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Volume 43 (1993)
- Issue 6 Pages 609-
- Issue 5 Pages 473-
- Issue 4 Pages 311-
- Issue 3 Pages 215-
- Issue 2 Pages 109-
- Issue 1 Pages 1-
Volume 43, Issue 5
Displaying 1-16 of 16 articles from this issue
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KOJI ISHIGURO1993 Volume 43 Issue 5 Pages 473-484
Published: September 01, 1993
Released on J-STAGE: October 21, 2009
JOURNAL FREE ACCESSI examined the localization of α1-antichymotrypsin (ACT) mRNA and ACT immunoreactivity (ACT-IR) in 12 brains obtained from elderly autopsy cases, including 4 of Alzheimer-type dementia. I investigated the relationship between the ACTmRNA and ACT-IR and the extent of β or tau deposits. In the brains without plaques and tangles, there were no detectable ACTmRNA signals in the gray matter, and those in the white matter were weak. In these brains, ACT-IR was generally weak. The brains with fl-plaques but no tangles showed weak ACT mRNA expression in the astrocytes in both the gray and white matter. They also showed weak ACT-IR in the astrocytes. In the Alzheimer brains with both plaques and tangles, ACTmRNA was expressed intensely in a majority of the astrocytes in the white and gray matter. Some senile plaque-associated astrocytes expressed ACTmRNA. ACT-IR was abundant in the white matter astrocytes. Among protease inhibitors and proteases, only ACT was associated with β-plaques. ACT-IR and ACT mRNA expression in astrocytes was well-correlated with the extent of β and tau deposits. It can be assumed that ACT plays an important role in amyloidogenesis.View full abstractDownload PDF (5509K) -
TOSHIO SHIMIZU1993 Volume 43 Issue 5 Pages 485-494
Published: September 01, 1993
Released on J-STAGE: October 21, 2009
JOURNAL FREE ACCESSTo evaluate Hymenoptera hypersensitivity among forestry workers, a questionnaire was given to 323 forestry workers. One hundred age-matched office workers with little chance of exposure to Hymenoptera sting in their occupation were also examined as a control group. Total serum IgE and yellow jacket venom (YJV) specific IgE antibody were measured in all subjects. The results were as follows.
1) The percentage of Hymenoptera hypersensitive subjects was significantly greater in forestry workers than control subjects. The number of sting exposures was significantly more frequent in forestry workers than control subjects and was closely correlated with episodes of hypersensitive reaction.
2) Total serum IgE, YJV specific IgE antibody titer and RAST positive rate were significantly higher in forestry workers than control subjects.
3) YJV specific IgE antibody titer was significantly higher in hypersensitive workers than in non-hypersensitive ones, although about one half of these subjects showed undetectable IgE antibody to the YJV. These findings suggest that a mechanism other than IgE-mediated hypersensitivity may also be involved in Hymenoptera-induced systemic reaction.View full abstractDownload PDF (1446K) -
NAOBUMI FUKUSIMA1993 Volume 43 Issue 5 Pages 495-506
Published: September 01, 1993
Released on J-STAGE: October 21, 2009
JOURNAL FREE ACCESSTo evaluate the effect of milk feeding on fibronectin in the perinatal period, we measured neonatal blood levels of fibronectin (Fn) and fibronectin synthesis stimulating activity (FnSA) in human breast milk.
The subjects were 107 infants including premature infants. Fn and FnSA concentration were measured by the immunoturbidimetry method and bioassay using human fetal fibroblast cell line (WI 38), respectively.
By multiple regression analysis, feeding volume and corrected gestational age showed positive coefficients to blood level of Fn. Very low birth weight infants fed with human milk showed a significantly higher level of Fn than those fed with milk formula. Infants with diseases such as infection, hypoxia, and bleeding showed significantly lower values of blood Fn concentration than normal infants.
Using gel chromatography (Sephadex G-100) and HPLC, three and four fractions of FnSA were detected in human breast milk, respectively. Two and three fractions with FnSA obtained by gel chromatography and HPLC presented immunoreactive EGF. One of the two fractions with FnSA obtained on heparin-binding affinity chromatography coincided with basic fibroblast growth facter.
