Blood coagulation factors of patients with functional uterine bleeding, uterine cancer, sterility, and of pregnant and puerperal women and oral contraceptive users were compared with those of controls having the normal menstrual cycle. Further, using sera from the above mentioned patients, comparative study was made on stasis thrombus.
The results obtained were as follows :
1. Blood coagulation factors of the patients with functional uterine bleeding were not significantly different from those of the controls.
2. The patients with uterine cancer did not show any difference in the factors except significant increase in fibrinogen.
3. The sterile patients had no significant difference from the controls.
4. Factor VII activity was significantly increased in the first trimester of pregnancy and then gradually increased with the advance of the month. Amount of fibrinogen was significantly augmented from the eight month of pregnancy.
5. In the puerperal women, both factor VII activity and fibrinogen were significantly increased within one week after delivery, and still remained so after one month. But prothrombin time did not show any change.
6. In the oral contraceptive users, factor VII activity and fibrinogen were significantly increased independent of duration of drug administration. No change was observed in prothrombin time.
7. Comparison between thrombus formation rates in sera from the pregnant and puerperal women and oral contraceptive users revealed that the rates in the first trimester were as low as those of healthy non-pregnant women, however, high after 20 weeks of pregnancy, in the puerperium and during usage of oral contraceptive drug.
8. Significant correlation was observed between period of pregnancy and factor VII activity.
9. From the above mentioned results, it was known that blood coagulation factors were activated nearly to the same degree in pregnant and puerperal women and oral contraceptive users, and that thrombus formation rates in sera from them were higher than in healthy non-pregnant women.
There was, however, no correlation between thrombus formation and activation of blood coagulation factors.
It is, therefore, assumed that not the activation of fibrinogen and factor VII but that of factors XI, XI and XII will have direct bearing on thrombus formation.

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In order to prevent surgical complications, such as suture insufficiency, bleeding and leakage of digestive fluid, surgical application of plastic adhesive, Aron alpha was used supplementarily in hand suture method, in mongrel dogs and clinical cases.
1) 2-layers suture covered with plastic adhesive was increased by 20% in the tensile strength than simple conventional anastomosed method. The tensile strength in which anastomosed area was sutured in 2-layers and covered with pericardium and glued over plastic adhesive was increased by 40% than 2-layers suture only.
2) 2-layers suture covered with plastic adhesive showed the pressure as much as 2 times of 2-layers suture only. 2-layers suture covered with pericardium and nylon mesh and glued over plastic adhesive had 2.5 times of pressure as compared to 2-layers suture only.
3) In experimental studies of mid-esophageal end-to-end anastomosis in which anastomosed areas were covered with pericardium, nylon mesh and vastus muscle fascia and glued over plastic adhesive, suture insufficiencies were encountered in less than control group.
4) Covered materials, such as pericardium, nylon mesh and plastic adhesive, were excellent substances, while vastus muscle fascia caused stenosis of anastomosed area.
5) In gastrotomy, all cases healed well and caused no suture insufficiency.
6) In colocolostomy, suture insufficiency could not be found and the group in which anastomosed area was covered with nylon mesh and glued over plastic adhesive resulted in marked stenosis of anastomosis.
7) Application of plastic adhesive in the anastomosis of inflammatory intestinal tract proved to be effective in all cases.
8) Plastic adhesive prevented a cholecystostomy and choledochotomy from leakage of bile and other complications.
9) Plastic adhesive protected against complications accompanied with operations of pancreas and liver.
10) Incidence of suture insufficiency was 40% in pancreatico duodenectomy and all insufficiencies, occured in choledocho jejunostomy.
11) Plastic adhesive did not disturb the wound healing, showed tissue affinity and embeded connective tissue. Furthermore, plastic adhesive did not show inflammatory reaction, but no absorption.
12) Plastic adhesive was used in 53 parts of 29 cases, proving effective in all.
13) Indications of plastic adhesive are follow;
a) removal of tensile strength in anastomosed area b) local rest c) prevention of leakage of digestive fluid d) substitution of serosa e) simplification of hemostasis and surgical technique f) reinforcement of anastomosed area of inflammatory digestive canal

