Kanzo
Online ISSN : 1881-3593
Print ISSN : 0451-4203
ISSN-L : 0451-4203
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Volume 19, Issue 1
Displaying 1-19 of 19 articles from this issue
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  • [title in Japanese]
    Leslie J. Schoenfield
    1978 Volume 19 Issue 1 Pages 1-8
    Published: January 25, 1978
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.19.1
    JOURNAL FREE ACCESS
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  • Studies on an out break of hepatitis A in an institute for the mentally retarted children
    Hideyasu NARA, Kenji SUZUKI, Takashi MOMMA, Masaomi OOKAWA, Hiroyasu K ...
    1978 Volume 19 Issue 1 Pages 9-21
    Published: January 25, 1978
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.19.9
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    The authors encountered an outbreak of acute hepatitis in an institute for the mentally retarted children in Aomori Prefecture.
    From the clinical and epidemiological investigations of affected 41 children and staffs, it was suggested to be typical out break of hepatitis A. Immune electron microscopy disclosed hepatitis A virus particles in stool specimens of four patients, which were collected in a few days before and after onset of symptoms. The antigen was further extracted and purified by ultracentrifugation.
    Subsequently, in the immune adherence hemagglutination test using this extracted antigen, a significant increased hepatitis A antibody of the paired sera was revealed. Thus, diagnosis of hepatitis A was confirmed serologically.
    Human immune serum globulin for protection against hepatitis was administered to the 80 individuals concerned, and was effective to prevent the manifestation of hepatitis A.
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  • A case with chronic nonhemolytic unconjugated hyperbilirubinemia
    (Crigler-Najjar syndrome Type II) with special reference of pathogenesis and classification of unconjugated hyperbilirubinemia
    Masaji NAMBU, Yuji YAMASHIRO, Yoko OIKAWA, Norio KOBAYASHI, Toshihiko ...
    1978 Volume 19 Issue 1 Pages 22-32
    Published: January 25, 1978
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.19.22
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    A patient, 40 year-old woman, with nonhemolytic unconjugated hyperbilirubinemia was reported. Jaundice was demonstrated in 9 of 11 siblings and all of them died at age three or four with kernicterus.
    Plasma disappearance of ICG and BSP showed normal initial disappearance. The serum bilirubin concentration was decreased and the bile bilirubin concentration was increased after an administration of bucolome. Most of the increased bilirubin in bile was ester form of direct bilirubin. Hepatic glucuronyltransferase revealed low activity. The elution pattern of liver supernate mixed with ICG or BSP remained the same as that of normal subject.
    These results suggest that the increased unconjugated bilirubin in the plasma is the results of a defect in hepatic bilirubin conjugation and of increased back flow of unconjugated bilirubin from the liver to the plasma.
    We classified unconjugated hyperbilirubinemias into four groups as follow: I, 1) Serum bilirubin concentration 10-50mg/dl, 2) The patient dies in infancy with kernicterus, 3) Familial occurrence is usual, 4) Effect of phenobarbital or bucolome on serum bilirubin is none. II, 1) 5-20mg/dl, 2) The patient survives into adult life. Kernicterus sometimes, 3) usual, 4) effective, III, 1) 2-5mg/dl, 2) The patient is well for life. Kernicterus never, 3) usual, 4) effective. IV, 1) 2-5mg/dl, 2) The patient is well for life. Kernicterus never, 3) never (?), 4) effective.
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  • Effects of choleretics on the erythritol clearance and BSP Tm in the dog
    Kenichi KITANI, Setsuko KANAI, Reiko MIURA, Miiko TSUCHIYA, Yoshiko MO ...
    1978 Volume 19 Issue 1 Pages 33-42
    Published: January 25, 1978
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.19.33
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    Changes in erythritol clearance, BSP Tm and bile salt excretion rate by choleresis induced by secretin, taurocholate, and bucolome were compared in dogs under pentobarbital anesthesia.Erythritol clearance was significantly increased by bucolome or by the increase in taurocholate infusion rate, while it was unchanged by secretin induced choleresis, with one exceptional study in which secretin administration increased erythritol clearance as well as bile salt excretion rate. BSP Tm was increased by the increase in taurocholate infusion rate but unchanged by either bucolome or secretin. These results are consistent with the view that the increase in BSP Tm by taurocholate is not due to the increase in canalicular bile flow but related with the excretion of taurocholate per se. One exceptional study in which secretin increased erythritol clearance and bile salt excretion rate suggests further study is needed for the understanding of the action of secretin which is usually thought to be a ductal (or ductular) choleretic.
