Kanzo
Online ISSN : 1881-3593
Print ISSN : 0451-4203
ISSN-L : 0451-4203
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Volume 19, Issue 9
Displaying 1-13 of 13 articles from this issue
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  • Studies on hepatic bile duct epithellal antigens in bile.
    Their origin, immunogenicity and tissue specificity
    Masaju SANO, Masahike ADACHI, Takao TAKEUCHI, Kenichi ITO, Satoaki MIM ...
    1978 Volume 19 Issue 9 Pages 835-839
    Published: September 25, 1978
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.19.835
    JOURNAL FREE ACCESS
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    The present study was conducted to confirm the presence of the antigens derived from hepatic bile duct epithelium in bile and to investigate cellular immunity to these antigens in patients with primary biliary cirrhosis.
    Antiserum to human bile protein was raised in rabbits and used in the following experiments. Three bile spepific proteins were demonstrated by double immunodiffusion method and eluted in the first fraction of Sephadex G-200 gel filtration. It was revealed, by immnofluorescence method, that some of them were derived from hepatic bile duct epithelium. No antigenic cross-reactivity was demonstrated between these antigens and hepatocyte membrane antigen (Meyer), thyroid, kidney, pancreas, uterus or skeletal muscle on two methods above.
    All of three patients with primary biliary cirrhosis showed positive LMT in the presence of these antigens. It was suggested that cellular immune respense to bile duct epithelial antigens play an important role in the pathogenesis of priary biliary cirrhosls.
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  • The study on hepatitis B anltigen and antibodies in heavy drinkers with chronic liver diseases in the Airin district
    Investigation with pathogenesis of chronic liver diseases in this district
    Masanori KAWA, Hitoshi ASAI, Kenichiro KIN, Shigeyoshi HARIHARA, Tetsu ...
    1978 Volume 19 Issue 9 Pages 840-847
    Published: September 25, 1978
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.19.840
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    In this district, patients without hepatic diseases gave a positive rate for HBsAg of approximately 2%, which is not so much different from the average of the entire Japanese population.
    Patiemts with chromic liver diseases gave an exceedixxgly low value of 5% (11 out of 244) for positivity of HBsAg. However, the positive rate for anti-HB antibodies (anti-HB and anti-HBc) accounted for 67% of patients withont hepatic diseases and 68% of patients with chronic liver diseases.
    It seems that infection with hepatitis B virus in adults, in many instances, terminates in a mere immune response of antibody production without establishing a chronic liver disease associated with a positivity of HBsAg.
    Changes that conform to the histological crlteria of alcoholic liver damage were seen in many instances.
    It may be pointed out that most of the chronic liver disease in this district seems to be caused by heavy drink of alcohol.
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  • A Study on the Interaction of the Therapeutic Agents for Hepatitis to the Damaged Liver Cells (2). Protection of Liver Cell Necrosis by the Synergistic Action of Glucagon and Insulin
    Kiwamu OKITA, Ken-ichi NODA, Yohei FUKUMOTO, Ryoko FUJII, Takahiro KOD ...
    1978 Volume 19 Issue 9 Pages 848-853
    Published: September 25, 1978
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.19.848
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    Generally speaking, acute hepatic failure accompanied with fulminant or subacute hepatitis is miserable in the therapy, so far. However, we have to make an effort to develope the suitable therapy. Recently we focus on the synergistic action of glucagon and insulin which was reported by Bucher and Swaffield. Although glucagon and insulin were simultaneously injected into the rat with D-galactosamine induced severe hepatitis, appearently the progression of the massive hepatic cell necrosis was blocked by this therapy. The both results by Bucher and us suggest the simultaneous injection of glucagon and insulin has two synergistic actions such as protection of progressive hepatic cell necrosis and promotion of hepatic regeneration. These results also suggest possible application of glucagon and insulin to the treatment of acute hepatic failure, theoretically.
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  • A Study on the Interaction of the Therapeutic Agents for Hepatitis to the Damaged Liver Cells (3). Application of Glucagon-Insulin Therapy to the Treatment of Acute and Chronic Hepatic Failure
    Kiwamu OKITA, Tsuyoshi AIBE, Shigeru KAYA, Masako MIYAZAKI, Masatomo Y ...
    1978 Volume 19 Issue 9 Pages 854-861
    Published: September 25, 1978
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.19.854
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    Theoretically, the therapy for acute hepatic failure aims at the protection of progressive hepatic necrosis and promotion of hepatic regeneration. In the 2nd report of this series, we confirmed that glucagon-insulin therapy will be satisfactory in this meaning and suggested possible application of this therapy for fulminant hepatitis. Therefore, we treated the cases of acute and chronic hepatic failure with glucagon-insulin therapy. As the conclusion, glucagon-insulin therapy improved appearently severe liver dysfunction and the mortality in these cases in comparison with our experiences before application of glucagon-insulin therapy. However, the biochemical mechanism of synergistic action of glucagon and insulin to protection of liver cell necrosis and promotion of hepatic regeneration is still unknown.
