21匹のモルモットからSEPを記録し, エタクリソ酸, フロセミド投与による変化を調べた.
1) SEPの平均は2.6mV±4.5mVであった.
2) エタクリン酸, フロセミド投与によりSEPは低下しその反応様式はCEPと大変良く類似していた.
3) ループ利尿剤の場合CEPが約15%に減衰して球形嚢に伝わると考えるとよく一致する所見が得られた.
4) 前回のアノキシアの実験と併せて考えると球形嚢への減衰率は10～15%位の幅があると考えるのが妥当のようである.

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The labyrinths of guinea pigs sensitized by horseradish peroxidase (HRP) were investigated by electronmicroscopy after challenging this antigen through the foram. stylomastoideum. Horizontal nystagmus toward the contralateral side was observed about fifteen minutes after challenging. The animals sacrified in this stage did not show endolymphatic hydrops, however, particles of HRP were observed in intracellular vesicles and basal lamina of the Reissner's membrane. This particles were took in dark cells of the stria vascularis, too. In the animals sacrified forty-eight hours after challenging HRP, endolymphatic hydrops could be observed. These findings were not observed in the control study and suggested that hyperpermeability of the Reissner's membrane and hypersecretion of the stria vascularis induced by antigen-antibody reactions were probable causes of endolymphatic hydrops.

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Single doses of 10% Glycerol, 500ml for 2 hours intravenously, produced significant hearing threshold shifts in 6 cases out of 9 cases with definite Meniere's disease.
Instead of orally administered Glycerol test, this intravenously administered Glycerol test may be adopted as a simple and easy method for diagnosis of reversible and fluctuative Meniere's disease. The difference between intravenously and orally administration has been discussed from the points of their side effects. The effects of a prompt improvement of the hearing in Meniere's disease by intravenously administered glycerol would be a strong indication of an osmotic effect than a metabolic one.

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The pupillary light reflex test and the mecholyl test by means of conjunctival instillation were performed successively on the same day in 44 cases with Meniere's disease. Although the results of both tests on the affected side in the attack stage were agreed in six of nine cases, the remaining three cases were positive in the mecholyl test alone. This may indicate that the mecholyl test is more adequate for ascertaining the existence of autonomic dysfunction in Meniere's disease than the light reflex test.

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Among 20 patients with Ménière's disease who had been tried for sampling the intra-sac-endolymph during epidural shunt operation, six specimens with lesser blood-contamination were selected for analysis using a flame photometer and electrophoresis.
The ionic concentration ratio of sodium to potassium of the samples was similar to those of the extracellular fluids. The protein concentrations were considerably higher than those of CSF obtained from the same patients.
Immunodiffusion test revealed that transferrin, C3 and C4 were present, however, β-lipoprotein could not be detected in the intra-sac-endolymph.

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A polarized light goniometer (abbreviated as Polgon) and a microcomputer were applied for the calculation of the real values of changes in shoulder angulation during stepping movement in normal subjects and patients with peripheral vestibular disorders.
Characteristic results were obtained from patients with Ménière's disease, showing larger means and variations as compared with those of normal subjects. The shoulder of the same side with affected ear usually showed larger values than those of another shoulder.
Those patients with sudden deafness accompanying vestibular disorder presented larger means and normal standard deviations. The results obtained from two patients with vestibular neuronitis were almost normal. Five subjects with other vestibular disorders showed larger means only when stepping with the eyes closed.

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The stepping test is a dynamic test for the evaluation of equilibratory function, whose accuracy is so high that it enables us to detect even a slightly compensatory stage labyrinthine disturbance undetectable with static equilibratory function tests. Because it is a equilibrium movement test, it requires a more precise adjustment of the pyramidal and extrapyramidal systems. A stepping test with eyes closed allows us to record and observe even a slightest disturbance of the pyramidal and extrapyramidal tract that cannot be demonstrated with static equilibratory function tests. In patients with unilateral labyrinthine disturbance, a deviation occurs during the stepping test. No publication is available, however, that deals with the time course change in the stepping record.
We recorded the center of gravity in the stepping test by KINETOGRAVICORDER and studied time-course change in the recording. Our findings were as follows:
Nine patients with unilateral Meniere's disease (in normal phase), selected as subjects, were instructed to face front in the dark. In that position, they performed steppings in an exact rhythm (1.2Hz) with eyes closed, while recordings were taken to examine the onset of deviation. Deviation started with the 8th to 17th step (average 12.4th step), or 6.4sec to 13.6sec (average 9.95sec) after the initiation of steppings.
The above results suggest that: (1) A voluntary movement due to central programming is eliminated by approximately about 12 steppings to be replaced by an extrapyramidal reflex. The period during which the said 12 steppings or thereabouts are performed (about 10sec) is the latent time for deviation, (2) a regular rhythm accelerates the manifestation of laterality in the motor reflex, (3) the imposition of regular rhythm has an element of the Jendrassik maneuver, so that it encourages the manifestation of deviation in steppings. We concluded therefore that the stepping test would yield sufficiently meaningful data even if the number of steps to be taken was reduced from that in the past test.

