Kanzo
Online ISSN : 1881-3593
Print ISSN : 0451-4203
ISSN-L : 0451-4203
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Volume 37, Issue 10
Displaying 1-12 of 12 articles from this issue
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  • [title in Japanese]
    [in Japanese]
    1996 Volume 37 Issue 10 Pages 539-542
    Published: October 25, 1996
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.37.539
    JOURNAL FREE ACCESS
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  • Study of IFN-β retreatment for patients with chronic hepatitis C who had transient response to initial IFN-α treatment
    Eiki MATSUSHITA, Shuichi KANEKO, Hiroshi KAWAI, Shuichi TERASAKI, Atsu ...
    1996 Volume 37 Issue 10 Pages 543-548
    Published: October 25, 1996
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.37.543
    JOURNAL FREE ACCESS
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    We studied the efficacy of Interferon (IFN)-β retreatment (total amount: 336MU) in ten patients with chronic hepatitis C who had transient response to the initial IFN-α therapy (total amount: more than 480MU). Nine patients had HCV genotype 1b and one patients had genotype 2a. Their concentration of serum HCV-RNA was more than 106 copy/ml. Five of ten patients (50%) had complete response (four patients had HCV genotype 1b, one had genotype 2a): normalization of ALT levels lasting six months post treatment, and four of them (three patients had genotype 1b, one had genotype 2a) had undetectable HCV-RNA for at least 6 months. There was no relation between the efficacy of IFN-β retreatment and HCV genotype, concentration of HCV-RNA and histological diagnosis. But some of the patients who had genotype 1b and high concentration of HCV-RNA had sustained response, therefore IFN-β retreatment seems to be useful for patients with chronic hepatitis C responded transiently to initial IFN-α treatment.
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  • Six cases of cytomegalovirus hepatitis in healthy adults
    Hidetoshi KANEMASA, Masaharu OHTA, Noriaki KOBAYASHI, Motonari SAKAI, ...
    1996 Volume 37 Issue 10 Pages 549-555
    Published: October 25, 1996
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.37.549
    JOURNAL FREE ACCESS
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    We experienced 6 cases with cytomegalovirus (CMV) hepatitis in previously healthy adults. Clinico-pathological studies were done for these 6 cases, who were compared with 10 cases of EB virus (EBV) hepatitis. CMV hepatitis frequently occurred in young man and in summer or autumn. The common clinical signs were fever and hepatosplenomegaly. The serum transaminase was slightly elevated. In comparison with EBV hepatitis, CMV hepatitis occurred in significantly older hosts than EBV hepatitis. Serum GPT in the cases of CMV hepatitis was significantly less than that of EBV hepatitis. Histopathological findings of the two cases showed mononuclear cell infiltration in portal area and in sinusoids, hepatocyte necrosis and bile duct damage. Inclusion body was not noted.
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  • Utility of ultrasonic angiography in detection of viable lesions and their management in the follow-up of treated patients with hepatocellular carcinoma (HCC)
    Tohru GOTO
    1996 Volume 37 Issue 10 Pages 556-562
    Published: October 25, 1996
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.37.556
    JOURNAL FREE ACCESS
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    Ultrasonic angiography (US-angiography), which unmasks the presence of small tumors by detecting arterial blood flow, can be used for diagnosing HCC of a small size. This study applied the method for the follow-up of treated HCC patients. The subjects were 6 HCC patients who had been treated with percutaneous ethanol injection therapy (PEIT), transcatheter arterial embolization (TAE) or transcatheter chemoinjection therapy (TAI). Viable lesions were detected by both hepatic CT and angiography in 3 of the 6 patients, and no viable lesions were seen by either of the two methods in the other 3 patients. Viable lesions were also positive on US-angiography in the 3 patients of the former group, while a viable lesion was seen in one of the 3 patients of the latter group. Additional PEIT was performed in the 4 patients, who were positive on US-angiography, with favourable outcome. Furthermore, US-angiography helped determine the portion for PEIT. Thus, US-angiography seems to be useful in the follow-up and management of treated HCC patients, and gives important information for performing additional PEIT.
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  • Assessment of the efficacy of microwave coagulation therapy for hepatocellular carcinoma by imaging techniques
    Kenji SO, Kiyohide KIOKA, Yasuko MORIYOSHI, Hiroko OKA, Shigeyoshi HAR ...
    1996 Volume 37 Issue 10 Pages 563-571
    Published: October 25, 1996
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.37.563
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    Microwave coagulation therapy (MCT) was done for 17 patients with hepatocellular car- cinoma. Eight of these patients underwent hepatic resection following MCT, and the results were assessed and compared with diagnostic imaging. In the early phase of the dynamic CT, the areas of coagulative necrosis by MCT demonstrated a remarkable low density without enhancement in all cases. In the early phase of the dynamic MRI, these areas also showed an evident low intensity without enhancement in all cases. This coagulative necrosis was confirmed in the cases that underwent hepatic resection. A fibrous capsule was formed around the MCT-coagulative necrotic areas. This capsule showed a rim of high intensity at T2 of MRI and the early phase of the dynamic MRI, and consequentry the boundaries were clear. In the present investigation, persistent tumors were found in the irradiated areas in 6 of the 17 patients treated with MCT. Within one month after MCT, diagnosis of the residual tumors could be done in three of the six cases at the early phase of the dynamic CT. Within almost the same period, diganosis of the residual tumors could be made at T1 of MRI in one of the six cases, and at T2 as well as at the early phase of the dynamic MRI in four of the six cases, each. We concluded that CT and MRI are very useful in evaluating the therapeutic effect of MCT because they can clearly detect any residual tumors since the early post-MCT phase.
