巻号一覧
前身誌
68 巻, 11 号
選択された号の論文の8件中1～8を表示しています
- |<
- <
- 1
- >
- >|
-
森 崇英, 福岡 正恒1992 年 68 巻 11 号 p. 1151-1157
発行日: 1992/11/20
公開日: 2012/09/24
ジャーナル フリーAlthough it is well established that the pituitary gonadotropins and prolactin are the primary regulators of ovarian function, steroidal and nonsteroidal molecules produced locally in the ovary have been implicated in the modulation of gonadotropin action as autocrine or paracrine regulators. Recent studies suggest that the cells of the immune system play important roles in regulating ovarian function, and the immune regulation of ovarian function has become one of the topics in the field of ovarian physiology. Since it has become clear that the immune factors, cytokines, show a wide range of biological functions, not only on immune cells but also on nonimmune cells, the physiological significance of the resident immune cells, the widespread distribution of which in mammalian ovaries has been known for a long time, has reattracted attention as a third kind of regulator of ovarian function. In this article, current knowledge of the regulatory roles of immune cells as well as the cytokines in ovarian physiology is reviewed.抄録全体を表示PDF形式でダウンロード (775K) -
Estrone SulfateとEstradiol17-Sulfate本庄 英雄, 岡田 弘二1992 年 68 巻 11 号 p. 1158-1166
発行日: 1992/11/20
公開日: 2012/09/24
ジャーナル フリーPlasma ethinylestradiol increases 47.6% when taken with ascorbic acid because of competition in producing sulfate conjugation. Thus the role of sulfates may be important.
Serum and urinary estrone sulfate (E1-S)in pregnancy and non - pregnancy were analyzed. Its serum peak during the menstrual cycle was 2.67±0.37ng/ml (mean±SE) and about ten times that of estradiol -17β. E1-S showed lower levels in malignant tissues of breast cancer and endometrial cancer. Increased sulfatase activity in the malignant tissue hydrolizes E1-S to E1, which may develop the tumors.
Serum estradiol 17-sulfate (E2-17-S) in pregnancy was first measured. As E2-17-S decreased, lipid peroxides increased. E2-17-S is converted to 2-OH or 4-OH E2-17-S, which act as lipid peroxide scavengers. Pregnancy-induced hypertension showed lower levels of E2-17-S. In vitro study using the human endothelial cell of the aorta, E2-17-S and 2-OH E2-17-S strongly suppressed lipid peroxidation, which precedes atheloscrelotic change.抄録全体を表示PDF形式でダウンロード (668K) -
小原 孝男1992 年 68 巻 11 号 p. 1167-1176
発行日: 1992/11/20
公開日: 2012/09/24
ジャーナル フリーPrimary hyperparathyroidism is nowadays not uncommon in Japan. The incidence is considered to be one in every 2,500 to 5,000 persons. Many advances have occurred in diagnosis, localization study, and treatment of the disease. Surgery remains the treatment of choice for patients with primary hyperparathyroidism. Notwithstanding, there are still controversies concerning the management of primary hyperparathyroidism. One of the current disputable points is whether the use of localization study in patients who are undergoing and initial operation is justified or not.
Another is whether unilateral exploration is justified or not. The basic reasons for these persistent controversies is the lack of consensus about incidence of multiglandular hyperplasia or double adenomas. Our observation implies that the incidence of hyperplasia or double adenomas among all the patients with primary hyperparathyroidism in Japan is lower than that in western countries. Since diagnostic accuracy of noninvasive localization studies has recently improved, it seems reasonable to adopt unilateral neck exploration in our country. It is also characteristic in Japan that the incidence of parathyroid carcinoma is relatively high (6%) compared with that reported in many other countries.抄録全体を表示PDF形式でダウンロード (1049K) -
田中 清宣, 福地 総逸1992 年 68 巻 11 号 p. 1177-1187
発行日: 1992/11/20
公開日: 2012/09/24
ジャーナル フリーThe aim of the present study is to explore whether the renal and cardiovascular response to clonidine in type II diabetic patients is different from that in control subjects, and to clarify the role of central α2-receptor in the regulation of cardiovascular response and sodium handling in type II diabetes mellitus (DM).