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ENG recordings were performed on a case of Ménière's disease during vertigenous attack. The ENG findings obtained in this case was summarized as follows; (1) Nystagmus directing to the non-affected side occurred immediately after the vertigenous attack (although it is generally said that nystagmus during this period occurs to the affected side). (2) The nystagmus to the non-affected side changed the direction to the affected side after a “transition period”. (3) During the transition period the eye movement was unstable and nystagmus occurred periodically either to the right or to the left. It has been revealed that nystagmus occurring during an acute Meniere's attack showed precarious, dynamic changes.

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我々の経験した55例のメニエール病症例につき, その年令分布・聴力型・聴力損失等を検討した. その結果, これらの項目については, 諸家の報告とほぼ同様の傾向を示した.
また, 新鮮例で経過観察の十分行なえた24例について, 保存的治療とめまいおよび聴力の経過を検討した. めまいについては, 95.8%の改善がみられたが, めまいの完全消失例はなかった. 聴力は, 62.5%が不変・33.3%が悪化を示した.
さらに, 3例の症例をあげ, 保存的治療とめまい・聴力の経過を示すとともに, 聴力の変動について, 保存的治療および手術治療に関する文献的考察を加えた.
以上の結果より, めまいの完全治癒・聴力の保存のために, よりよい治療法の確立が望まれることを強調した.

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メニエール病を中心に末梢性耳性めまいに対する薬効検定についてATP300mg/日と150mg/日 (4週間投与) の群間比較による二重盲検試験をメニエール病69例, その他の耳性めまい85例に施行した結果, 次の結論が得られた.
1) メニエール病を中心にした耳性めまい症例に対する抗めまい薬の薬効検定はめまいの程度・持続時間に対する効果, めまいの発作間隔の延長化, 内耳障害 (聴力, 平衡機能) に対する効果を客観的に評価すべきである.
2) ATP300mg/日とATP150mg/日4週間投与では主治医判定, 委員会判定ともに自覚症状より他覚症状に有意差がみられ, ATP300mg/日群の方が150mg/日群より優れていた.
3) 抗めまい薬の薬用量の決定には薬用量効果の検定による判定が望ましい.

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めまい疾患に有効とされる半夏白朮天麻湯 (半湯) と苓桂朮甘湯 (苓湯) をメニエール病患者に適用し, 次の成績を得た.
1. 自覚症状では, めまいおよびその随伴症状のうち, 首すじ, 肩のこり, 悪心, 嘔吐, 食欲不振などの改善度が著明に良好であった. これに対し, 耳鳴改善は良好でなかった.
2. 他覚所見では, ロンベルグ現象, 注視眼振の消失ないし減少例が多くみられたが, 難聴の改善は良好でなかった.
3. 全般的にみて, 2週間投与後より4週間投与後の改善度が極めて高く, 漢方薬の遅効性を意味するものと考えられる.
4. 副作用は半湯投与群に1例みられたが, 4週内服継続投与が可能であった.

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1981年の福岡大学病院耳鼻咽喉科における良性発作性頭位眩暈症は58例で, 全めまい患者330例の18%にあたり, 突発性難聴29例, メニエール病13例であった.
良性発作性頭位眩暈症で受診し, 初診時の発作以前にもめまい発作を有していたものが約半数にみられた. 初診後にも再発したものが9例 (15%) にみられたが, 一般に経過は数日～数週で自・他覚症状ともに消失したものが40例 (70%) であった.
文献的にも再発, 治癒遷延例が20～30%にみられており, 耳石器の局所的因子が発症のメカニズムの主因と思われるものの, プラスアルファーとしての発症誘因が重複・反復することで再発する可能性がある. また病変部も耳石器のみにとどまらず半規管系との関係や病因に関連して症状が持続する例もあり得ると考察した.

