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Volume 42 (1992)
- Issue 6 Pages 527-
- Issue 5 Pages 425-
- Issue 4 Pages 331-
- Issue 3 Pages 165-
- Issue 2 Pages 69-
- Issue 1 Pages 1-
Volume 42, Issue 6
Displaying 1-18 of 18 articles from this issue
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[in Japanese]1992 Volume 42 Issue 6 Pages 527-543
Published: November 01, 1992
Released on J-STAGE: October 21, 2009
JOURNAL FREE ACCESSDownload PDF (12009K) -
MORIO SAWAMURA1992 Volume 42 Issue 6 Pages 545-553
Published: November 01, 1992
Released on J-STAGE: October 21, 2009
JOURNAL FREE ACCESSMD90, a factor-dependent clone derived from an in vitro-adapted murine plasmacytoma parent cell line, proliferated in respose to murine and human interleukin (IL) -6, but not murine IL-1β, IL-2, IL-3, IL-4, IL-7, interferon (IFN) -γ, tumor necrosis factor (TNF) -α, granulocyte/macrophage-colony stimulating factor (GM-CSF), or lipopolysaccharide (LPS). IL-5 also promoted the proliferation of MD90 cells but to a much lesser extent. Anti-IL-5 monoclonal antibodies inhibited the proliferation of MD90 cells in response to IL-5 but not to IL-6. Anti-IL-6 monoclonal antibodies inhibited the proliferation of MD90 cells in response to IL-6 but not to IL-5. These results confirm the novel specificity of MD90 and demonstrate that MD 90 cells are directly responsive to IL-5 and IL-6. These data indicate that MD90 cells can serve as a simple bioassay for IL-5 /IL-6 and can be made monospecific for IL-5 or IL-6 using anti-IL-5 or anti-IL-6.View full abstractDownload PDF (1929K) -
COMPARISON WITH THE EFFECTS OF HYDRALAZINEHITOSHI ADACHI1992 Volume 42 Issue 6 Pages 555-564
Published: November 01, 1992
Released on J-STAGE: October 21, 2009
JOURNAL FREE ACCESSEffects of captopril and hydralazine on the cardiac β-adrenoceptor pathway in chronic heart failure were investigated. After myocardial infarction (MI) had been experimentally induced in rats, captopril (Cap) or hydralazine (Hyd) was administrated orally for four weeks. Then β-adrenoceptor density (Bmax) and cAMP yield, by either isoproterenol (ISO) -or forskolin-stimulation, were determined. Bmax was significantly increased in MI (N) rats (rats with MI without treatment) as compared with sham-operated rats (63.0 ± 4.6 vs. 38.8±4.4fmol/mg prot. : p<0.05). Cap-treatment of MI had no effect on receptor density (61.8±5.1fmol/mg prot.). On the other hand, Hyd-treatment of MI significantly increased Bmax (92.8 ± 4.6 : p< 0.01). The cAMP yield of MI (N) significantly declined as compared with that of sham operated rats. Both treatments, Cap or Hyd, increased cAMP yield following ISO-stimulation, but cAMP remained unchanged following forskolin-stimulation. Thus, in chronic heart failure due to myocardial infarction, the reactivity of myocytes to catecholamine deteriorate in spite of the increase in β-adrenergic receptor density. This is due to neither increasing receptor density nor improving the activity of the catalytic unit of adenylate cyclase. Captopril seems to improve the activity of G-protein. This regulatory effect of captopril in heart failure is different from that of hydralazine.View full abstractDownload PDF (1558K) -
MADOKA TATENO1992 Volume 42 Issue 6 Pages 565-575
Published: November 01, 1992
Released on J-STAGE: October 21, 2009
JOURNAL FREE ACCESSSingle photon emission computed tomography (SPECT) was performed in patients with ischemic heart diseases using 123I-metaiodobenzylguanidine (MIBG) and 201thallium chloride (Tl). Both radiopharmaceuticals accumulated in the normal myocardium, but not in the infarcted area. However, the size of the defected area with 123I-MIBG was larger than that with 201Tl.
To assess this discrepancy between 123I-MIBG and 201Tl, myocardial infarction was experimentally generated in rat hearts, by surgical occlusion of the coronary artery. On the acute phase, within 6 hours after the occlusion, the size of the defect with 125I-MIBG was larger than that with 201Tl, reflecting the absence of catecholamine granules accompanied by intact cardiac muscle cells.
In contrast, on the chronic phase beyond 18 hours after coronary artery occlusion, the distribution of 125I-MIBG was consistent with that of 201Tl, reflecting the absence of catecholamine granules and degenerative cardiac muscle cells.
