Kanzo
Online ISSN : 1881-3593
Print ISSN : 0451-4203
ISSN-L : 0451-4203
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Volume 16, Issue 12
Displaying 1-13 of 13 articles from this issue
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  • Biochemical Mechanism for Sequestration of Toxic Cadmium Ions in Rat Livers
    Takenobu KAMADA, Nobuhiro SATO, Toshihiko SUEMATSU, Fujiya FURUYAMA, F ...
    1975 Volume 16 Issue 12 Pages 841-850
    Published: December 25, 1975
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.16.841
    JOURNAL FREE ACCESS
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    The changes in mitochondrial respiratory activities and cytochrome concentrations of the liver were investigated when cadmium (Cd) was administered to the normal adult, normal young, and ethionine-fed adult rats (0.6% ethionine containing diet for twelve weeks).
    When 109Cd was given in vivo, it was accumulated predominantly in the liver supernatant. Adult rats following 7 days-administration of 30 ppm Cd as a drink water exhibited no change in liver mitochondrial function. However, young rats of 21 and 31 days old as well as the ethionine-fed rats treated in the same way as the adult showed an impairment of liver mitochondrial respiratory function. Cytochrome concentrations in liver mitochondria increased in Cd-administered, ethionine-fed rats, while mitochondrial protein increased with minimal change of mitochondrial cytochrome concentration in Cd-administered, young rat livers.
    It was found by the in vitro experiment that Cd was a strong uncoupler of oxidative phosphorylation, effective at a concentration of 5 × 10-7 M, and inhibited at 10-5 M the electron transfer between the substrate and cytochrome b in mitochondrial respiratory chain. When the adult rat liver supernatant was incubated either with adult or young rat liver mitochonrdrial suspension, the toxic effects of Cd on mitochondrial respiration significantly decreased. In contrast, the supernatant obtained from the young rats showed no effect. The liver supernatant obtained from 31 days old rats, pretreated with 3 mg of spironolactone per 25 g body weight for 3 days, had a prominent effect on diminution of Cd toxicity. It appers that the interaction of Cd with substance (s) in liver supernatant is of great significance for detoxification of Cd.
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  • Fasting serum bile acid level in chronic liver disease
    Chisato HIRAYAMA, Hironaka KAWASAKI, Shunichi KOGA, Toshitake IRISA, K ...
    1975 Volume 16 Issue 12 Pages 851-858
    Published: December 25, 1975
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.16.851
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    Fasting serum bile acid was extracted with Amberlite XAD-2 followed as determination with an enzymatic and fluorimetic technique. Normal value for serum bile acid was found to be 3±2n mole/ml. Serum bile acid was elevated markedly in acute viral hepatitis, and moderately in chronic liver disease, such as fatty liver, chronic hepatitis, liver cirrhosis and primary hepatoma in an increasing order. In chronic liver disease, serum bile acid level well correlated with a decrease of serum albumin and an increase of serum bilirubin, γ globulin, alkaline phosphatase, GOT and BSP rentention. These results sugget that fasting serum bile acid level is a good screening test for chronic liver disease to assess functional and morphological impairment of the liver.
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  • An application of leukocyte migration inhibition test in agarose medium to the diagnosis of 'hypersensitivity' type hepatic drug reactions
    Kiyotaka KAMEGAYA, Toshio MORIZANE
    1975 Volume 16 Issue 12 Pages 859-871
    Published: December 25, 1975
    Released on J-STAGE: January 19, 2010
    DOIhttps://doi.org/10.2957/kanzo.16.859
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    The identification of the offending drugs is often difficult in cases of unpredictable 'hypersensitivity' type hepatic drug reactions. The authors have applied leukocyte migration inhibition test in agarose medium developed by Clausen (1971) to the in vitro diagnosis of 'hypersensitivity' type hepatic injuries. This method proved to be useful and have some advantages compared to other in vitro immunological tests; namely, this method necessitates a relatively small amount of blood, no isotope is necessary, and the results come out in only 20 hours. The leukocyte migration inhibition occurred when liver specific antigen (Meyer zum Buschenfelde) mixed with drug was used as antigens in 10 out of 14 suspected cases of drug-induced hepatitis. The leukocyte migration inhibition test was negative when liver specific antigen mixed with drug was used as antigens in cases with generalized allergic manifestations as fever and skin rashes following drug administration and with normal liver function tests. In these cases the test was positive when autologous serum with drugs was applied as antigens.
