Kanzo
Online ISSN : 1881-3593
Print ISSN : 0451-4203
ISSN-L : 0451-4203
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Volume 24, Issue 8
Displaying 1-21 of 21 articles from this issue
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  • Serum sialic acid levels and serum sialyltransferase activities in patients with chronic liver disease
    Takaro ESAKI, Kiwamu OKITA, Masaaki OGINO, Masataka ODA, Wakako TSUBOT ...
    1983 Volume 24 Issue 8 Pages 829-835
    Published: August 25, 1983
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.24.829
    JOURNAL FREE ACCESS
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    We mesured the levels of serum sialic acid and sialyltransferase activities in the cases of chronic liver diseases.
    The levels of serum sialic acid was 7.2±0.8 μg/mg protein (normal subjects), 7.8±1.0 (chronic hepatitis), 7, 2±0.8 (liver cirrhosis) and 9.1±2.8 (hepatocellur carcinoma (HCC)). Its level in decompensated cirrhosis was lower than in compensated cirrhosis and in HCC of better condition Was significantly elevated.
    The elevation of serum sialic acid could be one of the markers suggesting existence of HCC in the course of chronic liver disease.
    Serum sialyltransferase activities was parallel to the levels of serum sialic acid among the cases of chronic liver diseases.
    Therefore, in conclusion, the elevation of those would reflect the abnormal carbohydrate metabolism in CanCer tissue.
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  • Clinical significance of a focal fat-free area in fatty liver
    Noboru HIROOKA, Masao OHTO, Kunio KIMURA, Yasuo IINO, Takashi SHINAGAW ...
    1983 Volume 24 Issue 8 Pages 836-843
    Published: August 25, 1983
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.24.836
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    Twenty-two patients with fatty liver who had a focal hypoechoic area mimicing primary liver tumor, demonstrated by ultrasound, were studied. Except for one case, the lesions were found only in the following three segments of the liver; (1) left lateral superior (5/22), (2) left medial, ventral part of the main trunk of the left portal vein (6/22), (3) in the right anterior segment near the gallbladder (10/22).
    Selective US-guided needle biopsy revealed that fat infiltration in the hypoechoic area was less than that in the surrounding hyperechoic area.
    The lesions showed characteristic findings in both echography and histology: a portal vein branch was found in the central portion of the area and the boundary of the area was defined by hepatic vein branches. These characteristics may be closely related with different hepatic perfusions between the lesion and the surrounding area. Based on this finding, it is proposed that a focal hypoechoic area representing a fat free area in fatty liver may be called "segmental pseudotumor".
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  • A morphological study on the chage of confluent necrotic areas in survivors from fulminant hepatic episodes as regeneration proceeds
    Shuichi SEKI, Narito KURIOKA, Shigeyoshi HARIHARA, Sukeo YAMAMOTO, Sus ...
    1983 Volume 24 Issue 8 Pages 844-852
    Published: August 25, 1983
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.24.844
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    We made a morphological study on the change of confluent necrotic areas in 7 patients with fulminant episodes as regeneration proceeded.
    In the early stage, there were drop-out of some sinusodal endothels, collapse of many sisusoids, and subendothelial formation of basement menbrane-like structures, a few months later, there was a rather decrease of sinusodal structures. So that, its decrease may be one of causes of portal hypertension.
    As the proliferative biliary epithelial cells, we could recognize "Clear cells" and "Dark cells", which had intracytoplasmic organells to various degree in development.
    Among them, dark cells with aboundant rough ER and free ribosomes played a major role of the formation of canalicular-ductular junction.
    Despite of the existence of visible lumen in light microscopy, the proliferated ductules were composed of the above descrived cells, so that the proliferation might arise in segments from the previouslyexistent biliary system.
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  • Long term follow-up of primary biliary cirrhosis: comparison of symptomatic and asymptomatic cases
    Yoshimi ITO, Masao OMATA, Katsuo UCHIUMI, Osamu YOKOSUKA, Junko MORI, ...
