc. which often annoyed us during hemodialysis. But it is said that hemodialysis by dialysate with acetate affects cardiac contraction of uremic patients. Now, we are sure that the multi-patient dialysate delivery system we devised recently has solved these problems. We researched uremic patients treated with dialysate with bicarbonate by the use of the system, and have obtained satisfactory results from this research.
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小林 快三
1978 年 7 巻 6 号 p.
1159
発行日: 1978/12/15
公開日: 2011/10/07
ジャーナル
フリー
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松村 誠, 望月 高明, 松本 憲夫, 繁本 茂憲, 村下 純二, 三好 信和, 中垣 満, 田口 一美
1978 年 7 巻 6 号 p.
1160-1162
発行日: 1978/12/15
公開日: 2011/10/07
ジャーナル
フリー
We have designed a series of experiments to create animal model of cardiac failure, which is resumbled to the clinical one and to evaluate the effect of assisted circulation using this model. The following results were obtained:
1) In Jogs, experimental production of myocardial burn was tried utilizing a specially designed electrode under the various conditions of DC and AC electricity. However, although the electrocardiographic and enzym studies revealed similar pattern to myocardial infarction, hemodynamically no typical failure could obtained.
2) Transapical insertion of balloon catheters with various capacities was made in calves to create outflow obstruction of the left ventricle. We could demonstrate a consistent relationship between the degree of stenosis and the course of experimental cardiac failure as followed: a) typical acute cardiac failure, b) chronic cardiac failure with continued for about one week and followed by sudden deterioration and c) chronic cardiac failure persisted over one week. Further, this model was proved to be sufficiently useful for experimental evaluation of transapical left ventricular bypass.
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横田 宗泰, 壁井 信之, 田島 秀朗, 梅津 光生, 桜井 靖久, 土屋 喜一
1978 年 7 巻 6 号 p.
1163-1166
発行日: 1978/12/15
公開日: 2011/10/07
ジャーナル
フリー
The air driven blood pump has been employed as an artificial heart for total and partial cardiac support. This type of blood pump showed good results in animal experiments. However, it still has some problem of durability of prosthetic valves and of solenoid valves. To solve this problem, we present a valveless pump driven by a linear motor. This pump consists of a ring shaped blood chamber which is sandwhiched between two stators of linear motor and of two rotors. Each of two rotors acts as a piston and a valve alternately. Movement of the rotor is controlled very easily, so that any desirable pattern of output flow can be generated.
A straight shape linear motor pump has been developed and is examind to obtaine the basic data for further development.
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―シミュレーション回路の設定パラメータと補助効果との関係―
鈴木 聖, 尾本 良三, 羽田野 隆, 上田 恵介, 横手 砧二, 鰐淵 康彦, 見田 恭一, 加納 隆, 小野 哲章
1978 年 7 巻 6 号 p.
1167-1170
発行日: 1978/12/15
公開日: 2011/10/07
ジャーナル
フリー
Electrical analog model of cardiovascular system has been developed to study the relation between the hemodynamic effects of circulatory assists and the values of lamped parameters. This model is designed to be variable in peripheral resistance and compliance, pulmonary resistance and compliance, venous return resistance and resistance of head and arms circulation.
As main results, (1) with VAB prominent decrease in mLAP has been observed corresponding to increase in venous return resistance, and (2) with AAB prominent decrease in mLAP has been observed corresponding to decrease in pulmonary compliance and to increase in peripheral compliance.
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―特に広大型とユタ大学型の比較について―
村下 純二, 望月 高明, 丸山 高司, 繁本 茂憲, 松村 誠, 三好 信和, 中垣 満, 田口 一美
1978 年 7 巻 6 号 p.
1171-1174
発行日: 1978/12/15
公開日: 2011/10/07
ジャーナル
フリー
Left ventricular bypass is an useful aid for treating left ventricular failure. We have confirmed the effectiveness of this method of treatment with acute and chronic experiments using calves. For the purpose of developing a perfect circuit for the application of left ventricular bypass to clinical cases, a comparison was made between the Hiroshima University type bypass circuit and the Utah University type bypass circuit. Avcothane ® treatment was made on the heretofore employed bypass circuit and satisfactory anti-thrombogenic effects were observed. By applying these circuits we were successful in safely and effectively conducting left ventricular bypass method on experimental cases for up to 48 days and on clinical cases for up to 172 hours.
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T. SHIMAKURA, K. KIN, H. KAIZUKA, S. NAKAE, T. ASAKURA, J. WADA
1978 年 7 巻 6 号 p.
1175-1178
発行日: 1978/12/15
公開日: 2011/10/07
ジャーナル
フリー
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高木 啓之, 堀田 寿郎, 成田 伍良, 高橋 虎男, 渥美 隆之, 野口 輝久
1978 年 7 巻 6 号 p.