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  • Studies on anticomplementary activity of liver disease sera
    A comparison to that of multiple myeloma and systemic erythematosus sera
    Takao MORITO, Mikio SATO, Tomoe NISHIMAGI, Syukou SUZUKI, Morio MASAKI ...
    1978 Volume 19 Issue 9 Pages 862-870
    Published: September 25, 1978
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.19.862
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    Anticomplementary activity of 25 sera with low complement level of patients with liver cirrhosis and chronic hepatitis was examined before and after heating at 56°C for 30 min. Amticomplementary activity was founed more frequently in unheated sera at 88.0% than in heated sera at 56.0%. In 22 of 25 sera, anticomplementary activity was higher in unheated sera than in heated sera. Among them, anticomplementary activity of 4 sera was markedly diminished after heating. Such diminution of anticomplementary activity of liver disease sera after heating was similar to that of sera of patients with systemic lupus erythematosus and contrarily to that of multiple myeloma sera in which anticomplementary activity increased after heating.
    This heat labile anticomplementary activity in liver disease sera was not sensitive to mercaptoethanol and appeared at the descending part of the first peak of Sephadex G-200 chromatography of serum, in which a presence of immune complex was also detected by Clq radioimmunoassay.
    These findings could suggest that the heat labile anticomplementary activity might be immune complex consisting of Ig-G antibody.
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  • Percutaneous Transhepatic Portography
    III. Clinical significance of intrahepatic shunt index measured by this technique
    Hirotaka MUSHA, Kenichi TAKAYASU, Yukio NAKAJIMA, Hirohumi KOHEN, Hide ...
    1978 Volume 19 Issue 9 Pages 871-879
    Published: September 25, 1978
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.19.871
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    Using the technique of percutaneous transhepatic portal vein catheterization, measurement of intrahepatic shunt was carried out in 33 patients with various liver diseases, consisting of 26 cases of cirrhosis, 3 cases of idiopathic portal hypertension and 4 others. Intrahepatic shunt index in cases of liver cirrhosis was much higher than other cases. The degree of intrahepatic shunt was correlated with serum albumin level, plasma retention and hepatic extraction rate of ICG. It was also found that cirrhotic patients in whom intrahepatic shunt was of high degree tended to have jaudice, ascites and abnormal glucose tolerance test. Scan scores calculated from liver scintigram according to the method of Castell and Johnson were also correlated with intrahepatic shunt index. It was concluded that measurement of intrahepatic shunt in patients with portal hypertension is usefull in the estimate of hepatic functional reserve, prognosis of the liver disease and operative risk.
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  • Asialoglycoproteinemia in primary hepatic cancer and its clinical significance
    Gen SOBUE, Akira KOSAKA, Kiich ASAI, Takeshi HATTORI, Satoshi YOSHIKAW ...
    1978 Volume 19 Issue 9 Pages 880-885
    Published: September 25, 1978
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.19.880
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    A case of a remarkable asialo-glycoproteinemia is presented. The case is a 40-year-old male of primary hepatic cancer. Among various serum glycoproteins tested, the concentration of desialylated form was markedly elevated in α2-HS-glycoprotein, transferrin and α1-antitrypsin. The ratio of glycoprotein (asialo-component plus sialo-component) was within normal limit. On transferrin, asialo-component was widely changed in the course of the disease, and remarkably related to the size of hepatic tumor. Eight persons of three generations of his relatives were checked, but none of them had asialo-glycoproteins in their sera.
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  • Cancer of the Bile Duct-Clinical and Pathological Study of Intramural Infiltrating Type
    Atsuyoshi ONITSUKA, Nagaki MATSUBARA, Jinzoh FUKUDA, Ryoshoh TOMIDA, H ...
    1978 Volume 19 Issue 9 Pages 886-893
    Published: September 25, 1978
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.19.886
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    Carcinoma of the bile duct is classified into four types from the view point of surgical pathology: (1) diffuse infiltrating type, (2) intramural infiltrating type, (3) nodular type, (4) papillary type. Among them, the second type has some characteristics compared with others. Fifteen cases of this type were encountered at the First Department of Surgery, Gifu University Hospital since 1959. They were investigated both in clinical and pathological aspects and the following conclusions were obtained.
    (1) Obstructed end of the bile duct by neoplastic involvement shows figure of pointed tip of the U-shape on percutaneous transhepatic cholangiogram. (2) Histologic study reveales tumor tissue is highly scirrhous with well differentiated tumor cells. (3) It is not infrequent that tumor cell extends beyond the margin of surgical specimen even when resection was performed in apparently normal portion. (4) Survivors more than two years is occasionally found in the case who had only decompression procedure as a palliative treatment. (5) Even in the case where resection is impossible, decompression of biliary tract by drainage through tumor tissue is feasible because of its biological behaviour.
