Oral administration of di-
n-butyltin to pregnant rats causes cleft mandible, cleft lower lip and/or fused ribs in the fetuses. However, a series of organotin compounds, such as tri-
n-butyltin, mono-
n-butyltin, and di-
tert-butyltin, were not found to be teratogenic in our previous reports. To clarify the teratogenic potential of the di-
n-butyl group, a teratological study was conducted on di-
n-butyl phosphate (DBP) in pregnant Wistar rats. The pregnant rats were treated orally with DBP (250, 500, 1000mg/kg/day) on days 7-17 of gestation. Cesarean sections were performed on day 20 of gestation. The fetuses from dams receiving DBP showed no evidence of external, visceral or skeletal abnormalities. DBP caused no maternal or fetal toxicities in any DBP-treated group. Under the conditions of this study, the no-observed-adverse-effect levels (NOAEL) for maternal and fetal toxicities were considered to be more than 1000mg/kg/day. These results suggest that DBP differs from di-
n-butyltin with respect to teratogenic effects. The presence of both a di-
n-butyl group and a stannum atom may be necessary to produce the sort of malformations caused by di-
n-butyltin.
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