    1983 Volume 24 Issue 8 Pages 853-859
    Published: August 25, 1983
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.24.853
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    The clinical course of primary biliary cirrhosis was evaluated in 30 unequivocal cases for a mean follow-up period of 45.5 months. The 5 year survival of 18 symptomatic patients was 31.5%, whereas all of the 12 asymptomatic patients lived more than 5 years. The survival rate of the asymptomatic patients did not differ from that of the general population, matched by age and sex. In the asymptomatic patients, serum bilirubin remained less than 1.0mg/dl for 60 months. In contrast, the serum bilirubin rapidly increased from 4.4mg/dl to 10.4mg/dl within 40 months in the symptomatic patients.
    The clinical course and prognosis of asymptomatic P.B.C. markedly differed from that of symptomatic P.B.C..
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  • Diagnostic value of liver scintigraphy, computed tomography and ultrasonography of fatal hepatitis
    Hideshi KOMORI, Masahiro HIRASA, Yasuyoshi IBUKI, Masatoshi KUDO, Kats ...
    1983 Volume 24 Issue 8 Pages 860-869
    Published: August 25, 1983
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.24.860
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    The purpose of this study was investigate the diagnostic value of liver scintigraphy, computed tomography (CT) and ultrasonography in acute hepatic failure, subacute hepatitis and acute hepatitis.
    By scintigraphy low uptake in the liver and high uptake in the spleen and bone marrow were observed in hepatic failure.
    However, uneven liver edge and heterogenous RI destribution were not corresponded to massive necrosis.
    In fulminant hepatitis, liver size and other findings were variable in patient by patient. But in subacute hepatitis, the findings were typical.
    The finding of left lobe swelling was observed in a half of patients with acute hepatic failure based on chronic hepatitis.
    Localized low density area by the CT was detected in most of the cases of subacute hepatitis, and acute hepatitis with submassive hepatic necrosis. But in fulminant hepatitis, that was rare.
    In these cases, irregular and strong lesion was also obsurved by ultrasonography.
    These findings by the CT and ultrasonography were corresponded to massive necrosis histrogically ultrasonography revealed narrowing of hepatic vein in fatal hepatitis.
    Localized low density area by the CT in subacute hepatitis was shown surrounding hepatic vein. We conclude that divelopment of massine hepatic necrosis concern to secondary hepatic ischemia.
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  • A morphometric study on regeneration of the human liver following hepatectomy by computed tomography
    Eizo OKAMOTO, Naoki YAMANAKA
    1983 Volume 24 Issue 8 Pages 870-877
    Published: August 25, 1983
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.24.870
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    A morphometric study has been carried out on the restoration of remnant hepatic volume (RHV) after various extent of hepatectomy in humans by serial computed tomography in 15 non-cirrhotics, 14 cirrhotics and 7 hepatic failures. Restoration of RHV has been observed only in patients with more than 10% hepatectomy. In non-cirrhotics with major hepatectomy (RHV less than 600cm3), an early rapid increasing phase was followed by a subsequent decreasing phase and then a slow increasing phase. Decreasing phase was absent in most non-cirrhotics with moderate hepatectomy (RHV 600-1000cm3) and cirrhotics. Daily increase rate of RHV during the first posthepatectomy month was inversely proportional to the RHV at operation restoring invariably to 800-900cm3 at the end of this month. Termination of regeneration was within 6 months in non-cirrhotics with moderate hepatectomy and from 6 to 12 months in those with major hepatectomy. It was delayed in cirrhotics. RHV has finally attained to an average of 90% of preoperative hepatic volume in non-cirrhotics and 81% in cirrhotics. The restoration of RHV was extremely poor in hepatic failures.
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  • Comparison of left gastric venography by percutaneous transhepatic catheterization and esophagoscopy in the diagnosis of esophageal varices
    Motohide TAKASHI, Masahiko IGARASHI, Shinichi HINO, Hirotaka MUSHA, Ke ...
    1983 Volume 24 Issue 8 Pages 878-884
    Published: August 25, 1983
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.24.878
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    84 patients with portal hypertension were examined by left gastric venography by percutaneous transhepatic catheterization and esophagoscopy. In 65 patients, reversed blood flow of the left gastric vein was detected, it flowed into esophageal varices in 50, into the azygos and/or hemiazygos vein in 25, a gastro-renal shunt in 15 and small miscellaneous collaterals in 45 patients. Although 100% of F3 varices by endoscopy and 72.2% of F2 varices were visualized by venography, only 7.7% of F1 varices were detected by venography. The diameters of esophageal varices showed a correlation with the F-finding and the cranial level of esophageal varices was also correlated with the L-finding by esophagoscopy. Patients with esophageal varices greater than 3mm in diameter by venography showed a high incidence of hematemesis and red colour change of the varices. No patient presented the so-called "local hyperhemodynamic state" of the left gastric vasa in our series.