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In general, the threshold of Galvanic body-sway is much lower than that of galvanic nystagmus. Therefore, in order to establish a clinical galvanic body-sway test for differential diagnosis between vestibular endorgan and retrocochlear lesions, we have studied on effects of galvanic stimulation on the body-sway by using the gravicorder. The galvanic stimuli were used by the stimulator, in which the DC-currents were controlled from 0.1mA to 1.0mA, and applied for 5sec. The test subjects stood on the gravicorder (Anima Co.) with feet together, eyes closed, and hands at sides.
The 10 induced galvanic body-sway were averaged by using the small digital computer PDP 11/34. The normal characteristics of the galvanic body-sway responses were measured in a group of 8 normal subjects. In these tests, the direction of body-sway, patterns of swaying, the latency of the initial sway were analyzed by the computer. In these normal subjects, the initial body-sway to the cathode sides appeared at 0.22 seconds in average after the galvanic stimulation (0.6mA), and then the second sway to the anode side deviated at 0.45 seconds in average after the start of the stimulation. Increasing stimulus current from 0.1mA to 1.0mA produced a linear increase in the galvanic-response amplitude. Therefore, the thresholds of the galvanic body-sway test could be measured by these test procedures. No side effects were observed in these galvanic stimulation under 0.6mA.

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Follow up study of ten cases with vestibular neuronitis those who were examined and treated at Yamaguchi University Hospital from 1976 to 1981 comparing especially the findings of writing test with those of vestibular function test. In the vestibular function test, all patient presented unilateral canal paresis by the caloric test and spontaneous nystagmus toward the healthy side. As for the writing test, nine cases showed deviation toward involved side with shortening in Fukuda's vertical writing test and eight cases showed micrographism with shortening in Sekitani's Square Drawing Test. And these pathological findings of writing test were evaluated to correlate to the change in vestibular function test.

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Literature on the vestibular neuronitis as one of the peripheral otogenic vertigo (in other word; retrolabyrinthine origin) was collected from the world-spread medical journals appeared in Excerpta Medica and so on, since 1909 when Ruttin firstly described and indicated this disorder to the recent paper till December 1981.
These search on the paper was supported (in part) by the Research Grant for the Intractable Diseases from the Ministry of Health and Welfare, Japan; as one part of the project of Vestibular Disorder Research Committee, the Ministry of Health and Welfare, Japan, since 1980.

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This paper deals with the findings obtained in a 9-year-old girl with vertigo who was diagnosed as having classical vestibular neuronitis. The case provided evidence that classical vestibular neuronitis could occur in children under 10 years with the symptom of vertigo.
She had neither remarkable subjective symptoms nor deviation of the extremities at 4 days after the onset. It appeared that vestibular neuronitis in young children recovered faster than in older cases who have more chances of being examined. At first visit (4 days after the onset) rotato-horizontal nystagmus to the intact side was remarkable. The nystagmus became less remarkable with time until it disappeared one month and a half after the onset. The caloric test revealed advanced CP (canal pareais). The patient under the discussion did not recover from this disorder throughout the observation period. The vestibular neuronitis findings obtained in a 9-year-old girl with vertigo were identical to those obtained in older people.

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In 1916 three French neurologists, Guillain, Barré and Strohl, presented their important paper describing 2 patients with polyneuritis. They emphasized the predominant motor weakness of the limbs with minimal sensory loss, hyporeflexia, elevated protein level in cerebrospinal fluid without cellular reaction and favourable prognosis. Since that time, the syndrome has been referred the Guillain-Barré syndrome, but the diagnostic limits of the disorder had been disputed because of inclusion of many types of acute and chronic polyneuritis under this title. In 1960, Osler and Sidell published a paper and set down diagnostic criteria which severely restricted the definition of the disorder. A new diagnostic criteria for the disorder was clearly proposed for field studies by an ad hoc NINCDS committee (1978) and Asbury (1981). These clinical study yields pathological and experimental evidences suggesting that GBS is an acute immune-mediated polyneuropathy (AIMP) and a distinctive entity. GBS is now one of the most frequent forms of acute polyneuritis.
Vestibular neuronitis is the term applied originally by Dix and Hallpike (1952) to a distinctive disturbance of vestibular function, characterized clinically by an abrupt and usually a single and severe attack of vertigo and by an absence of cochlear abnormality. The pathological site of the vestibular pathway and the nature of the affection have not been established. Consequently, there is confusion regarding its nosological situation.
In this article, the diagnostic criteria of the Guillain-Barré syndrome are reviewed and vestibular neuronitis is compared with it in order to refine the definition. In considering the clinical characteristics, there is some similarlity between vestibular neuronitis and Guillain-Barré syndrome. The only significant difference is that vestibular neuronitis is confined primarily to the vestibular nerve. Thus, it is suggested that vestibular neuronitis should be investigated in future with relation to AIMP as well as from the viewpoint of directly infectious or vascular etiology.

