Kanzo

[title in Japanese]

[in Japanese], [in Japanese]

2003 Volume 44 Issue 5 Pages 187-193
Published: May 25, 2003
Released on J-STAGE: March 31, 2009

DOIhttps://doi.org/10.2957/kanzo.44.187

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The immunostimulatory effects of a traditional herbal (Kampo) medicine, Sho-saiko-to in mice

A possible influence on drug-induced lymphocyte stimulation test

Nobuhiro OHTAKE, Kenji WATANABE

2003 Volume 44 Issue 5 Pages 194-203
Published: May 25, 2003
Released on J-STAGE: March 31, 2009

DOIhttps://doi.org/10.2957/kanzo.44.194

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We evaluated the effects of Kampo-medicines (Sho-saiko-to, Keishi-bukuryo-gann and Mao-bushi-saishin-to), or various mitogens (concanavalin A, anti-CD 3 monoclonal antibody and lipopolysaccharide) on drug-induced lymphocyte stimulation test (DLST). BALB/c mice were administered orally with Sho-saiko-to (SST) or vehicle (Control). In Control splenocytes, Sho-saiko-to showed mitogenic activity, and the constituent herb Kanzo had the strongest activity. In SST splenocytes, cytokine production by anti-CD 3 and mitogenic response by all mitogenes and medicines were enhanced. Some modulations in immune response were found also in SST hepatic mononuclear cells. The immunostimulatory activity of Sho-saiko-to, as a polyclonal mitogen in vitro and as an immunopotentiator in vivo, may confuse the diagnosis for side effects of Kampo-medicines using DLST.

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Usefulness of contrast harmonic B-mode imaging in the diagnosis of hepatic focal nodular hyperplasia

Toshifumi TADA, Takashi KUMADA, Seiki KIRIYAMA

2003 Volume 44 Issue 5 Pages 204-210
Published: May 25, 2003
Released on J-STAGE: March 31, 2009

DOIhttps://doi.org/10.2957/kanzo.44.204

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We investigated the usefulness of contrast harmonic imaging in the characterization of focal nodular hyperplasia (FNH). Gray scale sonography, Doppler sonography and contrast harmonic imaging with ultrasound contrast agent Levovist^® were performed on five patients with clinically diagnosed five FNHs. All nodules were evaluated vascular phase (early vascular phase and late vascular phase) and post vascular phase after injection of contrast agent. Four nodules showed hypoechoic lesions and one nodule isoechoic lesion on gray scale sonography, and three nodules showed centrifugal pulstile signal on Doppler sonography. On contrast harmonic imaging, all nodules showed central arterial supply with centrifugal filling pattern in early vascular phase and enhanced an equal amount the liver in post vascular phase. Contrast harmonic imaging seemed to be a promising characteristic modality for the diagnosis of FNH.

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Indication and limitation of surgical treatment for hepatocellular carcinoma with tumor thrombus in the portal vein

Osamu YAMAZAKI, Mitsuharu MATSUYAMA, Katsuhiko HORII, Sadatoshi SHIMIZ ...