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  • Studies on clinical significance of lipoprotein-X in the liver diseases
    (I) Appearance of an abnormal lipoprotein in rats with experimental cholestasis
    Toshihiko TAKENAMI
    1978 Volume 19 Issue 1 Pages 43-51
    Published: January 25, 1978
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.19.43
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    This study was carried out with D-galactosamine administrated rats and bile duct ligated rats, in order to throw some lights on the relationship between appearance of abnormal lipoprotein (Ab-Lp) and liver function. By the changes of liver function and histological findings, both animals showed liver injury with cholestasis. Then, Ab-Lp was detected in the sera of both animals by Bacto-agar electrophoresis. Electrophoretic patterns of these Ab-Lp seemed to be the same with rat lipoprotein-X which was reported by some investigators. As the conclusion, the appearance of Ab-Lp in the blood is closely related to cholestatic condition of the liver. However, the direct evidence of the mechanism of Ab-Lp formation is still remained unclear.
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  • Radioimmunoassay of ursodeoxycholic acid in serum
    Akiko TASHIRO, Hirosuke HASHIMOTO, Hisao TAJIRI, Toshio MIYATA, Akira ...
    1978 Volume 19 Issue 1 Pages 52-57
    Published: January 25, 1978
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.19.52
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    A sensitive and very specific radioimmunoassay for the measurement of serum ursodeoxycholic acid has been developed. Ursodeoxycholic acid-bovine serum albumin compound was used as antigen, and antiserum to this antigen was raised in rabbit. [11, 12-3H]-ursodeoxycholic acid was used as a radioactive tracer, and radioimmunoassay was carried out by the method of Simmonds et al. The percentage of bound radioactivity decreased linealy with a logarithmic increase in unlabeled ursodeoxycholic acid from 10 to 200 p moles. The antiserum showed extremely high specificity for ursodeoxycholic acid (free and conjugate), and the values by radioimmunoassay indicated a close correlation to those by gas-liquid chromatography. In normal subject, a small amount of ursodeoxycholic acid in serum was detected, and the level was 0.15±0.11n mole/ml. It seems that this conventinal radioimmunoassay could provide information about the metabolism of ursodeoxycholic acid in man.
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  • Studies on the clinical significance of oral galactose tolerance test
    Taizo HAYASHI, Shinichiro NAGAI, Yoshikiyo MISUGI, Shigeki TABA
    1978 Volume 19 Issue 1 Pages 58-66
    Published: January 25, 1978
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.19.58
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    Changes of blood lactate and pyruvate after 40g oral galactose tolerance test were examined in the healthy subjects and the patients with liver diseases and with diabetes. The findings of galactose tolerance test were classified 3 groups by the our standard previously reported, namely normal, moderate abnormal and far abnormal group.
    In the normal group, a transient significant elevations of blood lactate were observed after the loading. Blood pyruvate showed a transient increase such as lactate in both the healthy subjects and diabetics, but no significant changes in the liver diseases. In the moderate and far abnormal groups, the elevation of blood lactate and pyruvate diminished in order, and the peaks of these elevations deiayed compared with the normal group. After galactose loading the significant positive correlations between lactate and pyruvate were observed in healthy subjects and diabetics, but no correlation in the liver diseases. Contrary to the relationship of lactate and pyruvate, the significant negative correlations between lactate and NEFA were observed only in the abnormal groups after the loading.
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  • Serum thyroid hormone levels in patients with chronic Schistosomiasis japonica and liver diseases
    Kenichi KITANI, Masahiko IUCHI, Kyoko SHIBATA
    1978 Volume 19 Issue 1 Pages 67-74
    Published: January 25, 1978
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.19.67
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    The present investigation was carried out to clarify a possible hepatic involvement in balance of thyroidal hormones, especially in thyroxine T4→truodothyronine (T3) conversion, by means of CPBA for serum thyroxine biding capacity (TBC) measurement and RIA for serum T3, T4 and TSH measurements in 156 cases of Schistosomiasis Japonica complicated with liver diseases. TBC ranged within normal level in all groups of liver disease. T4 levels were normal or slightly higher, T3 levels were lower than normal level except in some hepatitic patients. TSH levels were generally higher. They were high in the cases of low T3 levels. There was no definite relation between T4 and TSH. In cirrhosis with sever hepatic dysfunction, T3 was low, TSH high and T4 normal or slightly lower. These findings suggest that human liver plays a signlficant role in T4→T3 conversion. It can be also suggested that TSH secretion is fed back by serum level of T3.