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(1) 慢性中耳炎50症例中27例 (54%) に眼振を認めた.
(2) 耳漏, 瘻孔症状の有無と眼振出現率に有意の差を認めた.
(3) 眼振を認めた27症例中, 健側向き眼振は17例, 患側向き眼振は10例であった. 患側向き眼振は, 内耳機能が障害されておらず且つ中耳炎の急性増悪期症例に多く見られた.
(4) 立直り障害, 偏倚現象, 温度眼振検査の異常は, めまいを伴う真珠腫性中耳炎に多く見られた.

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1) SMまたはKM投与中の患者48例に頭位および頭位変換眼振検査を施行した. 平均聴力域値はSM群16.4dB, KM群24.1dBとKM群にやや高い傾向があった.
2) 眼振は合計8例 (約16.7%) に観察された. 眼振 (+) 群のSM平均使用量は約23.2gと比較的少量で, 眼振発現とSM投与量との間には一定の関係は見られなかった.
3) 眼振 (+) 群での聴力域値は眼振 (-) 群のそれに比してやや高い傾向がみとめられた.
4) 観察された眼振は, 方向固定性の水平, 水平回旋混合性, 回旋性など様々であった. めまい感を自覚していた症例は眼振 (+) 例8例中3例に過ぎず, めまい感と眼振の強度との間にも比例関係はみられなかった.
5) 聴力障害に伴い平衡器も影響を受けてくるものと考えられるので, SM投与例には平衡機能検査もあわせて施行し, 平衡機能異常の早期発見に務める必要がある.

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A questionnaire had been set out to the patients with peripheral vestibulo-cochlear disorders who had been treated at least five years ago, on relation between the survival symptoms and their occupational reinstatements. The results were assayed in clinical and epidemiological view point.
The failure of “back-to-work” due to the vertiginous diseases was found in 15 patients (20.0%) —group B—, and found it in nine patients (11.4%) with another reasons —group C—. The remains (group A) succeeded to return to the same works.
The most influenced symptom to failure was “vertigo”, and tinnitus, anxiety, hearing disturbance in order, while the cochlear symptoms were significant higher in group A and C than in group B.
It was very interesting the fact that reinstatement would have been related with a “disturbed side” of inner ears, namely the left ear disturbed frequency was higher in group A with statistically significant than in group B, and the right ear frequently disturbed in opposite relations. Because this suggested to introduce a consideration of the behaviour science, the behaviour dynamics or the ergonomics into the medicine.

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A question and answer survey was made referring to motion sickness on vestibular disorders, which are benign paroxysmal positional vertigo (33), sudden deafness (28) and Ménière's disease (29), and compared them with that of the healthy persons (130).
There were many of those with the history of motion sickness statistically significant in benign paroxysmal positional vertigo compared with Ménière's disease and sudden deafness, showing severe symptoms. Those never experienced any motion sickness in the past were found more in sudden deafness and Ménière's disease than that in the healthy persons.
It can sufficiently be suggested that benign paroxysmal positional vertigo is an otolithic dysfunction. There are differences in seriousness and incidence of motion sickness between benign paroxysmal positional vertigo and other inner ear disorders as well as healthy persons, which identifies a relationship between the otolithic organ and motion sickness.