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  • Chemotherapy of liver cancer
    I. Treatment of hepatocellular carcinoma by intra-arterial infusion with cytostatic agent
    Mikio NISHIOKA, Kenichi NODA, Youhei FUKUMOTO, Takahiro KODAMA, Kiwami ...
    1978 Volume 19 Issue 9 Pages 894-900
    Published: September 25, 1978
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.19.894
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    Our experience in the treatment of inoperable hepatocellular carcinoma by the intra-arterial infusion with Mitomysin C (MMC) was reported. Of 26 patients given oral administration of 5Fu or FT-207, 5-10mg/kg of body weight/day, and intermittent intra-arterial infusion with 10-20mg of MMC, about 50% of the patients showed objective responses such as decrease of serum α-fetoprotein levels, decrease in distance of the liver edges from the costal margin and increased survival time. In the 27% of the patients, subjective responses were obtained. Of 13 control patients with hepatocellular carcinoma with oral adoministration of 5Fu or FT-207 alone, or intravenous injection of 4mg of MMC/twice a week, objective responses were observed in 7%. It indicates significant therapeutic effect of intra-arterial infusion of MMC on patients with Hepatocellular carcinoma.
    The best results were obtained for stage I of Vogel's functional classification of primary liver carcinoma. Patients with severe liver dysfunctions, decrease levels of peripheral lymphocytes, and high levels of serum alkaline phosphatase were unsuitable for such treatment.
    Siginficant decrease of serum hemoglobin levels were observed as a side effect of intra-arteral infusion of MMC.
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  • Prognosis of the patients with clinical symptom of acute hepatitis B
    Mineo KOJIMA, Nobuomi FUKUTA, Hiroshi HIROSE, Kazumichi UDO, Masaaki K ...
    1978 Volume 19 Issue 9 Pages 901-908
    Published: September 25, 1978
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.19.901
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    We studied on 43 patients with clinical symptom non-post transfusion acute hepatitis B who were admitted to our hospital and were followed up for more than three months, from January 1975 to 1977.
    The patients were divided into four types by high (210<) or low titer (29>) of anti-HBc and persistent or transient HBs antigenemia.
    The first type: negative or low titer of anti-HBc and transient HBs antigenemia was 35, the second type: high titer of anti-HBc and persistent HBs antigenemia was 3, the third type: high titer of anti-HBc and persistet HBs antigenemia was 5 and the fourth type: no negative or low titer of antiHBc and persistent HBs antigenemia was found.
    The liver histology was acute hepatitis in the first type of all ten cases, one of acute hepatitis and four of chronic hepatitis active stage in the third type, and one of acute hepatitis and chronic hepatitis active stage respectively in the second type.
    Compared between laboratry data of the third type and that of the first type, ZTT and AFP were higher significantly in the former than in the latter.
    In only four of the third type in all 43 cases, serum transaminase re-elevated after six to 12 months.
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  • Fifteen cases on eleven families of Rotor's disease special reference of pathognomy
    Toshihik NAMIHISA, Masaji NAMBU, Kazuro YOSHIDA, Yuji YAMASHIRO, Norio ...
    1978 Volume 19 Issue 9 Pages 909-916
    Published: September 25, 1978
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.19.909
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    The study on eleven families of fifteen patients with fulfilling criteria for Rotor's hyperbilirubinemia, in whom thirteen patients on ten families were observed in the suburbs of Naha City, revealed familial occurrence in at least thirteen cases. The detailed pedigrees were investigated on two families and it was suggested that Rotor's hyperbilirubinemia is inherited as an autosomal incomplete dominant trait.
    Serum bilirubin levels and plasma disappearance rate (K) and plasma retention rate (R) of indocyanine green (ICG) and sulfobromophthalein (BSP) were determined. The results were as follows; Serum bilirubin levels: total 5.6±2.6mg/dl (mean±SD), direct 3.5±1.3mg/dl. The direct bilirubin was dominant in thirteen cases, whereas the indirect bilirubin was dominant in two cases. KICG: 0.022±0.009 (n=14), R15ICG (retention rate at 15 minutes after intravenous injection of 0.5mg/kg BW of ICG): 63.9±13.6% (n=13), K.BSP: 0.028±0.006 (n=4), R30BSP (retention rate at 30 minutes after intravenous injection of 5.0mg/kg BW of BSP): 62.0±23.9% (n=5), R45BSP: 40.8±6.1% (n=7). The plasma disappearance rates were markedly low and the plasma retention rates were high in both ICG and BSP .
    Oral cholecystography was well visualized in 14 cases in whom it was performed. Biopsies of the liver were performed on 7 cases and the histologic appearance was almost normal.
    We advocate that Rotor's hyperbilirubinemia should be called Rotor's disease even in the case without familial occurrence, because this is characteristic in differential diagnosis of the constitutional hyperbilirubinemias.
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1978 Volume 19 Issue 9 Pages 917
    Published: September 25, 1978
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.19.917
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    1978 Volume 19 Issue 9 Pages 919-926
    Published: September 25, 1978
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.19.919
    JOURNAL FREE ACCESS
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