Kanzo
Online ISSN : 1881-3593
Print ISSN : 0451-4203
ISSN-L : 0451-4203
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Volume 36, Issue 11
Displaying 1-9 of 9 articles from this issue
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  • [title in Japanese]
    [in Japanese]
    1995 Volume 36 Issue 11 Pages 629-632
    Published: November 25, 1995
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.36.629
    JOURNAL FREE ACCESS
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  • Liver damage and asymptomatic carriers based on long-term follow-up study in cases with positive HCV (C100-3, N-14) antibody
    Study coducted in a high-epidemic area of HCV clarified by mass survey
    Masahiko SAITO, Takumi KAJIKAWA, Kyuya HARA, Tadashi UMEZONO, Toshikat ...
    1995 Volume 36 Issue 11 Pages 633-639
    Published: November 25, 1995
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.36.633
    JOURNAL FREE ACCESS
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    We screened 200 positive HCV (C100-3, N-14) antibody cases out of 1315 inhabitants. No liver damage was found in 103 cases (51.5%). We further classified 166 cases, which were followed up for 9 years, into three types of liver damage; Normal, Fluctuant and Abnormal. Each type comprised 27.7%, 57.8% and 14.5% respectively. In Abnormal type the ratio of known causes of HCV infection was higher. Fluctuant type had the tendency to change to Normal or Abnormal in a long period. We randomly selected 16 cases from Normal type. The half of them were asymptomatic carriers and the remaining were formerly infected cases. The former had higher levels of GOT, TTT, and ZTT than the latter.
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  • Multicenter trial of 24 weeks' alpha interferon therapy for chronic hepatitis C
    Comparison between two different administration schedules
    Tadao OKUNO, Kazuya HIGASHINO, Tsutomu IMOTO, Teruji OHOKA, Hiroaki OK ...
    1995 Volume 36 Issue 11 Pages 640-648
    Published: November 25, 1995
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.36.640
    JOURNAL FREE ACCESS
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    Two hundred and seventy patients with biopsy-proven chronic active hepatitis C received 6 MU of human lymphoblastoid interferon (HLBI), three times weekly (TIW) for 24 weeks (group 1: 66 patients) or 6 MU of HLBI daily for initial 2 weeks followed by TIW injections for 22 weeks (group 2: 204 patients). At the end of therapy, 33 of 66 patients of group 1 (50.0%) and 101 of 204 of group 2 (49.5%) had normal ALT levels. Six months after the end of treatment, sustained responders were still similar in the two groups (24 or 36.9% vs. 70 or 34.5%). Serum HCVRNA was lost in 31 of 57 patients of group 1 (54.4%) and 90 of 161 of group 2 (55.9%) at the end of therapy. At a follow-up of 24 weeks after treatment, HCVRNA was undetectable in 37.5% of group 1 and in 29.2% of group 2. There was no statistical significance in both ALT normalization and loss of serum HCVRNA between the two groups. In conclusion, the TIW administration of HLBI to patients with chronic hepatitis C showed a sustained response rate comparable to that achieved with initial 2 weeks daily administration followed by TIW injections.
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  • Serum levels of TNF-α, TNF receptor and ICAM-1 in patients with acute and fulminant viral hepatitis
    Ichiro NAKADATE, Koichi ABE, Yasuhiro TAKIKAWA, Kazuyuki SUZUKI
    1995 Volume 36 Issue 11 Pages 649-656
    Published: November 25, 1995
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.36.649
    JOURNAL FREE ACCESS
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    We measured serum concentrations of TNF-α, soluble TNF receptor (sTNFR) and soluble ICAM-1 (sICAM-1) in patients with acute hepatitis (AH), acute hepatitis severe form (AHS), fulminant hepatitis acute form (FHA), fulminant hepatitis subacute form (FHS) and late onset hepatic failure (LOHF). On admission, serum levels of TNF-α, sTNFR and sICAM-1 were markedly elevated in patients with acute viral hepatitis. In particular, sTNFR in FHA was significantly increased compared with AH and AHS. The increases in TNF-α, sTNFR and sICAM-1 were ameliorated following admission in AH and AHS, while deceased patients with FH or LOHF showed further increase in TNF-α and sTNFR. Significant correlations were observed between these markers and biochemical or coagulative data. We conclude that measurement of serum concentrations of TNF-α, sTNFR and sICAM-1 is useful in predicting the prognostic feature of acute viral hepatitis.
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  • Protective effects of DBcAMP on endotoxin induced hepatopathy following a partial hepatectomy in rats
    Koichi KUDOH, Akitoshi KAKISAKA, Shinichi KASAI
    1995 Volume 36 Issue 11 Pages 657-663
    Published: November 25, 1995
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.36.657
    JOURNAL FREE ACCESS
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    In order to clarify the effect and machanism of extrinsic cyclic AMP on endotoxin induced hepatopathy following a partial hepatectomy, doses of dibutyryl cyclic AMP (DBcAMP) at 15 mg/kg were administered to rats which had been administered 3.0mg/kg of lipopolysaccharide (Et) 24h after a 70% hepatectomy (70% Hx).
