Kanzo
Online ISSN : 1881-3593
Print ISSN : 0451-4203
ISSN-L : 0451-4203
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Volume 18, Issue 2
Displaying 1-10 of 10 articles from this issue
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  • Lipoprotein patterns in hepato-biliary diseases
    Takashi ANDO, Emiko SHIMONAKA, Masae SAKAI, Masaka KAWADE, Hiroshi YOS ...
    1977 Volume 18 Issue 2 Pages 73-78
    Published: February 25, 1977
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.18.73
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    Serum lipoprotein patterns in hepato-biliary diseases were examined by agarose gel electrophoresis. Lipoprotein patterns were classified in 9 types in view of the concentration of stained lipoprotein bands and their mobilities. In most of decompensated liver cirrhosis, pre-β band disappeared. (type A). In most of obstructive jaundice and acute cholestatic hepatitis with increased total bilirubin concentration, p band was only band present on electrophoresis (type L). The type A-L in which β band was narrow and cc-band disappeared was a sign of poor prognosis. The observation of lipoprotein pattern seems to be useful for the judgement of diagnosis and prognosis in hepato-biliary diseases.
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  • A clinicopathlogical study of acute hepatitis (The 2nd report)
    Kenichi KOBAYASHI, Shoji KAMEDA, Tatsuho SUGIMOTO, Kunihiko SUZUKI, Ke ...
    1977 Volume 18 Issue 2 Pages 79-84
    Published: February 25, 1977
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.18.79
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    An attempt was made to find reliable indices for the early recognition of fatal cases of acute viral hepatitis, using the values of serum proteins with rapid turnover. Prealbumin and α2-HS glycoprotein were measured in the sera of 44 cases by immunodiffusion method before the appearance of hepatic coma and/or gastrointestinal bleeding. The difference of the mean values of prealbumin between fatal and surviving cases of subacute hepatitis was not statistically significant. However, there was statistically significant difference between both groups in the mean values of α2-HS glycoprotein. The present results indicate the possibility of differentiating fatal cases from surviving ones at an early stage, using the reduction of α2-HS glycoprotein by a simple and reproducible immunodiffusion method.
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  • Detection and Clinical Significance of HB Core Antibody (Anti-HBc) in Viral Hepatitis, Type B.
    Katsuyuki TOKUYAMA, [in Japanese], [in Japanese]
    1977 Volume 18 Issue 2 Pages 85-95
    Published: February 25, 1977
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.18.85
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    The immunofluorescent complement technique was found to be useful for detecting anti-HBc. The technique is relatively easy to apply and sensitive, and can also be used for detecting HBcAg in liver tissues, although the procedure is semi-quantitative.
    The incidence of anti-HBc by the technique was 65.7% in 105 patients with various liver diseases. Anti-HBc was detected by the method in 100% of 27 cases with HBsAg, in 74.1% of 28 cases with anti-HBs and in 44.0% of 50 cases without HBsAg and anti-HBs. Patients of chronic hepatitis with sublobular hepatic necrosis had a high incidence of anti-HBc (92.3%).
    The incidence of anti-HBc was not affected by the history of blood transfusion or jaundice in the patients, and by the elevation of s-transaminase in the donors.
    Presence of anti-HBc does not directly effect the clinical onset and prognosis of viral hepatitis, type B and is a good marker to differentiate it from non-B hepatitis. It is speculated that anti-HBc might be an infectious antibody.
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  • HBs-Antigen in Autopsy Cases with Special Reference to Cirrhosis of the Liver and/or Hepatocellular Carcinoma
    Akio ABE, Shinji KUTSUKAKE, Kihachiro SHIMANO
    1977 Volume 18 Issue 2 Pages 96-100
    Published: February 25, 1977
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.18.96
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    In order to investigate HBs-Ag in liver tissues, 74 autopsy cases with cirrhosis of the liver and/or hepatocellular carcinoma were examined using Gomori's aldehyde fuchsin staining method.
    Results were as follows: HBs-Ag was found in the liver about 32% of all the cases. In cirrhosis HBs-Ag was observed more frequently in female cases. In hepatocellular carcinoma about 40% of the cases were positive for this stain in which male and female were nearly similar in the ratio. HBs-Ag was positive in about 25% of alcoholics, while no HBs-Ag was found in liver tissues of hypertrophic cirrhosis with marked fatty metamorphosis. It was noticed that eight cases had had the familial history of liver diseases. Two cases were found to be positive for this stain in the same family in which liver diseases had been observed in a cluster. Some aspects of HBs-Ag in liver diseases were clarified by this staining method using autopsy materials.
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  • Specific Gamma-Glutamyl Transpeptidase Isoenzymes Occurred in Sera of Patients with Hepatoma
    Norio SAWABU, Masatoshi NAKAGEN, Masao YONEDA, Hiroshi MAKINO, Shoni K ...
    1977 Volume 18 Issue 2 Pages 101-108
    Published: February 25, 1977
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.18.101
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    In view of carcinoembryonic properties with respect to γ-GTP, we investigated whether or not the hepatoma specific γ-GTP isoenzyme was found in the sera of the patients with hepatoma. Fractionations of serum γ-GTP were carried out in sera from 123 patients with various hepatobiliary diseases including 22 with hepatoma by polyacrylamide gradient gel electrophoresis. The γ-GTP isoenzymes in sera were separated by this method into twelve bands. The band II which was seen in the region near to ceruloplasmin could be detected only in the six out of 22 patients with hepatocellular carcinoma, but not in the patients with other diseases. In addition to the II band, extra band (II′) which was occupied between II and III band was found in only three of these six patients. Neither of the other band was characteristic for any groups of patients studied. The discovery of this hepatome specific γ-GTP isoenzyme seems to make it useful to examine γ-GTP isoenzyme patterns by this technique as one of diagnostic indices for hepatoma.
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  • An autopsy case of subacute liver atrophy with numerous multinucleated giant liver cells
    Makoto YAMAMOTO, Seigo ITO, Toshihiro MIZUNUMA, Yuichi HASEDA, Yukihir ...
    1977 Volume 18 Issue 2 Pages 109-116
    Published: February 25, 1977
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.18.109
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    A 73-year-old female with Hashimoto's thyroiditis proven histologically, has been received replacement therapy for hypothyroidism since four years ago. She had suddenly increasing jaundice. The biopsy liver specimen on the 19th hospital day showed marked cholestasis, spotty necrosis and severe infiltration of small round cells in the portal tracts, focally lymphfolliculoid. In addition, many multinucleated giant liver cells were recognizable throughout the lobules. On the 82th hospital day, she died of hepatic failure due to subacute liver atrophy. Histological section obtained on autopsy showed less of multinucleated giant liver cells than the biopsy liver. Multinucleated giant liver cells contained many bile plugs in the cytoplasm, suggesting that these cells were formed by fusion of hepatocytes.
    She had also positive Coombs' tests, very high cold agglutinin titers and abnormal results of other serological tests. Therefore, it was suggested that the liver disorder in the present case occurred in association with an autoimmune basis.
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1977 Volume 18 Issue 2 Pages 117
    Published: February 25, 1977
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.18.117
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1977 Volume 18 Issue 2 Pages 118
    Published: February 25, 1977
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.18.118
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1977 Volume 18 Issue 2 Pages 119
    Published: February 25, 1977
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.18.119
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    1977 Volume 18 Issue 2 Pages 120-144
    Published: February 25, 1977
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.18.120
    JOURNAL FREE ACCESS
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