Kanzo
Online ISSN : 1881-3593
Print ISSN : 0451-4203
ISSN-L : 0451-4203
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Volume 15, Issue 12
Displaying 1-16 of 16 articles from this issue
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  • A study on the pathogenesis of the families clustered with HB antigen positive chronic liver diseases
    Kenichi NAKAJIMA, Tatsuo SIMIZU, Saburo ONISHI, Yukitoki IKEHARA, Jun ...
    1974 Volume 15 Issue 12 Pages 743-749
    Published: December 25, 1974
    Released on J-STAGE: May 26, 2009
    DOIhttps://doi.org/10.2957/kanzo.15.743
    JOURNAL FREE ACCESS
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    A study on the incidence of HB antigen and antibody was carried out in 15 families clustered with HB antigen positive chronic liver diseases. Higher incidence of HB antibody, which were expected from their contagious situation in their family was not found in the healthy and HB antigen negative children. It was noteworthy that the lowest incidence was encountered among the children with HB antigen positive mother. Low incidence of HB antibody among the siblings was observed in families in which their parents were negative in HB antigen and antibodys. HL-A typing study suggested some genetically determined aspects of the host against HB antigen. It was concluded that HB antigen infection in the state of immunological tolerance (intrauterus) and predisposition of the host were basically important for persistence of HB antigen in the family.
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  • Serum antinuclear antibody in patients with hepatitis B antigen positive chronic persistent hepatitis and asymptomatic hepatitis B antigen carriers
    Yoshiro TAMAI, Hiroshi HOSHIKA, Masadju SANO, Kenichi ITO
    1974 Volume 15 Issue 12 Pages 750-755
    Published: December 25, 1974
    Released on J-STAGE: May 26, 2009
    DOIhttps://doi.org/10.2957/kanzo.15.750
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    Serum antinuclear antibody (ANA) was looked for in 202 patients with chronic liver disease and eleven asymptomatic carriers of the hepatitis B antigen (HB-Ag).
    ANA was found in seven cases (70%) of ten HB-Ag negative autoimmune hepatitis. On the contrary, in three cases of HB-Ag positive autoimmune hepatitis, the antibody was not found. Eight (27%) of 29 HB-Ag positive chronic hepatitis (active and inactive) and two (18%) of eleven asymptomatic carriers showed positive test for ANA. None of the patients with chronic aggressive hepatitis and liver cirrhosis had positive test for ANA.
    It is noteworthy that ANA was present concurrently with HB-Ag in some patients with chronic persistent hepatitis and asymptomatic carriers.
    As it has bcen demonstrated that HB-Ag particles were located in nucleus of hepatocyte in the patients with chronic persistent hepatitis and HB-Ag carrier, as evaluated by electromicroscopy, ANA in the sera associated with HB-Ag may be antibodies against the altered nuclear substances.
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  • Developement of Hepatocellular Carcinoma from Chronic Hepatitis with Mild Fibrosis
    Toshio SHIKATA, Shigeyuki YAMAZAKI, Teruko UZAWA
    1974 Volume 15 Issue 12 Pages 756-762
    Published: December 25, 1974
    Released on J-STAGE: May 26, 2009
    DOIhttps://doi.org/10.2957/kanzo.15.756
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    About 50% of hepatitic cirrhosis give rise to hepatocellular carcinoma, though it is uncommon for hepatocellular carcinoma to combine other kinds of cirrhosis, except for hemochromatosis. Furthermore, HB antigen is detected in high rate among cases with hepatocellular carcinoma. Those evidences are suggesting intimate causal relationship between hepatitis virus and hepatocellular carcinoma. It has been naturaly considered, so far, that hepatocellular carcinoma might develop during destruction and regeneration of the hepatocytes in fully developed liver cirrhosis. However, about 8% of hepatocellular carcinoma combined with liver fibrosis and 86% combined with liver cirrhosis. Attempt was made to determine HB antigen in the liver tissue of liver fibrosis with hepatocellular carcinoma using staining methods by dyes. HB antigen was found in non-cancerous liver tissue of 40% of those cases. Therefore, it may be concluded that, those fibrosis is caused by chronic hepatitis and hepatocellular carcinoma may develop not only on liver cirrhosis but also on chronic hepatitis showing mild fibrosis.
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  • Monoclonal γ-globulinemia associated with hepatobiliary diseases
    with special reference to a case of liver cirrhosis & multiple myeloma
    Hajime FUNAHASHI, Tadashi KANO
    1974 Volume 15 Issue 12 Pages 763-770
    Published: December 25, 1974
    Released on J-STAGE: January 19, 2010
    DOIhttps://doi.org/10.2957/kanzo.15.763
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    The presence of monoclonal gammaglobulinemia in twenty-six cases of hepatobiliary diseases was documented. Monoclonal gammopathy is generally benign with rare exception of the potentially malignant type in these diseases. The relation of the time of discovery of M-component to that of hepatobiliary disease is not clear.
    It is worth noticing a case in which myeloma and serum hepatitis coexisted for seven years, ultimately transformed to liver cirrhosis. In myeloma patient there is an increase in myeloma globulin and decreased synthesis of normal immunoglobulins and the immunodeficiency state such as myeloma may modify the progression of serum hepatitis to liver cirrhosis.
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  • Studies on Primary Liver Carcinoma (II)
    Relationship bctween Chronic schistosomiasis Japonica of the Liver and Hepatocellular Carcinoma
    Masamichi KOJIRO, Toshiro NAKASHIMA, Kazuyoshi SAKAMOTO, Yasuhiko KUBO ...
