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40 巻, 10 号
選択された号の論文の8件中1～8を表示しています
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百瀬 剛一1965 年 40 巻 10 号 p. 1267-1268,1253
発行日: 1965/01/20
公開日: 2012/09/24
ジャーナル フリーPDF形式でダウンロード (318K) -
1965 年 40 巻 10 号 p. 1269-1302
発行日: 1965/01/20
公開日: 2012/09/24
ジャーナル フリーPDF形式でダウンロード (3647K) -
中島 博徳, 倉持 正昭, 堀口 東司1965 年 40 巻 10 号 p. 1303-1307,1255
発行日: 1965/01/20
公開日: 2012/09/24
ジャーナル フリー被検血清に95% ethanolを加えてTBPを崩壊し, 蛋白より遊離したT4溶液を得, 標準血清を加えて従来の131I-T3resinuptakeの方法にて摂取率を測定, これと既知段階濃度のT4溶液につき同様にして得たresin摂取率の標準曲線とを対比し, 更に回収率で補正して, 求める血清T4濃度を得る.抄録全体を表示PDF形式でダウンロード (541K) -
第3報 先天性副腎過形成による副腎性器症候群の尿中性17-KS分画値について遠藤 治郎1965 年 40 巻 10 号 p. 1308-1318,1257
発行日: 1965/01/20
公開日: 2012/09/24
ジャーナル フリーThe urinary neutral 17-ketosteroids of eleven patients with congenital adrenal hyperplasia, of which 3 were of hypertensive form and 8 were of simple virilizing from, were fractionated on a gradient elution chromatographic column.
The urinary 17-ketosteroid excretion patterns seen in the first family members, consisting of parents, two unaffected children, two affected children and a patient's female baby, and seen in the second family members, of parents, an unaffected child and two affected children were also studied.
The findings are summerized as follows :
1) The urinary excretion of 11-deoxy-17-ketosteroids, especially of both androsterone and etiocholanolone were elevated in all eleven patients with congenital adrenal hyperplasia, but the excretion of dehydroisoandrosterone was elevated in only two cases of the simple virilizing form. In the simple virilizing from, the excretion of 11β-hydroxyandrosterone and 11-oxoetiocholanolone was elevated in all cases, whereas that of 11β-hydroxyetiocholanolone varied by cases, being normal, below normal or even zero in some instances. In the hypertensive form, the excretion values of individual 11-oxy-genated 17-ketosteroids were below normal or normal and therefore a significant decrease in the ratio of 11-oxygenated 17-ketosteroids to 11-deoxy-17-ketosteroids was observed.
2) An abnormal fraction, which is eluated into the more polar fraction than that of 11β-hydroxyetiocholanolone on the author's gradient elution chromatogram, was observed in the majority of patients with congenital adrenal hyperplasia of simple virilizing form. Eluant of this fraction indicates no characteristics of 17-ketosteroid by the Zimmermann reaction. This fraction was not found on the chromatogram in the patients of hypertensive form.
3) After zinc-Corticotropin stimulation in two cases of the simple virilizing form, increased excretion of individual 11-deoxy-17-ketosteroids and less increased excretion of individual 11-oxygenated 17-ketosteroids were seen. With SU4885 administration in four cases of this form, variable increases in the excretion of 11-deoxy-17-ketosteroids and remarkable decreases in the excretion of 11-oxygenated 17-ketosteroids, especially of 11β-hydroxyandrosterone and 11-oxoetiocholanolone, were observed.
4) A patient with congenital adrenal hyperplasia of simple virilizing form who became pregnant showed no definite increase in excretion of both androsterone and etiocholanolone during gestation and after delivery although glucocorticoid administration was omitted when the patient was known to be pregnant.