    The survival rates were 10.0% for the 70% Hx + Et group (control group), 80% for the group which was administered DBcAMP at both 1h before 70% Hx and 1h before Et administration (A group). Good results were obtained from both liver function and histological findings in the experimental treatment groups. The serum TNF activity 1h after administration of Et was significantly decreased in the experimental treatment groups. Also, the liver tissue blood flow was maintained following administration of DBcAMP.
    The results showed that DBcAMP was very effective against endotoxin induced hepatopathy following a partial hepatectomy.
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  • The significance of re-hepatectomy for intrahepatic recurrence after hepatectomy for hepatocellular carcinoma
    Shingi IMAOKA, Yo SASAKI, Hiroshi NAKANO, Hiroshi FURUKAWA, Osamu ISHI ...
    1995 Volume 36 Issue 11 Pages 664-668
    Published: November 25, 1995
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.36.664
    JOURNAL FREE ACCESS
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    The treatment for intrahepatic recurrence after hepatectomy for hepato-cellular carcinoma was discussed. Of 397 radically resected patients, 187 patients with intrahepatic recurrence were subjected to this study. Three and five year survival rates after treatment were 79%, 79% in re-hepatectomy (n=31) and 41%, 13% in transarterial chemoembolization (n=142)(p<0.002). Three year survival rate in percutaneous ethanol injection therapy was 71% (n=14). On matching the background factors, survival rate in re-hepatectomy was significantly superior than in transarterial chemoembolization.
    This study results in the consclusion that re-hepatectomy can be chosen as the first preferable treatment for intrahepatic recurrence under some conditions.
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  • Glutathione S-transferase and c-jun gene expression in rat chemical hepatocarcinogenesis
    Kunihiko ISHII, Motonobu SUGIMOTO, Kinji ITOH
    1995 Volume 36 Issue 11 Pages 669-676
    Published: November 25, 1995
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.36.669
    JOURNAL FREE ACCESS
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    In order to elucidate the evolution of glutathione S-transferase (GST-P) gene expression and the relationship between GST-P and c-jun gene expression in rat chemical hepatocarcinognesis, immunohistochemical study of GST-P and Northern blot analysis of GST-P and c-jun gene were performed on the diethylnitrosamine (DEN) treated rat liver. Male Wistar rats were treated with DEN for 4 weeks (4W-group) or 8 weeks (8 W-group), and the livers were examined in every 4 weeks after DEN withdrawal till 16 weeks and 12 weeks, respectively. Immunohistochemically, in the 4W-group rats, hyperplastic nodules with positive GST-P were recognized, but hepatic cancer was not detected. In the 8W-group, hepatic cancer was recognized, but cancer cells were negative for GST-P. GST-P gene expression was apparently dependent on the period of DEN administration. It was about four times higher in the livers of 8W-group obtained at 4 weeks after withdrawal than those of 4W-group at the same period. The GST-P expression seemed to correspond with the growth of the hyperplastic nodules though it decreased in the liver with advanced cancer. On the other hand, c-jun gene expression did not correlate with GST-P gene expression, but increased in the liver with advanced cancer. Therefore GST-P gene expression might be regulated by other factors besides c-jun gene product.
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  • A case report of repeated hepatic resection for recurrent hepatocellular carcinoma with cirrhosis after the previous resection with chronic hepatitis 10 years ago
    Yoshikazu KOKUBA, Masahiro SUENAGA, Hidetaka YAMANAKA, Tsuyoshi HATSUN ...
    1995 Volume 36 Issue 11 Pages 677-682
    Published: November 25, 1995
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.36.677
    JOURNAL FREE ACCESS
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    We reported a rare case of repeated hepatic resection for recurrent hepatocellular carcinoma accompanied by chronic hepatitis and cirrhosis respectively. The patient was 63 years old male with the history of left hepatectomy for hepatocellular carcinoma associated with non-A non-B chronic hepatitis in 1982. In the postoperative periodic examination, his serological test for HCV 2nd generation has been positive since July 1992. Then he was diagnosed as recurrent hepatoma of the right anterior-inferior segment (S5) in August 1992 and underwent hepatic re-resection. The surgical specimen of partial hepatectomy showed well differentiated hepatocellular carcinoma with established cirrhosis microscopically. The patient was seronegative for HBs antigen and HBs antibody, and seropositive for HCV antibody. This results showed continuous HCV infection caused chronic hepatitis and cirrhosis with hepatocellular carcinoma, respectively. There were no previous reports of repeated hepatic resection in the both stages as in this case.
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese]
    1995 Volume 36 Issue 11 Pages 683-685
    Published: November 25, 1995
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.36.683
    JOURNAL FREE ACCESS
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