Thirty-five diabetic inpatients aged 30-71 years (54.1±9.7) and ten control subjects (N) were enrolled in this study after their fasting plasma glucose had been improved. To evaluate the peripheral sympathetic nerve activity, 24-hour urinary catecholamine was measured, and pulse rate (PR) responses to a 30-second standing test was determined. On another day, blood pressure (BP), PR, plasma norepinephrine (PNE), cyclic AMP (p-cAMP), renin activity (PRA), aldosterone (PAC) and growth hormone (p-GH) were measured at 0, 30, 60, 90, 120, 150, 180 minutes following the oral administration of clonidine (150μg). Type II DM were classified as DM with hyper-response (DM-HR, n=12) when their PR decreased after clonidine more than that of N, and if not, they were classified as DM with normal response (DM-NR, n=23).
Urinary catecholamine excretions in type II DM were within the normal range. BP, PNE and p-cAMP were markedly decreased with clonidine in similar fashion in DM-NR, DM-HR and N. The percent changes of PNE were correlated positively with the changes of p-cAMP in both N and DM- NR (r=0.660 and 0.449, respectively), but not in DM-HR. No significant difference in the changes of p-GH (Δp-GH) and J GH (the area under the curve) following clonidine administration was observed in the three groups. The decrease in PR was correlated with neither Δp-GH (N: r=0.082, DM- NR: r=-0.400, DM-HR: r= 0.242) or∫GH (N : r= 0.191, DM-NR: r= 0.382, DM-HR: r= 0.162). The fractional excretion of sodium (FENa) decreased in N (p<0.01), increased in DM-NR (p<0.05) and did not change in DM-HR. The changes of FENa were not correlated with those of PRA and PAC.
These results suggest that there is an abnormal response to the central α2-adrenoceptor stimulation in some diabetic patients exhibiting a normal sympathetic response to standing, and that an abnormal renal sodium handling, probably resulting from altered α- adrenoceptor density in not only the central nervous system but also peripheral tissues, exists in the patients without peripheral sympathetic neuropathy.抄録全体を表示PDF形式でダウンロード (1116K) -
河野 哲郎, 松浦 講平, 本田 律生, 西村 弘, 田中 信幸, 岡村 均1992 年 68 巻 11 号 p. 1188-1196
発行日: 1992/11/20
公開日: 2012/09/24
ジャーナル フリーTo investigate the usefulness of a semi-quantitative assay of urinary luteinizing hormone (LH) for predicting ovulation, the relationship among urinary LH, serum LH, serum estradiol (E2) and ultrasonographic observations of follicles were examined in 32 infertile women (35 cycles) at spontaneous (7), clomiphene (13) or cyclofenil (3) induced or hMG (12) induced cycles. Their urine samples were collected 3 times a day for LH assay, starting from about the 10th cycle day or when follicles having a diameter of 10mm or more were detected to the day of ultrasonographical confirmation of follicle ruptures. In the morning on these days, blood was taken twice daily for LH and E2 determination at intervals of 30 min. In spontaneous cycles, urinary LH was (P<0.001) correlated to a significant extent with the serum LH and E2 levels, and follicle rupture was observed 1.9 days after the urine LH surge. In contrast, there was no significant correlation between the urine LH and serum LH or E2 levels in the ovulation induced cycles. In addition, the period from urine LH positive to follicle rupture was significantly (P<0.05) prolonged in those cycles compared with that in spontaneous cycles. These results suggested that the urine LH determination was good for predicting ovulation in spontaneous cycles, but it was also necessary to monitor the follicle sizes by ultrasonography in ovulation induced cycles.抄録全体を表示PDF形式でダウンロード (807K) -