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Ehrlich ascites tumor cells gradually took up Zn⁶⁵ from their environment of K R P and 0.9% NaCl medium, on incubation, at the temperature of 37°C.
Addition of metabolic inhibitors, amino acids, onco-static preparations and metal ions, changed the uptake of Zn⁶⁵.
1. The uptake of Zn⁶⁵ occurred more rapidly in the first 20 minutes, and the rafter it became slow.
2. 2:4-dinitrophenol and mono-iodoacetic acid at final 10^-3 M. concentration depressed the uptake Potassium cyanide markedly increased the uptake of Zn⁶⁵ in medium of K R P, but no changes occurred in medium of 0.9% NaCl.
3. Some amino acids like DL-penicillamine, D-penicillamine, L-histidine, glycine, L-cysteine and L-glutathione were added to the medium to the final concentration of 10^-3 M. Only penicillamine markedly inhibited, and others revealed no effect, except less inhibition by L-histidine.
4. Mitomycin C at final 1μg, 10μg, and 100μg concentration, Toyomycin 1μg, and 10μg, Nitro-min 100μg, and Tespamin 100μg concentration, gave no changes. Only Merphyrin at final 100μg concentration inhibited the uptake.
5. Fe³⁺, Fe²⁺, Co²⁺, Ni²⁺, Mn²⁺, Cu²⁺, and Mg²⁺ at final 10^-3 M concentration, inhibited the uptake of Zn⁶⁵ to various degrees. Particularly Fe³⁺ inhibited powerfully. But at final 10^-4M concentration, Ni²⁺, Co²⁺ and Mn²⁺ only inhibited the uptake moderately.

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Five autopsy cases of so-called isolated myocarditis were reported. Case 1 was a man aged 34, who had had a sudden onset of pain in the chest, dizziness, nausea and vomiting suggesting the signs of cardiac failure. He had fell into shock and died 3 days after the onset Histopathological examinations disclosed diffuse interstitial inflammatory cell infiltration throughout the myocardium, consisting of mononuclear cells, lymphocytes, plasma cells, eosinophils, leucocytes and cardiomyocytes. There was a pronounced associated parenchymatous changes with fatty change, loss of striation and granular fragmentation of the myofibrils. Case 2 was a man aged 68, who died of apoplectic fit. Besides massive hemorrhage into the brain, histopathological studies revealed granulomatous myocarditis characterized by the presence of focal non-caseating lesions consisting of epithelioid cells and multinucleated giant cells, which occasionally resembled tubercles. No granulomatous lesions were demonstrated in the other organs. The third case was a man aged 48 who had a chronic downhill clinical couse of ten months duration with difficulties in respiration, palpirarion, pulse irregularities and the physical signs of hypertrophy of the heart. At autopsy the heart was found enlarged, weighing 440g., and the visceral organs congested. Diffuse interstitial fibrosis was noted in the heart with varying degrees of degeneration of muscle fibers and a few rounded cell infiltration. Case 4 was a man aged 64, who died of the cancer of the right lung with widespread metastasis. An isolated involvement of the heart by nonspecific inflammatory changes was an unexpected microscopical finding of this case. The fifth case, a man aged 42, was of a typical case of sudden death due to myocarditis. Rounded cell infiltration, focal in character, was found isolated in the myocardium.
All 5 cases described were characterized by selective involvement of the heart by non-specific inflammatory lesions. Three cases were of more or less diffuse infiltrative variety, one was of granulomatous and the other was of chronic fibroblastic variety. No conclusive histological evidence was demonstrated suggestive of the possible causative mechanism. There was, however, a case in which subacute inflammatory changes in the thyroid and alveolitis of slight degree were found. It appeared that these lesions may suggest the possible relation of Fiedler's disease to myocarditis following infectious diseases.

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