    In summary, leukocyte migration inhibition test in agarose medium is very useful as an in vitro test for the diagnosis of 'hypersensitivity' type of drug-induced hepatitis, and the application of liver specific antigen with offending drugs is essential to the diagnosis of this type of hepatitis.
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  • The Prevalence of HBs-Ag and Anti-HBs in Young People in Gujo-gun, Gifu.
    Masaru SHIMIZU, Hidekatsu TAKAHASHI, MISAKO EGAWA, Naohiro OZAWA, Yosh ...
    1975 Volume 16 Issue 12 Pages 872-883
    Published: December 25, 1975
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.16.872
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    The frequencies of HBsAg and anti-HBs in 5, 128 people (80per cent of all) at the age of ten and from twelve to eighteen in Gujo-gun, Gifu, were 2.1% and 11.0%, respectively. These values are not so different from those reported in Japan. Overall the prevalence of HBs-Ag and anti-HBs increased from 10per cent of the age of eleven to 15 of that of fifteen, and thereafter kept the value throughout the age of eithteen. Therefore, it remains to investigate the frequencies of HBsAg and anti-HBs in much younger people in order to clarify the route of infection with HB-virus.
    Wide variation in the age prevalence of HBsAg and anti-HBs was found in the schools of villages or towns as well as in the hamlets within a same school area. Moreover, there was no relationship of the frequency of subtypes of HBsAg to that of anti-HBs in each grade of each school These suggest that HB-virus infection from carries with HBsAg would not occur in school life.
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  • Liver cirrhosis with two types of cytoplasmic inclusion bodies-A casc report
    Kennichi KAKUDO, Masami SAKURAI, Toru MIYAJI, Masamichi KUWASHIMA
    1975 Volume 16 Issue 12 Pages 884-888
    Published: December 25, 1975
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.16.884
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    Two types of cytoplasmic inclusion bodies, Mallory's alcohoic hyaline and HBs antigen, were found in a formalin fixed cirrhotic liver of morphologically alcoholic cirrhosis. Various histochemical methods were used to identify the inclusion bodies. It was found that the two types of the cytoplasmic inclusion bodies were quite different in their staining characteristics and in their distribution pattern in the liver. The alcoholic hyaline was distributed mainly in centrilobular area where fatty metamorphosis was severest, while the HBs antigen was distributed mainly in the lobules periphery where the fatty metamorphosis was mildest. No coexistence of the two types of inclusion bodies was found in a same hepatocyte. It appears that these inclusion bodies are quite different in quality.
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  • A case of secondary hepatic amyloidosis.
    Yoshiro KANDA, Yoshio FUKUYAMA, Hiromichi MORI, Toshio SUMIKOSHI, Taka ...
    1975 Volume 16 Issue 12 Pages 889-894
    Published: December 25, 1975
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.16.889
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    A 51 year old male presenting with marked hepatomegaly and laboratory data suggestive of metastatic liver carcinoma, is described.
    Amyloid deposition in the liver was uneven, the right lobe was affected more severely than the left lobe which was hypertrophied and showed only mild deposition.
    Liver scan mimicked multiple defects (false positive) and angiographic changes were compatible with different degree of amyloid deposition and compensatory hypertrophy of the left lobe.
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1975 Volume 16 Issue 12 Pages 895
    Published: December 25, 1975
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.16.895
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1975 Volume 16 Issue 12 Pages 896
    Published: December 25, 1975
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.16.896
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1975 Volume 16 Issue 12 Pages 897
    Published: December 25, 1975
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.16.897
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1975 Volume 16 Issue 12 Pages 898
    Published: December 25, 1975
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.16.898
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese]
    1975 Volume 16 Issue 12 Pages 899
    Published: December 25, 1975
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.16.899
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese]
    1975 Volume 16 Issue 12 Pages 900
    Published: December 25, 1975
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.16.900
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    1975 Volume 16 Issue 12 Pages 901-925
    Published: December 25, 1975
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.16.901
    JOURNAL FREE ACCESS
    Download PDF (1636K)
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