Kanzo
Online ISSN : 1881-3593
Print ISSN : 0451-4203
ISSN-L : 0451-4203
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Volume 57, Issue 6
Displaying 1-6 of 6 articles from this issue
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Review Article
  • The current state of liver regeneration therapy
    Isao Sakaida
    2016 Volume 57 Issue 6 Pages 269-279
    Published: June 20, 2016
    Released on J-STAGE: July 01, 2016
    DOIhttps://doi.org/10.2957/kanzo.57.269
    JOURNAL FREE ACCESS
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    Recent advancements of antiviral agents have enabled control of viral hepatitis. Meanwhile, liver cirrhosis caused by alcohol abuse or nonalcoholic steatohepatitis is continuing to increase; still, many patients with decompensated liver cirrhosis are awaiting liver transplants. Liver transplantation yields dramatic therapeutic effects, but problems such as shortage of donors, surgical invasiveness, immunological rejection, costs limit the number of transplantations. Basic studies and clinical trials of liver regeneration therapy through stem cell transplantation are advancing to supplement this restriction to the number of liver transplants. Clinical trials for liver cirrhosis have mainly utilized autologous bone marrow cells as a source of stem cells. Several recently reported randomized controlled studies have shown the effectiveness of these approaches. However, these studies differed in terms of the cell preparations utilized. Future clinical trials should be standardized in terms of cell numbers and injection route. With the advent of induced pluripotent stem cells, liver regeneration therapy has entered a new phase. The generation of a liver bud from induced pluripotent stem cells was reported, and a concept of organ bud transplantation therapy has been advocated. In Japan, the regulations have been revised to facilitate the implementation of regenerative medicine. These efforts towards early implementation may serve as a model for fast-tracking the implementation of new liver regeneration therapies.
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Original Article
  • The efficacy of transjugular liver biopsy (TJLB); a retrospective analysis
    Takaaki Sugihara, Masahiko Koda, Toshiaki Okamoto, Kenichi Miyoshi, To ...
    2016 Volume 57 Issue 6 Pages 280-286
    Published: June 20, 2016
    Released on J-STAGE: July 01, 2016
    DOIhttps://doi.org/10.2957/kanzo.57.280
    JOURNAL FREE ACCESS
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    Transjuglar liver biopsy (TJLB) has been regarded as an alternative method of percutaneous liver biopsy (PLB). Between 2007 and 2015, 10 patients who were performed TJLB were retrospectively enrolled in this study. The reasons for applying TJLB were coagulation disorder (n=5), ascites (n=4), hyperbilirubinemia (n=1). The median session counts of TJLB were 3 (2-5) times. Histological analysis confirmed the diagnosis in 7 patients (Drug-induced liver injury, Nonalcoholic steatohepatitis, Primary biliary cirrhosis, Tuberculosis, Amyloidosis, Diffuse large B-cell lymphoma, Adult T-cell Leukemia/Lymphoma). The median number of fragmentation was significantly larger in TJLB [6 (1-16) vs 2 (1-3)] (p=0.009). However the several sessions of the TJLB enabled us to gain the larger tissue length and similar area [17.7 (9.2-11.8) mm compared to those of PLB [15 (3.8-10.4) mm] (p=0.06) [21.1 (6-64) mm2 vs 24.4 (7.3-32.6) mm2]. In conclusion, TJLB was safely performed on the patients with hepatic failure and was useful tool for diagnosis.
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Case Report
  • A case of spontaneously regressive inflammatory pseudo-tumor in multiple organs (liver, lung, kidney)
    Shunzo Ikarashi, Atsunori Tsuchiya, Ohki Nakano, Yousuke Motai, Takash ...
    2016 Volume 57 Issue 6 Pages 287-294
    Published: June 20, 2016
    Released on J-STAGE: July 01, 2016
    DOIhttps://doi.org/10.2957/kanzo.57.287
    JOURNAL FREE ACCESS
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    A 76-year-old woman with rheumatoid arthritis was referred to our hospital with multiple tumors in the liver, lung and kidney, which were detected by abdominal ultrasonography and enhanced computed tomography. Further, the tumor in the right lobe of the liver was diffusely and slightly enhanced, and seemed to be invading the right kidney. Although the tumors had already decreased in size by the time of admission, we performed needle liver biopsy to rule out malignancy. Pathological findings revealed severe scarred lesions with inflammatory cell invasion. Follow-up ultrasonography and CT showed a decrease in size of all the tumors, apparently with time. Based on pathological findings and serial shrinkage of the tumors in imaging modalities, the patient was diagnosed with inflammatory pseudo-tumor (IPT). While cases of IPT in one or two organs have been previously reported, to the best of our knowledge, this is the first case report of IPT in three organs.
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