Although the clinical meanings of FnSA have not been clarified, our data indicate a new characteristic of human milk.View full abstractDownload PDF (1840K) -
YUHSUKE SEKI1993 Volume 43 Issue 5 Pages 507-517
Published: September 01, 1993
Released on J-STAGE: October 21, 2009
JOURNAL FREE ACCESSLevels of digoxin-like immunoreactive substance (DLIS) were measured in the urine from patients with idiopathic nephrotic syndrome (INS), secondary nephrotic syndrome (SNS) or poststreptococcal acute glomerulonephritis (PSAGN) by radioimmunoassay. DLIS was detected only in the urine from INS patients, not in that from patients with SNS or PSAGN. There was no correlation between the level of DLIS in urine and the increase in body fluid. An oral dose of prednisolone did not influence the level of DLIS. In each INS patient, the DLIS/creatinine ratio in urine was raised to the maximum level at the diuretic stage. In order to clarify the characteristics of DLIS in INS patients, DLIS was extracted from patients' urine using both gel-chromatography and affinity-chromatography. Then DLIS was purified with reversed-phase high-performance liquid chromatography. Its molecular weight and polarity were very similar to those of digoxin. The intravenous injection of an extract containing DLIS induced significant increases in both urine volume and urinary sodium excretion in rats. Moreover, the purified DLIS inhibited Nat, Kt-ATPase in vitro. These results suggest that DLIS in urine from INS patients is associated with the clinical state and has natriuretic activity.View full abstractDownload PDF (1345K) -
TSUNEHIRO ISHIDA, NORITAKA SUGAMATA, YOSHIKI TAKAI, JUN HORIGUCHI, YUK ...1993 Volume 43 Issue 5 Pages 519-524
Published: September 01, 1993
Released on J-STAGE: October 21, 2009
JOURNAL FREE ACCESSThe efficacy of fine-needle aspiration cytology (FNA) in the preoperative diagnosis of thyroid cancer was investigated. The subjects were 1540 patients with thyroid nodule in whom FNA was performed and in whom the histological diagnosis was obtained between 1975 and 1992. There were 580 thyroid carcinomas, 943 benign tumors and 17 cases of Hashimoto's diseases. The diagnostic value of FNA showed a sensitivity of 85%, specificity of 93% and accuracy of 90%. The rate of accuracy was higher in papillary carcinoma (90%), and lower in follicular carcinoma (60%). Moreover, it was higher in small carcinomas of 1.0 cm or less (89%). The false-positive rate was higher in Hashimoto's disease. FNA was more accurate than palpation and ultrasonography for the preoperative diagnosis of thyroid cancer. FNA is a more useful and reliable for benign or malignant diagnosis, small cancer and information on histological types. FNA should be used for the initial diagnosis of thyroid nodules.View full abstractDownload PDF (755K) -
MASARU TAMURA, NOBUO ONO, AKIRA ZAMA, MASARU NAKAMURA, HIDEYUKI KURIHA ...1993 Volume 43 Issue 5 Pages 525-529
Published: September 01, 1993
Released on J-STAGE: October 21, 2009
JOURNAL FREE ACCESSThirty-two cases of metastatic brain tumor from lung cancer were retrospectively analyzed. Median survival time after the treatment of metastatic brain tumor was 29 weeks (7 months), with the longest survival being 10 years. Factors such as surgical removal of the metastatic brain tumor, radiation therapy for the brain, and Karnofsky performance status of more than 80 were shown to be associated with significantly improved survival. Meningeal carcinomatosis was associated with poorer survival. Gender, age, single or multiple metastasis, histological type and chemotherapy were not associated with prognosis. Nine autopsy cases showed that the cause of death was mainly brain metastasis in two cases, and mainly progression of lung cancer with cachexia in 7 cases. For better treatment, cooperation among oncologists, radiologists, radiation oncologists, surgeons, neurosurgeons and psychiatrists must be improved.View full abstractDownload PDF (551K) -
KATSUYOSHI UEHARA, KEIJI SUZUKI1993 Volume 43 Issue 5 Pages 531-542
Published: September 01, 1993
Released on J-STAGE: October 21, 2009
