巻号一覧
前身誌
67 巻, 6 号
選択された号の論文の6件中1～6を表示しています
- |<
- <
- 1
- >
- >|
-
佐々木 悠, 白日 高歩, 鈴木 九五, 栄本 忠昭, 奥村 恂1991 年 67 巻 6 号 p. 655-665
発行日: 1991/06/20
公開日: 2012/09/24
ジャーナル フリーThis is a report of a quite rare case of occult papillary carcinoma of the thyroid in which the initial clinical manifestation was a solitary lung metastasis.
A 58-year-old woman was referred to the Fukuoka University Hospital because a coin lesion approximately 5cm in diameter was detected in the right lower lobe of the lung by routine roentgenographic examination. This abnormal finding by chest X-ray had been pointed out about fifteen years before. Although she did not remember the exact size of the lung tumor, it had grown minimally since that time. Otherwise, she had been in good health all her life. No abnormalities in clinical and laboratory tests were found on admission. The tumor was clinically suspected to be of benign nature (probably sclerosing hemangioma), and pulmonary lobectomy was performed. Microscopic examination of the tumor revealed a papillary carcinoma with focal areas of follicle formation and colloid production, consistent with metastatic thyroid carcinoma. Immunoperoxidase stain for thyroglobulin was strongly positive in the tumor, and this finding confirmed the thyroid origin.
Repeated physical examination of the thyroid gland, thyroid scan, and thyroid function tests were all unremarkable, however, she was closely followed up for two years. Then, a thyroid nodule with cystic change was detected on the ultrasonograrm. The patient underwent a right hemithyroidectomy, disclosing papillary adenocarcinoma histologically.
This case suggests that thyroid cancer should be considered as possible primary site in cases of long-standing coin lesion on chest X-rays in patients without remarkable complaints and in whom the primary site is unknown. A search of the literature has revealed only five cases with occult thyroid carcinoma associated with solitary pulmonary metastasis.抄録全体を表示PDF形式でダウンロード (3458K) -
西野 理一郎, 丸尾 猛, 松尾 博哉, 望月 眞人1991 年 67 巻 6 号 p. 666-681
発行日: 1991/06/20
公開日: 2012/09/24
ジャーナル フリーThe BeWo cell line, derived from choriocarcinoma, produces and releases human chorionic gonadotropin (hCG) and its α-and β-subunits. The authors have already reported that cAMP and EGF stimulated the production and secretion of hCG and its subunits by cultured BeWo cells. Therefore, in order to elucidate the role of signal transduction systems (cAMP-A-kinase system, DG-C-kinase system and Ca2+-calmodulin system) in the regulation of hCG (α, β) synthesis by human choriocarcinoma cells, effects of cholera toxin (CT), an activator of adenylate cyclase, phorbol 12-myristate 13-acetate (PMA), a protein kinase C activator, and Ca2+ ionophore A23187, an activator of Ca2+ modulation on hCG (α, β) production and secretion by BeWo cells cultured in a serum-free condition were evaluated. Immunoreactive hCG α, hCG β and hCG in the media and cultured cells were measured by each homologous RIA for hCG α, hCG β and hCG, respectively.
Addition of CT at a concentration of 100ng/ml into the medium caused extreme increases in the cellular levels of hCG α, hCG β and hCG together with remarkable increases in hCG α, hCG β and hCG levels in the medium. This stimulatory effect of CT was first observed on the increase of hCG α levels in cultured BeWo cells and medium at 3h, then observed on the increase of hCG β levels at 6h and was last detectable on the increase of hCG levels in the cultured cells and medium at 12h. Addition of PMA at a concentration of 100ng/ml into the medium caused an increase in the cellular and medium levels of hCG α,hCG β and hCG shortly (3h) after the exposure to PMA. Addition of A23187 at a concentration of 100ng/ml into the medium caused a slight increase in hCG α levels in the medium at 6h without accompanying the increase in those cellular levels. When added together, PMA potentiated the stimulatory effect of CT on hCG α, hCG β and hCG levels in the cultured BeWo cells and medium, while PMA did not potentiate the effect of A23187 in this experimental condition.