1179-1182
発行日: 1978/12/15
公開日: 2011/10/07
ジャーナル
フリー
Left atrio-, or left ventricular aortic bypass have been performed with Takagi's pump (Double-chambered alternate pumping paracorporeal device)in over 200 dogs under various conditions of the left ventricle.
Results obtained were as follows.
(1). In atrio-aortic bypass, device and the heart works to maintain the perfusion rate to the peripheral organs. Therefore, device regards the heart as only one of the peripheral organs, though the heart regards device so. They must compete each other. Consequently, failured left ventricle must work againt the increased aortic pressure produced by this bypass. This is not unloading, but loading the left ventricle.
(2) In left ventricular-aortic bypass, device is connected to pump blood out for left ventricle. Therefore, left ventricle does not need to work against the aortic pressure, and can be unloaded extremely.
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長谷川 嗣夫
1978 年 7 巻 6 号 p.
1183
発行日: 1978/12/15
公開日: 2011/10/07
ジャーナル
フリー
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北野 一郎, 兼古 悟, 杉木 健司, 数井 暉久, 草島 勝之, 安倍 十三夫, 田中 信行, 小松 作蔵
1978 年 7 巻 6 号 p.
1184-1186
発行日: 1978/12/15
公開日: 2011/10/07
ジャーナル
フリー
It is concluded that, in 20 mongrel dogs with Inderal (0.4mg/kg) + LAD ligation, under the heart rate between 80-120/min. Sapporo IABP system works effectively to have systolic unloading and diastolic augmentation with the deflation time 30-50%.
However, over the heart rate 120/min. this system does not function well as far as IABP effect is concerned.
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―新しい回路の試作とその効果―
木村 壮介, 小藤田 敬介, 福島 鼎, 清川 忠男, 井野 隆史, 原田 三紀夫, 長谷川 嗣夫
1978 年 7 巻 6 号 p.
1187-1190
発行日: 1978/12/15
公開日: 2011/10/07
ジャーナル
フリー
In the case of severe cardiogenic shock, the combined use of Intra-aortic Balloon Pumping (IABP) and Veno-arterial Bypass (VAB) is more effective than the separate use of the each. We made a device possessing the combined function of the above two in a single unit. It is composed of two parts, a oneway valve and a pulsatile chamber containing 30 ml balloon driven by AVCO-7 IABP system. (Fig. 1)
The venous cannula is connected to the valve and the chamber next. And this chamber pumps out blood to the ascending aorta directly through the arterial cannula. (Fig. 2) Balloon inflation of this device is designed to let out the blood in single direction, the arterial side. While the balloon deflation is designed to suck blood from both ends, the arterial and the venous sides.
Using the experimental model (Fig. 3), hemodynamic effects were observed by changing arterial pressure, heart rate and arterial cannula size.
As the arterial pressure decreases, the ratio of the venous inflow sucked into the chamber increases, (Fig. 4)
This means the device functions mainly as a counterpulsator while the arterial pressure maintains. And it functions as a pulsatile VAB device in accordance with the decline of the arterial pressure.
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大平 政人, 船田 隆, 船木 芳則, 飯田 茂穂, 吉田 千尋, 向井 恵一, 坂東 徹, 岩 喬
1978 年 7 巻 6 号 p.
1191-1194
発行日: 1978/12/15
公開日: 2011/10/07
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Experimental studies were made for the hemodyriamic comparison beteween the double balloon and the tripple balloon under the normal condition and the infarcted dogs.
The double balloon was rather effective for left ventricular function than the tripple. but the tripple was excellent in renal flow In clinical experience, IABP was applied to 7 patients with the severe heart failure.we used it pulsatile CPB during the operation about 2 cases. One case was performed IABP through the transthoaric cannulation because of severe leg arteriosclerosis, it was very useful method for this case.
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広瀬 豊, 阿久根 淳, 保浦 賢三, 小川 裕, 関 章
1978 年 7 巻 6 号 p.
1195-1198
発行日: 1978/12/15
公開日: 2011/10/07
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田中 信行
1978 年 7 巻 6 号 p.
1199
発行日: 1978/12/15
公開日: 2011/10/07
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フリー
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Y. MITAMURA, K. YAMAMOTO, T. MIKAMI, M. TAKAHASHI, K. NISHIURA, T. NAK ...
1978 年 7 巻 6 号 p.
1200-1203
発行日: 1978/12/15
公開日: 2011/10/07
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Intramyocardial oxygen and carbon dioxide tensions were measured continuously by a mass spectrometer to evaluate the effect of a transapical pneumatic driven diaphragm type LVAD on the normally perfused and ischemic canine heart. Findings were: (1) In the normally perfused hearts Pmo2 was 18.3±5.7mMHg (n=10) without pumping the LVAD and increased to 26.4±8.9mmHg during LVAD counterpulsation (p<0.005). Pmco2 was 45.3±5.3mmHg (n=10) with pump-off and decreased to 40.2±4.6 during left ventricular bypass (p<0.005). (2) In the ischemic hearts Pmco2 began to decline after the initial rise at an earlier time in the control than in LVAD counterpulsation group, which indicated that anaerobic metabolism was becoming inadequate to maintain cellular viability in a shorter time in the control than in LVAD implant group. The results suggest that the developed LVAD is effective in improving myocardial oxygen supply/demand ratio and salvaging the ischemic myocardium.