JOURNAL FREE ACCESSVarious mucosal lesion induced in the glandular stomach of female Wistar rat by oral N-methyl-N'-nitrosoguanidine (MNNG) were examined by autoradiography, and the process of gastric carcinogenesis was studied. Hyperplastic polyp, which often occurred in the distal pyloric glandular region, was highly complicated by adenoma and cancer. Autoradiography revealed several labelled cellular masses near the surface of the polyp, suggesting the involvement of these masses in carcinogenesis. Deep erosions were noted in the proximal pyloric region, but no carcinogenesis was noted except for regenerative atypical tissue and an accumulation of labeled cells. Downward proliferation (slipping-in), which occurred in the proximal pyloric glandular region, showed a high labelability in autoradiography. In this experiment, only downward adenomatous hyperplasia was formed in the submucosal layer, but carcinogenesis was considered possible in the stomach too, as submucosal cancer was noted in the small intestine. Since these mucosal lesions in rats can also be observed in the process of human gastric carcinogenesis, carcinogenetic experiments with MNNG in rats are considered useful for elucidating the process of human gastric carcinogenesis.View full abstractDownload PDF (8328K) -
SUSUMU OHWADA, SEIJI NAKAMURA, YOSHIFUMI TANAHASHI, YOSHIYUKI KAWASHIM ...1993 Volume 43 Issue 5 Pages 543-550
Published: September 01, 1993
Released on J-STAGE: October 21, 2009
JOURNAL FREE ACCESSThe incidence of early or superficial esophageal cancer has increased due to the development of iodine staining endoscopy. The strategy for treatment of early esophageal cancer has been recently changed with the introduction of endoscopic mucosal resection. We applied endoscopic mucosal resection using the method of Makuuchi and his co-workers to four patients with six lesions. Major complications such as uncontrollable bleeding or perforation were not encountered. Intra-mucosal squamous cell cancer was diagnosed in four lesions, and Barrett's esophagus in two. Carcinoma was incompletely resected in two patients, because one had vascular invasion of cancer cells and the other had cancer cells at the resective margin of the deep layer. These patients underwent additional irradiation therapy.
Endoscopic mucosal resection by the method of Makuuchi and his co-workers may be performed safely with minimal invasion and is the treatment of choice for early or superficial esophageal cancer.View full abstractDownload PDF (3252K) -
KOHEI KUROKAWA, YOSHIO ICHINOSE, HIROTOMO TAKAHASHI, TETSUJI OKUNO, YO ...1993 Volume 43 Issue 5 Pages 551-554
Published: September 01, 1993
Released on J-STAGE: October 21, 2009
JOURNAL FREE ACCESSA 66-year-old man entered our hospital because of severe macro-hematuria. He had been diagnosed as having localized prostate cancer at 59 years of age and had been undergoing hormonal therapy. By imaging, we diagnosed local recurrence of the prostate cancer with urethral bleeding. Hemostasis was immediately achieved by superselective chemoembolization and prostate size was decreased remarkably. One year after treatment, regrowth of the prostate was found by CT, but the size was still less than 50% of that before treatment.
Merit and demerit of arterial chemoembolization of the recurrent prostate cancer was discussed.View full abstractDownload PDF (918K) -
A REVIEW OF THE JAPANESE LITERATUREKIMITAKA KOGURE, YASUSHI TSUZUKI, TETSU ANDO, SATOSHI UCHIDA, TERUHISA ...1993 Volume 43 Issue 5 Pages 555-561
Published: September 01, 1993
Released on J-STAGE: October 21, 2009
JOURNAL FREE ACCESSThis paper describes case of a 73-year-old woman with an adenosquamous cell carcinoma and presents a review of this disease.
The patients was admitted to the hospital because of abdominal pain and vomiting due to acute cholangitis. Ultrasonography and computed tomography indicated that the tumor occupied the fundus of the gallbladder and some gallstones were present. The patient was operated on and remarkable swelling of abdominal lymph nodes, some of which adhered to the body of the pancreas, was noticed. Cholecystectomy was performed because it was impossible to completely dissect the lymph nodes and there was no invasion of the tumor to the adjacent organs.
Frozen section examination of the tumor showed it to be a squamous cell carcinoma but it was finally diagnosed as a well differentiated adenosquamous cell carcinoma with no metastasis in 12 b lymph node.
