Kanzo
Online ISSN : 1881-3593
Print ISSN : 0451-4203
ISSN-L : 0451-4203
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Volume 33, Issue 2
Displaying 1-15 of 15 articles from this issue
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  • Genotyping of hepatitis C virus and its clinical significance
    Nobuo TAKADA, Shujiro TAKASE, Akira TAKADA, Takayasu DATE
    1992 Volume 33 Issue 2 Pages 121-126
    Published: February 25, 1992
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.33.121
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    Hepatitis C virus (HCV) in Japan can be divided into the 4 genotypes, PT, K1, K2a, and K2b. However, clinical significance of the types of HCV is not well known. In the present study, genotyping of HCV was carried out in serum samples obtained from 71 Japanese, 12 Spanish and 11 Chinese with HCV related liver disease, using two different methods. In 58 non-cancer Japanese patients, K1 was 44 (75.9%), K2a was 9 (15.5%), and K2b was 4 (6.9%). PT was found in only one patient (1.7%) whose, hepatitis developed after transfusion of factor VIII preparation imported from the U.S.A. In 13 patients with hepatocellular carcinoma, K1 was found in 11 (84.6%). In particular, all alcoholic patients were positive for K1. In Spanish patients, K2 was not found in any cases. The prevalences were 38.5% (5 cases) for PT and 53.8% (7 cases) for Kl. In Chinese patients, the prevalences were 54.5% (6 cases) for K1, 36.4% (4 cases) for K2a, and 9.1% (1 case) for K2b. PT was not found in any cases. Thus, prevalences of HCV genotypes were quite different among the countries. These results suggest that the original type of HCV may be K1, and that PT may be a variant of the Western type, and K2 may be a variant of the Oriental type. These differences in the prevalences of the HCV types may be related to the difference of clinical features of HCV related liver diseases among the countries.
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  • Investigation of sequential changes occurring in hepatic lobules during the regeneration process after partial hepatectomy in rats, with emphasis on changes of the vascular system
    Reiko FUTAGAMI
    1992 Volume 33 Issue 2 Pages 127-138
    Published: February 25, 1992
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.33.127
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    The present study was performed to elucidate the actual regeneration process occurring after partial hepatectomy of the rat liver. Five-week-old male SD rats were subjected to two-thirds partial hepatectomy (PH), and vascular and lobular changes were investigated by means of an injection technique. In addition, cellular kinetics were studied with intraperitoneal administration of BrdU, and S-phase cells were detected immunohistochemically. Elongation and newly formed branching patterns of terminal portal, arterial and hepatic vein branches were recognized by the 3rd experimental day and increased thereafter. 28 days after PH, the terminal portal and hepatic vein branches of operated rats were recognized as 7th order, in clear contrast to the constant finding in control rats of 5th order during the present study. Dimensions of hepatic lobules in PH rats were larger than that of control animals during the entire experimental period of four weeks. Even on the 28th experimental day, the enlarged hepatic lobules of PH rats had not been restored to the size of control animals. The peak incidence of BrdU positive hepatocytes was noted 24 hours after the PH, with preferential localization in the peripheral zones of hepatic lobules. A relatively large number of BrdU positive periportal cellular elements and littoral cells were also detected on the 3rd experimental day. Special stress was laid on the important roles played by newly formed circulatory pathway in lobular hypertrophy and new lobular formation after PH.
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  • Vascular changes of the liver surface in chronic liver disease: A magnifying laparoscopic study
    Keiji SHIRASAKI, Akitaka SHIBUYA
    1992 Volume 33 Issue 2 Pages 139-146
    Published: February 25, 1992
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.33.139
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    Changes of the vascular pattern were investigated in patients with chronic liver disease using magnifying laparoscope, and were compared with histological finding. The earliest vascular change observed on the liver surface was an increased number of portal veins, which, however, decreased with the progression of disease, particularly in advanced liver cirrhosis. By contrast, the portal vein increased in size in liver cirrhosis. The features of arteriole, such as an increase in number, tortuosity, and network formation, were characteristically seen in advanced cirrhosis. Increased number of portal veins with few arterioles were the principal laparoscopic finding in patients without esophageal varices, whereas decreased number of portal veins with increased arterioles were seen predominantly in patient with esophageal varices. It is concluded that capsular vasculature in chronic liver disease is closely related to the intrahepatic derangement, by means of which magnifying laparoscopic feature can be shown to be a highly relevant indicator to the diagnosis of chronic liver disease.