    Patients who had collateral circulation involving a gastrorenal shunt or thea zygos system showed a tendency to a lower incidence of hematemesis.
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  • Transplantation of woodchuck hepatocellular carcinoma in nude mice
    Kenichi KOBAYASHI, Kenichi FUKUOKA, Fumiaki MATSUSHITA, Hideo MORIMOTO ...
    1983 Volume 24 Issue 8 Pages 885-889
    Published: August 25, 1983
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.24.885
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    Woodchuck hepatocellular carcinoma has been successfully transplanted into nude (athymic) mice. The morphology of heterotransplanted tumor is similar to that of naturally occurring hepatocellular carcinoma before transplantation. The growth rate of transplanted tumors during the first month, only two tumors appeared. However, definitive tumor growth was noted in 6 out of 20 nude mice about three months later. Seventeen out of 20 nude mice exhibited sustained tumor growth after six months. The woodchuck hepatocellular carcinoma in nude mice provides an in vivo model for the study of oncogenesis of human hepatocellular carcinoma related to hepatitis B virus.
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  • Plasma exchange in chronic drug-induced intrahepatic cholestasis
    Hiroko OKA, Hiroko TSUTSUI, Shuichi SEKI, Yasuhiro MIZOGUCHI, Shigeyos ...
    1983 Volume 24 Issue 8 Pages 890-896
    Published: August 25, 1983
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.24.890
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    A 40 year-old woman who had been in K. hospital with diagnosis of cholestatic hepatitis and shizophrenia for 13 months was transtered to our hospital because of increasing jaundice and itching.
    Onset, clinical course and histological finding of the liver suggest haloperidol-induced chronic intrahepatic cholestasis. Treatment with cholestyramine, corticosteroid and phenobarbital was unhelpful, but plasma exchange using an plasma separator with 3-5 litre fresh frozen plasma relieved the symptoms, and lowered plasma lipid level and total bilirubin. The improvement in the degree of pruritus was dramatic.
    The symptoms of patient with chronic intrahepatic cholestasis are intractable to traditional therapy. We believe that plasma exchange is worthy of trial in patients with chronic intrahepatic cholestasis.
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  • Continuous ultrafiltration and re-infusion of diuretic resistant ascites after surgical operation
    Kunio HIRAI, Shingi IMAOKA, Yo SASAKI, Osamu ISHIKAWA, Kenzo TANIGUCHI ...
    1983 Volume 24 Issue 8 Pages 897-901
    Published: August 25, 1983
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.24.897
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    A patient, 51 years male, complained of diuretic resistant ascites after an operation for hepatomawith liver cirrhosis. This ascites contained many cells and much of fibrin.
    Therefore, ultrafiltration before re-infusion of ascites must be performed in order to avoid the development of complicatlons.
    At first, ascited was concentrated after ultrafiltration, and then infused intravenously. However, it was so difficult to obtain enough urine volume and maintain normal range of electrolyte. Therefore, all ascites was continuously infused without concentration immediately after ultrafiltration.
    Consequently, it brought to maintain of satisfied urine volume and normal serum range of electrolyte and protein.
    Finally, ascites markedly decreased not to be necessary to perform re-infusion, namely 7200ml to 500ml per day.
    Considering this progress, a method of continuous infusion after ultrafiltration of ascites is the recommended therapy for diuretic resistant ascites.
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  • A case of metastatic bronchial carcinoid of the liver with carcinoid syndrome
    Hajime SUJINO, Ichiro TAKAGI, Shinji KUTSUKAKE, Akio ABE, Kihachiro SH ...
