Kanzo
Online ISSN : 1881-3593
Print ISSN : 0451-4203
ISSN-L : 0451-4203
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Volume 23, Issue 10
Displaying 1-18 of 18 articles from this issue
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  • Mechanisms of bile formation and cholestasis
    J.L. Boyer
    1982 Volume 23 Issue 10 Pages 1113-1116
    Published: October 25, 1982
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.23.1113
    JOURNAL FREE ACCESS
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  • Association between an HLA haplotype and development of chronic liver diseases or seroconversion from HBeAg to anti-HBe
    Takeshi SODEYAMA
    1982 Volume 23 Issue 10 Pages 1117-1124
    Published: October 25, 1982
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.23.1117
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    In order to investigate the role of immunogenetic control in the seroconversion from HBeAg to anti-HBe and its relation to the development of HBsAg positive chronic liver diseases, HLA-antigens were examined in chronic HBsAg carriers and their prevalence was compared with that in healthy controls and patients with HBsAg negative liver diseases.
    One hundred and eighty-six subjects with positive HBsAg followed up for more than 1 year were eligible for this study. They comprised 95 asymptomatic HBsAg carriers and 91 with HBsAg positive chronic liver diseases. One hundred and ninty-four HBsAg negative healthy subjects and 50 patients with HBsAg negative liver diseases were served as control.
    When all subjects with positive HBsAg were taken together, there were no HLA-antigens which were of prevalence statistically significant as compared to those in healthy controls. HLA-B 13, however, was detected in significantly high prevalence in those HBsAg carriers who had HBeAg still over 30 years old, as compared with healthy controls (p<0.016, R.R.=15.7). Most of these carriers with HBeAg had chronic liver diseases. In contrast, this HLA-antigen could never be detected in those HBsAg carriers who had anti-HBe in less than 30 years old.
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  • The relationships between seroconversion from HBe antigen to HBe antibody and alterations of serum antiviral agent, suppressor T-cell function in peripheral lymphocyte and circulating immune complex in the patients with type B chronic liver diseases
    Masao NAKAJIMA, Kazuo TAKEUCHI, Yuzo ENDO, Toshikazu SHINBO, Hiroyuki ...
    1982 Volume 23 Issue 10 Pages 1125-1132
    Published: October 25, 1982
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.23.1125
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    The relationships were investigated between serum antiviral agent (below called IFN) altering at the time of seroconversion from HBe antigen to HBe antibody, the function of suppressor T-cell in the peripheral lymphocyte, and the circulating immune complex (below called IC). The subjects were 104 patients with type B chronic liver diseases in whom HBe Ag. Ab system was followed by the M.O. method for at least six months. Seroconversion to HBe Ab was seen in 14 of 30 patients with HBe Ag. One of the 14 showed reversed seroconversion back to HBe Ag.
    IFN showed a marked tendency to decrease from the HBe Ag phase to the HBe Ab phase, clearly reflecting the activity of the hepatitis. The function of suppressor T-cell in seven patients who were observed with the serial course showed a probably transient reduction when seroconversion took place.
    These alterations in IFN and suppressor T-cell function followed those of acute type B hepatitis exhibiting a satisfactory course.
    IC tended to show high values when seroconversion occurred, and normal values before and after it. This pattern was just the opposite of that of suppressor T-cell function.
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  • Clinical studies on the cases of anti-HBe-positive chronic hepatitis with acute exacerbation
    Takashi NISHIHARA, Gotaro YAMADA, Motowo MIZUNO, Yuzi SAKAMOTO, Shingo ...
    1982 Volume 23 Issue 10 Pages 1133-1140
    Published: October 25, 1982
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.23.1133
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    Out of twenty-two patients with chronic liver disease who had been positive for HBsAg and anti-HBe during more than 6 months, 5 patients with chronic hepatitis showed high elevation of s-GPT. Increase in DNA polymerase (DNA-P) activity and appearance of Dane particles in sera were recognized in 4 of these 5 patients. In one case, values of anti-HBe became transiently judge-pended at the time of exacerbation, though being stationary in remaining 3 cases. In the immunohistological study of a liver biopsy specimen from one of these cases, cytoplasmic HBsAg was diffusely distributed, but HBcAg was rarely recognized. In the fifth case, however, the simultaneous infection with non-A, non-B hepatitis virus in a carrier of hepatitis B virus was suspected, because the patient was transfused in operation about 2 months before the developed acute exacerbation without increase of DNA-P activity. On the other hand, 17 of 22 cases showed normal s-GPT and no appearance of DNA-P activity in their sera.
