Kanzo
Online ISSN : 1881-3593
Print ISSN : 0451-4203
ISSN-L : 0451-4203
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Volume 18, Issue 8
Displaying 1-14 of 14 articles from this issue
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  • Serum Protein Changes in Sera from Patients with Liver Diseases
    Yohei FUKUMOTO, Mikio NISHIOKA, Daizo KAN, Tomiko OKA, Toshihiko TAKEN ...
    1977 Volume 18 Issue 8 Pages 521-531
    Published: August 25, 1977
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.18.521
    JOURNAL FREE ACCESS
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    A concentration of 20 serum proteins, in 96 patients with various liver diseases, was measured by an immuno-diffusion. These data were analyzed statistically in consideration of a difference of age and sex.
    It was shown that some special diagnostic patterns of serum protein alteration in acute hepatitis, persistent hepatitis, subacute hepatitis, chronic liver diseases and primary hepatocellular carcinoma were obtained. In addition, haptoglobin, hemopexin, albumin and prealbumin were significantly lower and immunoglobulin G, A and α1-antitrypsin were significantry higher in the active stage of chronic hepatitis than in inactive stage. Albumin, prealbumin, α2-HS glycoprotein, hemopexin, haptoglobin and transferrin recovered within normal range in acute hepatitis whose prognosis was favorable. A decrease of albumin, prealbumin, transferrin, haptoglobin, hemopexin and α1-acid glycoprotein indicated the severity of the hepatic damage.
    These findings suggest that the serum protein profiles are useful for the diagnosis of liver diseases.
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  • The serum bile acid level in obstructive jaundice in early infancy
    Yusaku TAZAWA, Tasuke KONNO, Astuko SAKAI
    1977 Volume 18 Issue 8 Pages 532-539
    Published: August 25, 1977
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.18.532
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    Nonsulfated bile acids in the serum were analysed by a gasliquid chromatography ac-cording to Makino et al.'s (J. Lipid Res., 15: 132, 1974) and Nakayama's (J. Lab. & Clin. Med., 69: 594, 1974) procedures. In 9 patients with neonatal hepatitis (average age: 87 days), the mean values of total serum bile acid, cholic acid and chenodeoxycholic acid were 20.0μg/ml, 8.0μg/ml and 11.9μg/ml, respectively. The ratio of cholic acid to chenodeoxycholic acid ranged from 0.07 to 1.67 (mean: 0.86). Whereas, in 9 patients with congenital biliary atresia (average age: 60 days), the mean values of total serum bile acid, cholic acid and chenodeoxy-cholic acid were 17.3μg/ml, 6.7μ/ml and 10.6 μg/ml, respectively. The ratio of cholic acid to chenodeoxycholic acid was less than 1.00 in all sera from patients with congenital biliary atresia. Lithocholic acid known as a toxic monohydroxy bile acid could not be detected in all sera taken from infants with neonatal hepatitis and congenital biliary atresia.
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  • Significance of e antigen and e antibody in liver diseases.
    Masanori NAKAMURA, Kazuo OKOCHI, Shunichi KOGA, Toshitake IRISA, Hiros ...
    1977 Volume 18 Issue 8 Pages 540-547
    Published: August 25, 1977
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.18.540
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    Eighty-six patients with HBsAg positive liver disease were subjected for e antigen and e antibody detection. Two of 8 patients with acute hepatitis (25%), 12 of 26 patients with chronic active hepatitis (46%) and 6 of 37 patients with cirrhosis (16%) were positive for e antigen. None of 3 patients with chronic persistent hepatitis and of 12 patients with hepatoma demonstrated e antigen. GOT, TTT and γ-globulin levels were higher in chronic hepatitis patient with e antigen than in those without it. Greater histological changes were also found in e antigen positive patients. e Antigen were more frequently detected in patients with high HBsAg titer, especially in those showing 1: 512 or higher HBsAg titer by reverse passive hemagglutination. No correlation between age and the frequency of e antigen detection was observed. A case of acute type B hepatitis with transient e antigenemia attained complete recovery. This case suggested that demonstration of e antigen was not necessarily a marker of development
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  • Clinical course on patients with primary hepatocellular carcinoma surviving longer than one year.
    Mikio NISHIOKA, Hideo NISHIMURA, Toshinori HARADA, Kojiro SHIGETA, Kiw ...
    1977 Volume 18 Issue 8 Pages 548-554
    Published: August 25, 1977
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.18.548
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    Twelve of seventy patients with primary hepatocellular carcinoma (PHC) treated between 1969 and 1975 have survived more than one year after diagnosis. The number of such patients tended to increase in the past several years. This improvement is the result of earlier diagnosis and a recent advance in treatments.
    A history prior to the presentation with PHC, a clinical course and laboratory investigations were reviewed in 12 patients surviving longer than one year. PHC followed chronic liver diseases in 8 patients and 5 patients had diabetes millitus. HBs-antigen was present in the sera of 7 patients. It suggests that HBs-positive patients and patients with chronicliver diseases complicated with diabetes mellitus have to be followed up carefully.
    Serum albumin and peripheral blood lymphocytes decreased significantly and serum bililubin and ac-fetoprotein increased in the end stage of patients with PHC. It indicates that those factors may serve as prognostic indicators.
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  • Alcoholic cirrhosis with repated attacks of hepatitis
    Jiro TAKEBAYASHI, Kenji JINNO, Nobuya SASAKI, Nobuyuki YAMADA, Akiyosh ...