These results suggest that myocardial SPECT with MIBG is useful for assessing the catecholamine distribution in ischemic heart diseases.View full abstractDownload PDF (5815K) -
REFERENCE TO THE ETIOLOGY OF ACUTE GASTRIC MUCOSAL LESIONSHIROSHI KOITABASHI1992 Volume 42 Issue 6 Pages 577-595
Published: November 01, 1992
Released on J-STAGE: October 21, 2009
JOURNAL FREE ACCESSThe elevation of blood viscosity due to a stress-dose of cinchophen has already been reported by Nagamachi and it is considered to be a factor in AGML development. Moreover, the decrease in erythrocyte deformability has been considered as a possible factor increasing blood viscosity. As reported earlier, hypersecretion of endogenous corticosteroid has been clarified as a background factor in the elevation of blood viscosity. Under stress, dilatation of the micro-blood vessels of the gastric mucosa, changes in intracapillary erythrocyte deformability and erythrocyte agglutination can occur. In this report, the author has proved that erythrocyte deformability becomes a peak at the time of maximum elevation of blood viscosity in rats treated with cinchophen micro-morphologically. Meanwhile, the relationship between Vitamin E and erythrocyte deformability has already been reported, and Vitamin E has the action of both anti-oxidation and cell membrane stabilization. In this experiment, we have also proved that Vitamin E increases erythrocyte deformability after cinchophen-induced stress. The results indicate that Vitamin E may be applicable as a preventive factor in AGML development clinically.View full abstractDownload PDF (9630K) -
TAKAHIRO FUKUDA1992 Volume 42 Issue 6 Pages 597-604
Published: November 01, 1992
Released on J-STAGE: October 21, 2009
JOURNAL FREE ACCESSIn this study, the effects of MNNG administration on alteration of the LDH isoenzyme pattern and activity level of alkaline phosphatase in gastric mucosae during carcinogenesis were investigated in a rat model.
The following results were as obtained :
1) In the MNNG-induced gastric cancer bearing animals, LDH5 and alkaline phosphatase values were significantly higher in gastric cancer tissue than in normal gastric mucosa.
2) During carcinogenesis, LDH5 value rose in 20-week-old rats to which MNNG had been administered. It was significantly higher (P < 0.01) in MNNG-administered 40-week-old rats than in control animals.
3) These data suggested that anaerobic metabolism of glucose in the gastric mucosa was activated prior to the macroscopic detection of carcinoma in MNNG treated rats.View full abstractDownload PDF (954K) -
MASATAKA ARAKI1992 Volume 42 Issue 6 Pages 605-615
Published: November 01, 1992
Released on J-STAGE: October 21, 2009
JOURNAL FREE ACCESSHistamine and polyamines in oxyntic mucosa seem to be associated with the pathogenesis of gastric ulcer and with its recovery. In the present study, the effect of dexamethasone and other glucocorticoids on the metabolism of histamine and polyamines was examined in fasted rats. The activity of histidine decarboxylase in rat oxyntic mucosa increased significantly after dexamethasone was injected s.c. to rats at doses larger than 0.4 mg per kg body weight. The maximum response of the HDC activity to dexamethasone (4 mg/kg) was observed at 8 hr after the treatment. The activity of ornithine decarboxylase increased at 4 hr and remained elevated for 16 hr following single injection of dexamethasone. Serum gastrin levels showed no significant increase for the first 4 hr and then rose significantly at 8 and 16 hr after dexamethasone treatment. Betamethasone was nearly as potent as dexamethasone in inducing the activity of decarboxylases, while neither prednisolone nor triamcinolone showed any significant effect. These data suggest that dexamethasone influences the metabolism of histamine and polyamines in rat oxyntic mucosa both directly and via increased gastrin release.View full abstractDownload PDF (1481K) -
HITOSHI TAKE, JUN'ICHI TAMURA, TAKAFUMI MATSUSHIMA, MORIO SAWAMURA, HI ...1992 Volume 42 Issue 6 Pages 617-621
Published: November 01, 1992
Released on J-STAGE: October 21, 2009
JOURNAL FREE ACCESSA case of multiple myeloma which showed a marked decline in CD 4 /CD 8 ratio is reported, and the relationship of cellular immunity to humoral immunodeficiency in this disease is discussed together with cases in the literature. The patient was a 57-year-old woman who showed a marked decline in CD 4 /CD 8 ratio associated with a decrease in CD 4-positive cells (CD 4 +) and an increase in CD 8-positive cells (CD8+). By examination with two-color flow cytometry, increases in CD 8 + and CD57 + were observed. Partial participation of decreased CD 4 + in humoral immunodeficiency in this disease has been suggested, and the current case supports this hypothesis. Further examinations of subsets of CD 8 +, in which some kinds of NK cells are also included, are considered to be necessary.View full abstractDownload PDF (598K) -
KUNIAKI TOMIOKA, HIDEKI SUZUKI, TOMIO INOUE, MITSUOMI MATSUMOTO, AKIRA ...1992 Volume 42 Issue 6 Pages 623-634
Published: November 01, 1992
Released on J-STAGE: October 21, 2009
JOURNAL FREE ACCESSThe utilization and preservation of reports on diagnostic radiology and physiology examinations in Gunma University Hospital was evaluated using a questionnaire, in advance of an online reporting system linked to the PACS (Picture Archiving and Communication System) being introduced into the hospital information system.