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  • Natural killer activities of peripheral blood lymphocytes in various chronic liver diseases and enhancement of natural killer activities by human IFN-α
    Nobuyuki HIRAI
    1982 Volume 23 Issue 10 Pages 1141-1149
    Published: October 25, 1982
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.23.1141
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    The natural killer (NK) activity of peripheral blood lymphocytes (PBL) from patients with various chronic liver diseases and controls was examined using 16 hr 51Cr-releasing cytotoxicity assay against YAC-1 and RSa cells. Partially, IFN-α was added in vitro to determine the degree of augmentation of NK activity against RSa.
    NK activity against YAC-1 was significantly higher in CAH & in LC than in controls or in CIH. NK activity against RSa was higher in CAH & in LC, while it was lower in LC+HCC than in controls.
    Augmentation of NK activity by IFN-α addition was observed in all cases tested. When 10000 IU/ml of IFN-α was added, the stimulation index of each group was not differ from one another.
    These results indicate that NK activity of PBL may be implicated with progression of chronic liver diseases, and that IFN may have an important role of controling the NK system even in chronic liver diseases.
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  • Percutaneous transhepatic portography
    Portography in portal systemic encephalopathy
    Motohide TAKASHI, Masahiko IGARASHI, Shinichi HINO, Hobuaki GOTOH, Hir ...
    1982 Volume 23 Issue 10 Pages 1150-1157
    Published: October 25, 1982
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.23.1150
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    In this study, the hemodynamics of the portal system and clinical findings were studied in patients with portal systemic encephalopathy but without hepatic failure. Seven cases of chronic recurrent encephalopathy (4 liver cirrhosis, 2 idiopathic portal hypertension, 1 Budd-Chiari syndrome) were examined and compared with twelve cases who had a gastro-renal shunt and/or splenorenal shunt but did not show encephalopathy as controls. The hemodynamic characteristics of portal systemic encephalopathy were: (1) blood of the superior mesenteric vein was flowing into systemic circulation, (2) the collateral channel was large and single, and (3) the portal vein and intrahepatic portal branches were narrow. The collateral channels were gastro-renal and/or spleno-renal shunts. There was no difference in portal vein pressure between the two groups. Esophageal varices were rare (one case) but gastric varices were often (three cases) in the encephalopathy group. There was no history of G.I. bleeding, and a history of ascites was elicited in only one case. High ICG retention, low molar ratio of amino acid (BCAA/AAA), and hyperammonemia following constipation were the characteristics of these seven cases. The total bilirubin, serum albumin and prothrombin time were not different from the control. The encephalopathy was well controlled by Lactulose or infusion of high concentrations of branched chain amino acid.
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  • Upper gastrointestinal bleeding in liver cirrhosis and alcohol ingestion
    Yuro SHIBAYAMA, Masafumi SAITOH, Kazuaki HASHIMOTO, Yoshikazu SAKAGUCH ...
    1982 Volume 23 Issue 10 Pages 1158-1165
    Published: October 25, 1982
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.23.1158
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    Gastrointestinal bleeding is a common complication in patients with liver cirrhosis and the main sources of hemorrhage are ruptured esophageal or gastric varices and acute gastric erosions. However, the mechanism leading to the onset of hemorrhage remains unclear, although some authors emphasize the importance of increased portal venous pressure in initiating a bleeding episode. We examined incidents related to the onset of hemorrhage in patients with liver cirrhosis, and we detected some patients with bleeding after alcohol intake. Then, we examined the effects of ethanol, its metabolite, acetaldehyde and catecholamine (epinephrine) released from the adrenal medulla and the adrenergic nerve terminals by ethanol and acetaldehyde on portal circulation, by means of the isolated perfused liver in the normal and cirrhosis rat. We clarified that ethanol itself have no effect on portal circulation. Acetaldehyde increased an intrahepatic portal vascular resistance in the normal liver, but not in the cirrhotic liver. Epinephrine increased markedly an intrahepatic portal vascular resistance in the normal and cirrhotic liver. Thus, it is possible that alcohol ingestion leads to the rupture of esophageal or gastric varices.
