Kanzo
Online ISSN : 1881-3593
Print ISSN : 0451-4203
ISSN-L : 0451-4203
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Volume 16, Issue 2
Displaying 1-7 of 7 articles from this issue
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  • A study on alcoholic liver injury as related to cell-mediated immunity
    Yasuhiro KATO, Keigo NISHIMURA, Kenichi KOBAYASHI, Jugoro TAKEUCHI
    1975 Volume 16 Issue 2 Pages 59-67
    Published: February 25, 1975
    Released on J-STAGE: January 19, 2010
    DOIhttps://doi.org/10.2957/kanzo.16.59
    JOURNAL FREE ACCESS
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    An attempt was made to study the mechanism for the development of alcoholic liver injury from the point of cell-mediated immunity. The subjects Were composed of 20 cases with liver injury and a history of drinking 80g or more alcohol every day for ten years or more. The leucocyte migration test was carried out on these cases according to Sobørg's method. The result was judged as positive when the inhibition occurred in 30% or more of the migration area to develop in the normal medium without additives. The positive results were found in 7 of 20 cases (35%) tested on the medium containing ethanol alone, in 6 of 17 cases (35%) on the ethanol and homologous liver homogenate added medium, in 5 of 15 cases (33%) on the homologous liver homogenate added medium, and in 6 of 19 cases (30%) in the medium containing purified HB Ag. Of 10 positive cases with the test (1) and/or (2), 5 cases were heavier drinkers taking 260g or more alcohol every day, and 4 of these 5 cases showed the histological change of liver cirrhosis of sublobular type. On the contrary, there were only two heavier drinkers taking 260g or more alcohol every day, and no liver cirrhosis of sublobular type was found in 10 negative cases. The leucocyte migration test was carried out on five cases of HB Ag positive alcoholic liver injury. The positive results were found in all cases on the medium containing purified HB Ag and in 2 of 5 cases on the ethanol alone.
    From these results, it may be suggested that in some patients with alcoholic liver injury, ethanol and HB Ag are related to the development of liver injury in the form of cell-mediated immunity.
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  • Studies on the cause of vacuolar degeneration of the hepatic cell
    (I)-Experimental production of vacuolar degeneration.
    Yukimura FUJIKAWA
    1975 Volume 16 Issue 2 Pages 68-78
    Published: February 25, 1975
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.16.68
    JOURNAL FREE ACCESS
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    In order to analyse the causative factors being responsible for development of vacuolar degeneration of the hepatic cell, several types of experiments; simultaneous loading of hypoxemia and hepatic congestion to the isolated perfused rat liver, and, in vivo, inhalation of hypoxic air, combination of hypoxic air inhalation and hepatic congestion, and hepatic congestion only, were performed. The simultaneous loading of hypoxia and hepatic congestion produced a severe grade of vacuolar degeneration of the hepatic cell in the central zone of liver lobule.
    The hypoxic air inhalation produced a very slight grade of and hepatic congestion a moderate grade of vacuolar degeneration. Morphological characteristics and distribution of the vacuole produced experimentally were quite similar with that of human being. From these experiments, it was concluded that two factors; a decrease in an oxygen supply to the hepatic cell and an elevation of a sinusoidal pressure, were necessary for development of vacuolar degeneration of the hepatic cell.
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  • Studies on the cause of vacuolar degeneration of the hepatic cell
    (II)-Studies of the human autopsy case.
    Yukimura FUJIKAWA
    1975 Volume 16 Issue 2 Pages 79-86
    Published: February 25, 1975
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.16.79
    JOURNAL FREE ACCESS
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    Causative factors being necessary for development of vacuolar degeneration of the hepatic cell were analysed in 30 autopsy cases.
    The vacuolar degeneration of the hepatic cell was the most frequently found in cardiac and pulmonary diseases and in the severe anemia patients having a congestion of the liver. In these cases, coexistence of a hypoxemia and an elevation of hydrostatic pressures in the sinusoid was warranted. The vacuolar degeneration was neither found in the case of hypoxemia without accompanying congestion of the liver nor in the case of hepatic congestion without accompanying hypoxemia.
    These results coincident with the conclusion of author's previous experimental study in which it was confirmed that two factors; a decrease in an oxygen supply to the hepatic cell and an elevation of hydrostatic pressures in the sinusoid, were necessary for development of vacuolar degeneration of the hepatic cell.