    1974 Volume 15 Issue 12 Pages 771-778
    Published: December 25, 1974
    Released on J-STAGE: January 19, 2010
    DOIhttps://doi.org/10.2957/kanzo.15.771
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    The etiologic relationship between parasitic liver diseases and primary liver carcinoma has been disputed. The present study is based on 24 autopsy cases of hepatoma associated with chronic hepatic schistosomiasis japonica with the intention to elucidate such interrelation, if any.
    Of the 4, 611 adult autopsies carried out at the Kurume University School of Medicine, there were 24 hepatoma livers with schistosomiasis japonica, which constituted 10.6% of all 277 cases With schistosomal infestation of the liver, and 122 hepatoma cases constituted 2.78% of all non-schistosomiasis cases. The difference in frequency was statistically significant. However, in the majority of the cases, septal cirrhosis or the B-or A' type of cirrhosis by Miyake's classification was the predominant gross anatomical feature. Typical schistosomal changes were recognized in the nontumorous tissue in only 4 cases.
    The positive rate for HB Ag in these 24 cases was 27%, which was mucll higher than that of general population, suggesting a complicating viral hepatitis preceding the de. velopment of hepatoma. The serum level of alpha-fetoprotein was generally low compared with that in hepatoma without schistosomiasis, the positivity rate being only 43%by the micro-Ouchterlony method.
    Gross anatomically, the cirrhotic oligonodular type of hepatoma (Nakashima-Okuda's classification) was most common, including one case with minimal hepatoma. From th view point of pathological anatomy, as well as clinically, no differences were noted between the hepatoma that has arisen in a liver with cryptogenic or posthepatitic cirrhosis and hepatoma that has complicated chronic schistosomiasis japonica. Thus, it is not feasible to conclude that chronic hepatic schistosomiasis is etiologically directly related to hepatoma or primary liVer carcinoma.
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  • The Treatment of Chronic Hepatitis and Liver Cirrhosis with D Penicillamine
    Toshihiko SHIBA, Kazuo YOSHINO, Shigeru TAO, Hiroshi NAKANO, Yasuro YA ...
    1974 Volume 15 Issue 12 Pages 779-786
    Published: December 25, 1974
    Released on J-STAGE: January 19, 2010
    DOIhttps://doi.org/10.2957/kanzo.15.779
    JOURNAL FREE ACCESS
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    D-Penicillamine was administered to nine patients with chronic hepatitis and seven patients with liver cirrhosis for three to seven months. Relative small daily dosis of the drug (800mg) was employed in order to reduce adverse effects such as rash and fever. There was a marked clinical and biochemical improvement in four out of nine chronic hepatitis. Three of these four patients with chronic hepatitis had previously failed to improve with corticoids and/or immunosuppressive drugs. Histological improvement of the liver, including a decrease of cell infiltration and reduction of fibrosis, was observed in three patients with chronic hepatitis. No biochemical and histological improvement was demonstrated in nine patients with liver cirrhosis.
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1974 Volume 15 Issue 12 Pages 787-790
    Published: December 25, 1974
    Released on J-STAGE: May 26, 2009
    DOIhttps://doi.org/10.2957/kanzo.15.787
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1974 Volume 15 Issue 12 Pages 791
    Published: December 25, 1974
    Released on J-STAGE: May 26, 2009
    DOIhttps://doi.org/10.2957/kanzo.15.791
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1974 Volume 15 Issue 12 Pages 792
    Published: December 25, 1974
    Released on J-STAGE: May 26, 2009
    DOIhttps://doi.org/10.2957/kanzo.15.792
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1974 Volume 15 Issue 12 Pages 793
    Published: December 25, 1974
    Released on J-STAGE: May 26, 2009
    DOIhttps://doi.org/10.2957/kanzo.15.793
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1974 Volume 15 Issue 12 Pages 794
    Published: December 25, 1974
    Released on J-STAGE: May 26, 2009
    DOIhttps://doi.org/10.2957/kanzo.15.794
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese]
    1974 Volume 15 Issue 12 Pages 795
    Published: December 25, 1974
    Released on J-STAGE: May 26, 2009
    DOIhttps://doi.org/10.2957/kanzo.15.795
    JOURNAL FREE ACCESS
    Download PDF (844K)
  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese]
    1974 Volume 15 Issue 12 Pages 796
    Published: December 25, 1974
    Released on J-STAGE: May 26, 2009
    DOIhttps://doi.org/10.2957/kanzo.15.796
    JOURNAL FREE ACCESS
    Download PDF (732K)
  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese]
    1974 Volume 15 Issue 12 Pages 797
    Published: December 25, 1974
    Released on J-STAGE: May 26, 2009
    DOIhttps://doi.org/10.2957/kanzo.15.797
    JOURNAL FREE ACCESS
    Download PDF (729K)
  • [title in Japanese]
    [in Japanese], [in Japanese]
    1974 Volume 15 Issue 12 Pages 798
    Published: December 25, 1974
    Released on J-STAGE: May 26, 2009
    DOIhttps://doi.org/10.2957/kanzo.15.798
    JOURNAL FREE ACCESS
    Download PDF (65K)
  • [title in Japanese]
    1974 Volume 15 Issue 12 Pages 799-837
    Published: December 25, 1974
    Released on J-STAGE: May 26, 2009
    DOIhttps://doi.org/10.2957/kanzo.15.799
    JOURNAL FREE ACCESS
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