5) In the first family, all members except two affected children showed normal urinary excretion for total 17-ketosteroid. However, the father showed an abnormally high 11-oxy-AND/11-oxy-ETIO ratio and a sister showed an increased excretion of predehydroisoandrosterone fraction. The mother and a patient's female baby showed a normal excretion pattern of all 17-ketosteroids. In the second family, the father, mother and a brother showed a normal excretion pattern of all 17-ketosteroids and normal responses to SU4885 administration.抄録全体を表示PDF形式でダウンロード (1457K) -
第4報 クッシソグ症候群ならびに肥満症の尿中性17KS分画値について遠藤 治郎1965 年 40 巻 10 号 p. 1319-1326,1259
発行日: 1965/01/20
公開日: 2012/09/24
ジャーナル フリーThe urinary neutral 17-ketosteroids in four patients with Cushing' syndrome due to adrenocortical adenoma, 5 patients with the syndrome due to bilateral adrenocortical hyperplasia and 9 patients with simple obesity were fractionated on a gradient elution chromatographic column.
For Cushing's syndrome of two cases due to adenoma and of two cases due to hyperplasia, administration of SU4885 or SU8874, Corticotropin and large doses of dexamethasone were performed and individual 17-ketosteroid responses were also studied. For simple obesity, administration of SU4885 in one case, of Corticotropin in three cases and of dexamethasone in one case were performed and individual 17-ketosteroid response were studied. The findings obtained were as follows.
1) In Cushing's syndrome, a low excretion of individual 11-deoxy-17-ketosteroids in cases of adenoma and normal or above normal exretion in cases of hyperplasia were observed. However, the AND/ETIO ratio was below normal in all patients studied.
2) In general, an increase in excretion of 11-oxygenated 17-ketosteroids, especially of 11β-hydroxyetiocholanolone was observed in cases due to hyperplasia, while it was upper border or above normal in cases due to adenoma. Therefore the ratio of 11-oxygenated 17-ketosteroids to 11-deoxy-17-ketosteroids showed a significant elevation in cases due to adenoma.
3) Following SU4885 or SU8874 administration, the excretion of 11-oxygenated 17-ketosteroids was decreased in cases of both adenoma and hyperplasia, while the excretion of 11-deoxy-17-ketosteroids was increased in cases due to hyperplasia and unchnaged to control in cases due to adenoma.
In cases due to hyperplasia, the excretion of individual 11-oxygenated 17-ketosteroids was markedly increased following corticotropin administration and was markedly decreased following the administration of large doses of dexamethasone. In cases due to adenoma, no definite changes in excretion of individual 11-oxygenated 17-ketosteroids to the control excretions were observed following the administration of corticotropin and dexamethasone.
4) In simple obesity, the excretion of individual 17-ketosteroids was within the normal range in the majority of cases. However, the excretion etiocholanolone was lower than that of androsterone and the AND/ETIO ratio tended to be elevated. Following corticotropin administration, responses of 11-deoxy-17-ketosteroids were less in two out of three cases. Following SU4885 and dexamethasone administration, responses of individual 17-ketosteroids were normal.抄録全体を表示PDF形式でダウンロード (1032K) -
河原 健1965 年 40 巻 10 号 p. 1327-1344,1261
発行日: 1965/01/20
公開日: 2012/09/24
ジャーナル フリーCatecholamine, as well as adrenal cortical hormone, has been recently recognized as indispensable to maintain the homeostasis of the circulatory system. There are few reports about the relation between adrenal cortical hormone and catecholamine in bilateral adrenalectomized patient. In this paper, the urinary output of catecholamine before and after adrenalectomy was investigated and the effects of cortisone, ACTH, and DOCA on urinary catecholamine excretion were also studied.
The results were as follows :
1) Adrenaline excretion decreased one third or one fifth of normal value after the bilateral adrenalectomy, and, even three years after the operation, the excretion still remained at low level. It is noteworthy that the urinary excretion of adrenaline was always found after the operation in all cases, although the quantity was small. It might be supposed that the persistent adrenaline is derived from chromaffine cells other than adrenal medulla.
2) On the other hand, the excretion of noradrenaline was about twice as much of that before the bilateral adrenalectomy at one month after the operation, and it rose up to three or four times at three months after surgery. But this elevated value declined again to normal level in about six or twelve months later.
3) The urinary excretion of noradrenaline, that increased after the bilateral adrenalectomy, was significantly decreased by cortisone, whereas there was no change by DOCA. These findings suggest that the excretion of noradrenaline is mostly influenced by glucocorticoid rather than mineralocorticoid.