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  • A case of sporadic porphyria cutanea tarda in heavy drinker associated with hepatitis C virus infection
    Keiji NAKASHO, Takashi NISHIGAMI, Kunio UEMATSU, Akira KINUGASA, Shige ...
    1996 Volume 37 Issue 10 Pages 572-579
    Published: October 25, 1996
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.37.572
    JOURNAL FREE ACCESS
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    A 48-year-old man with sporadic porphyria cutanea tarda (S-PCT) associated with hepatitis C virus (HCV) infection is reported.
    The patient had a history of excessive alcohol (AL) intake and blood transfusion. Serological tests for anti-HCV antibody and HCV RNA demonstrated persistent HCV infection. Blood chemistry showed abnormality in the levels of transaminases and γ-glutamyl transpeptidase. In a biopsy specimen from the liver, histological features of chronic active hepatitis, including piecemeal necrosis and spotty necrosis was observed, indicating possible involvement of HCV infection. Histological features of pericellular fibrosis and central sclerosis that suggest alcoholic liver disease (ALD) was also present. In addition, a moderate deposition of hemosiderin and lipofuscin was recognized in hepatocytes and Kupffer's cells. HCV and AL were thus considered to be involved in main etiology of the patient's chronic liver disease.
    Taken together, the simultaneous presence of chronic hepatitis, ALD and hemosiderin deposit in a liver biopsy specimen from a heavy drinker with HCV infection is considered as an important histological finding which suggests PCT under routine, light microscopical observation.
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  • Two cases of liver cirrhosis complicated with recurrent hepatic encephalopathy and portal trunk thrombosis
    Masakazu KOBAYASHI, Tetsuya ICHIJO, Masanori KOBAYASHI, Akihiro MATSUM ...
    1996 Volume 37 Issue 10 Pages 580-587
    Published: October 25, 1996
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.37.580
    JOURNAL FREE ACCESS
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    We reported two cases of liver cirrhosis characterized by recurrent hepatic encephlopathy concomitant with portal vein thrombosis.
    The first case was a 52-year-old male with liver cirrhosis type C. A thrombus was detected in the portal trunk by ultrasonography three years after the first episode of hepatic encephalopathy. Angiography revealed a portal vein thrombus and the cavernoustransformation of portal vein at the hepatic hilus. The main cause of hepatic encephalopathy in this case was supposed to be hepatic failure.
    The second case was a 52-year-old male with liver cirrhosis type B. He presented hepatic encephlopathy three months after the detection of a portal vein thrombus by ultrsonography. Angiography revealed a portal vein thrombus and a shunt formation from the superior mesenteric vein to the left gastric vein. The main cause of hepatic encephalopathy was supposed to be an increase in blood flow into the porto-systemic shunt due to the formation of portal vein thrombus. As an etiology of portal trunk thrombosis in these two cases a thrombus was considered to be formed on the basis of liver cirrhosis.
    Clinical features were different between the above two cases after the formation of thrombus in the trunk, possibly depending on the degrees in the development of intrahepatic collaterals and in the formation of porto-systemic shunt.
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  • A case of alcoholic liver cirrhosis with multiple space occupaied lesions by 99mTc-phytate, 99mTc-GSA and 67Ga-citrate
    Kenji SOGA, Keiko AIKAWA, Muneatsu TOSHIMA, Koichi SHIBASAKI
    1996 Volume 37 Issue 10 Pages 588-595
    Published: October 25, 1996
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.37.588
    JOURNAL FREE ACCESS
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    A 42-years-old man with a history of chronic alcoholism was admitted to our hospital because of jaundice and abdominal fullness. He was diagnosed as alcoholic liver cirrhosis by physical and laboratory examinations. CT scan and US showed hepatic atrophy, remarkable ascites and splenomegaly, and liver scintigram of 99mTc-phytate showed almost negligible uptake of 99mTc. After about 40 months, liver scintigrams of 99mTc-phytate, 99mTc-GSA and 67Ga-citrate showed multiple space occupying lesions in the liver and CT scan revealed the irregularity of intrahepatic density. So that, we needed the differentiated diagnosis from hepatocelular carcinoma and metastatic liver tumor. Although, US and celiac angiography showed no mass in the liver.
    Therefore, these findings of liver scintigrams were considered to reflect the fibrotic scars after necrosis of hepatic cells and reticuloendothelial cells.
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1996 Volume 37 Issue 10 Pages 596-597
    Published: October 25, 1996
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.37.596
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1996 Volume 37 Issue 10 Pages 598-599
    Published: October 25, 1996
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.37.598
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1996 Volume 37 Issue 10 Pages 600-601
    Published: October 25, 1996
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.37.600
    JOURNAL FREE ACCESS
    Download PDF (143K)
  • [title in Japanese]
    1996 Volume 37 Issue 10 Pages 602-606
    Published: October 25, 1996
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.37.602
    JOURNAL FREE ACCESS
    Download PDF (858K)
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