These findings suggest that cAMP-A-kinase system plays a major role in the signal transduction of hCG (α, β) synthesis and secretion by BeWo choriocarcinoma cells, and that DG-C-kinase system interacts synergistically with cAMP-A-kinase system in the regulation of hCG (α, β) synthesis and secretion by BeWo cells. Ca2+-calmodulin system appears to participate in the regulation of hCG α secretion without affecting the synthesis of hCG (α, β) in BeWo cells.抄録全体を表示PDF形式でダウンロード (1360K) -
工藤 千佳, 菊池 健次郎, 山地 泉, 小早川 洋, 山本 真根夫, 島崎 優, 坂本 孝志, 和田 篤志, 沢井 仁郎, 向 博也, 飯 ...1991 年 67 巻 6 号 p. 682-691
発行日: 1991/06/20
公開日: 2012/09/24
ジャーナル フリーRecently, we reported that the blunted natriuretic ability related to an attenuation of renal dopaminergic activity might play an important role in the hypertensive mechanisms of overweight patients with essential hypertension. On the other hand, the interrelationships between obesity, blood pressure and renal sodium handling in normotensives (NT) have not been clear. The purpose of the present study is to reveal the role of renal dopaminergic activity on renal sodium handling in overweight NT.
The study consisted of 52 hospitalized NT receiving a regular diet containing 200mEq of sodium, 75mEq of potassium, 2400kcal/day, who were divided into two groups of 31 non-obese (NNT) and 21 obese (ONT) subjects. NNT was categorized as the body mass index (BMI) less than, and ONT as the BMI equal to or more than, 25kg/m2. In the early morning, after overnight fasting, all subjects remained in a supine state and were examined for renal clearance. During the clearance period, mean arterial pressure (MAP), heart rate (HR), endogenous creatinine clearance (Ccr), urinary excretion of sodium (UNaV), fractional excretion of sodium (FENa) and of inorganic phosphorus (FEp) and urinary excretion of free dopamine (uDA) were determined.
There were no significant differences in age, HR, Ccr or UNaV between the two groups. Higher MAP and lower FENa were observed in ONT than in NNT, but the differences in these parameters were not statistically significant. However, FENa in ONT was significantly lower than in MAP-and Ccr-matched NNT. In addition, FENa correlated negatively with BMI in ONT, unlike in NNT. MAP was correlated positively with FENa, and a similar tendency was found between MAP and FEp in NNT, but not in ONT. On the other hand, there was no significant correlation between BMI and uDA in either NNT or ONT. This result was different from our previous data in patients with essential hypertension (EHT) in which BMI correlated with uDA positively in non-obese EHT and negatively in obese EHT.
These findings suggest that blunted natriuretic ability may exist in ONT, and the role of renal dopaminergic activity related to the attenuated natriuretic ability in ONT may be less important than in obese EHT.抄録全体を表示PDF形式でダウンロード (964K) -
岩佐 秀一, 大東 茂樹, 小崎 俊男, 清水 幸子, 小松崎 一則, 橋野 正史, 斎藤 裕, 矢内原 巧1991 年 67 巻 6 号 p. 692-701
発行日: 1991/06/20
公開日: 2012/09/24
ジャーナル フリーNineteen-hydroxyandrostenedione (19-OHA) is considered to be an obligatory intermediate of estrogen synthesis. To clarify the role of 19-OHA in the human ovary, the following experiments were undertaken. Ovarian and peripheral vein blood in mid follicular and luteal phase were obtained from 14 women during gynecological surgery. The concentrations of androstenedione (A), testosterone (T), 19-OHA, estrone (E1) and estradiol (E2) were measured by gas chromatography mass spectrometry using deuterium-labeled steroids as internal standard. The effect of human chorionic gonadotropin (hCG) on those steroids was also studied in mid luteal phase. The concentrations of 19-OHA in ovarian vein were 1.20±0.16ng/ml (mean±SE) in mid follicular and 0.78±0.18ng/ml in mid luteal phase. The steroid levels measured in ovarian vein were significantly higher than those in peripheral vein. Though the administration of hCG in mid luteal phase enhanced A and E2 levels in ovarian vein, the levels of T, 19-OHA and E1 were not altered. Significant correlation between the levels of E2 and A was observed while none of the steroids correlated with 19-OHA. These results suggest, for the first time, that 19-OHA is produced and secreted from the human ovary. The question as to the physiological and biosynthetic role of ovarian 19-OHA has to be answered in the future.抄録全体を表示PDF形式でダウンロード (808K) -
野津 和巳, 岡 暢之, 古家 寛司, 加藤 讓1991 年 67 巻 6 号 p. 702-709