矢野 公一, 伊藤 善也, 印鑰 史衛, 田口 哲夫, 滝本 昌俊, 奥野 晃正1992 年 68 巻 11 号 p. 1197-1204
発行日: 1992/11/20
公開日: 2012/09/24
ジャーナル フリー甲状腺欠損性の先天性甲状腺機能低下症の姉妹例を経験した。両親の血族結婚はなく, 甲状腺疾患の家族歴もなかった。姉妹とも新生児クレチン症マススクリーニングが行われる以前の出生である。どちらも新生児期から黄疸, 腹部膨満, 便秘等の典型的な先天性甲状腺機能低下症の症状を呈した。T4低下, TSH高値が確認され, 甲状腺剤による治療を開始した。その後の身体発育は正常であった。姉9歳, 妹7歳時に病型診断を行ったところ, 1231甲状腺摂取率はそれぞれ0.69%, 0.64%と著しく低下し,スキャンでも姉妹ともに全く甲状腺は描出されなかった。123I唾液血清比はそれぞれ41.3, 46.3と濃縮障害は認めないことから甲状腺欠損性の先天性甲状腺機能低下症と診断した。姉妹,母親はいずれも甲状腺自己抗体は陰性であった。姉妹ともにHLA A24(9)が陽性であり, 発症に免疫遺伝学的背景の関与がある可能性が示唆された。甲状腺欠損性の先天性甲状腺機能低下症の同胞例としては5家系目, そのうち本邦では2家系目の報告である。抄録全体を表示PDF形式でダウンロード (1094K) -
山岸 昌一, 宮腰 久嗣, 永井 幸広, 大沢 謙三, 小林 健一1992 年 68 巻 11 号 p. 1205-1214
発行日: 1992/11/20
公開日: 2012/09/24
ジャーナル フリーSpuriously high value of serum free triiodothyronine (FT3: Amerlex free T3 kit, Amersham, UK.) was noted accidentally on routine laboratory examination of two clinically euthyroid patients (case 1: FT3; 18.5pg/ml, FT4; 1.1ng/dl, T3; 103ng/dl, T4; 8.2μg/dl, TSH; 1.74μU/ml, case 2: FT3; 8.5pg/ml, FT4; 1.1ng/dl, T3; 137ng/dl, T4; 8.9μg/dl, TSH; 1.45μU/ml), the former with poorly controlled diabetes (FBG 253mg/dl, HbAic 12.1%) and the latter with essential hypertension (184/108mmHg). Although the hypertensive patient showed mild diffuse goiter, there was no evidence that the patients had autoimmune thyroid diseases because anti-thyroglobulin antibody tests measured by radioimmunoassay and MCHA, TGHA or TBII were all negative. Their serum levels of TBG were within the normal range. Further studies revealed that both patients' sera had unusual binding activity to labelled polyaminocarboxy T3 (125I-aT3) but not labelled T3 (125I-T3). Furthermore, this binding protein was precipitated by goat anti-human immunoglobulin G (IgG). The IgG purified from both patients' sera also showed strong binding activity to 125I-aT3, which was inhibited by unlabelled T3 in a dose dependent manner.
In conclusion, we found anti-T3 antibody in two clinically euthyroid patients with no apparent evidence of complicating autoimmune thyroid diseases. The stronger binding activity to polyaminocarboxy T3 rather than T3 may lead to the spuriously high value of serum FT3. The mechanisms of the production of such autoantibodies in our cases should be further investigated.抄録全体を表示PDF形式でダウンロード (789K) -
吉岩 あおい, 名畑 孝, 森本 茂人, 阪口 勝彦, 山懸 英久, 福尾 恵介, 荻原 俊男1992 年 68 巻 11 号 p. 1215-1223
発行日: 1992/11/20
公開日: 2012/09/24
ジャーナル フリーThis report describes a 48-year old female patient with Hashimoto's thyroiditis, distal-type renal tubular acidosis (d-RTA), Sjögren syndrome (SjS), and empty sella syndrome (ESS). She has been receiving replacement of thyroxine for Hashimoto's thyroiditis since 1967. She felt muscle weakness and numbness in the extremities and was found to have low serum potassium (2.9mEq/l) in 1987. Since then she has been administrated potassium chloride orally. She was admitted to our hospital because of recurrence of muscle weakness and numbness of the extremities in November 1990. Laboratory examination revealed that her serum levels of antimicrosomal antibody and anti-thyroglobulin antibody were highly positive (MCHA: x 210 x 100, and TGHA: x 100). Furthermore, she was revealed to have 1) d-RTA by oral tolerance tests with the administration of NH4Cl and NaHCO3, 2) SjS by Schirmer test and sialography, and 3) ESS by computed tomography and magnetic resonance imaging examinations of the pituitary. Association of Hashimoto's thyroiditis, d-RTA, SjS and ESS in this case may possibly be caused by common autoimmune mechanism.抄録全体を表示PDF形式でダウンロード (1543K)
- |<
- <
- 1
- >
- >|