4) The blood pressure was labile immediately after the bilateral adrenalectomy, but stabilized four days after the operation by a proper supply of corticoids. Only nine of twenty four cases required noradrenaline in order to maintain normal blood pressure during the operation ; none of the cases required it four days after the operation. The above results lead to the conclusion that the replacement therapy in adrenalectomized patients does not require catecholamine substitution.
5) The blood pressure fell markedly after the withdrawal of corticoid replacement therapy in bilateral adrenalectomized patients. It reterned to normal level by the administration of corticoids. Pressor effects of noradrenaline was slight in adrenalectomized patients, whereas the effect was increased by the combined administration of noradrenaline and glucocorticoid. These facts suggest that the role of noradrenaline is synergistic with corticoids.
6) The response of blood pressure to subcutaneous administration of noradrenaline was depressed soon after the bilateral adrenalectomy but it returned gradually to normal. This may be one of the reasons why the urinary excretion of noradrenaline increased after the adrenalectomy.抄録全体を表示PDF形式でダウンロード (1998K) -
II.蛋白同化Steroidおよび各種Steroid投与のラット骨に及ぼす影響西田 悦郎1965 年 40 巻 10 号 p. 1345-1357,1263
発行日: 1965/01/20
公開日: 2012/09/24
ジャーナル フリーStudies were made on the effects of protein anabolic steroids and other steroids on the growth of bone in female and castrated male rats. Thiry-five female and 45 male rats were respectively divided into 7 and 9 groups, each containing 5 animals. Male rats were castrated, and 3 weeks after the castration treatment was started.
The steroids administered were as follows 19-Nortestosterone decanoate (19-N.T.D.) [5mg per 10 days], 4-Chlorotestosterone acetate (4-Cl.T.A.) [1 mg daily], 4-Hydroxy-17α-methyltestosterone (OH-M.T.) [1mg daily], Testosterone propionate (T.P.) [1mg daily], Testosterone enanthate (T.E.) [2.5mg per 10 days], Estradiol benzoate (ED.B.) [50μg daily], Estradiol dipropionate (ED. D.P.) [0.5mg per 10 days], 17α-Hydroxyprogesterone capronate (H.P.C.) [6mg per 10 days], Cortisone acetate (C.A.) [2.5mg per 3 days], Dexamethasone phosphate (D.M.P.) [0.1mg per 2 to 3 days].
Food and water were supplied ad libitum, and treatments were performed during one month. Rats were sacrificed by exsanguination under ether anesthesia, and femora, adrenals, ovaries and the thymus were cleaned and weighed. Femora were radiographed, and were dried at 80°C overnight, and weighed again.
Results obtained were as follows : In the group of sexually mature and growing female rats receving T.E. or 19-N.T.D., the average value of dry weight of femora were remarkably higher than those in controls. Under the conditions of the present experiment, the administration of moderate and suitable doses of anabolic steroids and androgens induced a marked hypertrophy of bone and seemed not to inhibit the increase of the length of bone. In the rats treated with T.E. the weight of the ovaries and adrenals decreased, and in the group receiving 19-N.T.D. their weight decreased slightly.
The administration of esrogens produced a marked retardation in growth of bone and induced hypertophy of adrenals and atrophy of ovaries. There were no significant differences between the weights of bone, ovaries and adrenals in rats treated with progesterone and those in controls.
Corticosteroids remarkably inhibited the growth of bone in rats, and increased the weight of ovaries. Relationships between the growth of bone and adrenal, ovary and thymus were discussed.抄録全体を表示PDF形式でダウンロード (1857K) -
尿抽出物中のindividual free corticoidsおよびtetrahydrocompounds並に副腎静脈血中corticoidsの分離定量について鈴木 英生1965 年 40 巻 10 号 p. 1358-1363,1264
発行日: 1965/01/20
公開日: 2012/09/24
ジャーナル フリーI have found an excellent method by means of T.L.C. determining aldosterone and other usual corticoids in human urine and adrenal venous blood of dogs.
This method will be strongly recommended for its speediness (only 2-3 days), high recovery rate, (average : over than 85%), convenience and economy, particulary as routine work in the clinical laboratory.抄録全体を表示PDF形式でダウンロード (874K)
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