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  • The effect of antioxidant agent (α-tocopherol acetate) in carbon tetrachloride administrated Oryctolagus cuniculus liver disorder
    I. The histological findings of liver and the labolatory findings
    Isao YAMAJI, Masato FUNASAKO, Ryoji IZUMI, Ichiro NAKAYAMA, Yasuhisa H ...
    1975 Volume 16 Issue 2 Pages 87-94
    Published: February 25, 1975
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.16.87
    JOURNAL FREE ACCESS
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    There were many reports that malonyl-di-aldehyde (MDA) produced in oxidative state of lipids in microsomal fraction was caused the fatty degeneration of carbon tetrachloride administrated liver disorder (CCl4 Adm. L.).
    Therefore, we thought that antioxidants became the preventive roles of CCl4 Adm. L. and inhibited the production of MDA in the liver cells.
    This study was to investigate the protective roles of-tocopherol acetate (VE) from the histological and laboratory aspects of CCl4 Adm.L.,
    The results showed the protective factor of VE, because they had slight fatty degeneration, significant effects to GOT, GPT and albumin and increased concentration of cholesterol probably influenced by extrinsic factor, in acute phase of CCl4 Adm.L. for 4 weeks, treating with VE.
    In chronic phase of CCl4 Adm.L., no preventive data with VE were obtained.
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  • The effect of antioxidant agent (α-tocopherol acetate) in carbon tetrachloride administrated orytolagus liver disorders.
    II. The study of quantitative nintroblue tetrazolium test and lysosomal enzyme in white blood corpuscle
    Ryozi IZUMI, Ichiro NAKAYAMA, Isao YAMAZI, FUNASAKO, Yasuhisa HANANO, ...
    1975 Volume 16 Issue 2 Pages 95-99
    Published: February 25, 1975
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.16.95
    JOURNAL FREE ACCESS
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    Our study was to investigate the dynamics of lysosomal enzymes and nitroblue tetrazolium reduction test of W.B.C. in CCl4-administrated liver disorders (CCl4 adm. L.) and the action to the above enzymes of α-tocopherol acetate (VE) with the antioxidant agents.
    The results were as follows; The groups of CCl4 adm.L. were not discern more effective to VE but low activity in W.B.C. quantitative nitroblue tetrazolium reduction test, and also no significant correlation of W.B.C. lysosomal enzymes (β-gluculonidase and acid phosphatase) were obtained in chronic and acute phase of CCl4 adm.L.,
    The data with ultra-centrifugal fractions of W.B.C. concluded that VE had stabilizing factor because the lysosoma fractions in groups treating with VE was higher concentration than the groups of CCL4< adm.L.
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  • A Case of Idiopathic Acute Fatty Liver of Pregnancy
    Surviving After Treatment with Peritoneal Dialysis and Exchange Blood Transfusion
    Akira ICHINOHE, Masahiko IGARASHI, Takemi SASAKI, Naoyoshi TSUCHIYA, K ...
    1975 Volume 16 Issue 2 Pages 100-107
    Published: February 25, 1975
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.16.100
    JOURNAL FREE ACCESS
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    A 25-year-old primiparous woman was delivered of a female viable child on July 26, 1973, at full term. Immediately after delivery, she developed icterus, nausea, vomitting and oliguria with clouding of sensorium. Jaundice rapidly deepened, and she was rushed to our hospital on July 28. Because of oliguria and marked electrolyte imbalance, peritoneal dialysis was carried out immediately, which was followed by exchange transfusion using 6 liters of fresh blood. Sensorium was restore 24 hours after the start of treatment with improvement of electroencephalograms. Blood chemistry at the peak of disease included total protein of 3.8g, urea nitrogen 51mg, per 100ml, SGOT 60u. and SGPT 67u. Needle biopsy of the liver was carried out on the 28th hospital day, disclosing many fine fat droplets in the hepatocyte. The diagnosis of acute fatty liver of pregnancy was made.
    This seems to the first case that has ever survived this otherwise fatal disease treated with exchange transfusion. A review of the literature is ga ven with the discussion of treatment including exchange blood transfusion.
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1975 Volume 16 Issue 2 Pages 108
    Published: February 25, 1975
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.16.108
    JOURNAL FREE ACCESS
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