2003 Volume 44 Issue 5 Pages 211-221
Published: May 25, 2003
Released on J-STAGE: March 31, 2009

DOIhttps://doi.org/10.2957/kanzo.44.211

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One hundred and fifty patients diagnosed on imaging modalities between January 1994 and September 2001 were studied in terms of survival to investigate the indication and limitation of surgical treatment for patients with hepatocellular carcinoma and portal vein tumor thrombus (PVTT). Hepatectomy was performed in 24 (16%). Using Cox's regression model, the following independent prognostic factors were determined. 1) liver damage C or ascites, 2) more than 4 intrahepatic nodules, 3) patients without hepatectomy, 4) patients without transcatheter arterial embolization (TAE). In 53 non-surgical patients with liver damage C or ascites, median survival period and 1-year survival rate were 2.3 months and 6%, respectively. In 17 surgical patients with liver damage A or B without ascites, having no more than 3 intrahepatic nodules, the 1-, 3-, 5-year survival rates were 77%, 57% and 48%, respectively. Six of the 17 survived more than 3 years. The comparative survival rates for 15 patients who received TAE were 33%, 20% and 13% suggesting the usefulness of hepatectomy for patients with PVTT. However, in 7 surgical patients with liver damage A or B without ascites, having more than 4 intrahepatic nodules, 6 died of cancer within twelve months. The result of 1-year survival rate was 14% in surgical patients and 21% in 24 patients who underwent TAE. The independent prognostic factors particular in patients who received surgery were hepatic vein tumor thrombus and tumor macroscopic type.

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A study of combination therapy with IFN-β (twice a day) followed by rIFN-α 2b administered three times a week for 20 weeks in refractory chronic hepatitis C

Michio KATO, Akinori KASAHARA, Harumasa YOSHIHARA, Kazuhiro KATAYAMA, ...

2003 Volume 44 Issue 5 Pages 222-229
Published: May 25, 2003
Released on J-STAGE: March 31, 2009

DOIhttps://doi.org/10.2957/kanzo.44.222

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The usefulness of 3MIU of IFN-β administered twice daily for 4 weeks followed by 10MIU of rIFN-α 2b three times a week for 20 weeks was compared with 3MIU of IFN-β administered twice daily for 4 weeks followed by 10MIU of rIFN-α 2b three times a week for 12 weeks previously reported in patients with chronic hepatitis C having genotype 1b and high viral titers who are considered refractory to IFN treatment.
The rate of HCV RNA negativity at 24 weeks after the end of treatment was 16.7% (3/18) with the 10MIU of rIFN-α 2b three times a week for 20 weeks group. The pretreatment viral titers of the three patients with loss of HCV RNA were 2.1, 2.2 and 16.0Meq/ml.
The rate of HCV RNA negativity at 12 weeks after the end of treatment was 27.8% (5/18) in the 10MIU of rIFN-α 2b three times a week for 20 weeks group. This percentage was higher than that 15.8% (3/19) in the 10MIU of rIFN-α 2b three times a week for 12 weeks group. Furthermore, alanine aminotransferase (ALT) levels were normalized in 52.6% (10/19) in the 10MIU of rIFN-α 2b three times a week for 20 weeks group. This percentage was significantly higher than that 16.7% (3/18) in the 10MIU of rIFN-α 2b three times a week for 12 weeks group.
Intermittent administration following daily administration of IFN for 20 weeks was more effective than that for 12 weeks.

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Local recurrence of hepatocellular carcinoma with portal vein thrombosis after transcatheter arterial embolization and percutaneous ethanol injection therapy

Retrospective evaluation of three cases of resected hepatocellular carcinoma

Toshiro OGATA, Toshiya KAMIYAMA, Michiaki MATSUSHITA, Takakimi NAKAGAW ...

2003 Volume 44 Issue 5 Pages 230-236
Published: May 25, 2003
Released on J-STAGE: March 31, 2009

DOIhttps://doi.org/10.2957/kanzo.44.230

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A case of Toxocara cani infection with multiple hepatic nodules

Masashi HIROOKA, Norio HORIIKE, Eri KANEKO, Masanori ABE, Kojiro MICHI ...

2003 Volume 44 Issue 5 Pages 237-242
Published: May 25, 2003
Released on J-STAGE: March 31, 2009

DOIhttps://doi.org/10.2957/kanzo.44.237

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...

2003 Volume 44 Issue 5 Pages 243-244
Published: May 25, 2003
Released on J-STAGE: March 31, 2009

DOIhttps://doi.org/10.2957/kanzo.44.243

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...

2003 Volume 44 Issue 5 Pages 245
Published: May 25, 2003
Released on J-STAGE: March 31, 2009

DOIhttps://doi.org/10.2957/kanzo.44.245

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