Kanzo
Online ISSN : 1881-3593
Print ISSN : 0451-4203
ISSN-L : 0451-4203
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Volume 31, Issue 5
Displaying 1-21 of 21 articles from this issue
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  • Proleferative response of peripheral blood lymphocytes to recombinant hepatitis B core antigen in patients with hepatitis B
    Hiroshi HANADA, Mutsunori SHIRAI, Mikio NISHIOKA
    1990 Volume 31 Issue 5 Pages 493-499
    Published: May 25, 1990
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.31.493
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    The proliferation of peripheral blood mononuclear cells (PBMC) in response to recombinant hepatitis B core antigen (rHBcAg) was studied in patients with HBV infection. Significant proliferative responses of PBMC to rHBcAg were detected in patients with acute hepatitis B (AH-B), and HBeAg positive chronic active hepatitis B (CAH-B). There were no significant proliferative responses in other stages of HBV infection and control groups. A statistical correlation has been noticed between proliferation of PBMC and transamynase level in CAH-B. Proliferative responses decreased in convalascence stage of AH-B. As for proliferations of T-lymphocyte subsets, CD4+ cells responded to rHBcAg proliferatively but not GD8+ cells in AH-B and CH-B. rHBcAg-preactivated CD8+ cells inhibited the proliferation of CD4+ cells to rHBcAg. These results suggest that HBcAg specific lymphocytes may contribute to liver cell damage in HBV infection.
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  • Treatment of acute non-A, non-B hepatitis with interferon
    Masao OMATA, Minoru TADA, Kazuhiko HOSODA, Susumu TAKANO, Fumio IMAZEK ...
    1990 Volume 31 Issue 5 Pages 500-503
    Published: May 25, 1990
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.31.500
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    In order to prevent progression of acute non-A, non-B hepatitis, we have conducted a controlled trial with interferon. Eleven patients were treated with beta interferon, and 14 patients were served as untreated control. Chronicity rate at 12 month was 36% and 100% in treated and untreated, respectively. At 18 month of follow-up, 22% of treated and 100% of untreated patients with acute non-A, non-B hepatitis showed continued abnormality of liver function test. In addition, negative turn of anti-HCV antibody was observed in 3 of 6 in treated and in none of 9 untreated patients. These study revealed interferon treatment in acute phase may prevent the progression to chronicity.
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  • Interferon therapy on chronic type B hepatitis, defined as anti-HBe positive chronic liver disease with elevated transaminases
    Yasuji ARASE, Hiromitsu KUMADA, Kenji IKEDA, Kazuaki CHAYAMA, Satoru S ...
    1990 Volume 31 Issue 5 Pages 504-509
    Published: May 25, 1990
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.31.504
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    A few number of anti-HBe positive cases have active HBV reactivation and fluctuating or persistently elevated transaminase and have aggravated histollogically.
    We studied the efficacy of Alpha-Interferon (IFN) in chronic type B liver disease cases of anti-HBe positive chronic liver disease with elevated transaminase.
    The schedule of treatment was 6×106 Units of IFN given intramuscularly, two times weekly for three months. 14 of 24 cases had normal transaminases after three months.
    After the cessation of IFN treatment, in 6 of 8 cases GPT increased from normal value to abnormal value.
    Among 6 cases who were treated with IFN one time or two times weekly, GPT increased from normal value to abnormal value in one.
    IFN is effective in treatment of anti-HBe positive chronic type B hepatitis.
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  • Studies on complement systems in patients with primary biliary cirrhosis
    Takao MORITOH, Koichi SAITOH, Tomoe NISHIMAKI, Masahito KURODA, Tohru ...
    1990 Volume 31 Issue 5 Pages 510-515
    Published: May 25, 1990
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.31.510
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    Complement hemolytic activities (CH50, C3H50) and protein amounts of C3, C4 and split products C3d were studied in sera of patients with PBC, in which non-icteric patients were selected in order to avoid the influence of cholestasis on complement system. These complement values were considered from the points of complication of other autoimmune diseases in the patients and of granuloma in their liver.
    In the PBC patients without other autoimmune diseases, CH50 and C3d values were significantly higher than those of normal subjects (p<0.01), whereas C3 and C4 levels were normal. On the other hand, in the PBC patients complicated with other autoimmune diseases, CH50 levels were normal, whereas C4 levels were significantly lower than those of normal subjects (p<0.01). A positive correlation (p<0.05) between levels of C3 and C4 and also of CH50 and C3H50 were observed. In the PBC patients without other autoimmune diseases, mean levels of CH50, C3H50 and C3 of patients with granuloma in their liver were higher than those of patients without granuloma.
    These results would indicate that the complement system in PBC patients without other autoimmune diseases were activated through alternative pathway, whereas those in patients with PBC complicated with other autoimmune diseases were activated through classical pathway. Granuloma in the liver might be responsible for the abnormal activation of complement system.
