Kanzo
Online ISSN : 1881-3593
Print ISSN : 0451-4203
ISSN-L : 0451-4203
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Volume 46, Issue 1
Displaying 1-4 of 4 articles from this issue
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Editorial
Case Reports
  • A case of intraspousal transmission of HCV occurring after 50 years of marriage
    Michiyasu YAGURA, Akihisa TANAKA, Hajime TOKITA, Hiroshi KAMITSUKASA, ...
    Article type: Case Report
    2005 Volume 46 Issue 1 Pages 19-25
    Published: 2005
    Released on J-STAGE: November 24, 2006
    DOIhttps://doi.org/10.2957/kanzo.46.19
    JOURNAL FREE ACCESS
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    We reported a case of intraspousal transmission of HCV occurring after 50 years of marriage. A 72-year-old wife who had blood transfusion on delivery in 1955 was pointed out liver dysfunction in 1989 and had been followed up at our hospital since 1992. She was treated with interferon-α for 24 weeks in 1992 and 1994 with no response. On the other hand, a 77-year-old husband had been followed up at the near doctor because of diabetes mellitus and alcoholic liver disease since 1981. HCV Ab was negative on March 2000. On regular check-up, remarkable elevation of GOT 358 IU/l and GPT 700 IU/l was pointed out in September 2002 and referred to our hospital. Liver histology on admission was alcoholic fibrosis with hemosiderosis without piecemeal necrosis. Small amount of 3MU of interferon-α was administered b.i.w because of aging and diabetes mellitus since February 2003. HCV-RNA became negative after 7 months. Nucleotide sequence analysis of the 339 bases in the HCV NS5B gene by using serum from husband and wife demonstrated that both HCV was genotype 1b and 99.1% homology between them. Phylogenetic tree of HCV constructed by the neighhor-joining method showed that the spouses formed a significant cluster (100%). All possible routes of transmission were excluded by anamnestic evaluation except for sexual contact. From above findings, intraspousal transmission from wife to husband after 50 years of marriage was strongly suggested.
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  • A case of autoimmune hepatitis superimposed by Ukon-induced liver injury
    Yoshihide KIMURA, Manabu YAMAUCHI, Makoto NARITA, Norito OTANI, Seiji ...
    Article type: Case Report
    2005 Volume 46 Issue 1 Pages 26-32
    Published: 2005
    Released on J-STAGE: November 24, 2006
    DOIhttps://doi.org/10.2957/kanzo.46.26
    JOURNAL FREE ACCESS
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    A 50 year-old female developed jaundice after taking Ukon (a folk medicine made of Curcuma longa). Her clinical course and laboratory data including DLST fulfilled the criteria to a diagnosis with drug-induced ( “Ukon-induced” in this case) hepatitis. But, the abstinence from Ukon did not yield in complete recovery, and her residual hepatitis was then treated with prednisolone with a satisfactory outcome. She developed liver injury again 50 days after withdrawal of prednisolone, however, and at this stage her hepatitis was diagnosed as autoimmune hepatitis based on liver biopsy, positive SMA antibodies, and other findings. These two episodes of her hepatitis suggested the Ukon might have induced or triggered the development of autoimmune hepatitis de novo, or that her preexisting (cryptic) autoimmune hepatitis was affected by the superimposed Ukon-induced liver injury.
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  • A case of primary biliary cirrhosis exacerbating as acute hepatitis triggered by drug administration for malignant lymphoma
    Yasunobu FUKUDA, Hiroshi YOTSUYANAGI, Yoshiki KATAKURA, Toshiya ISHII, ...
    Article type: Case Report
    2005 Volume 46 Issue 1 Pages 33-40
    Published: 2005
    Released on J-STAGE: November 24, 2006
    DOIhttps://doi.org/10.2957/kanzo.46.33
    JOURNAL FREE ACCESS
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    A 56-year-old man, who underwent chemotherapy for non-Hodgkin lymphoma of central nervous system, was admitted four months after treatment for acute liver damage. Elevation of AST, ALT, bile duct enzymes and IgM was noted. Anti-mitochondrial antibody was positive. Liver biopsy specimen disclosed chronic active hepatitis with Scheuer's stage 1-2 primary biliary cirrhosis. Liver enzymes got normalized after treatment with ursodeoxycholic acid and bezafibrate. Acute onset of primary biliary cirrhosis may be associated with changes of immune response caused by chemotherapy or with immune response to other drugs.
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