Kanzo

[title in Japanese]

[in Japanese], [in Japanese], [in Japanese]

1996 Volume 37 Issue 7 Pages 353-356
Published: July 25, 1996
Released on J-STAGE: July 09, 2009

DOIhttps://doi.org/10.2957/kanzo.37.353

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Relationship between the duration of hepatitis C virus (HCV) infection and the effect of interferon therapy on hepatitis C

Yoshikazu TANAKA, Soichiro MIYAUCHI, Susumu YUYAMA, Kiyotaka KUROSE, A ...

1996 Volume 37 Issue 7 Pages 357-362
Published: July 25, 1996
Released on J-STAGE: July 09, 2009

DOIhttps://doi.org/10.2957/kanzo.37.357

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Several parameters (the difference of HCV genotypes, quantity of KCV-RNA, etc) are known as predictive parameters on the effect of interferon therapy for hepatitis C.
However relationship between the duration of HCV infection and the effect of interferon therapy is unclear.
The aim of our study was to clarify the relationship between the duration of HCV infection and the effect of interferon. Fifty-eight post transfusion hepatis C cases were treated with 192-720 MU of interferon. 14 cases within 3 years period of HCV infection showed high resolution rate (85.7%). 24 cases within 5 years period of HCV infection had 62.5% resolution. In 34 cases with over 5 years period of HCV infection the resolution rate was 26.5%. The group with over 3 years period of HCV infection showed no relationship between the duration of HCV infection and resolution rate.
The analysis by multivariative logistic model revealed that within 3 years period of HCV infection and the difference of HCV genotypes were significantly variable parameters for the effect of interferon therapy for hepatitis C patients.
These result suggest that interferon therapy for hepatitis C cases within 3 years period of HCV infection could be regarded to be a high resolution rate therapy.

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A prospective randamized admininstration of Stronger-Neo-Minophagen C as an adjuvant therapy for chronic hepatitis type C treated with interferon

Yoshiyuki SUZUKI, Kenji IKEDA, Satoshi SAITOH, Masahiro KOBAYASHI, Akk ...

1996 Volume 37 Issue 7 Pages 363-367
Published: July 25, 1996
Released on J-STAGE: July 09, 2009

DOIhttps://doi.org/10.2957/kanzo.37.363

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A prospective randamized trial was conducted to evaluate the efficacy of Stronger-Neo-Minophahgen-C (SNMC) as an adjuvant therapy in the interferon (IFN) treatment for patients with chronic hepatitis type C. Forty eligible patients were randamized into two groups: 20 with IFN alone and 20 with IFN plus SNMC. Normalization of alanine aminotransferase at the end of the treatment was found in 9 patients (45.0%) in the IFN alone group and 13 patients (68.4%) in the IFN plus SNMC group. The aminotransferase values at the first, sixth, and 12th months after the treatment showed no difference between the two treatment groups. Complete response rates showing sustained disappearance of serum HCV-RNA for six months after the treatment were 25.0% (5/20) and 26.3% (5/19) in the IFN alone group and in the IFN plus SNMC group, respectively.

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A clinical-pathological analysis of drug induced hepatitis

Our experience of last 5 years

Junko UMAKOSHI, Toshikazu MASUMOTO, SM Fazle Akbar, Kiyotaka KUROSE, K ...

1996 Volume 37 Issue 7 Pages 368-373
Published: July 25, 1996
Released on J-STAGE: July 09, 2009

DOIhttps://doi.org/10.2957/kanzo.37.368

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To evalute the recent changes in clinical presentation of drug induced hepatitis, we analyzed 72 cases diagnosed histopathologicaly by liver biopsy comparing 42 cases between 1976-1988 and 28 cases between 1989-1994.
The largest proportion of hepatitis was due to antibiotics and followed by drugs for cardiovascular system. It was noteworthy that the herbal medicine caused hepatitis during the last 5 years. Recently the positive rate of lymphocyte blastogenesis by drug and the incidence of eosinophilia have been showing a decreasing tendency (p<0.05). Biochemical findings and clinical symptoms characteristics of allergy are also getting scarce. Thus, it is necessary to reconsider the criteria regarding diagnosis of drug induced hepatitis.

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Effects of prostaglandin E₁ on actin and Ca⁺⁺-ATPase in hepatic sinusoidal endotheliumelectron cytochemical analysis

Hiroaki YOKOMORI, Masayo ODA, Yoshitaka KAMEGAYA, Nobuhiro TSUKADA, Hi ...