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  • Study on inhibition of hepatic fibrosis in rat induced with carbon tetrachloride
    Hitoshi KUWANA
    1978 Volume 19 Issue 1 Pages 75-81
    Published: January 25, 1978
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.19.75
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    Some experimental studies of L-azetidine-2-carboxylic acid (AZC) and colchicine were carried out to clarify their inhibitory effect on rat liver fibrosis induced with carbon tetrachloride.
    After treatments of AZC or colchicine, serum, urine and tissue levels of hydroxyproline were determined as measures of hepatic collagen synthesis and degradation. And also a few liver function tests and histological examinations were perfbrmed.
    Group II showed the increase of tissue level of hydroxyproline with the development of cirrhosis, cell necrosis and fatty degeneration. Group III and IV had significantly less histological changes, tissue hydroxyproline and liver functions were similar to those of normal levels. Moreover, the extent of hepatic fibrosis was remarkably decreased.
    These results show that AZC and colchicine seem to diminish liver damage with the inhibition of hepatic fibrosis.
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  • A case of accessory liver
    Tooru FUJIWARA, Kensuke TSUNEMITSU, Kohtaro UEDA, Akira NAMBA, Akio GO ...
    1978 Volume 19 Issue 1 Pages 82-85
    Published: January 25, 1978
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.19.82
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    In the malformations of liver, the occurrence of accessory liver is very rare. Since Wagner (1861) has first reported the accessory liver, the total number of the cases reported are twenty or so in literature till present.
    When we operated on a patient, a 45-year-old man, for cholelithiasis, we found accidentally a accessory liver beneath the fundus of the gallbladder. It sprang from the serosal surface of the gallbladder and was detached from the main liver.
    By histological examination, their fundamental structure was almost similar to those of the normal liver, but the arrangement of central veins and liver cell cords were irregular. And the accessory liver contained small bile ducts in its stalk which connected with the gallbladder.
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  • A case of giant hemangioma of the liver, associated with Kasabach-Merritt syndrome
    Satoshi KAKIUCHI, Shinsei TAGAWA, Kouichi HAMAGUCHI, Shigeki KATO, Kaz ...
    1978 Volume 19 Issue 1 Pages 86-92
    Published: January 25, 1978
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.19.86
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    A case of Kasabach-Merritt syndrome was presented.
    42 year-old man, Bank clerk, was admitted in this hospital because of fullness in the epigastrium. Liver edge was felt by 16 cm. below the tip of xiphoid process. Laboratory findings and ICG test were within normal limits, except slightly higherγ-GTP and LAP level .Diagnosis of huge hemangioma occuring mainly in entire parts of the left lobe and the quadrate lobe was confirmed through peritoneoscope and selective hepatic arteriography. Platelet number, facter V and fibrinogen level were found to be decreased. On the contrary, FDP level was increased. Scintiscanning using 131I-fibrinogen revealed significant increase in uptake of radioactivities coincidentry to region of the tumor, suggesting the presence of intravascular coagulation.
    Heparin and antiplasmin were given intravenously, although with no beneficial effect. The tumor was successfully resected. All of the coagulation factors returned to normal level rapidly after the operation. Resected tumor weighed 2500gr. Microscopically, cavernous hemangioma with positive signs for intravascular coagulation was confirmed.
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1978 Volume 19 Issue 1 Pages 93
    Published: January 25, 1978
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.19.93
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1978 Volume 19 Issue 1 Pages 94
    Published: January 25, 1978
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.19.94
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese]
    1978 Volume 19 Issue 1 Pages 95
    Published: January 25, 1978
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.19.95
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1978 Volume 19 Issue 1 Pages 96
    Published: January 25, 1978
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.19.96
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1978 Volume 19 Issue 1 Pages 97
    Published: January 25, 1978
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.19.97
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1978 Volume 19 Issue 1 Pages 98
    Published: January 25, 1978
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.19.98
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese]
    1978 Volume 19 Issue 1 Pages 99
    Published: January 25, 1978
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.19.99
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    1978 Volume 19 Issue 1 Pages 100-127
    Published: January 25, 1978
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.19.100
    JOURNAL FREE ACCESS
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