The recovery rate was 83% (83/100). And the following results were obtained.
1. Reports made by specialists are necessary, irrespective of the grade and complexity of examinations.
2. Reports have to be written in correspondence with clinical problems.
3. For ease of film-report matching, some schemas should be added to sentence-form reports.
4. The format of reports, including the language, expression and extent of comments, may be modified in accordance with the speciality or career of the referring doctor.View full abstractDownload PDF (2097K) -
KIMITAKA KOGURE, YASUSHI TSUZUKI, MITSUGU MURATANI, TERUO OGAWA, MASAT ...1992 Volume 42 Issue 6 Pages 635-642
Published: November 01, 1992
Released on J-STAGE: October 21, 2009
JOURNAL FREE ACCESSA method of left lateral segmentectomy, based on liver anatomy is discussed. The ramifying form of the portal vein, hepatic artery and bile duct of the left lateral segment (LLS) was investigated in five cadaveric livers using the dissection technique.
The ramifying form of the portal vein of the LLS was similar among the five cadaveric livers, whereas a remarkable variation was found in the branching pattern of hepatic arteries and bile ducts.
Six clinical cases in which left lateral segmentectomy was performed, viz, two cases of intrahepatic cholelithiasis, one case of metastatic carcinoma from rectal cancer and three cases of hepatocellular carcinoma, are discussed.
It was concluded that the control method (“by round ligament technique”) was better for performing the left lateral segmentectomy than other techniques including the “by falciforme ligament technique”, because the branching pattern of hepatic arteries and bile ducts at the umbilical portion is quite variable.
In cases with malignant tumors in the LLS left lateral segmentectomy is indicated when portal thrombosis from the cancer does not extend into the portal vein of the left median segment.View full abstractDownload PDF (1695K) -
ICHIROU YOSHIDA, SUSUMU ISHIKAWA, AKIO OHTAKI, YOSHIMI OHTANI, KAZUHIR ...1992 Volume 42 Issue 6 Pages 643-646
Published: November 01, 1992
Released on J-STAGE: October 21, 2009
JOURNAL FREE ACCESSTen patients with bilateral emphysematous bulla were operated on during the period from 1987 to 1992. Eight of these patients underwent simultaneous bilateral bullectomy through a median sternotomy. No mortality or morbidity was encountered. Bilateral simultaneous resection through a median sternotomy is an excellent approach for bilateral emphysematous bulla except giant bulla of the lower lobe which is located above the diaphragma.View full abstractDownload PDF (506K) -
YASUSHI SATOH, KYOUICHIROU TSUDA, YOSHIROU HAMADA, SUSUMU ISHIKAWA, AK ...1992 Volume 42 Issue 6 Pages 647-653
Published: November 01, 1992
Released on J-STAGE: October 21, 2009
JOURNAL FREE ACCESSThree patients with chronic Stanford type A dissecting aneurysm were successfully operated upon using continuous retrograde cerebral perfusion (CRCP) during profound hypothermic circulatory arrest. Following profound hypothermic (14-15°C) circulatory arrest for 30-40 minutes, CRCP was started with a flow rate of 120-550ml/min to maintain a superior vena caval pressure of 15-20 mmHg. The circulatory arrest time was 56-101 minutes. The longer retrograde cerebral perfusion time induced prolonged wakefullness, but no serious neurological complications were encountered. In conclusion, CRCP is useful for cerebral protection during profound hypothermic circulatory arrest.View full abstractDownload PDF (1784K) -
SHIGEKI MURATA, TETSUYA KOYANO, MOTOI KANOH, SEIICHIROH KISHI, TETSUO ...1992 Volume 42 Issue 6 Pages 655-659
Published: November 01, 1992
Released on J-STAGE: October 21, 2009
JOURNAL FREE ACCESSDermatofibrosarcoma protuberans is a protuberant tumor developing in the skin, which is relatively rare in Japan. The tumor respected here developed on the shoulder and was treated by surgery and irradiation. A 24-year-old female had complained of a tumor on the right shoulder for ten years. She was admitted to our hospital because of rapid growth of the tumor over the previous year. The tumor was 8.4 × 6.8cm in size, elastic and soft in consistency. Its surface showed teleangiectasia. A uniform, low density echo pattern was observed in the internal region by ultrasonography. At surgery the tumor was well fixed to the skin and had abundant blood vessels on its surface, but it was loosely adherent to the fascia. The tumor was excised with the skin and connective tissues. The pathological findings exhibited a typical pattern of dermatofibrosarcoma protuberans. To prevent recurrence, Linac irradiation was done. The patient is well 11 months after the operation.View full abstractDownload PDF (2325K) -