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  • Experimental studies on resectability of the liver in Hemorrhagic Shock
    Particulary in comparison with arterial and portal hemorrhage
    Mitsuo NENOHI
    1982 Volume 23 Issue 10 Pages 1166-1176
    Published: October 25, 1982
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.23.1166
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    Changes of liver function and resectability of the liver in hemorrhagic shock were evaluated after shock or preshock, which was induced in dogs by rapid and intermittent bleeding from the femoral artery (Group I) or the portal vein (group II), and maintained from 0 to 30 minutes, with or without hepatectomy.
    4 week survival rate was limited to within 15 minutes in shock in Group I, and to immediately after shock and within 15 minutes in preshock in Group II, respectively.
    When 40% hepatectomy was added in hemorrhagic shock, the survival rate was limited to immediately after shock in Group I, while in Group II 40% hepatectomy could not be tolerated even immediately after shock and it was limited to 40% hepatectomy immediately after preshock.
    ICG Rmax and plasma cyclic-AMP response to glucagon administration correlated well with their prognosis.
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  • Cruveilhier-Baumgarten disease
    Yi Qin LIN, Osamu HIDAKA, Tsutomu TOMIOKA, Takashi ORIBE, Ryozo YOSHIN ...
    1982 Volume 23 Issue 10 Pages 1177-1183
    Published: October 25, 1982
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.23.1177
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    A 51-year-old woman with cholecystolithiasis was transferred to Nagasaki University Hospital for an evaluation of splenomegaly, venous marking on the abdomen, and a small sized morphologically normal liver. Pancytopenia was pointed out by a blood examination. Esophageal varices were demonstrated by an esophagography. Computed tomography, ultrasonography and abdominal angiography revealed splenomegaly, non-cirrhotic small liver and patent umbilical and paraumbilical veins. A percutaneous transhepatic portography (PTP) demonstrated large tortuous umbilical and paraumbilical veins arising from the left portal branch, and then partially bypassed through the bilateral ileac veins into the inferior vena cava. A PTP portal vein pressure increased to 335mmH2O. According to these findings, preoperative diagnosis of Cruveilhier-Baumgarten disease was established. Laparatomy revealed a small sized, smooth surfaced liver, suggestive of diminished intrahepatic portal circulation and dilatated umbilical and paraumbilical veins. Splenectomy and hepatic periarterial neurectomy were performed on this patient to reduce the augmented portal pressure and to provide an increase of hepatic arterial blood flow. Splenectomy provided to reduce the portal pressure within normal limits. A morphologically normal liver was confirmed by a wedged biopsy of the liver. The postoperative course was uneventful with diminished esophageal varices.
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  • Primary sclerosing cholangitis: Report of two autopsied cases and a review of fifty-one cases reported in Japan
    Nobuyasu ITO, Akinori OISHI, Yukihiko TAMEDA, Yoshitane KOSAKA, Hideo ...
    1982 Volume 23 Issue 10 Pages 1184-1192
    Published: October 25, 1982
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.23.1184
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    Diagnosis of primary sclerosing cholangitis (PSC), especially in the exclusion of a bile duct carcinoma, is often difficult. Two autopsied cases with PSC are reported. A 80-year-old woman with localized lesion of the hepatic bile duct died 11 months later, despite external drainage. And, a 79-year-old woman with diffuse lesion of the extrahepatic bile duct died 1 month later by agranulocytosis.
    We have reviewed clinical features in fifty-one cases reported in Japan. Male to female ratio was 2:1, and age ranged 11-84 years, mean 54. Only 3 cases (6%) associated with chronic ulcerative colitis. 24 of 35 cases (69%) have been survived for a mean of 20 months but 11 cases (31%) died and a mean duration from onset to death was 13 months. The poor prognosis of cases with PSC in Japan may be due to a smaller number of cases following long periods.
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  • A case study of various histological changed minute hepatocellular carcinoma with special reference to ultrastructural observation
    Takafumi ICHIDA, Takashi KOJIMA, Mamoru NAKANO, Hiroshi NANASAWA, Kyoi ...
