In 1935 H. S. Mitchell and W. M. Dodge found that hyperglycemia, glycosuria and cataract have developed in rats given diets containing high percentage of lactose. Its pathogenesis, however, has not yet been cleared.
Prof. Tokumitsu and his collaborators, from the results of various experiments, have emphasized the possibility that in generalized diseases the active substance, which causes the main symptoms of these diseases, and which is produced from the functionally, i. e., quantitatively or qualitatively aberrant organs, may be found in the blood.
From such a viewpoint the author, using the blood sugar level as indicator, attempted to examine the pathogenesis of Lactose Diabetes in rats fed on diets containing 70% lactose.
The results are briefly as follows:
1) The fasting blood sugar level of the rats fed on lactose diets, after the earlier stage of hypoglycemia, becomes hyperglycemia, and at this time glycosuria is observable.
2) Hypoglycemia of these rats seems to be caused by the quantitative increase of insulin in the peripheral blood, which is probably due to the hyperfunction of the islets of Langerhans of pancreas.
3) The above mentioned hyperglycemia is actively caused by the hyperglycemia producing substance which comes out of the qualitatively aberrant adrenal cortex. In this case, medulla does not play and important part.
This hyperglycemia producing substance proves to be a steriod.

抄録全体を表示

We measured the urinary 17-KS about 20 cases of Diabetes mellitus by Zimmermann-Masuda's methode, the results were following-15 cases were decreased, especially in cases of combined with hepatic hypofunction and pulmonary tuberculosis.
The results of experimental alloxan-diabetic rabbits were following: excretion of urinary 17-KS in diabetic phase were increased and turned to proximately normal in recovering phase.
Therefore we suppose that in diabetic patients pituitary-adrenal axis is disturbed and in alloxan-diabetic rabbits the urinary 17-KS are increased as a signe of the general addaptation syndrom for the diabetogenic impulse.

抄録全体を表示

At our department the skin is regarded as an endocrinic organ that secretes the hormone “Esophylaxin”.
Many biological works about “Esophylaxin” had been already reported and the subject is still continued to be studied.
Intending to clarify the relation between the functions of the adrenal cortex and those of the skin, the author investigated how the skin is influenced upon when the adrenal cortex is damadged and when it is promoted its functions, using methylene blue disappearing reaction, quaddel resorption time, salicylic acid percutaneous resorption test, catalase count in the skin and tissue respiration of the skin as the standard of measuring.
In these experiments, the rabbit is used as material.
The results obtained run as follows.
1. When the functions of the adrenal cortex are destroyed cauterizing about half of the bilateral sides of the adrenal or by extirpating one side of the adrenals as well as cauterizing about half of the of the other, it is found that the skin functions are essentially rather elevated in about 24 hours after procedure.
2. When the functions of the adrenal cortex are promoted with injection of strong-Interenin, Cortisone or ACTH, it is found that the skin functions are elevated for once, but after 24 hours after injection they are essentially rather diminished at any case except that of ACTH injection.
When ACTH is injected they are both elevated in 8 hours and in 24 hours after injection.
3. In the case of double plantations of the adrenal cortex, the functions of the skin show the same results as in the case of Iaterenin, namely, they are diminished.

抄録全体を表示