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  • Clinical significance of serum level of thrombomodulin in several liver diseases: especially in acute liver failure
    Kenji MORI, Hiroyuki SHIRASAWA, Michiari OKUDA, Kozo KAYANO, Aogu YAMA ...
    1992 Volume 33 Issue 2 Pages 147-152
    Published: February 25, 1992
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.33.147
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    We measured serum level of thrombomOdulin (TM), which is known to be a maker of injured vascular endothelial cell, in several liver diseases. In the patients of acute liver failure, significant increase of serum level of TM was observed, as compared with acute hepatitis. Although it has been noted that there is a tendency of correlation between serum level of TM and creatinine, remarkable increase of serum TM in acute liver failure was observed in the patients Without renal failure. These results suggest that a increase of serum level of TM predict the development of with acute liver failure. This observation indicated possible involvement of intravascular coagulation in pathogenesis of acute liver failure.
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  • Plasma volatile fatty acids in liver dysfunction, especially after hepatectomy and in surgical liver disorder
    Keiichi HORI
    1992 Volume 33 Issue 2 Pages 153-160
    Published: February 25, 1992
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.33.153
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    We investigated the relationship between blood volatile fatty acids (VFA) and liver failure and liver dysfunction after hepatectomy. Plasma VFA was measured, using gaschromatography. The total VFA value (μmol/l) in peripheral blood are 110.9±20.1 in healthy subjects (n=10), 124.5±32.9 in patients with liver cirrhosis (n=6) and 250.6±131.7 (n=6) in patients with hepatic failure. In hepatic failure, the VFA values are highest, especially propionic acid (C3), caproic acid (C6) and caprylic acid (C8). In patients with liver cirrhosis, the total VFA value inportal blood is abouttwice as high as the value in peripheral blood (p<0.01). The concentration of VFA in peripheral blood showed no significant change after hepatectomy, but C8 increased in early period (p<0.05). In SD rats with liver cirrhosis, the concentration of C3 and C6 is also high. Weconclude that higher blood levels of C3, C6 and C8 may be associated with liver failure.
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  • Rat hepatocyte/in situ nick translation assay as a screening model to detect chemical carcinogens
    Nobuo TSUTSUMI, Kohji MIYAZAKI, Kazumitsu NAGAFUCHI, Kazuhiko DATE
    1992 Volume 33 Issue 2 Pages 161-166
    Published: February 25, 1992
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.33.161
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    Primary cultured hepatocytes have been applied to in situ nick translation method to detect DNA single-strand breaks by chemicals. Dimethylnitrosamine (DMN) and aflatoxin B1 (AFB1) were used as well-known hepatocarcinogens and lysophosphatidylcholine (LPC), phospholipase A2 (PLA2) and lithocholic acid (LCA) were used as suspected carcinogens. DNA damages by DMN, AFB1 and LCA could be detected at higher than 2×10-5M, 1.6×10-7M and 5×10-7M respectively, whereas LPC and PLA2 did not induce DNA damages. Compared with unscheduled DNA synthesis (UDS) and alkaline elution technique, this system is far more sensitive than the former and more simple than the latter. Thus, this assay can be used as a screening model which possesses metabolic activation systems for carcinogenicity of many other chemicals.
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  • A case of hepatocellular carcinoma in primary biliary cirrhosis positive for anti-HCV
    Kojiro HATA, Shosbiro NAGAYAMA, Shigeaki HATAKEYAMA, Showgo OHKOSHI, T ...
    1992 Volume 33 Issue 2 Pages 167-173
    Published: February 25, 1992
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.33.167
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    We report a case of hepatocellular carcinoma (HCC) in primary biliary cirrhosis (PBC) positive for anti-HCV.
    A 63-year-old woman with a history of blood transfusion was admitted to the hospital in April 1986 for hepatic encephalopathy, and diagnosed as liver cirrhosis. Since December 1987 she had been followod up with a dianosis of PBC because of elevated level of alkaline phosphatase, positive for anti-mitochondrial antibody and pruritus. In March 1990 she was readmitted for occurrence of general malaise and elevated level of alpha-fetoprotein. Abdominal US and CT demonstrated two tumors measuring 2.5cm in diameter at S6 and S8 in the liver, and celiac angiography revealed hypervascular lesions in the same areas. Histology obtained from tumor biopsy showed well-differentiated HCC, and laparoscopic liver biopsy showed PBC (Scheuer's stage 4). The test on hepatitis viruses markers was negatiVe for HBsAg but positive for anti-HCV (C-100). HCV infection was confirmed in this patient by positive anti-HCV core and detection of HCV RNA as well as anti-HCV. It was suggested that there were some relations between the chronic HCV infection and the occurrence of HCC in PBC.