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末梢前庭迷路の機能異常を伴う疾患としてメニエール病, 突発性難聴, 薬物中毒, 良性発作性頭位めまい症, 前庭神経炎の5疾患とその対照として中枢疾患につき, 実際鑑別診断して行く上でどの様な検査項目がどの程度判別に寄与しているかを計量的に検討するため林の数量化II類の方法を用いて分析した. 判別すべき疾患は6グループあり解は5軸まで得られたが判別寄与の高い第3軸までについて軸の意味づけと, それぞれの軸について偏相関係数の大きい検査の意義について検討した. ここでは各軸について1検査のみを述べる. 第1軸は大きく中枢性疾患と末梢性疾患を判別する軸でOKPテストがこの判別に重要な検査であると解釈できた. 第2軸はメニエール病, 突発性難聴, 薬物中毒と良性発作性頭位めまい症, 前庭神経炎を判別する軸で聴力検査がこの判別に重要であると解釈できた. 第3軸は良性発作性頭位めまい症と前庭神経炎とを判別する軸でありこの判別に重要な検査はカロリックテストのCPの有無であると解釈でぎた.

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ラット半規管膨大クプラの発生過程を, 走査及び透過電顕を用いて観察し, 以下の如く明らかにした.
1. 胎生15日目ではクプラはほとんどの例で見られず, 半規管膨大部未成熟感覚上皮表面は Kinocilium とともに微絨毛が見られた.
2. 胎生16日目では, クプラは認められたが量的にも少なく, 表面構造も一定しなかった. 支持細胞上にはクプラ様の無構造物質が認められた. この時期で感覚毛の一部には未熟ながら階段状を呈するものが出てきた.
3. 胎生17. 18日目になると, クプラは量的にも増加し, 露出した感覚毛も少なくなる. 辺縁部では支持細胞上に一致した無構造物質隆起が多数観察され, クプラ辺縁突起部と連続している所見が得られた.
4. 19日目になると, クプラ下腔の構造はまだ未熟だが, 量的にも, 表面構造にもほぼ成熟した所見を得た. さらに透過電顕で, 索状構造と, その内部に網状・線維状構造を認めた.
5. 生後では1日目ですでに形態学的にほぼ完成された所見を呈していた.
6. 以上の事によりラットにおいては, クプラの発生時期は胎生16日目で, その起源はクリスタ上皮内支持細胞であろうと考えられた.

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Utricular macula of the normal guinea pigs were studied. The surface of the sensory epithelia of the macula was examined using SEM and X-ray microanalyzer. Some specimens were also freeze-cracked and observed in the same way. Numerous granular substances were observed on the surface of the sensory epithelia. It was also found that these granular substances were transformed into the otolithic crystal. There were many protrusions from the surface of the supporting cells surrounding the sensory hair cells. These protrusions and granular substances contained some amount of calcium. In the cracked specimens, small granules were found in some cells and these granules also contained some amount of calcium. Therefore, it is suggested that precursors of otoconia may be secreted from the supporting cells.

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As a mechanism of the attack of Meniere's disease, membrane breake theory is proposed. The detailed observation of the effects induced by the mixture of endolymph with perilymph was considered to be useful for the diagnosis and treatment of vertiginous disease. We ruptured the saccular membrane of the guinea pig and observed the effects functionally and morphologically.
Functionally, horizontal-rotatory-mixing spontaneous nystagmus to the healthy side was observed, however, behavioral observation evealed no deviating tendency.
Morphologically, the degenerations of the sensori-epithelium, which were resemble to that induced by drug intoxication or accerating stimulus, were found in the maculae and the cristae ampullares. There were only slight disorders at the organ of Corti. Many vacuoles and vesicles and partial swelling were observed in the marginal cells, these findings were resemble to that of the dark cells and transitional cells of the cristae ampullares.
By these results, discussions were made on the relationship among the range of degeneration, endolymphatic flow and the attack of Meniere's disease.

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The blood capillaries in the stria vascularis and the spiral ligament were studied by electron microscopy with freeze-fracture and thin section methods including tracer experiments of horseradish peroxidase (HRP) and microperoxidase (MP) in guinea pigs. The capillaries in both tissues, composed of non-fenestrated endothelial cells, are connected by tight junctions, and contain about the same number of micropinocytotic vesicles. After intravascular administration, both of tracers were found to have been transported to the basal lamina in the stria vascularis, but they were absent in the spiral ligament. The tight junctions between capillary endothelial cells in the stria vascularis prevented the penetration of HRP, but sometimes allowed the penertation of MP. On the other hand, that of the spiral ligament was impermeable to both tracers. Almost all micropinocytotic vesicles of the stria capillaries contained both tracers. In the spiral ligament some micropinocytotic vesicles were stained with both tracers, but others were unstined. It is concluded that the capillaries of the stria vascularis are similar to the muscle capillaries, whereas those of the spiral ligament are similar to the brain capillaries.