    1977 Volume 18 Issue 8 Pages 555-564
    Published: August 25, 1977
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.18.555
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    The patients in this study were 43 and 53 year-old men. They were constant drinkers and consumed over 150 g of ethanol per day for a period of 20 to 30 years before initial hospitalization. They had alcoholic hepatitis, with and without cirrhosis. Alcoholic hepatitis subsided after 2 months of admission. After hospitalization, the patient who had abstained returned to their previous drinking habits. They had repeated attacks of hepatitis on 6 to 7 occasions within a space of 4 to 5 years. Laparoscopic examination and liver biopsy were undertaken repeatedly during the 4 to 5 year follow-up period. In these observations, cirrhosis developed in one patient with alcoholic hepatitis within 2 years. In the other patients, the transition of portal cirrhosis to postnecrotic cirrhosis occurred within 1 year.
    In this report, it is revealed that alcoholic hepatitis plays a prominent role in the progressionof cirrhosis.
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  • An autopsy case report of primary hepatocellular carcinoma, cured by arterial infusion chemotherapy
    Shozo MIYAKE, Shigeharu MIMOTO, Tetsu WATANABE, Osamu SUZUKI, Yasuyosh ...
    1977 Volume 18 Issue 8 Pages 565-570
    Published: August 25, 1977
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.18.565
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    A 56 year-old male patient was admitted to the Nippon Kokan Hospital with a chief complaint of dullness in the epigastrium in Feburary, 1974. He was previously found to have asmall hepatic tumor in the right lobe during his first admission in Feburary, 1972, for the treatment of gastric ulcer. On physical examination the tumor mass was palpated and radioisotopic scanning of the liver using 198Au colloid revealed a "cold" area in the lower portion of the right lobe. Laboratory examination disclosed an elevated level of serum Alphafetoprotein as high as 10, 217 ng/ml by radioimmunoassay method. Selective celiac angiography showed that the tumor vessels were proliferated over the almost entire right lobe. Subsequently the one shot infusion chemotherapy using Mitomycin C 20 mg was performed through the Seldinger catherter wedged in the celiac artery. The immunological treatment with Hasumi Vaccine was started 4 days after the infusion chemotherapy. The hepatic tumor apparently responded to the therapy resulting in the diminution of the liver size which suggested a disappearance of the tumor. The level of Alpha-fetoprotein was returned to the normal range (8 ng/ml).
    One year and 10 months after the infusion chemotherapy, he died suddenly of the ruptureof esophageal varices.
    Histological examination revealed that there were no cancer cells in any portion of the liver. Moreover the liver was without cirrhotic changes, although there was a walnut sized scar tissue at the lower portion of right lobe of the liver and number of coiled branches of hepatic arteries and portal veins with thorombi occupied these fibrous tissues.
    These data suggest that this is a rare case of primary hepatocellular carcinoma resultingin complete cure by a combination of chemotherapy and immunological treatment.
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  • A case of human infecton of Fasciola sp.
    Tsutomu MATSUI, Masahiro TAMURA, Fumio YAMANAKA, Toshio HASHIMOTO, Tad ...
    1977 Volume 18 Issue 8 Pages 571-578
    Published: August 25, 1977
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.18.571
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    Besides this report, 22 cases of human infection with Fasciola hepatica have been reported in Japan.
    The present case is a 66 years old famer who has lived in Nara Prefecture since his birth.
    His complaints were irregular fever and discomfort sensation on the right hypochondrium.
    A clinical examination revealed high eosinophilia, increase in γ-globulin, IgG, IgM and IgE, and slight elevation of GOT, GPT, Al-P and LAP.
    A skin test with Fasciola hepatica antigen was positive.
    A precipitation bands were observed between the patient's serum and Fasciola hepatica antigen using the Ouchterlony double immunodiffusion method and immunoelectrophoretic method.
    Liver scintigraphy with 99mTc revealed a massive defect occupying the whole left lobe.
    Displacement of the left hepatic artery and the disappearance of its peripheral branches were observed on selective celiac angiogram.
    Laparoscopic examination showed a white and yellow coated nodular surface and a brownish green tumor on the inferolateral part of the left hepatic lobe.
    Microscopy of the liver specimen therefrom showed the presence of eosinophilic granuloma.
    Repeated examinations by the AMS III method revealed the presence of Fasciola eggs in feces, the size being 140μ and 62μ wide.
    The tumor in the left hepatic lobe disappeared by the daily dose of 50 mg/Kg bithionol on every other day for 40 days, and the clinical findings were improved during and after treatment.
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1977 Volume 18 Issue 8 Pages 579
    Published: August 25, 1977
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.18.579
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1977 Volume 18 Issue 8 Pages 580
    Published: August 25, 1977
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.18.580
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1977 Volume 18 Issue 8 Pages 581
    Published: August 25, 1977
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.18.581
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1977 Volume 18 Issue 8 Pages 582
    Published: August 25, 1977
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.18.582
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese]
    1977 Volume 18 Issue 8 Pages 583
    Published: August 25, 1977
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.18.583
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese]
    1977 Volume 18 Issue 8 Pages 584
    Published: August 25, 1977
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.18.584
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    1977 Volume 18 Issue 8 Pages 585-604
    Published: August 25, 1977
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.18.585
    JOURNAL FREE ACCESS
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