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  • Cellular autoimmunity against bile derived autoantigen in patients with primary biliary cirrhosis
    Shinji IWASAKI, Takashi MAEDA, Saburo ONISHI, Yasutake YAMAMOTO
    1990 Volume 31 Issue 5 Pages 516-523
    Published: May 25, 1990
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.31.516
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    To determine the autoantigen involved in the bile duct injury in primary biliary cirrhosis (PBC), we purified antigens from human bile juice using SDS-PAGE and Western immunoblotting (WB). Corresponding antigen of rabbit antisera used in this study was proved to exist on microvilli of bileduct epithelial cell, but not on the bile canaliculi. Bile antigen fractionated by 30-50% satured ammonium sulphate was separated into two major protein bands (B1, B2) on WB using rabbit antisera. Lymphocyte proliferation against B1 was observed selectively in patients with PBC (p<0.01), and B1 stimulated T cell, not non T cell. B1 was bile specific sialoglycoprotein, which never react with anti MHC class I, MHC class II, anti secretory IgA, M2 positive PBC sera, anti laminin or anti type IV collagen. In conclusion B1 specific autoimmune mechanism is involved in the pathogenesis of PBC.
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  • Clnical signficance of the assay of 7S and type IV collagen in the sera of patients with various liver diseases
    Comparison wth P-III-P and laminin P1 concentrations
    Shogo IGARASHI, Naoya FUNAKI, Terumasa HATAHARA, Tohru INOUE
    1990 Volume 31 Issue 5 Pages 524-530
    Published: May 25, 1990
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.31.524
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    7S and type IV collagen concentrations in the sera of 293 patients wth various liver diseases were assayed.
    Normal values obtained from 20 healthy male adults were 3.48±1.10ng/ml for 7S and 99.3±24.8ng/ml for type IV collagen. Serum levels exceeding 5ng/ml for 7S and 140ng/ml for type IV collagen were defined as positive. Rate of positivity was higher in hepatocellular carcinoma (HCC) (86.1%), metastatic liver cancer (Meta-Ca) (73.3%), liver cirrhosis (LC) (76.9% for 7S and 66.2% for type IV) and alcoholic liver diseases (ALD) (41.2% for 7S, 55.9% for type IV). The assayed values were high in the order of Meta-Ca, HCC, LC and ALD. Between HCC with LC and without LC, assayed values were not significantly different.
    Coefficients of correlation between 7S and type IV in each disease groups were 0.55 to 0.83. In HCC, 7S and type IV showed high correlationship with laminin P1 or P-III-P.
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  • Dynamics of Ito cells in minimal hepatic fibrosis induced by local tissue damage
    Yasushi YAMAGUCHI, Yukio YOKOI, Kenichiro MASTUZAKI, Toshihiko NAMIHIS ...
    1990 Volume 31 Issue 5 Pages 531-535
    Published: May 25, 1990
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.31.531
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    We have found desmin, which is a cytoskeletal protein, in the cytoplasm of Ito cells (fat-storing cells) accompanied with actin, and have observed the dynamics of Ito cells by marking them with desmin in experimental fibrosis induced by the administration of carbon tetrachloride or heterogeneic serum and by local injections of high concentrations of ethanol into liver lobules. In this study we observed the relation between Ito cells and hepatic fibrosis by minimal liver damage, i.e. by injection of 0.05ml physiologic saline solution through a 27 gauge injection needle, or piercing by 27 gauge injection needle, or piercing by glass needle with the same diameter as the injection needle. In the first few days after treatment Ito cells having a swollen cytoplasm appeared around the necrotic area after injection or piercing, increased in number after mitosis, and then fibrosis appeared in the area where Ito cells gathered. On subsequent days Ito cell processes extended and attached to those of neighbouring cell, and formed fiber bundles. Ito cells decreased in number when fiber bundles formed a fibrous septa. These results strongly suggested that Ito cells had a important role in hepatic fibrosis and were precursor cells of myofibroblasts.
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  • Endotoxemia in patients with chronic liver diseases
    Evaluation of endotoxin assay and results by a new method of plasma pretreatment
    Hiroshi FUKUI, Munesuke MATSUMOTO, Shigenobu TSUJITA, Mototsugu MATSUM ...