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  • Consecutive follow up of liver volume change measured by computed tomography in a survived case of idiopathic acute fatty liver of pregnancy
    Toshio IBE, Masayasu MATSUMURA, Shigenori TAMAJU, Yuji KOJIMA, Jiro IK ...
    1992 Volume 33 Issue 2 Pages 174-181
    Published: February 25, 1992
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.33.174
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    A 36-year-old woman, gravida 3, para 3, was noticed jaundice and consciousness disturbance in 38th week gestation. At the hospital day 2, the liver volume measured by computed tomography showed atrophic size; about 703cm3, then it was rapidly turned to normal size; about 1390cm3, at the hospital day 8. The liver specimen obtained at the hospital day 12 showed almost the absence of necrosis. This liver volume change was probably due to the alteration of individual liver cells from atrophic to normal size.
    The liver function was improved in parallel with the enlargement of the liver volume. Therefore, we emphasize that the serial measurement of liver volume by computed tomography is useful for the judgement of the prognosis of IAFLP.
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  • A case of hepatocellular carcinoma with a huge portal-systemic shunt via the inferior mesenteric vein and liver cirrhosis
    Shigekazu TAKEMURA, Hiroaki KINOSHITA, Kazuhiro HIROHASHI, Shoji KUBO, ...
    1992 Volume 33 Issue 2 Pages 182-186
    Published: February 25, 1992
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.33.182
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    We reported a resected case of hepatocellular carcinoma (HCC) with a huge portal-systemic shunt via the inferior mesenteric vein (IMV) and liver cirrhosis.
    Laboratory data showed the disturbance of liver function. However the patient has had no hepatic encephalopathy and gastro-intestinal bleeding. The percutaneous tanshepatic portography revealed the backflow to inferior vena cava via IMV. Thereafter we performed hepatectomy for HCC without ligation of IMV after the measurement of portal blood flow by ultrasonic transient flowmeter. Postoperative clinical course was good without the appearance of hepatic encephalopathy and esophageal varices.
    As a result, ligation of the huge shunt is not indicated if the patient has diffuse liver disease without hepatic encephalopathy and gastro-intestinal bleeding, because the other collateral pathways may be getting worse by the ligation of the shunt.
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  • Hepatic graft-versus-host disease in a patient without engraftment after allogenic bone marrow transplantation
    Kenichi OTOSHI, Nobuyuki ONAKA, Nobuo IWATA, Masahiro HARA, Nobuyuki O ...
    1992 Volume 33 Issue 2 Pages 187-190
    Published: February 25, 1992
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.33.187
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    A case of acute graft-versus-host disease (GVHD) following unengrafted bone marrow transplantation (BMT) is reported, an occurrence that has not been documented previously. Bone marrow unengraftment is unusual, and marrow engraftment generally precedes GVHD occurring after BMT. Our patient developed liver dysfunction associated with right upper quadrant pain and jaundice after allogenic BMT.
    Histological examination showed hepatic GVHD, but the clinical manifestations were compatible with hepatic venoocclusive disease. Thus, when severe liver dysfunction occures following unengrafted marrow transplantation, it is necessary to consider the possibility of hepatic GVHD.
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  • Demonstration of apoptosis (programmed cell death) in rat hepatoma tissue transplanted in the muscle
    Kazunori FUKUDA, Masamichi KOJIRO
    1992 Volume 33 Issue 2 Pages 191-192
    Published: February 25, 1992
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.33.191
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  • High incidence of hepatocellular carcinoma in the endemic area for hepatitis C virus
    Hajime TOKITA, Masaru SHIMIZU, Mineo KOJIMA, Fumio TSUDA
    1992 Volume 33 Issue 2 Pages 193-194
    Published: February 25, 1992
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.33.193
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese]
    1992 Volume 33 Issue 2 Pages 195
    Published: February 25, 1992
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.33.195
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1992 Volume 33 Issue 2 Pages 196
    Published: February 25, 1992
    Released on J-STAGE: January 19, 2010
    DOIhttps://doi.org/10.2957/kanzo.33.196
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    1992 Volume 33 Issue 2 Pages 197-211
    Published: February 25, 1992
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.33.197
    JOURNAL FREE ACCESS
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