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佐藤 育男, 石井 潔, 野城 真理, 朝倉 貞二, 和田 寿郎
1978 年 7 巻 6 号 p.
1204-1207
発行日: 1978/12/15
公開日: 2011/10/07
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The purpose of this paper is to study whether or not diaphragm pacing can reduce afterload of the right heart after cardiac surgery in the acute experiments.
In the preliminary experiments, 10 animals were used. Bilateral diaphragm pacing showed decreases in pulmonary arterial (PAP), superior vena caval (SVCP) and left atrial pressure (LAP) and also increase in pulmonary arterial blood flow (PABF). Then cavo-pulmonary arterial anastomosis was made to simulate the failing right side of the heart, using 6 animals in the experiments. During diaphragm pacing only to the right side, mSVCP (-12%), mLAP (-21%), rPAP (-15%) decreased, SVC-rPA blood flow (+23%) increased and thus rPAR (-28%) reduced.
These results suggest diaphragm pacing is useful in reducing afterload of the right heart due, in part, to negative pressure in the chest cavity by diaphragm pacing.
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小林 繁夫, 高橋 英世, 菅原 修二, 西山 博司, 伊藤 宏之, 苅谷 庸子, 榊原 欣作, 青木 利三郎, 若井 秀治, 中山 芳則, ...
1978 年 7 巻 6 号 p.
1208-1211
発行日: 1978/12/15
公開日: 2011/10/07
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The experimental studies on left ventricular assist circulation using a pulsatile roller-pump has been carried out to establish the treatment of refractory left ventricular power failure.
Mongrel dogs, weighing 12 to 24kg, were used in these experiments. The blood pump was setted between left atrium and descending aorta, and drived being synchronized with animal's own heart beat. Although the systolic pressure of the left ventricle was decreased to practically zero during 80ml/kg/min. of bypass flow, the diastolic pressure of the left ventricle fell down to negative range occasionally, and under these conditions, arterial PO
2decreased gradually. It suggested that unusual negative pressure in left atrium resulted in the high pulmonary vascular resistance and the disturbance of blood oxygenation was disturbed.
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万代 矩之, 藤田 邦雄, 大屋 厚夫, 原 浩平, 谷崎 真行, 関 洲二, 寺本 滋
1978 年 7 巻 6 号 p.
1212-1215
発行日: 1978/12/15
公開日: 2011/10/07
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IABP was utilized in mongrel dogs with cardiogenic shock caused by occlusion of the left anterior descending coronary artery. It's emodynamic effectiveness was proved by increase in cardiac output, increase in LV max dp/dt and decrease in left ventricular enddiastolic pressure. It's metabolic effectiveness was the increase of Cyclic-AMP in the infarcted myocardium. IABP satisfactorily supported two patients who were in severe cardiogenic shock after open heart surgery. It was concluded that IABP was useful procedure for cardiogenic shock and severe postcardiotomy state.
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松田 昌葺, 岡田 昌義, 米田 紘造, 矢野 惇, 河合 勝, 麻田 栄
1978 年 7 巻 6 号 p.
1216-1219
発行日: 1978/12/15
公開日: 2011/10/07
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Poor prognosis of mitral regurgitation (MR) following acute myocardial infarction (AMI) has been well known. To decrease the mortality rate in this sever complication of AMI, we have attempted IABP in dogs with MR or AMI+MR experimenta ally. MR was made by cutting a few chordae tendia neae of the mitral valve through the left atrial appendage and AMI was produced by multiple ligation of the coronary artery. The size of induced myocardial infarction was approximately 30% of the free wall of the left ventricle.
Consequently, with initiation of IABP, a fall of 7% in left ventricular systolic pressure and 13% in left atrial mean pressure, and an increase of 23% in cardiac output were observed in MR group, a fall of 9% in left ventricular systolic pressure and 17% in left atrial mean pressure, and an incraese of 30% in cardiac output were obtained in AMI+MR group. Hemodynamic changes with IABP in comparison with MR group and AMI+MR group, were more effective in the latter, because diastolic augmentation as well as systolic unloading was adequately in the latter.
As above described, IABP improved hemodynamics significantly, but death due to pulmonary edema and hemoptysis was seen in 6 out of 12 dogs, when left atrial mean pressure elevated higher than 30mmHg.
So, it could be concluded that IABP was effective enough in AMI+MR group to improve hemodynamics, and clinical application was recommended.
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尾本 良三
1978 年 7 巻 6 号 p.
1220
発行日: 1978/12/15
公開日: 2011/10/07
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