    1990 Volume 31 Issue 5 Pages 536-542
    Published: May 25, 1990
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.31.536
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    We measured plasma endotoxin in 47 patients with chronic liver disease by The chromogenic substrate assay after conventional and our improved plasma treatment. Endotoxin in the precipitate after the perchloric acid treatment was neutralized and solubilized by adding triethylamine. Endotoxin concentrations in the supernatant and precipitate were measured by substrate S-2423, Toxicolor test® and Endospecy®. Irrespective of the kind of substrate the recovery rate of endotoxin in the supernatant in the conventional acid method was much lower than that in the heating method. In cirrhotics a large amount of endotoxin was detected in the precipitate. When total endotoxin concentraiton both in the supernatant and the precipitate was calculated by our new acid method, it was correlated negatively to serum albumin, cholinesterase, HDL-cholesterol and transferrin and was correlated positively to serum total bilirubin in chronic alcoholics. Endotoxemia detected by our new acid method may reflect spillover endotoxemia in chronic alcoholics.
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  • Wilson's disease -Two clinicopathological features with different prognosis-
    Hiroshi ICHIMIYA, Tomoyuki HIGUCHI, Naoki HISHIDA, Hisao HAYASHI, Nobu ...
    1990 Volume 31 Issue 5 Pages 543-549
    Published: May 25, 1990
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.31.543
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    For better understanding the disease entity, we evaluated the two clinico-pathological features, acute and non-acute forms of Wilson's disease. The liver histology of non-acute form was characterized by various combinations of parenchymal fatty change and portal fibrosis. The prognosis of non-acute form was excellent when penicillamine was administered. Patients with acute form died from acute hepatic failure associated with renal failure. The liver pathology specific to the non-acute form was superimposed by cholestasis, coagulative necrosis, submassive collapse, and poor regeneration. The data suggest that diagnosis before acute manifestation is essential in patients with Wilson's disease.
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  • Pulsed Doppler for tumor blood flow in hepatocellular carcinoma
    Kazuaki YASUHARA, Masao OHTO, Shoichi MATSUTANI, Yuusuke ARITA, Junji ...
    1990 Volume 31 Issue 5 Pages 550-557
    Published: May 25, 1990
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.31.550
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    By means of pulsed Doppler method, tumor blood flow of 79 hepatocellular carcinomas was studied. The waveforms of Doppler signals were divided into three types: high-speed pulsatile waveform (8 tumors), low-speed pulsatile waveform (43) and continuous waveform (60). In relation to the tumor size, detection rate of Doppler wave increased from 66.7 to 100% as the size increased. The speed of tumor blood flow also gained as the size increased.
    Comparative study of blood flow by Doppler method and hepatic angiography revealed three relations such as high-speed pulsatile wave and arterio-portal sbunting, low-speed pulsatile wave and tumor vessels, and continuous wave and tumor stain. In conclusion, pulsed Doppler method may be a useful technique in study of tumor blood flow in detail.
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  • Significance of systematic subsegmentectomy of the liver for hepatocellular carcinoma from the view point of the long-term result
    Susumu YAMASAKI, Hiroshi HASEGAWA, Masatoshi MAKUUCHI, Tadatoshi TAKAY ...
    1990 Volume 31 Issue 5 Pages 558-564
    Published: May 25, 1990
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.31.558
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    We have performed subsegmentectomies for hepatocellular carcinomas (HCC) in cirrhosis using ultra-sonic examination, considering intra-hepatic extension of HCC via the portal vein. Hepatectomized cases were divided into three groups by the operative procedure undergone: Non-anatomical partial resection (Group A, n=179), anatomical subsegmentectomy (Group B, n=117) and anatomical resection more than one segment (Group C, n=127). Cases with highly injured liver function were significantly more in Group A than other two, however, the grades of cancer extension in the three group were almost same. The 5-year survival rates were 45.1% in Group A and 48.3% in B. Those suggest that factors such as 1) even in small HCC indicated for small range resection, such as partial resection or subsegmentectomy, occult intrahepatic metastases are beyond the subsegment, 2) presence of multicentric carcinogenesis in cirrhosis and 3) how the effect of treatment for recurrences is, are stronger than the operative procedure, non-anatomical or anatomical.
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  • A case of early autoimmune chronic active hepatitis with clinically acute onset and histological features of acute hepatitis
    Toshinori KAMIYAMA, Namiki IZUMI, Shigeru KOJIMA, Katsuaki SUGIURA, Sh ...
    1990 Volume 31 Issue 5 Pages 565-569
    Published: May 25, 1990
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.31.565
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    A 61-year-old woman with acute history of jaundice and general fatigue was admitted to our hospital. Liver function tests revealed elevation of total bilirubin and transaminase, concomitantly with marked hyper gammaglobulinemia. Hepatitis B antigen/antibody and IgM hepatitis A antibody were negative. Liver biopsy specimen showed marked infiltration of the inflammatory cells, mainly consisted of plasma cells along the sinusoidal surface, and ballooning of the hepatocytes and some acidophilic bodies were noted.