1996 Volume 37 Issue 7 Pages 374-381
Published: July 25, 1996
Released on J-STAGE: July 09, 2009

DOIhttps://doi.org/10.2957/kanzo.37.374

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We have reported that PGE₁ enhances bile flow by increasing bile canalicular contractions through Ca⁺⁺-calmodulin-actomyosin system. The present study was designed to elucidate the effects and action sites of PGE₁ on the hepatic microvasculature at the sinusoidal level. Male Wistar strain male were used. PGE₁ was continuously infused for 1hr at 50ng/min/100g b.w. through a mesenteric vein catheter. Hepatic sinusoidal blood flow was measured by laser Doppler flowmetry before and after the beginning of PGE₁ infusion. The sinusoidal endothelial fenestrae (SEF) were observed by scanning electron microscopy. The ultrastructal localizations of the Ca⁺⁺-ATPase activity were observed in rat liver treated with or without PGE₁ by electron cytochemical method of Ando. Hepatic sinusoidal blood flow (before: 39.02±23.23ml/min/100g, after 15min: 55.16±2.36, p<0.05) were increased by PGE₁ infusion with no changes in portal venous pressure and systemic arterial pressure. Morphometric analysis revealed that the SEF were significantly increased in diameter in zone 1 of the PGE₁ infused livers (control: 98.2±42.7nm, PGE₁-infused: 279.7±158.3nm, p<0.001). By transmission microscopy, the microfilaments were evident in the subplasmalemmal region and around the SEF in the hepatic sinusoidal endothelium. These filaments were specifically decorated with heavy meromyosin, providing evidence that they were actin filaments. The Ca⁺⁺-ATPase activity identified on the sinusoidal endothelial plasma membranes was increased by the portal infusion of PGE₁ via a mesenteric vein catheter. In conclusion PGE₁ causes an increase in hepatic sinusoidal blood flow, at least in part, by the relaxation of hepatic sinusoidal endothelial cells, i.e. the actin filamentst-mediated dilatation of SEF possibly due to the extrusion of intracytoplasmic free Ca⁺⁺-through the activation of Ca⁺⁺-pump ATPase on the plasma membranes.

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Case report: Induction of AIH with severe jaundice, high titres of ANAs and elevated transaminase after IFN therapy

Yukitoki IKEHARA, Masahiro AMENOMORI, Yoshihiro FUKUDA

1996 Volume 37 Issue 7 Pages 382-386
Published: July 25, 1996
Released on J-STAGE: July 09, 2009

DOIhttps://doi.org/10.2957/kanzo.37.382

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A 56-year-old female was admitted because of liver dysfunction. Liver biopsy revealed chronic active hepatitis (CAH-2A). All hepatitis virus markers, including HBsAg and HCV (II), were negative, as was antinuclear antibodies (ANAs). Because of her history of blood transfusion and fluctuation of transaminase levels, interferon (HL-BI) therapy was started. After two injections of IFN, transaminase levels elevated, ANA titres rose and jaundice developed. Steroid therapy reduced the symptoms and improved the laboratory findings. This is the first case in which autoimmune hepatitis (AIH) has been induced by just two injections of IFN, although it has been reported from repeated injections of IFN.

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Appearance of creatine phosphokinase-linked immunoglobulin associated with interferon therapy in a case of chronic hepatitis C

Michiyasu YAGURA, Daijiro IGA, Tetsuya MOMOSE, Yoko MITSUHASHI, Hirosh ...

1996 Volume 37 Issue 7 Pages 387-392
Published: July 25, 1996
Released on J-STAGE: July 09, 2009

DOIhttps://doi.org/10.2957/kanzo.37.387

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A 66-year-old woman diagnosed as having chronic hepatitis C was admitted because of laparoscopic examination and interferon (IFN) therapy. The level of transaminase did not normalize during IFN treatment and elevated after stopping of IFN treatment and the serum CPK value also elevated which was suspected of hypothyroidism associated with IFN treatment. The value of TSH, antibodies to thyroid microsomal antigen (MCHA) increased, and the value of T₃ and T₄ were decreased, respectively. Serum CPK isozyme electrophoresis and immunofixation electrophoresis showed CPK-IgA (λ) complex (CPK-linked immunoglobulin). This complex had gradually disappeared without no therapy, following the normalization of the value of CPK, GPT, TSH, T₃ and T₄. Retrospectively, we examined TSH, T3, T4, MCHA, antibodies to thyroglobulin, CPK and its isozyme by using the preserved sera before IFN treatment and three months after IFN treatment which showed all within normal limits or negative. These findings might suggest that IFN treatment induced CPK-linked immunoglobulin independently or associated with hypothyroidism. In patients on IFN therapy showing persistant high level of CPK, CPK-linked immunoglobulin should be considered.

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A case of liver cirrhosis with exaggerated portal vein thrombosis after endoscopic injection sclerotherapy (EIS) for esophageal varices

Yukio OHTSUKA, Nobyuoshi YANAGISAWA, Takeshi OINUMA, Keiko FUJIWARA, A ...

1996 Volume 37 Issue 7 Pages 393-399
Published: July 25, 1996
Released on J-STAGE: July 09, 2009

DOIhttps://doi.org/10.2957/kanzo.37.393

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A 56-years-old cirrhotic female was admitted to our hospital for management of diabetes mellitus. Though portal venous system on ultrasonograpy was unremarkable on admission, a thrombus was detectable in the splenic vein on 50th hospital day. EIS was performed on 100th hospital day for management of ruptured esophageal varices which might be triggered by the spontaneously developed portal thrombus. Thereafter the thrombus rapidly extended to the main portal trunk and intrahepatic portal branches, and liver function became/deteriorated in parallel with development of the portal thrombus. But liver function restored in a short time probably due to the development of collateral hepatopetal flow via cavernous transformation. We speculated that development of the thrombus might be triggered by coagulopathy after the procedure of EIS in this cirrhotic patient. Our case suggests that careful therapeutic selection for management esophageal varices in cirrhotic patient with portal thrombus is needed.

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese]

1996 Volume 37 Issue 7 Pages 400-401
Published: July 25, 1996
Released on J-STAGE: July 09, 2009

DOIhttps://doi.org/10.2957/kanzo.37.400

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...

1996 Volume 37 Issue 7 Pages 402-403
Published: July 25, 1996
Released on J-STAGE: July 09, 2009

DOIhttps://doi.org/10.2957/kanzo.37.402

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