発行日: 1991/06/20
公開日: 2012/09/24
ジャーナル フリーThe incidence of abnormal thyroid function related to autoimmune disorders was examined in a district of Shimane Prefecture in 1988. Thyroid microsomal antibodies (MCPA) in sera were measured in a general population of 1,646, including 678 males and 968 females, aged 57.8±14.8 (mean±SD) yr. MCPA titer was defined as high (<1:128), low (1:16, 1:32, 1:64) or negative (<1:16) according to the highest dilution of test serum capable of agglutinating gelatin particles coated with the appropriate antigen. Test of MCPA revealed high titers in 141 subjects (group A), low in 43 subjects (group B) and negative in 1,462 (group C). Twenty-four patients with overt thyroid disorders were found in groups A and B: five with Graves' disease, two with Hashimoto' s thyroiditis and 15 with goiter in group A, and two with goiter in group B. In the remaining 119 subjects in group A and 41 subjects in group B, serum free T4 (FT4) and TSH levels were measured. According to abnormalities in the levels of serum FT4 and/or TSH, their thyroid function was divided into the following 3 subgroups: 1) hyperthyroid (FT4>2.0ng/dl, TSH<0.4μU/ml), 2) latent hypothyroid (0.8<FT4<2.0ng/dl, TSH>5.0μU/ml) and 3) hypothyroid (FT4<0.8ng/dl, TSH>5.0μU/ml). The hyperthyroid group consisted of two patients in group A and one in group B. Ten latent hypothyroid patients were found in group A and two in group B. Hypothyroidism was found in four patients in group A. The incidence of abnormal thyroid function was not different between group A (16 out of 119, 13.4%) and group B (three out of 41, 7.3%). Graves' disease and primary myxedema were found in one patient each in group B; these patients had no subjective symptoms but showed low titers of MCPA. These findings suggest that not only high titers of MCPA but also low titers of MCPA are closely related to abnormal thyroid function.抄録全体を表示PDF形式でダウンロード (719K) -
宮川 善二郎, 千葉 博, 平戸 久美子, 細川 隆, 石塚 雄作, 矢内原 巧1991 年 67 巻 6 号 p. 710-720
発行日: 1991/06/20
公開日: 2012/09/24
ジャーナル フリーThe serum prolactin levels in human girls are thought to be increased gradually throughout puberty, but some authors have reported that prolactin decreases transitorily before menarche. Prolactin has not been shown to play a significant role on the initiation of human pubertal development. However, in immature female rats, it is thought that prolactin is one of the most important hormones during sexual maturation.
In experiment I, the serum concentrations of prolactin, estradiol (E2) and dehydroepiandrosterone-sulfate (DHA-S) in immature female rats were measured. Prolactin increases gradually before vaginal opening and tends to decrease after vaginal opening, while E2 increases throughout sexual maturation. No significant changes were noticed in DHA-S levels.
In experiment II, sulpiride, which raises serum prolactin level, was injected daily in to 4 groups of immature female rats starting from 14, 21, 28, and 35 days of age till the day before vaginal opening. Physiological saline solution was injected daily in to age-matched controls. On the day of vaginal opening, serum levels of prolactin, E2 and DHA-S were studied, weights of bodies and internal genital organs were measured, and corpora lutea of the ovaries were inspected.
Vaginal opening was accelerated in the group of rats injected with sulpiride 5mg every morning from 14 days of age (p<0.05).
The weights of their bodies and internal organs were less than those of the control rats (p<0.05). Percent of ovaries which contained corpora lutea were lower than the controls. Although their serum levels of prolactin tended to be supressed, three hormone levels were not different from those of control rats on the day of vaginal opening. However, when mean prolactin levels were depicted on the day of vaginal opening in both groups, a peak was noticed at 37 days of life, indicating that the secretion pattern of this hormone has been programmed according to the day of life. There was a close relation between prolactin and DHA-S levels (p<0.05). No significant relation between prolactin and E2 levels was noticed.
The possible role of prolactin and DHA-S on the regulation of sexual development is suggested. To our knowledge,this is the first demonstration of a significant relation between prolactin and DHA-S in immature female rats.抄録全体を表示PDF形式でダウンロード (986K)
- |<
- <
- 1
- >
- >|