    Serum antinuclear antibody, anti-smooth muscle antibody and anti-DNA antibody were positive, but LE cells were not detected. 20mg prednisolone was prescribed and rapid improvement was observed in transaminase, total bilirubin and gemmaglobulin. Six months later, second liver biopsy was performed, which revealed marked improvement of inflammatory cell infiltration. It is noteworthy that in a part of patients with autoimmune chronic acitve hepatitis, acute onset is occasionally seen clinically and histological features of liver biopsy are consistent with acute hepatitis. In such a case, even if the histological diagnosis of the liver biopsy is acute hepatitis, prednisolone administration shoud be started when clinical features are consistent with autoimmune chronic active hepatitis.
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  • A case of ruptured hepatic artery aneurysm with hepatic arterio-portal vein fistula
    Tadao HIROMURA, Yutaka MORITA, Hidekazu SANO, Yoshimi NAKANISHI
    1990 Volume 31 Issue 5 Pages 570-575
    Published: May 25, 1990
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.31.570
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    A 21-year-old man was referred to our hospital with the chief complaint of increasing gastrointestinal bleeding. He had sustained a penetrating abdominal injury 4 months ago and received a liver suture at that time. The patient then developed liver abscess and drainage was performed. Ultrasonography and computed tomography (CT) revealed a hepatic arterio-portal venous communication via the abscess cavity. Angiography showed that an aneurysm of the right hepatic artery ruptured into the abscess cavity which communicated with the portal vein. Surgical treatment failed because of persistent venous bleeding due to portal hypertension as well as the presence of massive adhesion around the porta hepatis. Transcatheter arterial embolization (TAE), however, was successfully performed. The sign of gastrointestinal bleeding and portal hypertension disappeared after TAE. CT showed that the abscess cavity was reduced with thrombosis. Therefore, the development of pseudoaneurysm is to be kept in mind following a traumatic abdominal injury. TAE should be made available as a first choice in the therapeutic procedure.
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  • Hepatic bile cyst, as a side effect of transcatheter oily chemoembolization
    Report of a case
    Shotaro TSURUTA, Satoshi MITSUOKA, Heiichiro TAJIMA, Masayoshi SHIMA, ...
    1990 Volume 31 Issue 5 Pages 576-580
    Published: May 25, 1990
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.31.576
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    A 74-year-old man was admitted because of a hepatic tumor. Since the diagnosis of hepatocellular carcinoma was obtained clinically, transcatheter oily chemoembolization (TOCE) was performed. The tumor size decreased markedly, but the recurrence of the tumor was also recognized. The second TOCE was performed five months after the first TOCE. A sterile hepatic bile cyst was detected by CT scan twenty four days after the second TOCE.
    Since bile ducts are supplyed predominantly by hepatic arteries, it appears that bile duct infarction and bile cyst formation occur due to the second TOCE in the case.
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  • Analysis of local immunological mechanisms involved in tumor growth inhibition in experimental hepatic tumor
    Hironobu KOHDA, Chihiro SEKIYA, Masumi KANAI, Yukinori YOSHIDA, Masayo ...
    1990 Volume 31 Issue 5 Pages 581-582
    Published: May 25, 1990
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.31.581
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  • Hepatic metabolism of insulin and glucagon in warm ischemic liver and the role of ischemic damage by Coenzyme Q10 pretreatment
    Kazuhiro HANAZAKI, Takai KURODA, Shoji KAJIKAWA, Naoto HORIGOME, Futos ...
    1990 Volume 31 Issue 5 Pages 583-584
    Published: May 25, 1990
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.31.583
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  • Diagnosis of hepatocellular carcinoma for ultrasound-guided biopsy specimen after indocyanine green injection
    Toshihiro HIGASHI, Masato TANIMIZU, Naoki KUWAHARA, Tatsurou TAKENAMI, ...
    1990 Volume 31 Issue 5 Pages 585-586
    Published: May 25, 1990
    Released on J-STAGE: January 18, 2010
    DOIhttps://doi.org/10.2957/kanzo.31.585
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  • Immunohistochemical study for PIVKA-II in hepatocellular carcinoma
    Ryuichi NOUNO, Masao YOSHITAKE, Shotaro SAKISAKA, Hideaki OGATA, Yasuo ...
    1990 Volume 31 Issue 5 Pages 587-588
    Published: May 25, 1990
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.31.587
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  • Prevalence of antibody to hepatitis C virus in heavy drinkers with liver disease
    Satoshi SHIMIZU, Kendo KIYOSAWA, Takeshi SODEYAMA, Eiji TANAKA, Kaname ...
    1990 Volume 31 Issue 5 Pages 589-590
    Published: May 25, 1990
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.31.589
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1990 Volume 31 Issue 5 Pages 591
    Published: May 25, 1990
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.31.591
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1990 Volume 31 Issue 5 Pages 592
    Published: May 25, 1990
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.31.592
    JOURNAL FREE ACCESS
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