SUSUMU OHWADA, AKIO YANAGISAWA, TAKAYUKI YANAGISAWA, IZUMI TAKEYOSHI, ...1992 Volume 42 Issue 6 Pages 661-666
Published: November 01, 1992
Released on J-STAGE: October 21, 2009
JOURNAL FREE ACCESSA 54-year-old woman with ulcerative colitis coexisting with pyoderma gangrenosum and arthritis is presented. Colonoscopy showed severe inflammation on the left side of the colon and the findings of a biopsy specimen were compatible with active ulcerative colitis. Pyoderma gangrenosum was diagnosed on the basis of clinically and bacteriobogically negative findings. Colotic arthritis was rheumatoid factor negative and there were no radiographic findings. She was diagnosed as having an initial attack of the severe type of ulcerative colitis, and treated with enema adminstration of prednisolone and oral administration of salazosulfapyridine. Remission of colonic manifestations and the arthritis were obtained in accordance with normaligation of C reactive protein.
Extra-intestinal manifestations of ulcerative colitis are skin lesions, uveitis, arthralgis and arthritis, liver impairment, cholangitis and so on. Coexistence of pyoderma gangrenosum and arthritis with ulcerative colitis was rare in Japan according toour review of the Japanese literature.View full abstractDownload PDF (1041K) -
YUHJI TAMURA, TOSHIKATU INOUE, TADASHI TOMIZUKA1992 Volume 42 Issue 6 Pages 667-673
Published: November 01, 1992
Released on J-STAGE: October 21, 2009
JOURNAL FREE ACCESSIdiopathic interstitial pneumonia has an unknown etiology and a poor prognosis. Here we report a case of acute idiopathic interstitial pneumonia that presented with fever of unknown origin and was effectively treated with steroid pulse therapy. The patient was a 71-year-old woman. She visited our clinic as an outpatient with chief complaints of fever, malaise and polyarthralgia and was admitted for detailed examination and treatment. At that time we suspected bronchial pneumonia and administered antibiotics, but without effect. We then initiated examinations for fever of unknown origin. Respiration worsened after admission and the combined findings of a chest x-ray and respiratory function tests led to the diagnosis of acute idiopathic interstitial pneumonia. Treatment consisted of steroid pulse therapy (methylprednisolone, total dose = 6, 000mg). Symptoms improved markedly after this therapy. Moreover, after adding the immunosuppressant agent cyclophosphamide we were able to gradually reduce the steroid dose.
The group of diseases designated as acute idiopathic interstitial pneumonia apparently consists of diseases clinically responsive to steroid pulse therapy, and other non-responsive diseases. Thus, according to pathology, a new classification and new therapies shoud be developed.View full abstractDownload PDF (1920K) -
AKIRA OGAWA, SHIRO SUGIHARA, YUKIO KUBOTA, MANABU HONMA1992 Volume 42 Issue 6 Pages 675-681
Published: November 01, 1992
Released on J-STAGE: October 21, 2009
JOURNAL FREE ACCESSOne autopsy case of a latent paraganglioma of the urinary bladder is reported. The patient, a 46-year-old woman, died as a result of the ventricular septal defect. Paragangliomas consisting of seven tumors were present in the urinary bladder. The largest one in seven tumors was three millimeters in diameter and six similar tumors were noticed in the muscle layer around the tumor. Some multicentric tumors have been reported in cases of multiple endocrine neoplasia (MEN) and often associated with anomalies. Although the present case does not belong to MEN, this is the seventh report of a multicentric paraganglioma of the urinary bladder.View full abstractDownload PDF (3094K) -
1992 Volume 42 Issue 6 Pages 683-686
Published: November 01, 1992
Released on J-STAGE: October 21, 2009
JOURNAL FREE ACCESSDownload PDF (866K) -
1992 Volume 42 Issue 6 Pages 687-693
Published: November 01, 1992
Released on J-STAGE: October 21, 2009
JOURNAL FREE ACCESSDownload PDF (1307K)
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