    1983 Volume 24 Issue 8 Pages 902-908
    Published: August 25, 1983
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.24.902
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    This is a case study about carcinoid syndrome due to liver metastasis from bronchial carcinoid. The patient, a 59-year-old man, was admitted because of fever and abdominal tumor. During admission he had several episodes of fever, facial flushing, tachycardia and diarrhea. About two-thirds of the liver had been occupied by the tumor and the serum serotonin level was 0.69μg/ml and urinary 5-hydroxyindoleacetic acid was 64.1mg/24 hrs.
    The extended right lobectomy was carried out. The patient has experienced no carcinoid syndrome since that time. Histologic examination of the resected tissue revealed metastatic carcinoid tumor of which cells showed trabecular or ribbon and rosette-like structure, and were argyrophillic. Under electron microscopy specific secretary granules were identified in the cytoplasm of the tumor cells. These tumor cells could be cultured and observed by phase contrast microscopy. The value of serotonin secreted in the medium was 17.9ng/ml.
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  • An autopsied case of hepatocellular carcinoma with metastases to the heart and spleen
    Kentaro YOSHIOKA, Mayumi IZUCHI, Masayoshi OKAYAMA, Hayato MATSUNAGA, ...
    1983 Volume 24 Issue 8 Pages 909-913
    Published: August 25, 1983
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.24.909
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    A 67-year-old man admitted with the chief complaint of remittent fever. Liver scintiscan revealed poor up-take of the left hepatic lobe. Computed tomography and ultrasonography showed a large tumor mass of the left lobe. Carcinoma cells were shown by aspiration cytology under the real-time ultrasonic guidance, and then the diagnosis of hepatocellular carcinoma (HCC) was made. Celiac angiography revealed a large tumor stain in the left lobe, and one-shot arterial infusion of 20mg of mitomycin C was made. On the 51st hospital day, jaundice was noticed, and on the 62nd hospital day, the patient died of pulmonary congestion. Autopsy showed HCC with metastases to the lungs, lymphnodes, peritoneum, diaphragm, mesentery, vertebral bodies, heart and spleen.
    It is rare for HCC to metastasize to either the heart or the spleen.
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  • An autopsy case of hepatocellular carcinoma with metastatic gastric cancer like Borrmann type II and hyperlipidemia
    Satoshi NAKAMURA, Hiroshi MAKINO, Eisuke TAKAZAKURA, Akitaka NONOMURA
    1983 Volume 24 Issue 8 Pages 914-918
    Published: August 25, 1983
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.24.914
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    A 69-year-old man admitted to Kurobe City Hospital with a complaint of epigastralgia. He was diagnosed as having hepatocellular carcinoma by an increased plasma α-fetoprotein and the abnormalities of hepatic scintigram and selective celiac angiography. Endoscopic examination revealed ulcerative lesion of the stomach suggesting Borrmann type II and the specimens of the stomach by punch biopsy demonstrated tubular adenocarcinoma.
    Hyperlipidemia was present as a paraneoplastic syndrome.
    At autopsy, liver weighed 4170g without liver cirrhosis. Histologically, liver tumor was hepatocellular carcinoma (Edmondson; Gr. II) and gastric tumor with bile production was identical with liver tumor. But the tumor architecture of the stomach changed from trabecular pattern to tubular pattern near the site of gastric mucosa, and was concordant with the findings of the specimens by punch biopsy. Multiple tumor thrombi in the portal system suggested that hepatocellular carcinoma retrogradely metastasized stomach through the portal system.
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese]
    1983 Volume 24 Issue 8 Pages 919
    Published: August 25, 1983
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.24.919
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1983 Volume 24 Issue 8 Pages 920
    Published: August 25, 1983
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.24.920
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1983 Volume 24 Issue 8 Pages 921
    Published: August 25, 1983
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.24.921
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  • [title in Japanese]
    [in Japanese], R.G Thurman, Y Israel, [in Japanese], [in Japanese], [i ...
    1983 Volume 24 Issue 8 Pages 922
    Published: August 25, 1983
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.24.922
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1983 Volume 24 Issue 8 Pages 923
    Published: August 25, 1983
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.24.923
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1983 Volume 24 Issue 8 Pages 924
    Published: August 25, 1983
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.24.924
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1983 Volume 24 Issue 8 Pages 925
    Published: August 25, 1983
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.24.925
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  • [title in Japanese]
    1983 Volume 24 Issue 8 Pages 926-946
    Published: August 25, 1983
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.24.926
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