In spite of the non-radical operation, the postoperative course was uneventful and without recurrence, and the patient is engaged in normal activities as of 2 years and 9 months after the operation.
Adenosquamous cell carcinoma of the gallbladder has been thought to be the result of squamous metaplasia of adenocarcinoma of the gallbladder. As it advances rapidly, resectable cases are rare, with only 15 resected cases having been reported in Japan.View full abstractDownload PDF (2183K) -
YOSHIYUKI SAKATA, TERUO KUSABA, MITSUHIRO KAMIYOSHIHARA, HIROSHI MATSU ...1993 Volume 43 Issue 5 Pages 563-568
Published: September 01, 1993
Released on J-STAGE: October 21, 2009
JOURNAL FREE ACCESSA 30-year-old woman was found to have a mass in the mesentery by ultrasonography and CT. She had anemia, hyper-γ-globulinemia and an elevated sedimentation rate. At operation a 4 × 3 × 3.3cm mass was resected, and it was proved by pathological examination to be plasma cell type of Castleman's lymphoma. Her postoperative course was favorable, and all abnormal laboratory values returned to normal after excision of the mass.View full abstractDownload PDF (2411K) -
TETSUO ANZAI, TETSUYA KOYANO, SHIGEKI MURATA, SEIICHRO KISHI, ICHIRO K ...1993 Volume 43 Issue 5 Pages 569-573
Published: September 01, 1993
Released on J-STAGE: October 21, 2009
JOURNAL FREE ACCESSA 78-years-old woman was admitted with a solitary pulmonary nodule (18mm by CT) and it's peripheral athelectasis in the left lower lobe. She complained of cough and low grade fever of two months duration, but at the time of admission she had no subjective symptoms. The nodule was homogenous with a sharp margin, and neither spicular formation nor pleural indentation was noted. Therefore, we could not make a final diagnosis of benign tumor, because of the peripheral change. She underwent left lower lobectomy and hilar lymph node dissection. Histological diagnosis of the node was sclerosing hemangioma and that of the peripheral lung was pneumonitis with epithelioid cell granuloma. It is rare for benign lung tumors to cause peripheral atelectasis and/or pneumonitis, even relatively large ones. From data of lung cancer cases, bronchial changes probably need to include peripheral pulmonary atelectasis and pneumonitis.
To treat pulmonary tumor, we have to consider that benign tumor may include peripheral atelectasis and/or pneumonitis even relatively small sized cases.View full abstractDownload PDF (2195K) -
YUKIO KOIBUCHI, SHIGEYUKI MINAGUCHI, OSAMU TESHIGAWARA, YUKITAKA YAMAG ...1993 Volume 43 Issue 5 Pages 575-579
Published: September 01, 1993
Released on J-STAGE: October 21, 2009
JOURNAL FREE ACCESSBrunner's gland tumor of the duodenum is a rare entity. We report two patients with this disease, which was discovered due to anemia and tarry stool. A 42-year-old man with duodenal ulcer visited our hospital because of tarry stool. Small intestinal series revealed a small filling defect in the second portion of the duodenum. The tumor was resected endoscopically, and the histological diagnosis was Brunner's gland adenoma. A 70-year-old woman complained of anemia during admission because of brain infarction. Upper endoscopic examination revealed a polypoid lesion in the duodenal bulb. The histological diagnosis of the biopsy specimen was Brunner's gland hyperplasia.
Brunner's gland hyperplasia or adenoma is not a premalignant condition. Endoscopic resection accompanying treatment for chronic duodenitis is the treatment of choice for Brunner' s gland hyperplasia or adenoma.View full abstractDownload PDF (1618K) -
1993 Volume 43 Issue 5 Pages 581-584
Published: September 01, 1993
Released on J-STAGE: October 21, 2009
JOURNAL FREE ACCESSDownload PDF (695K) -
1993 Volume 43 Issue 5 Pages 585-586
Published: September 01, 1993
Released on J-STAGE: October 21, 2009
JOURNAL FREE ACCESSDownload PDF (358K) -
1993 Volume 43 Issue 5 Pages 587-607
Published: September 01, 1993
Released on J-STAGE: October 21, 2009
JOURNAL FREE ACCESSDownload PDF (3682K)
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