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In recent years, glycerol or loop diuretic agents are known to be the drugs considered to reduce endolymphatic hydrops, there by it has been used for the diagnosis and partially a therapy for the inner ear dizziness.
In this present study, the above agents and generally used various diuretic agents have been administrated to animals experimentally, and those effects against the stria vascularis were observed by electron microscopy.
The change in substance-permeability of the stria vascularis by diuretics were reviewed by a tracer using horseradish peroxidase. Subsequently, the following results were obtained.
1) After intravenous injection of furosemide and bumetanide, temporary reversible change was observed at the stria vascularis.
2) By the tracer study, furosemide has an action of easing the leakage of substances to the endolymphatic space.
3) By oral administration of furosemide, no abnormality was observed.
4) Metholazone as a thiazide type diuretic agent in its intravenous injection caused slight changes.
5) Intravenous injection of potassium canrenoate as an antialdosterone drug was proved to show the same effect as that of loop diuretic agents.
6) Glycerol, mannitol and isosorbide showed no marked change in the inner ear.

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1. 耳石器における機能と形態の並行的観察を試みた.
2. 24匹の白色モルモットを5群に分け, 生食注射のコントロール, ストマイ (250kg/mg, 隔日7回) 投与群及び同時に Methyl B₁₂ 500μg/kg, 連日14回投与群で比較した.
3. パラレルスイングでは, コントロール群が前后不変で比は1に近いのに比し, ストマイ単独群では, 2週及び4週后ともに, 振幅は半分以下に減少して, 耳石-眼反射での障害が示された. Methyl B₁₂ 同時投与群では減少率は75%近くに止まり, 4週后ではコントロールに近く回復した. 位相のずれはコントロール以外全て増大した.
4. コントロール並びにストマイ投与群で耳石結晶の走査電顕による観察を試みた. 前者では耳石の形や大きさに多態性がみられたのに比べて後者では形が均一化され, 大きさも小型化し稜も鈍化し, ストマイの耳石生成障害が示された.
5. 以上の結果につき若干の文献学的考察も加えた.

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正常モルモット4匹について反復回転刺激をおこない回転後眼振のRD現象を調べ, ビンカミン2mg/kg腹腔内投与のRD現象に対する作用を, 対照群6匹と比較した.
投与群, 非投与群のいづれにも回転後眼振のRD現象は認められたが, 両群の間にRD現象獲得に差は得られなかった.

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比重の異なる薬剤を1側の中耳腔に注入する事によって, 比重の違いに応じた, 内耳性の方向交代性 (上向性及び下向性) 頭位眼振のモデルを作成する事ができた. エチルアルコールでは左右側位で方向交代性下向性, Nose up で非注入側向き, Nose down で注入側向きの頭位眼振が出現した. 重水では左右側位で方向交代性上向性, Nose up で注入側向き, Nose down で非注入側向きの頭位眼振が出現した. またアルコールを中耳腔に注入した兎側頭骨標本において, 外側半規管膨大部周辺に染色性の異なる遊出物を認めた.

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When catapres, which is known to decrease the blood pressure (BP), was injected intravenously, suppression on per-rotational nystagmus was observed in both beat number (BN) and fast phase eye velocity (FPEV), (P<0.05, t-test). Slow phase eye velocity (SPEV) of per-rotational nystagmus was less affected. Decrements of nystagmus BN and FPEV were more pronounced in the nystagmus beating toward the side of artifically narrowed vertebral artery than the one beating to contralateral side. This influence of blood pressure change upon VOR were supposed to be a ischemia occurring in CNS rather than that in the peripheral vestibular system.

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メニエール病25例をはじめとするめまい患者85例に圧受容器反射検査とCMIおよび矢田部ギルフォード性格検査を行なった. メニエール病めまい発作期には交感神経緊張傾向にあり, 性格的には神経症的, 情緒不安定を示すものが多かった. 性格的な問題が自律神経異常をひきおこし, めまいへつながるのではないかと考えられた.

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