    1982 Volume 23 Issue 10 Pages 1193-1202
    Published: October 25, 1982
    Released on J-STAGE: January 19, 2010
    DOIhttps://doi.org/10.2957/kanzo.23.1193
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    A 64-year-old male with alcoholism was admitted to our hospital because of ascites. Diagnosis of liver cirrhosis was made based on clinical data and celiac angiography revealed tumor stain in the right hepatic lobe. Surgical enuclation of the tumor was carried out and light and electron microscopic study of the resected tumor (1.7×2.0×2.2cm diameter) was made.
    Histological findings showed the encapsulated tumor producing the bile and septal formation in some area of the tumor. The tumor mainly consisted of clear cells, but some parts revealed pseudoglandular pattern. Both globular and reticular hyaline bodies revealed the same staining pattern following luxal fast blue stain. Azan-Mallory's stain and PAS stain in the tumor cells.
    Electron microscopy showed that these bodies were composed of conglomerated fibrils with parallel array and randomly oriented arrangements. No membrane structure was detected arround the Mallory bodies and the fibrils revealed 100-200Å in diameter. No tumor cells derived from bile duct cells were detected in pseudoglandular pattern.
    Morphogenesis of the bodies in relation to minute hepatocellular carcinoma remains to be clarified.
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  • Minute hepatocellular carcinoma with obstructive jaundice: Report of a successful resection
    Toshiyuki KATO, Yukifumi SAITO, Masayuki NIWA, Kazuei OGOSHI, Shigeru ...
    1982 Volume 23 Issue 10 Pages 1203-1210
    Published: October 25, 1982
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.23.1203
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    A 36-year-old man was admitted with recurrent episodes of obstructive jaundice, epigastralgia and fever. Endoscopic retrograde cholangiogram revealed irregular filling defect in the common hepatic duct and nonfilling of the right hepatic duct. A tumor mass of hepatic duct was suspected.
    At operation a tumor mass (0.8×4.0cm) in the common hepatic duct was removed and its histological finding was hepatocellular carcinoma. Subsequently a second operation right hepatic lobectomy was performed successfully.
    The primary hepatocellular carcinoma of the right lobe was small (1.5×1.0cm) but it invaded the right intrahepatic duct forming a tumor mass (3.0×2.5×1.8cm) in the duct.
    Minute hepatocellular carcinoma which grows into the biliary tree and secondly obstructs is very rarely reported. The patient is well 10 months after hepatic lobectomy.
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  • Transcatheter arterial embolization in recurrent hepatomas
    Ryusaku YAMADA, Haruki NAKATSUKA, Kenji NAKAMURA, Morio SATO, Nobuyuki ...
    1982 Volume 23 Issue 10 Pages 1211-1215
    Published: October 25, 1982
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.23.1211
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    Transcatheter arterial embolization was performed in two patients with recurrent hepatoma. Case 1, a 65-year-old man, who had been undergone right hepatectomy for hepatoma 2 years ago, had a relapse of tumor in the stump of the residual liver. Middle hepatic artery which fed the tumor was embolized. After embolization, serum α-fetoprotein level markedly decreased from 28200ng/ml to 5ng/ml and follow-up angiography revealed complete disappearance of the tumor stain. Two years after embolization, this patient is still in healthy condition without re-elevation of α-fetoprotein level. Case 2, a 72-year-old male, was undergone wedge resection of hepatoma in the left lobe. Three years after the operation, angiography revealed multiple tumor stains in the both lobes. Bilateral hepatic arteries were embolized respectively. Sixteen months later, this patient is still alive with relatively good condition. It is concluded, therefore, that transcatheter arterial embolization is an effective therapy for recurrent hepatoma.
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1982 Volume 23 Issue 10 Pages 1216
    Published: October 25, 1982
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.23.1216
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1982 Volume 23 Issue 10 Pages 1217
    Published: October 25, 1982
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.23.1217
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1982 Volume 23 Issue 10 Pages 1218
    Published: October 25, 1982
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.23.1218
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1982 Volume 23 Issue 10 Pages 1219
    Published: October 25, 1982
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.23.1219
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    1982 Volume 23 Issue 10 Pages 1220-1247
    Published: October 25, 1982
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.23.1220
    JOURNAL FREE ACCESS
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